Andrew Yang, PhD
Assistant Professor
Neurology
School of Medicine

Our lab studies the molecular logic of crosstalk between the brain and body. We develop new approaches to decode the meaning, mechanisms, and therapeutic relevance of unexpected protein and immune cell communication across brain barriers. By deciphering the general principles by which the periphery communicates with the brain, we will understand and rationally modulate key intercellular pathways to confer greater resilience against brain aging and neurodegeneration.

Education & Training

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• BS Mechanical Engineering, Materials Science MIT
• PhD Bioengineering Stanford University

Websites

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• Yang Lab (yanglab-ucsf.org)
• Neuroscience Faculty Webpage (neurograd.ucsf.edu)
• Sandler Fellows Webpage (fellows.ucsf.edu)

Publications (15)

Top publication keywords:
Choroid PlexusProteomeAgingTyrosine-tRNA LigaseMethionine-tRNA LigaseTranscriptomeAlzheimer DiseaseBlood-Brain BarrierProteomicsMicrogliaAstrocytesTranscytosisDisease SusceptibilityBlood ProteinsBrain

• A protocol for collection and infusion of cerebrospinal fluid in mice.
  STAR protocols 2023 Kaur A, Shuken S, Yang AC, Iram T
• Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling.
  Stem cell reviews and reports 2022 Argouarch AR, Schultz N, Yang AC, Jang Y, Garcia K, Cosme CG, Corrales CI, Nana AL, Karydas AM, Spina S, Grinberg LT, Miller B, Wyss-Coray T, Abyzov A, Goodarzi H, Seeley WW, Kao AW
• A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.
  Nature 2022 Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, …
• Exercise plasma boosts memory and dampens brain inflammation via clusterin.
  Nature 2021 De Miguel Z, Khoury N, Betley MJ, Lehallier B, Willoughby D, Olsson N, Yang AC, Hahn O, Lu N, Vest RT, Bonanno LN, Yerra L, Zhang L, Saw NL, Fairchild JK, Lee D, Zhang H, McAlpine PL, Contrepois K, …
• Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics.
  American journal of human genetics 2021 He Z, Le Guen Y, Liu L, Lee J, Ma S, Yang AC, Liu X, Rutledge J, Losada PM, Song B, Belloy ME, Butler RR, Longo FM, Tang H, Mormino EC, Wyss-Coray T, Greicius MD, Ionita-Laza I

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• CD4+ T cells contribute to neurodegeneration in Lewy body dementia.
  Science (New York, N.Y.) 2021 Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, Channappa D, Henderson VW, Keller A, Aigner L, Galasko DR, Davis MM, Poston KL, Wyss-Coray T
• Dysregulation of brain and choroid plexus cell types in severe COVID-19.
  Nature 2021 Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, Gate D, McNerney MW, Channappa D, Cobos I, Ludwig N…
• Cell type-selective secretome profiling in vivo.
  Nature chemical biology 2020 Wei W, Riley NM, Yang AC, Kim JT, Terrell SM, Li VL, Garcia-Contreras M, Bertozzi CR, Long JZ
• Physiological blood-brain transport is impaired with age by a shift in transcytosis.
  Nature 2020 Yang AC, Stevens MY, Chen MB, Lee DP, Stähli D, Gate D, Contrepois K, Chen W, Iram T, Zhang L, Vest RT, Chaney A, Lehallier B, Olsson N, du Bois H, Hsieh R, Cropper HC, Berdnik D, Li L, Wang EY, …
• Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues.
  Cell reports 2020 Chen MB, Yang AC, Yousef H, Lee D, Chen W, Schaum N, Lehallier B, Quake SR, Wyss-Coray T
• Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.
  Nature 2020 Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, Greicius M, Wagner AD, Aigner L, …
• Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis.
  Cell 2019 Yehl K, Lemire S, Yang AC, Ando H, Mimee M, Torres MT, de la Fuente-Nunez C, Lu TK
• Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.
  Nature medicine 2019 Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno LN, Yang AC, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, …
• CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
  Nature 2019 Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T
• Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.
  Journal of the American Chemical Society 2018 Yang AC, du Bois H, Olsson N, Gate D, Lehallier B, Berdnik D, Brewer KD, Bertozzi CR, Elias JE, Wyss-Coray T