Andrew Krystal, MD
Professor
Psychiatry
School of Medicine

He is Board Certified in Clinical Neurophysiology by the American Board of Clinical Neurophysiology and the American Board of Psychiatry and Neurology and Board Certified in Psychiatry by the American Board of Psychiatry and Neurology. He is a pioneer in the application of computational modeling to the study of biomarker development using EEG in patients with depression and sleep disorders and application of biomarkers in treatment development clinical trials. He also has extensive experience in clinical and research personalization of therapies for the treatment of patients with mood disorders. He has been the principal investigator of more than 50 single-site and multi-site clinical trials.

• Hyperarousal features in the sleep architecture of individuals with and without insomnia.
  Journal of sleep research 2024 Di Marco T, Scammell TE, Sadeghi K, Datta AN, Little D, Tjiptarto N, Djonlagic I, Olivieri A, Zammit G, Krystal A, Pathmanathan J, Donoghue J, Hubbard J, Dauvilliers Y
• Feasibility and Acceptability of Mindfulness-based Stress Reduction and Prenatal Sleep Classes for Poor Prenatal Sleep Quality: Pilot Randomized Controlled Trial.
  Behavioral sleep medicine 2024 Felder JN, Mirchandaney R, Manber R, Cuneo J, Krystal A, Solomon N, Janette S, Zhang L, Moran P, Mashash M, Epel E, Hecht FM
• Effect of daridorexant on sleep architecture in patients with chronic insomnia disorder - A pooled post hoc analysis of two randomized Phase 3 clinical studies.
  Sleep 2024 Di Marco T, Djonlagic I, Dauvilliers Y, Sadeghi K, Little D, Datta AN, Hubbard J, Hajak G, Krystal A, Olivieri A, Parrino L, Puryear CB, Zammit G, Donoghue J, Scammell TE
• Stereoelectroencephalography Electrode Implantation for Inpatient Workup of Treatment-Resistant Depression.
  Neurosurgery 2024 Starkweather CK, Sugrue LP, Cajigas I, Speidel B, Krystal AD, Scangos K, Chang EF
• Association of Biomarkers of Neuronal Injury and Inflammation With Insomnia Trajectories After Traumatic Brain Injury: A TRACK-TBI Study.
  Neurology 2024 Werner JK, Albrecht J, Capaldi VF, Jain S, Sun X, Mukherjee P, Williams SG, Collen J, Diaz-Arrastia R, Manley GT, Krystal AD, Wickwire E, TRACK-TBI Investigators
• Sleep Physiology and Neurocognition Among Adolescents With Attention-Deficit/Hyperactivity Disorder.
  Journal of the American Academy of Child and Adolescent Psychiatry 2024 Lunsford-Avery JR, Carskadon MA, Kollins SH, Krystal AD
• Human Anterior Insular Cortex Encodes Multiple Electrophysiological Representations of Anxiety-Related Behaviors.
  bioRxiv : the preprint server for biology 2024 Lee AM, Sturm VE, Dawes H, Krystal AD, Chang EF
• Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements.
  Frontiers in human neuroscience 2024 Johnson KA, Dosenbach NUF, Gordon EM, Welle CG, Wilkins KB, Bronte-Stewart HM, Voon V, Morishita T, Sakai Y, Merner AR, Lázaro-Muñoz G, Williamson T, Horn A, Gilron R, O'Keeffe J, Gittis AH, Neumann …
• Cognitive behavioural therapy for insomnia reduces actigraphy and diary measured sleep discrepancy for individuals with comorbid insomnia and major depressive disorder: A report from the TRIAD study.
  Sleep medicine 2023 Spina MA, Bei B, Rajaratnam SW, Krystal A, Edinger JD, Buysse DJ, Thase M, Manber R
• Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder.
  Brain stimulation 2023 Fan JM, De B, Frank AC, Basich-Pease G, Norbu T, Morrison MA, Larson P, Starr PA, Krystal AD, Lee AM
• Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial.
  JAMA network open 2023 Morin CM, Chen SJ, Ivers H, Beaulieu-Bonneau S, Krystal AD, Guay B, Bélanger L, Cartwright A, Simmons B, Lamy M, Busby M, Edinger JD
• Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Fan JM, Kudo K, Verma P, Ranasinghe KG, Morise H, Findlay AM, Vossel K, Kirsch HE, Raj A, Krystal AD, Nagarajan SS
• Comparative short-term safety and efficacy of hypnotics: A quantitative risk-benefit analysis.
  Journal of sleep research 2023 Cheung JMY, Scott H, Muench A, Grunstein RR, Krystal AD, Riemann D, Perlis M
• Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice.
  Journal of sleep research 2023 Krystal AD
• The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.
  Psychiatry research 2023 McCall WV, Mercado K, Dzurny TN, McCloud LL, Krystal AD, Benca RM, Rosenquist PB, Looney SW
• Association Between Insomnia and Mental Health and Neurocognitive Outcomes Following Traumatic Brain Injury.
  Journal of neurotrauma 2023 Wickwire EM, Albrecht JS, Capaldi VF, Jain S, Gardner RC, Smith MT, Williams SG, Collen J, Schnyer DM, Giacino JT, Nelson LD, Mukherjee P, Sun X, Werner JK, Mosti CB, Markowitz AJ, Manley GT, Krystal …
• Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study.
  Journal of affective disorders 2023 Darrow SM, Pizzagalli DA, Smoski M, Mathew SJ, Nurnberger J, Lisanby SH, Iosifescu D, Murrough JW, Yang H, Weiner RD, Sanacora G, Keefe RSE, Song A, Goodman W, Whitton AE, Potter WZ, Krystal AD
• Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.
  Journal of visualized experiments : JoVE 2023 Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD
• Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.
  Brain stimulation 2023 Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD
• Closed-loop neurostimulation for the treatment of psychiatric disorders.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2023 Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, Krystal AD
• Objective sleep duration and response to combined pharmacotherapy and cognitive behavioral insomnia therapy among patients with comorbid depression and insomnia: a report from the TRIAD study.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2023 Edinger JD, Smith ED, Buysse DJ, Thase M, Krystal AD, Wiskniewski S, Manber R
• Do Insomnia Treatments Improve Daytime Function?
