Anthony Defranco, PhD
Professor Emeritus
Microbiology and Immunology
School of Medicine

Websites

Show all (1) Hide

• Profile at UCSF Cancer Center (cancer.ucsf.edu)

Videos

Show all (1) Hide

• Basic Immunology: Nuts and Bolts of the Immune System (youtube.com)

Grants and Projects

Show all (16) Hide

• Molecular and Cellular Immunology, NIH, 1988-2024
• Organ-specific autoimmunity resulting from two genetic defects in tolerance, NIH, 2018-2023
• B cell TLRs and germinal centers, NIH, 2015-2017
• The role of Apobec3 enzymes in regulation of marginal zone B cells, NIH, 2013-2016
• BCR regulation of antibody responses, NIH, 2014-2015
• Innate immune regulation of inflammation and adaptive immunity, NIH, 2008-2014
• Regulation of B lymphocyte proliferation by antigen, NIH, 1984-2014
• Cell Type-Specific Roles of TLR Signaling In Immune Responses, NIH, 2008-2013
• Regulation of B Lymphocyte Proliferation by Antigen, NIH, 1984-2012
• Immune Tolerance and Autoimmunity, NIH, 1900-2012
• Cytoskeleton and Signal Transduction in Host Defense, NIH, 1994-2010
• Transfusion Biology and Medicine, NIH, 1996-2006
• Regulation of B Lymphocyte Proliferation by Antigen, NIH, 1984-2005
• Lps-induced Signaling in Macrophages, NIH, 1993-2001
• Regulation of Immune System Cells by Bacterial Products, NIH, 1987-1990
• Selective Gene Ablation in Mature B Lymphocytes, NIH, 1998-1900

Publications (164)

Top publication keywords:
Lymphocyte ActivationAcute Coronary SyndromeReceptors, Antigen, B-CellToll-Like ReceptorsMyeloid Differentiation Factor 88Prasugrel HydrochlorideB-LymphocytesToll-Like Receptor 9B-Lymphocyte Subsetssrc-Family KinasesSignal TransductionDendritic CellsImmunoglobulin MAntibody FormationGerminal Center

• Overview of Signal Transduction by Receptors of Immune Cells.
  Reference Module in Life Sciences 2025 Anthony L DeFranco
• Signaling Pathways Downstream of TLRs and IL-1 Family Receptors.
  Reference Module in Life Sciences 2025 Anthony L DeFranco
• Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model.
  Proceedings of the National Academy of Sciences of the United States of America 2024 Yin M, Smith JA, Chou M, Chan J, Jittayasothorn Y, Gould DB, Caspi RR, Anderson MS, DeFranco AL
• Thrombotic risk in patients with acute coronary syndromes discharged on prasugrel or clopidogrel: results from the PROMETHEUS study.
  European heart journal. Acute cardiovascular care 2023 Chiarito M, Cao D, Sartori S, Zhang Z, Vogel B, Spirito A, Smith KF, Weintraub W, Strauss C, Toma C, DeFranco A, Effron MB, Stefanini G, Keller S, Kapadia S, Rao SV, Henry TD, Pocock S, Sharma S, …
• Antithrombotic strategy variability in atrial fibrillation and obstructive coronary disease revascularised with percutaneous coronary intervention: primary results from the AVIATOR 2 international registry.
  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2022 Chandrasekhar J, Baber U, Sartori S, Goel R, Nicolas J, Vogel B, Snyder C, Kini A, Briguori C, Witzenbichler B, Iakovou I, Sardella G, Marzo K, DeFranco A, Stuckey T, Chieffo A, Colombo A, Shlofmitz R…

