Ankit Khambhati, PhD
Assistant Professor
Neurological Surgery
School of Medicine

Khambhati's research seeks to understand the organization of human brain circuits and how disruption of these circuits give rise to functional brain network disorders.

At UCSF, Khambhati leads a research program specialized in the development of network neurotechnology to map and modulate the neural pathways that facilitate large-scale communication within interconnected brain networks. His research group uses a multi-modal approach that integrates network science and control theory with direct brain electrical recordings, implantable devices, and neurostimulation to develop strategies for brain network control and repair. As a collaborator on highly interdisciplinary teams, he investigates the translational potential of this technology for treatment-resistant neuropsychiatric disorders.

Khambhati earned his bachelor’s degree in electrical and computer engineering from Carnegie Mellon University and his doctorate in bioengineering from the University of Pennsylvania. He completed a postdoctoral fellowship in neuroengineering at UCSF. He is a member of the American Epilepsy Society and the Institute of Electrical and Electronics Engineers.

• State-dependent effects of responsive neurostimulation depend on seizure localization.
  Brain : a journal of neurology 2024 Chiang S, Khambhati AN, Tcheng TK, Loftman AP, Hasulak NR, Mirro EA, Morrell MJ, Rao VR
• Graph and Network Control Theoretic Frameworks.
  Statistical Methods in Epilepsy 2024 Ankit N. Khambhati, Sharon Chiang
• Corticography and human intracranial neurophysiology.
  Reference Module in Neuroscience and Biobehavioral Psychology 2024 Lingyun Zhao, Ankit N. Khambhati, Patrick W. Hullett, Edward F. Chang
• Utility of Chronic Intracranial Electroencephalography in Responsive Neurostimulation Therapy.
  Neurosurgery clinics of North America 2023 Khambhati AN
• Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.
  Journal of visualized experiments : JoVE 2023 Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD
• Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.
  Brain stimulation 2023 Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD
• Closed-loop neurostimulation for the treatment of psychiatric disorders.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2023 Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, Krystal AD
• 46. Amygdala-Hippocampus Coherence is a Biomarker of Predominant Symptom Sets in Patients With Depression.
  Biological Psychiatry 2023 Joshua Cohen, Joline M. Fan, Kristin K. Sellers, Ankit N. Khambhati, Heather E. Dawes, Katherine W. Scangos, Vikram R. Rao, Leo P. Sugrue, Philip A. Starr, Edward F. Chang, Andrew D. Krystal
• Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.
  Brain stimulation 2023 Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD
• Changes in intracranial neurophysiology associated with acute COVID-19 infection.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2023 Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD
• Decoding naturalistic affective behaviour from spectro-spatial features in multiday human iEEG.
  Nature human behaviour 2022 Bijanzadeh M, Khambhati AN, Desai M, Wallace DL, Shafi A, Dawes HE, Sturm VE, Chang EF
• Intracranial electroencephalographic biomarker predicts effective responsive neurostimulation for epilepsy prior to treatment.
  Epilepsia 2022 Scheid BH, Bernabei JM, Khambhati AN, Mouchtaris S, Jeschke J, Bassett DS, Becker D, Davis KA, Lucas T, Doyle W, Chang EF, Friedman D, Rao VR, Litt B
• Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.
  Frontiers in human neuroscience 2021 Scangos KW, Khambhati AN, Daly PM, Owen LW, Manning JR, Ambrose JB, Austin E, Dawes HE, Krystal AD, Chang EF
• Effects of anterior thalamic nuclei stimulation on hippocampal activity: Chronic recording in a patient with drug-resistant focal epilepsy.
  Epilepsy & behavior reports 2021 Silva AB, Khambhati AN, Speidel BA, Chang EF, Rao VR
• Evidence of state-dependence in the effectiveness of responsive neurostimulation for seizure modulation.
  Brain stimulation 2021 Chiang S, Khambhati AN, Wang ET, Vannucci M, Chang EF, Rao VR
• Early seizure spread and epilepsy surgery: A systematic review.
  Epilepsia 2020 Andrews JP, Ammanuel S, Kleen J, Khambhati AN, Knowlton R, Chang EF
• Corticocortical Evoked Potentials and Patient Response Reveal Networks Underlying Depression.
  Biological Psychiatry 2020 Katherine Scangos, Ghassan Makhoul, Ankit N. Khambhati, Kristin K. Sellers, Edward F. Chang, Andrew D. Krystal
• Functional brain network reconfiguration during learning in a dynamic environment.
  Nature communications 2020 Kao CH, Khambhati AN, Bassett DS, Nassar MR, McGuire JT, Gold JI, Kable JW
• Model-based design for seizure control by stimulation.