  Journal of clinical medicine 2023 Watson NF, Bertisch SM, Morin CM, Pelayo R, Winkelman JW, Zee PC, Krystal AD
• Should Trazodone Be First-Line Therapy for Insomnia? A Clinical Suitability Appraisal.
  Journal of clinical medicine 2023 Pelayo R, Bertisch SM, Morin CM, Winkelman JW, Zee PC, Krystal AD
• International Consensus Statement on Obstructive Sleep Apnea.
  International forum of allergy & rhinology 2023 Chang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera JE, Bartley BL, Billings ME, Boon MS, Bosschieter P, Braverman I, Brodie K, Cabrera-Muffly C, Caesar R, …
• Alliance for Sleep Clinical Practice Guideline on Switching or Deprescribing Hypnotic Medications for Insomnia.
  Journal of clinical medicine 2023 Watson NF, Benca RM, Krystal AD, McCall WV, Neubauer DN
• Wake Up America: National Survey of Patients' and Physicians' Views and Attitudes on Insomnia Care.
  Journal of clinical medicine 2023 Benca RM, Bertisch SM, Ahuja A, Mandelbaum R, Krystal AD
• What Should Be the Focus of Treatment When Insomnia Disorder Is Comorbid with Depression or Anxiety Disorder?
  Journal of clinical medicine 2023 Morin CM, Bertisch SM, Pelayo R, Watson NF, Winkelman JW, Zee PC, Krystal AD
• Long-Term Use of Insomnia Medications: An Appraisal of the Current Clinical and Scientific Evidence.
  Journal of clinical medicine 2023 Zee PC, Bertisch SM, Morin CM, Pelayo R, Watson NF, Winkelman JW, Krystal AD
• Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.
  Brain stimulation 2023 Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD
• Changes in intracranial neurophysiology associated with acute COVID-19 infection.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2023 Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD
• Recognition and Management of Obstructive Sleep Apnea in Psychiatric Practice.
  The Journal of clinical psychiatry 2023 Benca RM, Krystal A, Chepke C, Doghramji K
• Longitudinal study to assess antidepressant treatment patterns and outcomes in individuals with depression in the general population.
  Journal of affective disorders 2022 Ohayon MM, McCue M, Krystal A, Selzler KJ, Chrones L, Lawrence D, Côté ML
• Publisher Correction: State-dependent responses to intracranial brain stimulation in a patient with depression.
  Nature medicine 2022 Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD
• Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program.
  Journal of affective disorders 2022 Epperson CN, Rubinow DR, Meltzer-Brody S, Deligiannidis KM, Riesenberg R, Krystal AD, Bankole K, Huang MY, Li H, Brown C, Kanes SJ, Lasser R
• Solriamfetol treatment of excessive daytime sleepiness in participants with narcolepsy or obstructive sleep apnea with a history of depression.
  Journal of psychiatric research 2022 Krystal AD, Benca RM, Rosenberg R, Schweitzer PK, Malhotra A, Babson K, Lee L, Bujanover S, Strohl KP
• Examining Experiences of Poor Sleep During Pregnancy: A Qualitative Study to Inform the Development of a Prenatal Sleep Intervention.
  Global advances in health and medicine 2022 Felder JN, Mirchandaney R, Harrison J, Manber R, Cuneo J, Krystal A, Epel E, Hecht F
• Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.
  Nature and science of sleep 2022 Lunsford-Avery JR, Edinger JD, Krystal AD
• Randomized controlled trial of digital cognitive behavior therapy for prenatal insomnia symptoms: effects on postpartum insomnia and mental health.
  Sleep 2022 Felder JN, Epel ES, Neuhaus J, Krystal AD, Prather AA
• Links between the brain and body during sleep: implications for memory processing.
  Trends in neurosciences 2022 Whitehurst LN, Subramoniam A, Krystal A, Prather AA
• Telemedicine-delivered cognitive-behavioral therapy for insomnia in alcohol use disorder (AUD): study protocol for a randomized controlled trial.
  Trials 2022 Arnedt JT, Cardoni ME, Conroy DA, Graham M, Amin S, Bohnert KM, Krystal AD, Ilgen MA
• Trajectories of Insomnia in Adults After Traumatic Brain Injury.
  JAMA network open 2022 Wickwire EM, Albrecht JS, Capaldi VF, Jain SO, Gardner RC, Werner JK, Mukherjee P, McKeon AB, Smith MT, Giacino JT, Nelson LD, Williams SG, Collen J, Sun X, Schnyer DM, Markowitz AJ, Manley GT, …
• What Is Insomnia?
  JAMA 2021 Krystal AD, Ashbrook LH, Prather AA
• A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials.
  Molecular psychiatry 2021 Sforzini L, Worrell C, Kose M, Anderson IM, Aouizerate B, Arolt V, Bauer M, Baune BT, Blier P, Cleare AJ, Cowen PJ, Dinan TG, Fagiolini A, Ferrier IN, Hegerl U, Krystal AD, Leboyer M, McAllister-…
• Correction to: Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Pizzagalli DA, Smoski M, Ang YS, Whitton AE, Sanacora G, Mathew SJ, Nurnberger J, Lisanby SH, Iosifescu DV, Murrough JW, Yang H, Weiner RD, Calabrese JR, Goodman W, Potter WZ, Krystal AD
• Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.
  Frontiers in human neuroscience 2021 Scangos KW, Khambhati AN, Daly PM, Owen LW, Manning JR, Ambrose JB, Austin E, Dawes HE, Krystal AD, Chang EF
• Closed-loop neuromodulation in an individual with treatment-resistant depression.
  Nature medicine 2021 Scangos KW, Khambhati AN, Daly PM, Makhoul GS, Sugrue LP, Zamanian H, Liu TX, Rao VR, Sellers KK, Dawes HE, Starr PA, Krystal AD, Chang EF
• Diagnosing and Treating Insomnia in Adults and Older Adults.