Show all (159 more) Hide

• Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection.
  The Journal of Immunology 2022 Mianmian Yin, Jennifer A Smith, Marissa Chou, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco
• Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells.
  The Journal of Immunology 2022 Mianmian Yin, Kamir J Hiam, Irina Proekt, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Matthew Spitzer, Mark S Anderson, Anthony L DeFranco
• Correlation of autoantigen-specific Treg frequency with development of spontaneous organ-specific autoimmunity in a mouse model of uveitis.
  The Journal of Immunology 2021 Mianmian Yin, Kamir Hiam, Irina Proekt, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco
• T-cell receptor repertoire of mice with organ-specific autoimmunity resulting from a partial defect in T cell negative selection and dendritic cell enhancement.
  The Journal of Immunology 2021 Mianmian Yin, Jennifer A Smith, Marissa Chou, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco
• The Role of MAP Kinases, Phosphatidylinositol 3-Kinase, and Ceramide in LPS-induced Signaling in Macrophages.
  2020 Anthony L DeFranco, Alexander J Finn, Julie Hambleton, Mary T Crowley, Mary Lee MacKichan, Steven L Weinstein
• Prasugrel use and clinical outcomes by age among patients undergoing PCI for acute coronary syndrome: from the PROMETHEUS study.
  Clinical research in cardiology : official journal of the German Cardiac Society 2020 Chandrasekhar J, Baber U, Sartori S, Aquino M, Moalem K, Kini AS, Rao SV, Weintraub W, Henry TD, Vogel B, Ge Z, Muhlestein JB, Weiss S, Strauss C, Toma C, DeFranco A, Claessen BE, Keller S, Baker BA, …
• Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes.
  ImmunoHorizons 2019 Wigton EJ, DeFranco AL, Ansel KM
• Associations between use of prasugrel vs clopidogrel and outcomes by type of acute coronary syndrome: an analysis from the PROMETHEUS registry.
  Journal of thrombosis and thrombolysis 2019 Ge Z, Baber U, Claessen BE, Chandrasekhar J, Chandiramani R, Li SX, Sartori S, Kini AS, Rao SV, Weiss S, Henry TD, Kapadia S, Muhlestein B, Strauss C, Toma C, DeFranco A, Effron MB, Keller S, Baker BA…
• Use of prasugrel and clinical outcomes in African-American patients treated with percutaneous coronary intervention for acute coronary syndromes.
  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2019 Faggioni M, Baber U, Chandrasekhar J, Sartori S, Weintraub W, Rao SV, Vogel B, Claessen B, Kini A, Effron M, Ge Z, Keller S, Strauss C, Snyder C, Toma C, Weiss S, Aquino M, Baker B, Defranco A, …
• Use of prasugrel vs clopidogrel and outcomes in patients with and without diabetes mellitus presenting with acute coronary syndrome undergoing percutaneous coronary intervention.
  International journal of cardiology 2018 Faggioni M, Baber U, Chandrasekhar J, Sartori S, Claessen BE, Rao SV, Vogel B, Effron MB, Poddar K, Farhan S, Kini A, Weintraub W, Toma C, Sorrentino S, Weiss S, Snyder C, Muhlestein JB, Kapadia S, …
• The prevalence, predictors and outcomes of guideline-directed medical therapy in patients with acute myocardial infarction undergoing PCI, an analysis from the PROMETHEUS registry.
  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2018 Ge Z, Baber U, Claessen BE, Farhan S, Chandrasekhar J, Li SX, Sartori S, Kini AS, Rao SV, Weiss S, Henry TD, Vogel B, Sorrentino S, Faggioni M, Kapadia S, Muhlestein B, Strauss C, Toma C, DeFranco A, …
• Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul.
  Frontiers in immunology 2018 DeFranco AL
• Associations Between Complex PCI and Prasugrel or Clopidogrel Use in Patients With Acute Coronary Syndrome Who Undergo PCI: From the PROMETHEUS Study.
  The Canadian journal of cardiology 2017 Chandrasekhar J, Baber U, Sartori S, Aquino M, Kini AS, Rao S, Weintraub W, Henry TD, Farhan S, Vogel B, Sorrentino S, Ge Z, Kapadia S, Muhlestein JB, Weiss S, Strauss C, Toma C, DeFranco A, Effron MB…
• B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Tian M, Hua Z, Hong S, Zhang Z, Liu C, Lin L, Chen J, Zhang W, Zhou X, Zhang F, DeFranco AL, Hou B
• Associations Between Chronic Kidney Disease and Outcomes With Use of Prasugrel Versus Clopidogrel in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Report From the PROMETHEUS Study.
  JACC. Cardiovascular interventions 2017 Baber U, Chandrasekhar J, Sartori S, Aquino M, Kini AS, Kapadia S, Weintraub W, Muhlestein JB, Vogel B, Faggioni M, Farhan S, Weiss S, Strauss C, Toma C, DeFranco A, Baker BA, Keller S, Effron MB, …
• Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.
  Journal of leukocyte biology 2017 Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P
• Use of prasugrel vs clopidogrel and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention in contemporary clinical practice: Results from the PROMETHEUS study.
