Angelique Di Domenico, PhD, MSc
Assistant Professor
Institute for Neurodegenerative Diseases
School of Medicine

Angelique received her B.S. in psychology in 2010 and her M.S. in neuroscience with a specialization in neurodegeneration in 2012 at King’s College London, England. She worked under the guidance of Dr. Frank Hirth investigating the effects of TDP-43 on Excitatory Amino Acid Transporter 1 (EAAT1) using a transgenic drosophila model of TDP-43 related ALS. In 2013 she started her Ph.D.

Show full bio (140 words) Hide full bio

work in Biomedicine at the University of Barcelona, Spain and joined Dr. Antonella Consiglio’s laboratory. Her thesis focused on evaluating the glial contributions to Parkinson’s disease (PD) pathogenesis using induced pluripotent stem cells (iPSC). She was awarded her Ph.D. in 2017 and joined the Croft group at NYSCF as a Postdoctoral Fellow in January of 2019 until March 2021. She was focused on investigating the pathogenic mechanisms in PD astrocytes, as well as microglia and their effect on dopaminergic neurons using a combination of 2D and 3D organoid cell culture models, analyzing with non-biased automated analysis softwares (imaris, metamorph, harmony). She is now an Assistant Professor at University California, San Francisco working at the Institute of Neurodegenerative diseases (IND) under the guidance of Nobel laureate Stanley B. Prusiner focused on tau prionopathy.

Awards

Show all (1) Hide

• The Life Sciences, City of Barcelona Award, Barcelona City Council, 2020

Education & Training

Show all (4) Hide

• Diversity, Equity, and Inclusion Champion Training University of California 2022
• PhD Biomedicine University of Barcelona 2017
• MSc Neuroscience, specialization in neurodegenerative diseases King's College London 2012
• BSc Psychology Goldsmith's University of London 2010

Websites

Show all (4) Hide

• Twitter (twitter.com)
• LinkedIn (linkedin.com)
• IND (ind.ucsf.edu)
• Research Gate (researchgate.net)

Publications (6)

Top publication keywords:
NeurogliaInduced Pluripotent Stem CellsDopaminergic NeuronsReceptors, Neurokinin-3Preoptic AreaMesencephalonPrion ProteinsAstrocytesArcuate Nucleus of HypothalamusCoculture TechniquesMuscle CellsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Integrin alpha6Parkinson DiseaseGerstmann-Straussler-Scheinker Disease

• Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson’s disease
  JCI Insights 2024 Meritxell Pons-Espinal, Lucas Blasco-Agell, Irene Fernandez-Carasa, Pol Andrés-Benito, Angelique di Domenico, Yvonne Richaud-Patin, Valentina Baruffi, Laura Marruecos, Lluís Espinosa, Alicia Garrido, …
• CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes.
  Neuron 2020 Barbar L, Jain T, Zimmer M, Kruglikov I, Sadick JS, Wang M, Kalpana K, Rose IVL, Burstein SR, Rusielewicz T, Nijsure M, Guttenplan KA, di Domenico A, Croft G, Zhang B, Nobuta H, Hébert JM, Liddelow SA…
• Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease.
  Stem cell reports 2019 di Domenico A, Carola G, Calatayud C, Pons-Espinal M, Muñoz JP, Richaud-Patin Y, Fernandez-Carasa I, Gut M, Faella A, Parameswaran J, Soriano J, Ferrer I, Tolosa E, Zorzano A, Cuervo AM, Raya A, …
• iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology.
  Molecular neurobiology 2017 Matamoros-Angles A, Gayosso LM, Richaud-Patin Y, di Domenico A, Vergara C, Hervera A, Sousa A, Fernández-Borges N, Consiglio A, Gavín R, López de Maturana R, Ferrer I, López de Munain A, Raya Á, …
• Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD.
  Human molecular genetics 2013 Diaper DC, Adachi Y, Lazarou L, Greenstein M, Simoes FA, Di Domenico A, Solomon DA, Lowe S, Alsubaie R, Cheng D, Buckley S, Humphrey DM, Shaw CE, Hirth F
• Suppression of the GnRH pulse generator by neurokinin B involves a κ-opioid receptor-dependent mechanism.
  Endocrinology 2012 Grachev P, Li XF, Kinsey-Jones JS, di Domenico AL, Millar RP, Lightman SL, O'Byrne KT