  The Journal of clinical psychiatry 2021 Rosenberg RP, Krystal AD
• Design of the National Adaptive Trial for PTSD-related Insomnia (NAP Study), VA Cooperative Study Program (CSP) #2016.
  Contemporary clinical trials 2021 Krystal JH, Chow B, Vessicchio J, Henrie AM, Neylan TC, Krystal AD, Marx BP, Xu K, Jindal RD, Davis LL, Schnurr PP, Stein MB, Thase ME, Ventura B, Huang GD, Shih MC, CSP 2016 Study Team
• Optimizing Treatment for Insomnia.
  The Journal of clinical psychiatry 2021 Krystal AD
• Examining suicide assessment measures for research use: Using item response theory to optimize psychometric assessment for research on suicidal ideation in major depressive disorder.
  Suicide & life-threatening behavior 2021 McCall WV, Porter B, Pate AR, Bolstad CJ, Drapeau CW, Krystal AD, Benca RM, Rumble ME, Nadorff MR
• Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults.
  JAMA network open 2021 Insel PS, Mohlenhoff BS, Neylan TC, Krystal AD, Mackin RS
• Challenges in Managing Insomnia in Older People.
  The Journal of clinical psychiatry 2021 Krystal AD
• Evaluating lemborexant for the treatment of insomnia.
  Expert opinion on pharmacotherapy 2021 Zammit G, Krystal A
• Cost-effectiveness of digital cognitive behavioral therapy (Sleepio) for insomnia: a Markov simulation model in the United States.
  Sleep 2021 Darden M, Espie CA, Carl JR, Henry AL, Kanady JC, Krystal AD, Miller CB
• State-dependent responses to intracranial brain stimulation in a patient with depression.
  Nature medicine 2021 Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD
• Correction to: Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis.
  Journal of patient-reported outcomes 2020 Dias-Barbosa C, Matos R, Vernon M, Carney CE, Krystal A, Puelles J
• Optimizing computation of overnight decline in delta power: Evidence for slower rate of decline in delta power in insomnia patients.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2020 Lunsford-Avery JR, Edinger JD, Krystal AD
• Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis.
  Journal of patient-reported outcomes 2020 Dias-Barbosa C, Matos R, Vernon M, Carney CE, Krystal A, Puelles J
• Effectiveness of Sequential Psychological and Medication Therapies for Insomnia Disorder: A Randomized Clinical Trial.
  JAMA psychiatry 2020 Morin CM, Edinger JD, Beaulieu-Bonneau S, Ivers H, Krystal AD, Guay B, Bélanger L, Cartwright A, Simmons B, Lamy M, Busby M
• Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.
  Current biology : CB 2020 Shi G, Yin C, Fan Z, Xing L, Mostovoy Y, Kwok PY, Ashbrook LH, Krystal AD, Ptácek LJ, Fu YH
• Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study.
  JMIR mHealth and uHealth 2020 Lunsford-Avery JR, Keller C, Kollins SH, Krystal AD, Jackson L, Engelhard MM
• Blinding and bias in a hypnotic clinical trial.
  Human psychopharmacology 2020 McCall WV, Benca RM, Rumble ME, Krystal AD
• Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy.
  Journal of affective disorders 2020 Krystal AD, Mittoux A, Lindsten A, Baker RA
• An exploratory analysis of the association of circadian rhythm dysregulation and insomnia with suicidal ideation over the course of treatment in individuals with depression, insomnia, and suicidal ideation.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2020 Rumble ME, McCall WV, Dickson DA, Krystal AD, Rosenquist PB, Benca RM
• Omitted Conflict of Interest Disclosures.
  JAMA psychiatry 2020 Krystal AD
• Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020 Pizzagalli DA, Smoski M, Ang YS, Whitton AE, Sanacora G, Mathew SJ, Nurnberger J, Lisanby SH, Iosifescu DV, Murrough JW, Yang H, Weiner RD, Calabrese JR, Goodman W, Potter WZ, Krystal AD
• Is cellular energy monitoring more responsive to hypoxia than pulse oximetry?
  Sleep & breathing = Schlaf & Atmung 2020 Hatch GM, Ashbrook L, Prather AA, Krystal AD
• Efficacy of Digital Cognitive Behavioral Therapy for the Treatment of Insomnia Symptoms Among Pregnant Women: A Randomized Clinical Trial.
  JAMA psychiatry 2020 Felder JN, Epel ES, Neuhaus J, Krystal AD, Prather AA
• A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.
  Nature medicine 2020 Krystal AD, Pizzagalli DA, Smoski M, Mathew SJ, Nurnberger J, Lisanby SH, Iosifescu D, Murrough JW, Yang H, Weiner RD, Calabrese JR, Sanacora G, Hermes G, Keefe RSE, Song A, Goodman W, Szabo ST, …
• The assessment and management of insomnia: an update.
  World psychiatry : official journal of the World Psychiatric Association (WPA) 2019 Krystal AD, Prather AA, Ashbrook LH
• Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.
  The American journal of psychiatry 2019 McCall WV, Benca RM, Rosenquist PB, Youssef NA, McCloud L, Newman JC, Case D, Rumble ME, Szabo ST, Phillips M, Krystal AD
• A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors.
  Neuron 2019 Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, Chong SYC, Chen JA, Coppola G, Geschwind D, Krystal A, Ptácek LJ, Fu YH
• Genetics of the human circadian clock and sleep homeostat.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2019 Ashbrook LH, Krystal AD, Fu YH, Ptácek LJ
• Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.
  The Journal of neuropsychiatry and clinical neurosciences 2019 Scangos KW, Ahmad HS, Shafi A, Sellers KK, Dawes HE, Krystal A, Chang EF
• Sleep therapeutics and neuropsychiatric illness.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2019 Krystal AD
• British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update.
  Journal of psychopharmacology (Oxford, England) 2019 Wilson S, Anderson K, Baldwin D, Dijk DJ, Espie A, Espie C, Gringras P, Krystal A, Nutt D, Selsick H, Sharpley A
• Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder.