  Journal of neural engineering 2020 Ashourvan A, Pequito S, Khambhati AN, Mikhail F, Baldassano SN, Davis KA, Lucas TH, Vettel JM, Litt B, Pappas GJ, Bassett DS
• Emerging roles of network analysis for epilepsy.
  Epilepsy research 2019 Stacey W, Kramer M, Gunnarsdottir K, Gonzalez-Martinez J, Zaghloul K, Inati S, Sarma S, Stiso J, Khambhati AN, Bassett DS, Smith RJ, Liu VB, Lopour BA, Staba R
• Virtual resection predicts surgical outcome for drug-resistant epilepsy.
  Brain : a journal of neurology 2019 Kini LG, Bernabei JM, Mikhail F, Hadar P, Shah P, Khambhati AN, Oechsel K, Archer R, Boccanfuso J, Conrad E, Shinohara RT, Stein JM, Das S, Kheder A, Lucas TH, Davis KA, Bassett DS, Litt B
• White Matter Network Architecture Guides Direct Electrical Stimulation through Optimal State Transitions.
  Cell reports 2019 Stiso J, Khambhati AN, Menara T, Kahn AE, Stein JM, Das SR, Gorniak R, Tracy J, Litt B, Davis KA, Pasqualetti F, Lucas TH, Bassett DS
• Functional control of electrophysiological network architecture using direct neurostimulation in humans.
  Network neuroscience (Cambridge, Mass.) 2019 Khambhati AN, Kahn AE, Costantini J, Ezzyat Y, Solomon EA, Gross RE, Jobst BC, Sheth SA, Zaghloul KA, Worrell G, Seger S, Lega BC, Weiss S, Sperling MR, Gorniak R, Das SR, Stein JM, Rizzuto DS, Kahana…
• O20. Resting State Whole Brain Network Activity in Depression From Intracranial EEG Signals.
  Biological Psychiatry 2019 Katherine Scangos, Ankit N. Khambhati, Patrick Daly, Alia Shafi, Heather Dawes, Andrew Krystal, Edward F. Chang
• Virtual Cortical Resection Reveals Epileptic Network Characteristics in Pediatric Patients with Focal Cortical Dysplasia. (S36.003).
  Neurology 2019 Jeremy N. Wong, Samuel B. Tomlinson, Erin C. Conrad, Ankit N. Khambhati, Eric D. Marsh
• 126 Postictal EEG Activity in Pediatric and Adult Patients Undergoing Epilepsy Surgery: A Network Perspective.
  Neurosurgery 2018 Samuel Tomlinson, Ankit Khambhati, Rebecca M Kamens, Brenda E Porter, Eric D Marsh
• Correction: Subgraphs of functional brain networks identify dynamical constraints of cognitive control.
  PLoS computational biology 2018 Khambhati AN, Medaglia JD, Karuza EA, Thompson-Schill SL, Bassett DS
• Subgraphs of functional brain networks identify dynamical constraints of cognitive control.
  PLoS computational biology 2018 Khambhati AN, Medaglia JD, Karuza EA, Thompson-Schill SL, Bassett DS
• Alterations of network synchrony after epileptic seizures: An analysis of post-ictal intracranial recordings in pediatric epilepsy patients.
  Epilepsy research 2018 Tomlinson SB, Khambhati AN, Bermudez C, Kamens RM, Heuer GG, Porter BE, Marsh ED
• Integrating EEG and MEG Signals to Improve Motor Imagery Classification in Brain-Computer Interface.
  International journal of neural systems 2018 Corsi MC, Chavez M, Schwartz D, Hugueville L, Khambhati AN, Bassett DS, De Vico Fallani F
• Beyond modularity: Fine-scale mechanisms and rules for brain network reconfiguration.
  NeuroImage 2017 Khambhati AN, Mattar MG, Wymbs NF, Grafton ST, Bassett DS
• Modeling and interpreting mesoscale network dynamics.
  NeuroImage 2017 Khambhati AN, Sizemore AE, Betzel RF, Bassett DS
• Crowdsourcing seizure detection: algorithm development and validation on human implanted device recordings.
  Brain : a journal of neurology 2017 Baldassano SN, Brinkmann BH, Ung H, Blevins T, Conrad EC, Leyde K, Cook MJ, Khambhati AN, Wagenaar JB, Worrell GA, Litt B
• A network engineering perspective on probing and perturbing cognition with neurofeedback.
  Annals of the New York Academy of Sciences 2017 Bassett DS, Khambhati AN
• Emerging Frontiers of Neuroengineering: A Network Science of Brain Connectivity.
  Annual review of biomedical engineering 2017 Bassett DS, Khambhati AN, Grafton ST
• Recurring Functional Interactions Predict Network Architecture of Interictal and Ictal States in Neocortical Epilepsy.
  eNeuro 2017 Khambhati AN, Bassett DS, Oommen BS, Chen SH, Lucas TH, Davis KA, Litt B
• Evolution of brain network dynamics in neurodevelopment.
  Network neuroscience (Cambridge, Mass.) 2017 Chai LR, Khambhati AN, Ciric R, Moore TM, Gur RC, Gur RE, Satterthwaite TD, Bassett DS
• A Powerful DREADD: Revealing Structural Drivers of Functional Dynamics.
  Neuron 2016 Khambhati AN, Bassett DS
• Dynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy.
  PLoS computational biology 2015 Khambhati AN, Davis KA, Oommen BS, Chen SH, Lucas TH, Litt B, Bassett DS
• A translational platform for prototyping closed-loop neuromodulation systems.
  Frontiers in neural circuits 2013 Afshar P, Khambhati A, Stanslaski S, Carlson D, Jensen R, Linde D, Dani S, Lazarewicz M, Cong P, Giftakis J, Stypulkowski P, Denison T
• Neural dynamics of image representation in the primary visual cortex.
  Journal of physiology, Paris 2012 Yan X, Khambhati A, Liu L, Lee TS