Antonin Weckel, PhD
Postdoctoral Scholar
Dermatology
School of Medicine

Publications (21)

Top publication keywords:
Integrin alpha6beta1Cell AdhesionStreptococcal InfectionsEndometriosisSkinAdhesins, BacterialIntegrin alpha3beta1Bacterial ProteinsBacterial AdhesionStreptococcus pyogenesDeciduaDendritic CellsT-Lymphocytes, RegulatoryComplement C4b-Binding ProteinIntegrin alpha6beta4

• Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation.
  bioRxiv : the preprint server for biology 2023 Dhariwala MO, DeRogatis AM, Okoro JN, Weckel A, Tran VM, Habrylo I, Ojewumi OT, Tammen AE, Leech JM, Merana GR, Carale RO, Barrere-Cain R, Hiam-Galvez KJ, Spitzer MH, Scharschmidt TC
• Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.
  Immunity 2023 Weckel A, Dhariwala MO, Ly K, Tran VM, Ojewumi OT, Riggs JB, Gonzalez JR, Dwyer LR, Okoro JN, Leech JM, Bacino MS, Cho GD, Merana G, Anandasabapathy N, Kumamoto Y, Scharschmidt TC
• A Novel CovS Variant Harbored by a Colonization Strain Reduces Streptococcus pyogenes Virulence.
  Journal of bacteriology 2023 Plainvert C, Rosinski-Chupin I, Weckel A, Lambert C, Touak G, Sauvage E, Poyart C, Glaser P, Fouet A
• FLG Deficiency in Mice Alters the Early-Life CD4+ T-Cell Response to Skin Commensal Bacteria.
  The Journal of investigative dermatology 2022 Gonzalez JR, Celli A, Weckel A, Dhariwala MO, Merana GR, Ojewumi OT, Okoro J, Dwyer LR, Tran VM, Meyer JM, Mauro TM, Scharschmidt TC
• Intestinal inflammation alters the antigen-specific immune response to a skin commensal.
  Cell reports 2022 Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC

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• Streptococcus pyogenes infects human endometrium by limiting the innate immune response.
  The Journal of clinical investigation 2021 Weckel A, Guilbert T, Lambert C, Plainvert C, Goffinet F, Poyart C, Méhats C, Fouet A
• Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.
  Cell reports. Medicine 2020 Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC
• MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
  The Journal of Immunology 2020 Michael G Constantinides, Verena M. Link, Samira Tamoutounour, Andrea C. Wong, P. Juliana Perez-Chaparro, Seong-Ji Han, Y. Erin Chen, Kelin Li, Sepideh Farhat, Antonin Weckel, Siddharth R. …
• Permissive Fatty Acid Incorporation Promotes Staphylococcal Adaptation to FASII Antibiotics in Host Environments.
  Cell reports 2019 Kénanian G, Morvan C, Weckel A, Pathania A, Anba-Mondoloni J, Halpern D, Gaillard M, Solgadi A, Dupont L, Henry C, Poyart C, Fouet A, Lamberet G, Gloux K, Gruss A
• Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
  Cell host & microbe 2019 Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC
• MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
  Science (New York, N.Y.) 2019 Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua …
• Streptococcus pyogenes infects human endometrium by limiting its immune response.
  bioRxiv 2019 Antonin Weckel, Thomas Guilbert, Clara Lambert, Céline Plainvert, François Goffinet, Claire Poyart, Céline Méhats, Agnès Fouet
• The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.
  Frontiers in immunology 2019 Ermert D, Laabei M, Weckel A, Mörgelin M, Lundqvist M, Björck L, Ram S, Linse S, Blom AM
• Permissive Fatty Acid Incorporation in Host Environments Promotes Staphylococcal Adaptation to FASII Antibiotics.
  bioRxiv 2019 Gérald Kénanian, Claire Morvan, Antonin Weckel, Amit Pathania, Jamila Anba-Mondoloni, David Halpern, Audrey Solgadi, Laetitia Dupont, Céline Henry, Claire Poyart, Agnès Fouet, Gilles Lamberet, Karine …
• C4BP-mediated complement evasion in streptococcal infections: How the good guys turn bad.
  Molecular Immunology 2018 Antonin Weckel, Michal Magda, Matthias Mörgelin, Jutamas Shaughnessy, Martin Lundqvist, Peter Rice, Lars Björck, Sara Linse, Sanjay Ram, Anna Blom, David Ermert
• The N-terminal domain of the R28 protein promotes emm28 group A Streptococcus adhesion to host cells via direct binding to three integrins.
  The Journal of biological chemistry 2018 Weckel A, Ahamada D, Bellais S, Méhats C, Plainvert C, Longo M, Poyart C, Fouet A
• Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion.
  Journal of immunology (Baltimore, Md. : 1950) 2018 Ermert D, Weckel A, Magda M, Mörgelin M, Shaughnessy J, Rice PA, Björck L, Ram S, Blom AM
• A new complement evasion strategy: How S. pyogenes exploits IgGs to recruit more C4BP.
  Molecular Immunology 2017 David Ermert, A. Weckel, M. Magda, J. Shaughnessy, J. Kaplan, M. Mörgelin, L. Björck, P.A. Rice, S. Ram, A.M. Blom
• Complete Genome Sequence of Streptococcus pyogenes emm28 Clinical Isolate M28PF1, Responsible for a Puerperal Fever.
  Genome announcements 2015 Longo M, De Jode M, Plainvert C, Weckel A, Hua A, Château A, Glaser P, Poyart C, Fouet A
• Investigating how the highly virulent Streptococcus pyogenes AP1 strain binds and interacts with human C4BP to evade complement attack.
  Molecular Immunology 2013 D. Ermert, A. Weckel, I.-M. Frick, L. Björck, A. Blom
• Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells.
  The Journal of biological chemistry 2013 Ermert D, Weckel A, Agarwal V, Frick IM, Björck L, Blom AM