  Journal of psychiatric research 2019 McCall WV, Benca RM, Rumble ME, Case D, Rosenquist PB, Krystal AD
• Sleep Pharmacogenetics: The Promise of Precision Medicine.
  Sleep medicine clinics 2019 Krystal AD, Prather AA
• An Electrophysiological Biomarker That May Predict Treatment Response to ECT.
  The journal of ECT 2019 Scangos KW, Weiner RD, Coffey EC, Krystal AD
• Circadian Preference as a Moderator of Depression Outcome Following Cognitive Behavioral Therapy for Insomnia Plus Antidepressant Medications: A Report From the TRIAD Study.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2019 Asarnow LD, Bei B, Krystal A, Buysse DJ, Thase ME, Edinger JD, Manber R
• Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers.
  Journal of Alzheimer's disease : JAD 2019 La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E
• The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.
  Nature reviews. Drug discovery 2018 Krystal AD, Pizzagalli DA, Mathew SJ, Sanacora G, Keefe R, Song A, Calabrese J, Goddard A, Goodman W, Lisanby SH, Smoski M, Weiner R, Iosifescu D, Nurnberger J, Szabo S, Murrough J, Shekhar A, Potter …
• Effect of γ-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy.
  International journal of clinical pharmacology and therapeutics 2018 Szabo ST, Kandra K, Krystal AD
• Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management.
  Anesthesia and analgesia 2018 Dominguez JE, Krystal AD, Habib AS
• Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications.
  Journal of sleep research 2018 Herring WJ, Roth T, Krystal AD, Michelson D
• Screening extremely obese pregnant women for obstructive sleep apnea.
  American journal of obstetrics and gynecology 2018 Dominguez JE, Grotegut CA, Cooter M, Krystal AD, Habib AS
• Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families.
  Sleep medicine 2018 Ohayon MM, Black J, Krystal AD, Shapiro CM, Swick TJ, Bogan R, Wells CC
• An Ultra-miniaturized Near Infrared Spectroscopy System to Assess Sleep Apnea in Children with Down Syndrome.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2018 Beppler EC, Dieffenderfer J, Songkakul T, Krystal A, Bozkurt A
• A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease.
  Sleep medicine reviews 2018 Dominguez JE, Habib AS, Krystal AD
• Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories.
  Journal of consulting and clinical psychology 2018 Bei B, Asarnow LD, Krystal A, Edinger JD, Buysse DJ, Manber R
• Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression.
  The Journal of clinical psychiatry 2018 McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal AD, Sampson SM, Morales O, Nelson BG, Latoussakis V, George MS, Lisanby SH, …
• Dr McClintock and Colleagues Reply.
  The Journal of clinical psychiatry 2018 McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal A, Sampson S, Morales O, Nelson BG, George MS, Lisanby SH
• The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review.
  Journal of affective disorders 2017 Rumble ME, Dickson D, McCall WV, Krystal AD, Case D, Rosenquist PB, Benca RM
• Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation?
  Anesthesiology 2017 Goucher Miranda H, Krystal AD, Fierro MA
• Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder.
  The international journal of neuropsychopharmacology 2017 Connor KM, Ceesay P, Hutzelmann J, Snavely D, Krystal AD, Trivedi MH, Thase M, Lines C, Herring WJ, Michelson D
• Adverse Effects of Hypnotic Medications.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2017 Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN
• Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2017 Evans JL, Nadler JW, Preud'homme XA, Fang E, Daughtry RL, Chapman JB, Attarian D, Wellman S, Krystal AD
• Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial.
  Sleep 2017 Carney CE, Edinger JD, Kuchibhatla M, Lachowski AM, Bogouslavsky O, Krystal AD, Shapiro CM
• Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2017 Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D
• Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data.
  Psychopharmacology 2017 Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D
• A randomised trial of peri-operative positive airway pressure for postoperative delirium in patients at risk for obstructive sleep apnoea after regional anaesthesia with sedation or general anaesthesia for joint arthroplasty.
  Anaesthesia 2017 Nadler JW, Evans JL, Fang E, Preud'Homme XA, Daughtry RL, Chapman JB, Bolognesi MP, Attarian DE, Wellman SS, Krystal AD
• Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2017 Edinger JD, Manber R, Buysse DJ, Krystal AD, Thase ME, Gehrman P, Fairholme CP, Luther J, Wisniewski S
• Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2017 Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL
• Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar.
  American journal of human biology : the official journal of the Human Biology Council 2017 Samson DR, Manus MB, Krystal AD, Fakir E, Yu JJ, Nunn CL
• Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia.
  Sleep 2017 Krystal AD, Preud'homme XA
• Insomnia Patients With Objective Short Sleep Duration Have a Blunted Response to Cognitive Behavioral Therapy for Insomnia.
  Sleep 2017 Bathgate CJ, Edinger JD, Krystal AD
• Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi.
  JAMA psychiatry 2017 Krystal AD, Prather AA
• National Sleep Foundation's sleep quality recommendations: first report.
  Sleep health 2016 Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, …
• Sleep and Mood: Chicken or Egg?
  Biological psychiatry 2016 Ptáoek LJ, Fu YH, Krystal AD
• Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research.
  Clinical psychology review 2016 Lunsford-Avery JR, Krystal AD, Kollins SH
• Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial.
  The Journal of clinical psychiatry 2016 Manber R, Buysse DJ, Edinger J, Krystal A, Luther JF, Wisniewski SR, Trockel M, Kraemer HC, Thase ME
• Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials.
  Depression and anxiety 2016 Carlezon WA, Krystal AD
• Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.
  Trends in pharmacological sciences 2016 Jacobsen JPR, Krystal AD, Krishnan KRR, Caron MG
• Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2016 Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D
• Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA.
  The American journal of psychiatry 2016 McCall WV, Benca RM, Rosenquist PB, Riley MA, McCloud L, Newman JC, Case D, Rumble M, Krystal AD
• Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study.
