Andrew Capacci, PhD
Associate Professor
Institute for Neurodegenerative Diseases
School of Medicine

Publications (12)

Top publication keywords:
AldehydesOrganophosphorus CompoundsGlycogen Synthase Kinase 3AlkylationStereoisomerismCyclin-Dependent KinasesIridiumSulfhydryl CompoundsCatalysisPalladiumAlkenesPhenolsRhodiumMolecular StructureNF-E2-Related Factor 2

• Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
  Journal of medicinal chemistry 2024 Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen T, Choi CK, Gilfillan R, Gonzalez-Lopez de Turiso F, Gu C, Hoemberger M, Johnson DS, Jones JH, Kadakia E, Kirkland M, Lin EY, Liu Y, Ma B, Magee T,…
• Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
  ACS chemical neuroscience 2023 Amaral B, Capacci A, Anderson T, Tezer C, Bajrami B, Lulla M, Lucas B, Chodaparambil JV, Marcotte D, Kumar PR, Murugan P, Spilker K, Cullivan M, Wang T, Peterson AC, Enyedy I, Ma B, Chen T, Yousaf Z, …
• Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.
  Bioorganic & medicinal chemistry letters 2019 Ma B, Lucas B, Capacci A, Lin EY, Jones JH, Dechantsreiter M, Enyedy I, Marcotte D, Xiao G, Li B, Richter K
• CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling.
  Science signaling 2018 Henry KL, Kellner D, Bajrami B, Anderson JE, Beyna M, Bhisetti G, Cameron T, Capacci AG, Bertolotti-Ciarlet A, Feng J, Gao B, Hopkins B, Jenkins T, Li K, May-Dracka T, Murugan P, Wei R, Zeng W, …
• Direct, enantioselective α-alkylation of aldehydes using simple olefins.
  Nature chemistry 2017 Capacci AG, Malinowski JT, McAlpine NJ, Kuhne J, MacMillan DWC

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• Efficient chiral monophosphorus ligands for asymmetric Suzuki-Miyaura coupling reactions.
  Organic letters 2012 Tang W, Patel ND, Xu G, Xu X, Savoie J, Ma S, Hao MH, Keshipeddy S, Capacci AG, Wei X, Zhang Y, Gao JJ, Li W, Rodriguez S, Lu BZ, Yee NK, Senanayake CH
• Diastereoselective intramolecular Friedel-Crafts alkylation of tetralins.
  Organic letters 2011 Liébert C, Brinks MK, Capacci AG, Fleming MJ, Lautens M
• A general and special catalyst for Suzuki-Miyaura coupling processes.
  Angewandte Chemie (International ed. in English) 2010 Tang W, Capacci AG, Wei X, Li W, White A, Patel ND, Savoie J, Gao JJ, Rodriguez S, Qu B, Haddad N, Lu BZ, Krishnamurthy D, Yee NK, Senanayake CH
• Copper catalyzed asymmetric propargylation of aldehydes.
  Journal of the American Chemical Society 2010 Fandrick DR, Fandrick KR, Reeves JT, Tan Z, Tang W, Capacci AG, Rodriguez S, Song JJ, Lee H, Yee NK, Senanayake CH
• Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation.
  Organic letters 2010 Tang W, Capacci AG, White A, Ma S, Rodriguez S, Qu B, Savoie J, Patel ND, Wei X, Haddad N, Grinberg N, Yee NK, Krishnamurthy D, Senanayake CH
• Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation.
  Organic letters 2010 Tang W, Qu B, Capacci AG, Rodriguez S, Wei X, Haddad N, Narayanan B, Ma S, Grinberg N, Yee NK, Krishnamurthy D, Senanayake CH
• A facile and practical synthesis of N-acetyl enamides.
  The Journal of organic chemistry 2009 Tang W, Capacci A, Sarvestani M, Wei X, Yee NK, Senanayake CH