Andrew Folick, MD, PhD
Clinical Instructor
Medicine
School of Medicine

I am an endocrinologist with clinical and basic science research interest in how the brain regulates metabolism and metabolic disease. My research explores intricate links between lipid metabolism, hypothalamic innate immune responses, and metabolic homeostasis. Clinically, I practice in the Endocrinology Clinic at the San Francisco General Hospital with a focus on lipid disorders and weight management.

Education & Training

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• Residency Internal Medicine UCSF 06/2018
• M.D. Medical School Baylor College of Medicine 06/2016
• Ph.D Developmental Biology Baylor College of Medicine 12/2014
• B.S. Molecular, Cell and Developmental Biology UCLA 2007

Grants and Projects

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• Lipolysis and Oleoylethanolamide Signaling in the Regulation of Longevity, NIH, 2013-2015

Publications (10)

Top publication keywords:
Lipid MetabolismHypothalamusMolecular ChaperonesHomeostasisMicroscopyMicrogliaCaenorhabditis elegans ProteinsLongevityLysosomesObesityBrain DiseasesCaenorhabditis elegansSpectrum Analysis, RamanLipidsMetabolic Diseases

• Lysosome lipid signalling from the periphery to neurons regulates longevity.
  Nature cell biology 2022 Savini M, Folick A, Lee YT, Jin F, Cuevas A, Tillman MC, Duffy JD, Zhao Q, Neve IA, Hu PW, Yu Y, Zhang Q, Ye Y, Mair WB, Wang J, Han L, Ortlund EA, Wang MC
• Metabolic factors in the regulation of hypothalamic innate immune responses in obesity.
  Experimental & molecular medicine 2022 Folick A, Cheang RT, Valdearcos M, Koliwad SK
• Discordant Timing of Hypoglycemic Agent Screening Causing Delayed Diagnosis of Sulfonylurea-Induced Hypoglycemia.
  AACE clinical case reports 2022 Folick A, Cheng C, Chu SN, Rick JW, Rushakoff RJ
• Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis.
  Frontiers in endocrinology 2021 Folick A, Koliwad SK, Valdearcos M
• Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity.
  Developmental cell 2019 Ramachandran PV, Savini M, Folick AK, Hu K, Masand R, Graham BH, Wang MC

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• Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
  Science (New York, N.Y.) 2015 Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC
• In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy.
  Journal of the American Chemical Society 2014 Fu D, Yu Y, Folick A, Currie E, Farese RV, Tsai TH, Xie XS, Wang MC
• Label-free imaging of lipid dynamics using Coherent Anti-stokes Raman Scattering (CARS) and Stimulated Raman Scattering (SRS) microscopy.
  Current opinion in genetics & development 2011 Folick A, Min W, Wang MC
• Role of lipid metabolism in smoothened derepression in hedgehog signaling.
  Developmental cell 2010 Yavari A, Nagaraj R, Owusu-Ansah E, Folick A, Ngo K, Hillman T, Call G, Rohatgi R, Scott MP, Banerjee U
• Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes.
  Genetics 2007 Call GB, Olson JM, Chen J, Villarasa N, Ngo KT, Yabroff AM, Cokus S, Pellegrini M, Bibikova E, Bui C, Cespedes A, Chan C, Chan S, Cheema AK, Chhabra A, Chitsazzadeh V, Do MT, Fang QA, Folick A, …