  The primary care companion for CNS disorders 2016 Krystal AD, Mittoux A, Meisels P, Baker RA
• Hibernation in a primate: does sleep occur?
  Royal Society open science 2016 Blanco MB, Dausmann KH, Faherty SL, Klopfer P, Krystal AD, Schopler R, Yoder AD
• Shining evolutionary light on human sleep and sleep disorders.
  Evolution, medicine, and public health 2016 Nunn CL, Samson DR, Krystal AD
• Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.
  Biological psychiatry 2016 Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, …
• Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia.
  Sleep 2016 Bathgate CJ, Edinger JD, Wyatt JK, Krystal AD
• The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia.
  Human psychopharmacology 2016 Krystal AD, Zammit G
• Recognizing and managing insomnia in primary care and specialty settings.
  The Journal of clinical psychiatry 2016 Krystal AD, Sorscher AJ
• Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504.
  The Journal of clinical psychiatry 2016 Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD, Veterans Affairs Cooperative Study #504 Group
• Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial.
  Trials 2016 Morin CM, Edinger JD, Krystal AD, Buysse DJ, Beaulieu-Bonneau S, Ivers H
• New Developments in Insomnia Medications of Relevance to Mental Health Disorders.
  The Psychiatric clinics of North America 2015 Krystal AD
• Insomnia disorder.
  Nature reviews. Disease primers 2015 Morin CM, Drake CL, Harvey AG, Krystal AD, Manber R, Riemann D, Spiegelhalder K
• Current, emerging, and newly available insomnia medications.
  The Journal of clinical psychiatry 2015 Krystal AD
• Restricting Benzodiazepines to Short-Term Prescription.
  JAMA psychiatry 2015 Krystal JH, Stossel S, Krystal AD
• Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression.
  Brain stimulation 2015 Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal AD, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O'Reardon JP, Gilmer WS, Jain…
• Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2015 Peterchev AV, Krystal AD, Rosa MA, Lisanby SH
• Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial.
  Sleep medicine 2015 Ivgy-May N, Ruwe F, Krystal A, Roth T
• A multi-site randomized clinical trial to reduce suicidal ideation in suicidal adult outpatients with Major Depressive Disorder: Development of a methodology to enhance safety.
  Clinical trials (London, England) 2015 McCall WV, Benca RM, Rosenquist PB, Riley MA, Hodges C, Gubosh B, McCloud L, Newman JC, Case D, Rumble M, Mayo M, White KH, Phillips M, Krystal AD
• Traumatic brain injury detection using electrophysiological methods.
  Frontiers in human neuroscience 2015 Rapp PE, Keyser DO, Albano A, Hernandez R, Gibson DB, Zambon RA, Hairston WD, Hughes JD, Krystal A, Nichols AS
• The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial.
  Schizophrenia research 2014 Tek C, Palmese LB, Krystal AD, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S
• Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials.
  Biological psychiatry 2014 Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal AD, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, Michelson D
• Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders.
  Journal of affective disorders 2014 Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal AD, Laughren T, Macfadden W, Marin R, Nierenberg AA, Tohen M
• A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain.
  Sleep 2014 Goforth HW, Preud'homme XA, Krystal AD
• Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.
  The journal of ECT 2014 McClintock SM, Choi J, Deng ZD, Appelbaum LG, Krystal AD, Lisanby SH
• Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial.
  The Lancet. Neurology 2014 Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M, Lines C, Roth T, Herring WJ
• Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2014 Greve DN, Duntley SP, Larson-Prior L, Krystal AD, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ
• Insomnia in HIV-infected patients: pathophysiologic implications.
  AIDS reviews 2014 Low Y, Goforth H, Preud'homme X, Edinger J, Krystal A
• The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks.
  Journal of psychopharmacology (Oxford, England) 2013 Krystal AD, Zhang W, Davidson JR, Connor KM
• Therapeutic approaches for shankopathies.
  Developmental neurobiology 2013 Wang X, Bey AL, Chung L, Krystal AD, Jiang YH
• The relationship of sleep with temperature and metabolic rate in a hibernating primate.
  PloS one 2013 Krystal AD, Schopler B, Kobbe S, Williams C, Rakatondrainibe H, Yoder AD, Klopfer P
• Optimizing the Pharmacologic Treatment of Insomnia: Current Status and Future Horizons.
  Sleep medicine clinics 2013 Minkel J, Krystal AD
• Does physiological hyperarousal enhance error rates among insomnia sufferers?
  Sleep 2013 Edinger JD, Means MK, Krystal AD
• Obstructive sleep apnea and delirium: exploring possible mechanisms.
  Sleep & breathing = Schlaf & Atmung 2013 Mirrakhimov AE, Brewbaker CL, Krystal AD, Kwatra MM
• Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study.
  Sleep 2013 Roth T, Krystal A, Steinberg FJ, Singh NN, Moline M
• Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications.
  Sleep medicine reviews 2013 Krystal AD, Richelson E, Roth T
• Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.
  The Journal of clinical psychiatry 2013 Krystal AD, Benca RM, Kilduff TS
• Psychiatric disorders and sleep.
  Neurologic clinics 2012 Krystal AD
• Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder.
  Psychiatry research 2012 Rosenquist PB, Krystal A, Heart KL, Demitrack MA, McCall WV
• Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls.
  International urogynecology journal 2012 Preud'homme XA, Amundsen CL, Webster GD, Krystal AD
• Shift work disorder case studies: applying management principles in clinical practice.
  The Journal of clinical psychiatry 2012 Krystal AD, Roth T, Simon RD
• Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity.
  The primary care companion for CNS disorders 2012 Krystal AD, McCall WV, Fava M, Joffe H, Soares CN, Huang H, Grinell T, Zummo J, Spalding W, Marshall R
• Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2012 Low Y, Goforth HW, Omonuwa T, Preud'homme X, Edinger J, Krystal A
• Prevalence and comorbidity of nocturnal wandering in the U.S. adult general population.
  Neurology 2012 Ohayon MM, Mahowald MW, Dauvilliers Y, Krystal AD, Léger D
• Loop diuretics have anxiolytic effects in rat models of conditioned anxiety.
