Anna Victoria Molofsky, MD, PhD
Associate Professor
Psychiatry
School of Medicine
Awards
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- Freeman Prize for Basic Research- BBRF, 2019
- Pew Biomedical Scholar, 2017
- NIH New Innovator Award, 2017
- Burroughs Wellcome Career Award for Medical Scientists, 2015
- Harold M. Weintraub Graduate Student Award, 2006
- Phi Beta Kappa, 1997
Education & Training
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- B.A. Amherst College
- Adult Psychiatry Residency University of California-San Francisco
- M.D. University of Michigan
- Ph.D University of Michigan
Websites
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- Biomedical Sciences Graduate Program (bms.ucsf.edu)
- Anna Molofsky Lab (annamolofskylab.org)
- Neuroscience Graduate Program (neurograd.ucsf.edu)
Grants and Projects
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- Microglial remodeling of the extracellular matrix in memory circuits, NIH, 2020-2025
- Astrocyte-microglial communication in developmental synapse formation, NIH, 2019-2023
- Coordinate regulation of neural circuit remodeling by glia: a prospective molecular approach, NIH/NIMH, 2017-2022
- Investigating innate immune mechanisms of synapse remodeling by glia, Pew Charitable Trusts, 2017-2021
- Astrocyte-Encoded Regional cues in Developmental Synapse Formation., Burroughs Wellcome Fund, 2015-2020
Publications (31)
Top publication keywords:
Superior ColliculiStromal CellsNF-E2-Related Factor 1Zebrafish ProteinsSynapsesNeurogenesisCyclin-Dependent Kinase Inhibitor p16RhombencephalonNeuronsMicrogliaMotor NeuronsMesencephalonInterleukin-33AstrocytesImmune System
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Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.
Cell 2020 Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV -
Astrocytes and Microglia: In Sickness and in Health.
Trends in neurosciences 2020 Vainchtein ID, Molofsky AV -
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.
Science (New York, N.Y.) 2018 Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV -
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.
Nature 2003 Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ -
Publisher Correction: Circuit and molecular architecture of a ventral hippocampal network.
Nature neuroscience 2021 Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA
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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.
eLife 2021 Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI -
In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain.
Nature communications 2021 Silva NJ, Dorman LC, Vainchtein ID, Horneck NC, Molofsky AV -
A protective signal between the brain’s supporting cells in Alzheimer’s disease.
Nature 2021 Jerika J. Barron, Anna V. Molofsky -
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH.
ACS sensors 2021 Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW -
Reactive astrocyte nomenclature, definitions, and future directions.
Nature neuroscience 2021 Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt… -
Astrocyte-immune cell interactions in physiology and pathology.
Immunity 2021 Han RT, Kim RD, Molofsky AV, Liddelow SA -
Circuit and molecular architecture of a ventral hippocampal network.
Nature neuroscience 2020 Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA -
Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity.
Trends in immunology 2020 Rosenberg MF, Molofsky AV -
The immune system and psychiatric disease: a basic science perspective.
Clinical and experimental immunology 2019 Bennett FC, Molofsky AV -
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.
Immunity 2019 Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB -
Demystifying Microglia: And Now the Work Begins.
Immunity 2019 Dorman LC, Molofsky AV -
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes.
Nature neuroscience 2018 Kelley KW, Nakao-Inoue H, Molofsky AV, Oldham MC -
Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.
Neuron 2018 Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH -
Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function.
Annual review of physiology 2017 Poskanzer KE, Molofsky AV -
Astrocyte development: A Guide for the Perplexed.
Glia 2015 Molofsky AV, Deneen B -
Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.
Nature 2014 Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH -
Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions.
Glia 2013 Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC -
Chapter 36 Mechanisms of Astrocyte Development.
Patterning and Cell Type Specification in the Developing CNS and PNS 2013 A.V. Molofsky, C. Hochstim, B. Deneen, D. Rowitch -
Regional astrocyte allocation regulates CNS synaptogenesis and repair.
Science (New York, N.Y.) 2012 Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SP, Merkle F, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH -
Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.
Development (Cambridge, England) 2012 Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH -
Astrocytes and disease: a neurodevelopmental perspective.
Genes & development 2012 Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH -
Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.
Developmental biology 2009 He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ -
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.
Nature 2006 Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ -
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.
Genes & development 2005 Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R -
Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.
Cold Spring Harbor symposia on quantitative biology 2005 Pardal R, Molofsky AV, He S, Morrison SJ -
Diverse mechanisms regulate stem cell self-renewal.
Current opinion in cell biology 2004 Molofsky AV, Pardal R, Morrison SJ