  American heart journal 2017 Baber U, Sartori S, Aquino M, Kini A, Kapadia S, Weiss S, Strauss C, Muhlestein JB, Toma C, Rao SV, DeFranco A, Poddar KL, Chandrasekhar J, Weintraub W, Henry TD, Bansilal S, Baker BA, Marrett E, …
• Innate B cells cleave to the marginal zone.
  Nature immunology 2017 DeFranco AL
• Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.
  PloS one 2016 Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL
• LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
  The Journal of clinical investigation 2016 Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL
• Germinal centers and autoimmune disease in humans and mice.
  Immunology and cell biology 2016 DeFranco AL
• MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.
  PLoS pathogens 2016 Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M
• The germinal center antibody response in health and disease.
  F1000Research 2016 DeFranco AL
• Sex-related differences in outcomes among men and women under 55 years of age with acute coronary syndrome undergoing percutaneous coronary intervention: Results from the PROMETHEUS study.
  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2016 Chandrasekhar J, Baber U, Sartori S, Faggioni M, Aquino M, Kini A, Weintraub W, Rao S, Kapadia S, Weiss S, Strauss C, Toma C, Muhlestein B, DeFranco A, Effron M, Keller S, Baker B, Pocock S, Henry T, …
• Triggering of organ-specific autoimmunity through synergy of defects in key tolerance checkpoints.
  The Journal of Immunology 2016 Irina Proekt, Corey Miller, Marion Jeanne, Kayla Fasano, Clifford A Lowell, Douglas Gould, Mark S Anderson, Anthony L DeFranco
• Signaling Pathways Downstream of TLRs and IL-1 Family Receptors.
  Encyclopedia of Immunobiology 2016 Anthony L. DeFranco
• B Lymphocytes: Receptors.
  eLS 2015 Anthony L DeFranco
• APOBEC3 enzymes restrict marginal zone B cells.
  European journal of immunology 2015 Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M
• Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Rookhuizen DC, DeFranco AL
• MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases.
  Journal of Experimental Medicine 2014 Minjia Yu, Hao Zhou, Junjie Zhao, Nengming Xiao, Sanjoy Roychowdhury, David Schmitt, Bingqing Hu, Richard M. Ransohoff, Clifford V. Harding, Amy G. Hise, Stanley L. Hazen, Anthony L. DeFranco, Paul L.…
• MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases.
  The Journal of experimental medicine 2014 Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X
• Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL
• B cell-specific loss of Lyn kinase leads to autoimmunity.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Lamagna C, Hu Y, DeFranco AL, Lowell CA
• Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
  Science signaling 2013 Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL
• Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA
• Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.
  Immunity 2013 Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y
• Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A
• Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells.
  Nature immunology 2012 Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F
• Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control.
  PloS one 2012 Kim CC, Nelson CS, Wilson EB, Hou B, DeFranco AL, DeRisi JL
• Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Wheeler ML, Defranco AL
• Contribution of Toll-like receptor signaling to germinal center antibody responses.
  Immunological reviews 2012 DeFranco AL, Rookhuizen DC, Hou B
• Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Thompson AL, Johnson BT, Sempowski GD, Gunn MD, Hou B, DeFranco AL, Staats HF
• B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.
  Immunity 2012 Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F
• Lyn deficiency affects B-cell maturation as well as survival.
  European journal of immunology 2011 Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R
• Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells.
  European journal of immunology 2011 Gross AJ, Proekt I, DeFranco AL
• Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.
  Nature immunology 2011 Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A
• B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA
• Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV
• Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response.
  Immunity 2011 Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee LM, Coffman RL, Bachmann MF, DeFranco AL
• Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88.
  Blood 2011 Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA
• The antibacterial C-type lectin RegIIIgamma maintains spatial segregation between microbiota and host in the intestine.