  PloS one 2012 Krystal AD, Sutherland J, Hochman DW
• Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly.
  Anesthesiology 2012 Flink BJ, Rivelli SK, Cox EA, White WD, Falcone G, Vail TP, Young CC, Bolognesi MP, Krystal AD, Trzepacz PT, Moon RE, Kwatra MM
• A WASO sub-group analysis of a 6-month study of eszopiclone 3 mg.
  Sleep medicine 2012 Krystal AD, Huang H, Zummo J, Grinnell T, Marshall RD
• How the circadian rhythm affects sleep, wakefulness, and overall health: background for understanding shift work disorder.
  The Journal of clinical psychiatry 2012 Krystal AD
• The consensus sleep diary: standardizing prospective sleep self-monitoring.
  Sleep 2012 Carney CE, Buysse DJ, Ancoli-Israel S, Edinger JD, Krystal AD, Lichstein KL, Morin CM
• Insomnia is frequent in schizophrenia and associated with night eating and obesity.
  Schizophrenia research 2011 Palmese LB, DeGeorge PC, Ratliff JC, Srihari VH, Wexler BE, Krystal AD, Tek C
• The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study.
  Sleep 2011 Low Y, Preud'homme X, Goforth HW, Omonuwa T, Krystal AD
• Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia.
  Sleep 2011 Krystal AD, Lankford A, Durrence HH, Ludington E, Jochelson P, Rogowski R, Roth T
• Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes.
  Biological psychiatry 2011 Rose JE, McClernon FJ, Froeliger B, Behm FM, Preud'homme X, Krystal AD
• Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis.
  Archives of general psychiatry 2011 Edinger JD, Wyatt JK, Stepanski EJ, Olsen MK, Stechuchak KM, Carney CE, Chiang A, Crisostomo MI, Lineberger MD, Means MK, Radtke RA, Wohlgemuth WK, Krystal AD
• Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients?
  Journal of psychiatric research 2011 Carney CE, Moss TG, Harris AL, Edinger JD, Krystal AD
• Pharmacological advances in the treatment of insomnia.
  Current pharmaceutical design 2011 Richey SM, Krystal AD
• Antidepressant and Antipsychotic Drugs.
  Sleep medicine clinics 2010 Krystal AD
• Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia.
  Sleep 2010 Krystal AD, Durrence HH, Scharf M, Jochelson P, Rogowski R, Ludington E, Roth T
• Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)).
  Psycho-oncology 2010 Flynn KE, Shelby RA, Mitchell SA, Fawzy MR, Hardy NC, Husain AM, Keefe FJ, Krystal AD, Porter LS, Reeve BB, Weinfurt KP
• British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders.
  Journal of psychopharmacology (Oxford, England) 2010 Wilson SJ, Nutt DJ, Alford C, Argyropoulos SV, Baldwin DS, Bateson AN, Britton TC, Crowe C, Dijk DJ, Espie CA, Gringras P, Hajak G, Idzikowski C, Krystal AD, Nash JR, Selsick H, Sharpley AL, Wade AG
• The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2010 Krystal AD, Zammit GK, Wyatt JK, Quan SF, Edinger JD, White DP, Chiacchierini RP, Malhotra A
• Treatment of insomnia in depressed insomniacs: effects on health-related quality of life, objective and self-reported sleep, and depression.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2010 McCall WV, Blocker JN, D'Agostino R, Kimball J, Boggs N, Lasater B, Haskett R, Krystal A, McDonald WM, Rosenquist PB
• Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study.
  Brain stimulation 2010 Janicak PG, Nahas Z, Lisanby SH, Solvason HB, Sampson SM, McDonald WM, Marangell LB, Rosenquist P, McCall WV, Kimball J, O'Reardon JP, Loo C, Husain MH, Krystal A, Gilmer W, Dowd SM, Demitrack MA, …
• In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications.
  Sleep 2010 Krystal AD
• Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study.
  The Journal of urology 2010 Krystal AD, Preud'homme XA, Amundsen CL, Webster GD
• Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia.
  Sleep 2010 Krystal AD, Edinger JD
• A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia.
  Sleep 2010 Ancoli-Israel S, Krystal AD, McCall WV, Schaefer K, Wilson A, Claus R, Rubens R, Roth T
• Using difficulty resuming sleep to define nocturnal awakenings.
  Sleep medicine 2010 Ohayon MM, Krystal A, Roehrs TA, Roth T, Vitiello MV
• A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression.
  The Journal of clinical psychiatry 2009 Krystal AD, Harsh JR, Yang R, Yang RR, Rippon GA, Lankford DA
• The treatment of primary insomnia.
  CNS spectrums 2009 Krystal AD
• The pharmacologic management of insomnia in patients with HIV.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2009 Omonuwa TS, Goforth HW, Preud'homme X, Krystal AD
• A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice.
  Sleep medicine reviews 2009 Krystal AD
• Modeling slow-wave activity dynamics: does an exponentially dampened periodic function really fit a single night of normal human sleep?
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2008 Preud'homme XA, Lanquart JP, Krystal AD, Bogaerts P, Linkowski P
• Assessing depression symptoms in those with insomnia: an examination of the beck depression inventory second edition (BDI-II).
  Journal of psychiatric research 2008 Carney CE, Ulmer C, Edinger JD, Krystal AD, Knauss F
• Measuring sleep quality.
  Sleep medicine 2008 Krystal AD, Edinger JD
• Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008 Lisanby SH, Husain MM, Rosenquist PB, Maixner D, Gutierrez R, Krystal A, Gilmer W, Marangell LB, Aaronson S, Daskalakis ZJ, Canterbury R, Richelson E, Sackeim HA, George MS
• Effects of antipsychotic medications on sleep in schizophrenia.
  International clinical psychopharmacology 2008 Krystal AD, Goforth HW, Roth T
• Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder.
