Anjali Jacob, MD, PhD
Clinical Fellow
Medicine
School of Medicine

Publications (8)

Top publication keywords:
Cell Self RenewalPluripotent Stem CellsCell DifferentiationWnt Signaling PathwayFeeder CellsPulmonary AlveoliInduced Pluripotent Stem CellsCell LineageOrganoidsCell Culture TechniquesThyroid Nuclear Factor 1LungAlveolar Epithelial CellsEpithelial CellsGenes, Reporter

• Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors.
  Cell stem cell 2020 Hurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, …
• Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells.
  Nature communications 2020 Mithal A, Capilla A, Heinze D, Berical A, Villacorta-Martin C, Vedaie M, Jacob A, Abo K, Szymaniak A, Peasley M, Stuffer A, Mahoney J, Kotton DN, Hawkins F, Mostoslavsky G
• Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells.
  Nature protocols 2019 Jacob A, Vedaie M, Roberts DA, Thomas DC, Villacorta-Martin C, Alysandratos KD, Hawkins F, Kotton DN
• Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium.
  Stem cell reports 2018 McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN
• Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.
  Cell stem cell 2017 Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, …
• Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification.
  Development (Cambridge, England) 2017 Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN
• Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells.
  The Journal of clinical investigation 2017 Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton…
• Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
  Cell stem cell 2017 McCauley KB, Hawkins F, Serra M, Thomas DC, Jacob A, Kotton DN