Andrew Mendiola, PhD
Visiting Scientist
Business Service Ctr
Chancellor/EVC/FAS
Awards
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- Oral Presentation Award, Aegean Confences: 16th Intl Conf on Innate Immunity, 2019
- Postdoctoral Fellowship, National MS Society, 2018-2021
- Immunology T32 Postdoc Fellowship, University of California, San Francisco, 2017-2018
- ASNeuro Travel Award, American Society for Neurochemistry, 2017
- Presidential Dissertation Fellowship, University of Texas, San Antonio, 2016-2017
- Trainee Poster Award, American Association for Immunologist, 2016
- Best Grad Student Presentation for Immunology, University of Texas, San Antonio, 2016
- Travel Award, Retina Research Foundation/ARVO, 2015
- Best Grad Student Presentation for Immunology, University of Texas, San Antonio, 2015
- RISE Predoctoral Fellowship, UTSA, NIH, 2013-2017
Education & Training
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- Ph.D. Cell & Molecular Biology University of Texas at San Antonio 05/2017
- Postdoc Neuroimmunology Gladstone Institutes, UCSF
Interests
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- Oxidative Stress
- Neuroinflammation
- Neurodegeneration
- Diabetic Retinopathy
- Neurovascular Unit
- Microglia
- Multiple Sclerosis
- Autoimmunity
- Alzheimer's Disease
- Innate Immunity
Websites
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- @@andrewmendiola on Twitter (twitter.com)
Grants and Projects
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- Epigenomic regulation of oxidative stress-producing innate immunity in neuroinflammation, NIH/NINDS, 2022-2024
- In vivo imaging and profiling of mechanisms of T-cell recruitment and activation during neuroinflammation, National Multiple Sclerosis Society, 2018-2021
- Functional profiling of ligand-selective activation of complement receptor 3 in macrophages, NIH/NIAID UCSF Immunology T32, 2017-2018
Publications (20)
Top publication keywords:
CX3C Chemokine Receptor 1Blood-Brain BarrierTauopathiesInflammationRemyelinationEncephalomyelitis, Autoimmune, ExperimentalNeurogenic InflammationInterleukin-1betaMultiple SclerosisCentral Nervous System DiseasesDemyelinating DiseasesMicrogliaFibrinogenChemokine CX3CL1Alzheimer Disease
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Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.
Nature immunology 2023 Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico… -
Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina.
Frontiers in immunology 2023 Church KA, Rodriguez D, Mendiola AS, Vanegas D, Gutierrez IL, Tamayo I, Amadu A, Velazquez P, Cardona SM, Gyoneva S, Cotleur AC, Ransohoff RM, Kaur T, Cardona AE -
Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination.
Journal of neurochemistry 2022 Mendiola AS, Church KA, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE -
Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner.
ASN neuro 2022 Sarker B, Cardona SM, Church KA, Vanegas D, Velazquez P, Rorex C, Rodriguez D, Mendiola AS, Kern TS, Domingo ND, Stephens R, Muzzio IA, Cardona AE -
BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis.
Brain : a journal of neurology 2021 Petersen MA, Tognatta R, Meyer-Franke A, Bushong EA, Mendiola AS, Yan Z, Muthusamy A, Merlini M, Meza-Acevedo R, Cabriga B, Zhou Y, Thomas R, Ryu JK, Lassmann H, Ellisman MH, Akassoglou K
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ApoE and immunity in Alzheimer's disease and related tauopathies: Low-density lipoprotein receptor to the rescue.
Neuron 2021 Mendiola AS, Tognatta R, Yan Z, Akassoglou K -
Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma.
The American journal of pathology 2021 Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK -
Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
Nature neuroscience 2020 Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Acevedo RM, … -
Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
Nature immunology 2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff … -
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
Nature immunology 2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff … -
Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2019 Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ -
Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant.
Frontiers in cellular neuroscience 2018 Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich SS, Parker-Thornburg J, Soto-Ospina A, Araque P, Ransohoff RM, Cardona AE -
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.
Nature immunology 2018 Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, … -
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
Neuron 2017 Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee… -
The IL-1β phenomena in neuroinflammatory diseases.
Journal of neural transmission (Vienna, Austria : 1996) 2017 Mendiola AS, Cardona AE -
Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy.
Frontiers in cellular neuroscience 2017 Mendiola AS, Garza R, Cardona SM, Mythen SA, Lira SA, Akassoglou K, Cardona AE -
TGFβ induces BIGH3 expression and human retinal pericyte apoptosis: a novel pathway of diabetic retinopathy.
Eye (London, England) 2016 Betts-Obregon BS, Mondragon AA, Mendiola AS, LeBaron RG, Asmis R, Zou T, Gonzalez-Fernandez F, Tsin AT -
Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformans In Vitro Requires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species.
Infection and immunity 2016 Hole CR, Leopold Wager CM, Mendiola AS, Wozniak KL, Campuzano A, Lin X, Wormley FL -
Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina.
ASN neuro 2015 Cardona SM, Mendiola AS, Yang YC, Adkins SL, Torres V, Cardona AE -
The role of microglia in diabetic retinopathy.
Journal of ophthalmology 2014 Grigsby JG, Cardona SM, Pouw CE, Muniz A, Mendiola AS, Tsin AT, Allen DM, Cardona AE