  Archives of general psychiatry 2008 Pollack M, Kinrys G, Krystal A, McCall WV, Roth T, Schaefer K, Rubens R, Roach J, Huang H, Krishnan R
• Psychomotor performance deficits and their relation to prior nights' sleep among individuals with primary insomnia.
  Sleep 2008 Edinger JD, Means MK, Carney CE, Krystal AD
• It is time to take a stand for medical research and against terrorism targeting medical scientists.
  Biological psychiatry 2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff…
• Report of two cases where sleep related eating behavior occurred with the extended-release formulation but not the immediate-release formulation of a sedative-hypnotic agent.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2008 Chiang A, Krystal A
• Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study.
  Sleep 2008 Krystal AD, Erman M, Zammit GK, Soubrane C, Roth T, ZOLONG Study Group
• Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia.
  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 2008 Krystal AD, Thakur M, Roth T
• Sleep quality varies as a function of 5-HTTLPR genotype and stress.
  Psychosomatic medicine 2007 Brummett BH, Krystal AD, Ashley-Koch A, Kuhn CM, Züchner S, Siegler IC, Barefoot JC, Ballard EL, Gwyther LP, Williams RB
• Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations.
  Sleep 2007 Walsh JK, Krystal AD, Amato DA, Rubens R, Caron J, Wessel TC, Schaefer K, Roach J, Wallenstein G, Roth T
• Long-term issues in the treatment of sleep disorders.
  CNS spectrums 2007 Roth T, Krystal AD, Lieberman JA
• Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.
  Psychosomatic medicine 2007 Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, Züchner S, Ashley-Koch A, Barefoot JC, Williams RB
• Psychotic disorder in a patient with central and extrapontine myelinolysis.
  Psychiatry and clinical neurosciences 2007 Lim L, Krystal A
• The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder.
  Biological psychiatry 2007 Krystal AD, Davidson JR
• Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2007 Krystal A, Fava M, Rubens R, Wessel T, Caron J, Wilson P, Roth T, McCall WV
• Treating the health, quality of life, and functional impairments in insomnia.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2007 Krystal AD
• A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder.
  The Journal of clinical psychiatry 2007 Carney CE, Segal ZV, Edinger JD, Krystal AD
• Sleep and psychiatric disorders: future directions.
  The Psychiatric clinics of North America 2006 Krystal AD
• Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2006 Zammit GK, Corser B, Doghramji K, Fry JM, James S, Krystal A, Mangano RM
• A polysomnography study of eszopiclone in elderly patients with insomnia.
  Current medical research and opinion 2006 McCall WV, Erman M, Krystal AD, Rosenberg R, Scharf M, Zammit GK, Wessel T
• Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder.
  Biological psychiatry 2006 Fava M, McCall WV, Krystal A, Wessel T, Rubens R, Caron J, Amato D, Roth T
• Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2006 Walsh JK, Perlis M, Rosenthal M, Krystal A, Jiang J, Roth T
• Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial.
  Archives of internal medicine 2005 Edinger JD, Wohlgemuth WK, Krystal AD, Rice JR
• An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia.
  Sleep medicine 2005 Roth T, Walsh JK, Krystal A, Wessel T, Roehrs TA
• A comparison of placebo and no-treatment during a hypnotic clinical trial.
  International journal of clinical pharmacology and therapeutics 2005 Mccall WV, Perlis ML, Tu X, Groman AE, Krystal A, Walsh JK
• The effect of insomnia definitions, terminology, and classifications on clinical practice.
  Journal of the American Geriatrics Society 2005 Krystal AD
• Hypnotics should be considered for the initial treatment of chronic insomnia. Pro.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2005 Wohlgemuth WK, Krystal AD
• The possibility of preventing functional impairment due to sleep loss by pharmacologically enhancing sleep.
  Sleep 2005 Krystal AD
• Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia.
  The Journal of clinical psychiatry 2004 Perlis ML, McCall WV, Krystal AD, Walsh JK
• Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine.
  Psychopharmacology 2004 Singh J, Zarate CA, Krystal AD
• Depression and insomnia in women.
  Clinical cornerstone 2004 Krystal AD
• Introduction: Definitions, measurements, and management in insomnia.
  The Journal of clinical psychiatry 2004 Krystal AD, Roth T
• Panel discussion: changing how we think about insomnia.
  The Journal of clinical psychiatry 2004 Ancoli-Israel S, Benca RM, Edinger JD, Krystal AD, Mendelson W, Moldofsky H, Petrie J, Roth T, Walsh JK, Winkelman J, Special Issues Board Panel Members
• The changing perspective on chronic insomnia management.
  The Journal of clinical psychiatry 2004 Krystal AD
• Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia.
  Sleep 2003 Krystal AD, Walsh JK, Laska E, Caron J, Amato DA, Wessel TC, Roth T
• Subtyping primary insomnia: is sleep state misperception a distinct clinical entity?
  Sleep medicine reviews 2003 Edinger JD, Krystal AD
• Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT.
  The Journal of neuropsychiatry and clinical neurosciences 2003 Krystal AD, Weiner RD, Dean MD, Lindahl VH, Tramontozzi LA, Falcone G, Coffey CE
• Insomnia in women.
  Clinical cornerstone 2003 Krystal AD
• NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.
  Sleep 2002 Krystal AD, Edinger JD, Wohlgemuth WK, Marsh GR
• The use of valerian in neuropsychiatry.
  CNS spectrums 2001 Krystal AD, Ressler I
• Treatment of the modal patient: does one size fit nearly all?
  The journal of ECT 2001 Sackeim HA, Devanand DP, Lisanby SH, Nobler MS, Prudic J, Heyer EJ, Ornstein E, Weiner RD, Krystal AD, Coffey CE, Greenberg RM, Husain M, Lite MS, Fernandez P, Gaines GY
• Prediction of the utility of a switch from unilateral to bilateral ECT in the elderly using treatment 2 ictal EEG indices.
  The journal of ECT 2000 Krystal AD, Holsinger T, Weiner RD, Coffey CE
• The development and retrospective testing of an electroencephalographic seizure quality-based stimulus dosing paradigm with ECT.