  Inflammatory Bowel Diseases 2011 S Vaishnava, K Severson, K Ruhn, J Benjamin, X Yu, B Hu, M Yamamoto, A Defranco, E Wakeland, L Hooper
• Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F
• Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
  The Journal of experimental medicine 2010 Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA
• The B-Cell Antigen Receptor.
  Topley \u0026 Wilson\u0027s Microbiology and Microbial Infections 2010 Anthony L. DeFranco
• Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice.
  European journal of immunology 2010 Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL
• Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL
• "Dangerous crystals".
  Immunity 2008 DeFranco AL
• Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL
• Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms.
  Immunity 2008 Hou B, Reizis B, DeFranco AL
• Lipid rafts and B cell signaling.
  Seminars in cell & developmental biology 2007 Gupta N, DeFranco AL
• Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics.
  Nature immunology 2006 Gupta N, Wollscheid B, Watts JD, Scheer B, Aebersold R, DeFranco AL
• TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements.
  The Journal of biological chemistry 2005 Nishiya T, Kajita E, Miwa S, Defranco AL
• Bcl10 can promote survival of antigen-stimulated B lymphocytes.
  Blood 2005 Tian MT, Gonzalez G, Scheer B, DeFranco AL
• Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors.
  The Journal of biological chemistry 2004 Nishiya T, DeFranco AL
• Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation.
  Molecular biology of the cell 2003 Gupta N, DeFranco AL
• Signaling mutations and autoimmunity.
  Current directions in autoimmunity 2003 Yu CC, Mamchak AA, DeFranco AL
• Making and breaking tolerance.
  Current opinion in immunology 2002 Ohashi PS, DeFranco AL
• Vav and the B cell signalosome.
  Nature immunology 2001 DeFranco AL
• Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells.
  International immunology 2001 Tian MT, Chou CH, DeFranco AL
• Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Richards JD, Davé SH, Chou CH, Mamchak AA, DeFranco AL
• Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.
  Current biology : CB 2001 Yu CC, Yen TS, Lowell CA, DeFranco AL
• B-cell activation 2000.
  Immunological reviews 2000 DeFranco AL
• CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
  Immunity 2000 Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF
• Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta.
  Journal of leukocyte biology 2000 Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL
• Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.
  The Journal of experimental medicine 2000 Fitzer-Attas CJ, Lowry M, Crowley MT, Finn AJ, Meng F, DeFranco AL, Lowell CA
• Cell signaling and cytokine induction by lipopolysaccharide.
  Novel Cytokine Inhibitors 2000 Mary Lee MacKichan, Anthony L. DeFranco
• The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes.
  The Journal of biological chemistry 1999 Harmer SL, DeFranco AL
• Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog.
  The Journal of biological chemistry 1999 MacKichan ML, DeFranco AL
• Positive and negative roles of the tyrosine kinase Lyn in B cell function.
  Seminars in immunology 1998 DeFranco AL, Chan VW, Lowell CA
• Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.
  Current biology : CB 1998 Chan VW, Lowell CA, DeFranco AL
• The role of tyrosine kinases and map kinases in LPS-induced signaling.
  Progress in clinical and biological research 1998 DeFranco AL, Crowley MT, Finn A, Hambleton J, Weinstein SL
• A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.
  The Journal of experimental medicine 1997 Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL
• Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
  Immunity 1997 Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA
• Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.
  Molecular and cellular biology 1997 Harmer SL, DeFranco AL
• The complexity of signaling pathways activated by the BCR.
  Current opinion in immunology 1997 DeFranco AL
• Receptor tails unlock developmental checkpoints for B lymphocytes.
  Science (New York, N.Y.) 1996 Roth PE, DeFranco AL
• The two-headed antigen. B-cell co-receptors.
  Current biology : CB 1996 DeFranco AL
• Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Hambleton J, Weinstein SL, Lem L, DeFranco AL
• Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase.
  The Journal of biological chemistry 1996 Richards JD, Gold MR, Hourihane SL, DeFranco AL, Matsuuchi L
• Assembly of the truncated immunoglobulin heavy chain D mu into antigen receptor-like complexes in pre-B cells but not in B cells.
  Immunity 1996 Horne MC, Roth PE, DeFranco AL
• Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages.
