Andrew Lechner, MD, PhD
Clinical Fellow
Medicine
School of Medicine

Grants and Projects

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• Myeloid cell regulation of adult lung alveologenesis post-pneumonectomy, NIH, 2016-2018
• Lung Injury and Shock Pathogenesis in Y. pestis Sepsis, NIH, 2005-2009
• Physiology of the Lung in Starvation, NIH, 1986-1990
• Lung Development During Intrauterine Ethanol Exposure, NIH, 1986-1987
• Lung Structure and Function in Perinatal Malnutrition, NIH, 1983-1985

Publications (15)

Top publication keywords:
Adenosine A1 Receptor AntagonistsTh2 CellsFontan ProcedureMacrophages, AlveolarVirulence FactorsPurinesBronchitisShock, SepticPeritonitisProtective AgentsAcute Lung InjuryLymphatic VesselsYersinia pestisPneumonectomyPlague

• Plastic Bronchitis in Adult and Pediatric Patients: A Review of its Presentation, Diagnosis, and Treatment.
  Missouri medicine 2021 Patel N, Patel M, Inja R, Krvavac A, Lechner AJ
• Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.
  Cell stem cell 2017 Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR
• Persistent Pathology in Influenza-Infected Mouse Lungs.
  American journal of respiratory cell and molecular biology 2016 Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR
• Evidence for lung epithelial stem cell niches.
  BMC developmental biology 2015 Donne ML, Lechner AJ, Rock JR
• Adenosine A1 receptor antagonist, L-97-1, improves survival and protects the kidney in a rat model of cecal ligation and puncture induced sepsis.
  European journal of pharmacology 2014 Wilson CN, Vance CO, Lechner MG, Matuschak GM, Lechner AJ

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• Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.
  Developmental cell 2012 Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK
• A novel post-exposure medical countermeasure L-97-1 improves survival and acute lung injury following intratracheal infection with Yersinia pestis.
  Innate immunity 2011 Wilson CN, Vance CO, Doyle TM, Brink DS, Matuschak GM, Lechner AJ
• Acute lung injury and the acute respiratory distress syndrome: pathophysiology and treatment.
  Missouri medicine 2010 Matuschak GM, Lechner AJ
• Septic shock and nonpulmonary organ dysfunction in pneumonic plague: the role of Yersinia pestis pCD1- vs. pgm- virulence factors.
  Critical care medicine 2010 Doyle TM, Matuschak GM, Lechner AJ
• Acute hypoxia decreases E. coli LPS-induced cytokine production and NF-kappaB activation in alveolar macrophages.
  Respiratory physiology & neurobiology 2010 Matuschak GM, Nayak R, Doyle TM, Lechner AJ
• Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages.
  Journal of neuroimmunology 2006 Mukhopadhyay S, Das S, Williams EA, Moore D, Jones JD, Zahm DS, Ndengele MM, Lechner AJ, Howlett AC
• Teaching principles of cardiovascular function in a medical student laboratory.
  Advances in physiology education 2005 Gupta S, Westfall TC, Lechner AJ, Knuepfer MM
• Hypoxic suppression of E. coli-induced NF-kappa B and AP-1 transactivation by oxyradical signaling.
  American journal of physiology. Regulatory, integrative and comparative physiology 2004 Matuschak GM, Lechner AJ, Chen Z, Todi S, Doyle TM, Loftis LL
• Cocaine enhances susceptibility to endotoxemic shock in a subset of rats.
  Critical care medicine 2004 Knuepfer MM, Bloodgood TA, Matuschak GM, Lechner AJ
• Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholamines.
  Critical care medicine 2003 Macarthur H, Couri DM, Wilken GH, Westfall TC, Lechner AJ, Matuschak GM, Chen Z, Salvemini D