  The journal of ECT 2000 Krystal AD, Weiner RD, Lindahl V, Massie R
• ECT stimulus intensity: are present ECT devices too limited?
  The American journal of psychiatry 2000 Krystal AD, Dean MD, Weiner RD, Tramontozzi LA, Connor KM, Lindahl VH, Massie RW
• EEG effects of ECT: implications for rTMS.
  Depression and anxiety 2000 Krystal AD, West M, Prado R, Greenside H, Zoldi S, Weiner RD
• Stationarity and redundancy of multichannel EEG data recorded during generalized tonic-clonic seizures.
  Brain topography 2000 Zoldi SM, Krystal A, Greenside HS
• New methods of time series analysis of non-stationary EEG data: eigenstructure decompositions of time varying autoregressions.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 1999 Krystal AD, Prado R, West M
• Zolpidem for persistent insomnia in SSRI-treated depressed patients.
  The Journal of clinical psychiatry 1999 Asnis GM, Chakraburtty A, DuBoff EA, Krystal A, Londborg PD, Rosenberg R, Roth-Schechter B, Scharf MB, Walsh JK
• EEG correlates of the response to ECT: a possible antidepressant role of brain-derived neurotrophic factor.
  The journal of ECT 1999 Krystal AD, Weiner RD
• Sleep in peri-menopausal and post-menopausal women.
  Sleep medicine reviews 1998 Krystal AD, Edinger J, Wohlgemuth W, Marsh GR
• Low-dimensional chaos in bipolar disorder?
  Archives of general psychiatry 1998 Krystal AD, Greenside HS
• The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient.
  The journal of ECT 1998 Krystal AD, Watts BV, Weiner RD, Moore S, Steffens DC, Lindahl V
• Changes in seizure threshold over the course of electroconvulsive therapy affect therapeutic response and are detected by ictal EEG ratings.
  The Journal of neuropsychiatry and clinical neurosciences 1998 Krystal AD, Coffey CE, Weiner RD, Holsinger T
• The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy.
  Electroencephalography and clinical neurophysiology 1997 Krystal AD, Zaidman C, Greenside HS, Weiner RD, Coffey CE
• Implementing a hospital-wide pain management strategy.
  Canadian journal of nursing administration 1997 Krystal A, Carr J, Gavaghan K, Porterfield P, Turner L
• Neuropsychiatric considerations in the use of electroconvulsive therapy.
  The Journal of neuropsychiatry and clinical neurosciences 1997 Krystal AD, Coffey CE
• A comparison of EEG signal dynamics in waking, after anesthesia induction and during electroconvulsive therapy seizures.
  Electroencephalography and clinical neurophysiology 1996 Krystal AD, Greenside HS, Weiner RD, Gassert D
• The empirical identification of insomnia subtypes: a cluster analytic approach.
  Sleep 1996 Edinger JD, Fins AI, Goeke JM, McMillan DK, Gersh TL, Krystal AD, McCall WV
• Effect of ECT treatment number on the ictal EEG.
  Psychiatry research 1996 Krystal AD, Weiner RD, Coffey CE, McCall WV
• The relative ability of three ictal EEG frequency bands to differentiate ECT seizures on the basis of electrode placement, stimulus intensity, and therapeutic response.
  Convulsive therapy 1996 Krystal AD, Weiner RD, Gassert D, McCall WV, Coffey CE, Sibert T, Holsinger T
• Cost effectiveness of maintenance ECT.
  Convulsive therapy 1995 Steffens DC, Krystal AD, Sibert TE, Moore SD, Weiner RD
• ECT seizure duration: reliability of manual and computer-automated determinations.
  Convulsive therapy 1995 Krystal AD, Weiner RD
• Seizure threshold in electroconvulsive therapy (ECT) II. The anticonvulsant effect of ECT.
  Biological psychiatry 1995 Coffey CE, Lucke J, Weiner RD, Krystal AD, Aque M
• Seizure threshold in electroconvulsive therapy: I. Initial seizure threshold.
  Biological psychiatry 1995 Coffey CE, Lucke J, Weiner RD, Krystal AD, Aque M
• Ambulatory cassette polysomnography: findings from a large cohort of drug-free insomnia patients.
  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 1995 Edinger JD, Erwin CW, Fins AI, Marsh GR, Krystal AD
• The ictal EEG as a marker of adequate stimulus intensity with unilateral ECT.
  The Journal of neuropsychiatry and clinical neurosciences 1995 Krystal AD, Weiner RD, Coffey CE
• ECT seizure therapeutic adequacy.
  Convulsive therapy 1994 Krystal AD, Weiner RD
• The present use of electroconvulsive therapy.
  Annual review of medicine 1994 Weiner RD, Krystal AD
• The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study.
  Biological psychiatry 1993 Krystal AD, Weiner RD, McCall WV, Shelp FE, Arias R, Smith P
• Low-Frequency Ictal EEG Activity and ECT Therapeutic Impact.
  Convulsive therapy 1993 Krystal AD, Weiner RD
• EEG evidence of more "intense" seizure activity with bilateral ECT.
  Biological psychiatry 1992 Krystal AD, Weiner RD, Coffey CE, Smith P, Arias R, Moffett E
• Ambulatory polysomnography: technical aspects and normative values.
  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 1992 McCall WV, Erwin CW, Edinger JD, Krystal AD, Marsh GR
• The electrophysiology of ECT: relevance to mechanism of action.
  Clinical neuropharmacology 1992 Weiner RD, Krystal AD, Coffey CE, Smith P
• The monitoring and management of electrically induced seizures.
  The Psychiatric clinics of North America 1991 Weiner RD, Coffey CE, Krystal AD
• Shared features of neuroleptic malignant syndrome and alcohol abuse complications.
  The Journal of clinical psychiatry 1990 Krystal AD, McEvoy JP
• Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder.
  The Journal of neuropsychiatry and clinical neurosciences 1990 Krystal A, Krishnan KR, Raitiere M, Poland R, Ritchie JC, Dunnick NR, Hanada K, Nemeroff CB