  The Journal of biological chemistry 1996 Crowley MT, Harmer SL, DeFranco AL
• Signal transduction by the B-cell antigen receptor.
  Annals of the New York Academy of Sciences 1995 DeFranco AL, Richards JD, Blum JH, Stevens TL, Law DA, Chan VW, Datta SK, Foy SP, Hourihane SL, Gold MR
• Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events.
  The Journal of experimental medicine 1995 Hambleton J, McMahon M, DeFranco AL
• Tyrosine phosphatases and the antibody response.
  Science (New York, N.Y.) 1995 DeFranco AL, Law DA
• Lymphocyte development. Intrinsic checkpoints for lineage progression.
  Current biology : CB 1995 Roth PE, DeFranco AL
• Transmembrane signaling by antigen receptors of B and T lymphocytes.
  Current opinion in cell biology 1995 DeFranco AL
• Examination of the role of MAP kinase in the response of macrophages to lipopolysaccharide.
  Progress in clinical and biological research 1995 DeFranco AL, Hambleton J, McMahon M, Weinstein SL
• Lymphocyte activation and effector functions Editorial overview.
  Current Opinion in Immunology 1995 Anthony L. DeFranco, Robert L. Coffman
• Structure and Function of the B-Cell Antigen Receptor.
  Lymphocyte Activation 1994 Anthony L. DeFranco, Jonathan H. Blum, Tracy L. Stevens, Debbie A. Law, Vivien W.-F. Chan, Shaun P. Foy, Sandip K. Datta, Linda Matsuuchi
• Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes.
  Current opinion in immunology 1994 DeFranco AL
• A mutation of the mu transmembrane that disrupts endoplasmic reticulum retention. Effects on association with accessory proteins and signal transduction.
  Journal of immunology (Baltimore, Md. : 1950) 1994 Stevens TL, Blum JH, Foy SP, Matsuuchi L, DeFranco AL
• Biochemistry of B lymphocyte activation.
  Advances in immunology 1994 Gold MR, DeFranco AL
• Mechanism of B cell antigen receptor function: transmembrane signaling and triggering of apoptosis.
  Advances in experimental medicine and biology 1994 DeFranco AL, Mittelstadt PR, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L
• Structure and function of the B-cell antigen receptor.
  Chemical immunology 1994 DeFranco AL, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L
• Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction.
  The Journal of biological chemistry 1993 Blum JH, Stevens TL, DeFranco AL
• B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn.
  Current biology : CB 1993 Law DA, Chan VW, Datta SK, DeFranco AL
• Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14.
  Journal of immunology (Baltimore, Md. : 1950) 1993 Weinstein SL, June CH, DeFranco AL
• Signaling the insulin receptor way.
  Current biology : CB 1993 DeFranco AL
• Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line.
  Molecular and Cellular Biology 1993 A M Shapiro, M S Schlissel, D Baltimore, A L DeFranco
• Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line.
  Molecular and cellular biology 1993 Shapiro AM, Schlissel MS, Baltimore D, DeFranco AL
• Induction of early response genes by cross-linking membrane Ig on B lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1993 Mittelstadt PR, DeFranco AL
• Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins.
  Journal of immunology (Baltimore, Md. : 1950) 1993 Gold MR, Crowley MT, Martin GA, McCormick F, DeFranco AL
• Structure and function of the B cell antigen receptor.
  Annual review of cell biology 1993 DeFranco AL
• Tyrosine phosphorylation and the mechanism of signal transduction by the B-lymphocyte antigen receptor.
  EJB Reviews 1993 Anthony L. Defranco
• Tyrosine phosphorylation and the mechanism of signal transduction by the B-lymphocyte antigen receptor.
  European journal of biochemistry 1992 DeFranco AL
• Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.
  The Journal of biological chemistry 1992 Weinstein SL, Sanghera JS, Lemke K, DeFranco AL, Pelech SL
• Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression.
  Molecular immunology 1992 Law DA, Gold MR, DeFranco AL
• Tyrosine phosphorylation of phospholipase C-gamma 2 upon cross-linking of membrane Ig on murine B lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1992 Hempel WM, Schatzman RC, DeFranco AL
• Autoimmunity. Hidden lymphocytes.
  Nature 1992 DeFranco AL
• The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Matsuuchi L, Gold MR, Travis A, Grosschedl R, DeFranco AL, Kelly RB
• Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1992 Gold MR, Chan VW, Turck CW, DeFranco AL
• bcl-2 to the rescue.
  Current biology : CB 1992 DeFranco AL
• All about B cells.
  Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991 DeFranco AL
• Regulation of anti-immunoglobulin-induced B lymphoma growth arrest by transforming growth factor beta 1 and dexamethasone.
  International immunology 1991 Gold MR, Gajewski TF, DeFranco AL
• Signal transduction. Immunosuppressants at work.
  Nature 1991 DeFranco AL
• Between B cells and T cells.
  Nature 1991 DeFranco AL
• Expression of phospholipase C isozymes by murine B lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Hempel WM, DeFranco AL
• Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Weinstein SL, Gold MR, DeFranco AL
• Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Gold MR, Matsuuchi L, Kelly RB, DeFranco AL
• Mutational analysis of antigen receptor regulation of B lymphocyte growth. Evidence for involvement of the phosphoinositide signaling pathway.
  The Journal of biological chemistry 1991 Page DM, Gold MR, Fahey KA, Matsuuchi L, DeFranco AL
• Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor.
  Nature 1990 Gold MR, Law DA, DeFranco AL
• Antigen Receptor-Induced Cell Cycle Arrest in WEHI-231 B Lymphoma Cells Depends on the Duration of Signaling before the G1 Phase Restriction Point.
  Molecular and Cellular Biology 1990 Dawne M. Page, Anthony L. Defranco
• Antigen receptor-induced cell cycle arrest in WEHI-231 B lymphoma cells depends on the duration of signaling before the G1 phase restriction point.
  Molecular and Cellular Biology 1990 D M Page, A L DeFranco
• Antigen receptor-induced cell cycle arrest in WEHI-231 B lymphoma cells depends on the duration of signaling before the G1 phase restriction point.
  Molecular and cellular biology 1990 Page DM, DeFranco AL
• Immunology. Tolerance: a second mechanism.
  Nature 1989 DeFranco AL
• B lymphocytes in human disease edited by Graham Bird and Jane E. Calvert, Oxford Medical Publications, 1988. £55.00 (xxviii + 513 pages) ISBN 0 19 2615734.
  Trends in Immunology 1989 Anthony L. DeFranco
• Signal transduction by the antigen receptor of B lymphocytes.
  Cold Spring Harbor symposia on quantitative biology 1989 DeFranco AL, Page DM, Blum JH, Gold MR
• Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
  Advances in experimental medicine and biology 1989 DeFranco AL, Gold MR
• Fate of self-reactive B cells.
  Nature 1988 DeFranco AL
• Cell-cell interactions in the antibody response.
  Nature 1988 DeFranco AL
• Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells.
  Journal of immunology (Baltimore, Md. : 1950) 1988 Page DM, DeFranco AL
• Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Gold MR, Jakway JP, DeFranco AL
• Cross-linking membrane IgM induces production of inositol trisphosphate and inositol tetrakisphosphate in WEHI-231 B lymphoma cells.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Fahey KA, DeFranco AL
• B-lymphocyte signal transduction in response to anti-immunoglobulin and bacterial lipopolysaccharide.
  Immunological reviews 1987 DeFranco AL, Gold MR, Jakway JP
• Phorbol esters and dioctanoylglycerol block anti-IgM-stimulated phosphoinositide hydrolysis in the murine B cell lymphoma WEHI-231.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Gold MR, DeFranco AL
• Molecular aspects of B-lymphocyte activation.
  Annual review of cell biology 1987 DeFranco AL
• Transmembrane signaling reactions generated in B cells in response to anti-IgM or lipopolysaccharide.
  Advances in experimental medicine and biology 1987 DeFranco AL
• Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide.
  Science (New York, N.Y.) 1986 Jakway JP, DeFranco AL
• Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Jakway JP, Usinger WR, Gold MR, Mishell RI, DeFranco AL
• Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium.
  Journal of immunology (Baltimore, Md. : 1950) 1986 LaBaer J, Tsien RY, Fahey KA, DeFranco AL
• Separate control of B lymphocyte early activation and proliferation in response to anti-IgM antibodies.
  Journal of immunology (Baltimore, Md. : 1950) 1985 DeFranco AL, Raveche ES, Paul WE
• Can resting B cells present antigen to T cells?
  Federation proceedings 1985 Ashwell JD, DeFranco AL, Paul WE, Schwartz RH
• Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation.
  The Journal of experimental medicine 1984 Ashwell JD, DeFranco AL, Paul WE, Schwartz RH
• Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes.
  The Journal of experimental medicine 1984 DeFranco AL, Ashwell JD, Schwartz RH, Paul WE
• Growth regulation of a B-cell lymphoma via the antigen receptor.
  Current topics in microbiology and immunology 1984 DeFranco AL
• Cell cycle analysis of lymphocyte activation in normal and autoimmune strains of mice.
  Journal of immunology (Baltimore, Md. : 1950) 1982 Raveche ES, Steinberg AD, DeFranco AL, Tjio JH
• Frequency of B lymphocytes responsive to anti-immunoglobulin.
  The Journal of experimental medicine 1982 Defranco AL, Raveche ES, Asofsky R, Paul WE
• Long term growth of B-lymphocytes.
  Annals of the New York Academy of Sciences 1982 Paul WE, DeFranco A, Sredni B, Howard M
• Regulation of growth and proliferation in B cell subpopulations.
  Immunological reviews 1982 DeFranco AL, Kung JT, Paul WE