Andrew Burghardt
Specialist
Radiology
School of Medicine

Osteoporosis, rheumatoid arthritis, and bone acquisition and development are the principle focus application areas for his research. As a Principal Investigator he has been awarded two R01s from NIH related to the standardization of HR-pQCT and the development of 3D statistical mapping techniques for population-based analyses of bone quality. He is a co-investigator on a number of significant NIH-funded multicenter skeletal health projects, including Osteoporotic Fractures in Men (MrOS), and the Epidemiology of Diabetes Interventions and Complications (EDIC). He was a member of the joint International Osteoporosis Foundation, ASBMR, and ECTS working group that produced guidelines for the use of HR-pQCT in skeletal health studies. Recently his research interests have expanded to include the development of standardized methods for using HR-pQCT in pediatric populations through collaborations with Stanford University. At UCSF he is developing a multidisciplinary program to study skeletal development in transgender youth. Finally, he is a founding member of the SPECTRA group (Study GrouP for XTrEme-CT in RA) that aims to develop standard methods to detect and quantify early signs of progression and treatment response in rheumatoid arthritis using HR-pQCT.

• The Bone, Exercise, Alendronate, and Caloric Restriction (BEACON) trial design and methods.
  Contemporary clinical trials 2024 Beavers KM, Wolle BR, Ard JD, Beavers DP, Biehl O, Brubaker PH, Burghardt AJ, Calderone CT, Carballido-Gamio J, Fanning J, Kohrt WM, Love M, MacLean CM, Nicklas BJ, Stapleton J, Swanson CM, Weaver AA,…
• Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-standing Type 1 Diabetes.
  Diabetes care 2024 Sinha Gregory N, Burghardt AJ, Backlund JC, Rubin MR, Bebu I, Braffett BH, Kenny DJ, Link TM, Kazakia GJ, Barnie A, Lachin JM, Gubitosi-Klug R, de Boer IH, Schwartz AV, DCCT/EDIC Research Group
• HR-pQCT cross-calibration using standard vs. Laplace-Hamming binarization approach.
  JBMR plus 2024 Sadoughi S, Subramanian A, Ramil G, Zhou M, Burghardt AJ, Kazakia GJ
• Risk Factors for Bone Microarchitecture Impairments in Older Men with Type 2 Diabetes - The MrOS Study.
  The Journal of clinical endocrinology and metabolism 2024 Faraj M, Schwartz AV, Burghardt AJ, Black D, Orwoll E, Strotmeyer ES, Vittinghoff E, Banfi G, Lombardi G, Woods G, Lui LY, Bouxsein M, Napoli N
• ORMIR_XCT: A Python package for high resolution peripheral quantitative computed tomography image processing.
  The Journal of Open Source Software 2024 Michael T. Kuczynski, Nathan J. Neeteson, Kathryn S. Stok, Andrew J. Burghardt, Michelle A. Espinosa Hernandez, Jared Vicory, Justin J. Tse, Pholpat Durongbhan, Serena Bonaretti, Andy Kin On Wong, …
• Association entre la Cystatine C, eGFRcys et eGFRdiff, et la densité volumétrique osseuse évaluée par scanner périphérique de haute résolution (HR-pQCT) dans la cohorte MrOS (Osteoporotic Fractures in Men Study Research Group).
  Revue du Rhumatisme 2023 E. Koumakis, A. Potok, K. Ensrud, A. Burghardt, N. Lane, K.S. Freeland, C. Ginsberg, J.A. Cauley
• Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography.
  Journal of visualized experiments : JoVE 2023 Al-Khoury Y, Finzel S, Figueiredo C, Burghardt AJ, Stok KS, Tam LS, Cheng I, Tse JJ, Manske SL
• The Added Value of High-Resolution Peripheral Quantitative Computed Tomography in Fracture Risk Prediction.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Lorentzon M, Burghardt AJ
• Interactions Between HR-pQCT Bone Density and D3 Cr Muscle Mass (or HR-pQCT Bone Structure and HR-pQCT Muscle Density) in Predicting Fractures: The Osteoporotic Fractures in Men Study.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Kirk B, Harrison SL, Zanker J, Burghardt AJ, Orwoll E, Duque G, Cawthon PM
• Recommendations for High-resolution Peripheral Quantitative Computed Tomography Assessment of Bone Density, Microarchitecture, and Strength in Pediatric Populations.
  Current osteoporosis reports 2023 Gabel L, Kent K, Hosseinitabatabaei S, Burghardt AJ, Leonard MB, Rauch F, Willie BM
• A Laplace-Hamming Binarization Approach for Second-Generation HR-pQCT Rescues Fine Feature Segmentation.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Sadoughi S, Subramanian A, Ramil G, Burghardt AJ, Kazakia GJ
• Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis.
  Calcified tissue international 2023 Heilmeier U, Burghardt AJ, Tse JJ, Kapoor P, Stok KS, Manske S, Voll RE, Schett G, Finzel S
• Interpretation of Bone Mineral Density Z-Scores by Dual-Energy X-Ray Absorptiometry in Transgender and Gender Diverse Youth Prior to Gender-Affirming Medical Therapy.
  Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 2022 Lee JY, Fan B, Montenegro G, Long RK, Sanda S, Capodanno G, Schafer AL, Burghardt AJ, Rosenthal SM, Fung EB
• Biochemical Markers of Bone Turnover in Older Adults With Type 1 Diabetes.
  The Journal of clinical endocrinology and metabolism 2022 Rubin MR, de Boer IH, Backlund JC, Arends V, Gubitosi-Klug R, Wallia A, Sinha Gregory N, Barnie A, Burghardt AJ, Lachin JM, Braffett BH, Schwartz AV
• Corrigendum to: CT Muscle Density, D3Cr Muscle Mass, and Body Fat Associations With Physical Performance, Mobility Outcomes, and Mortality Risk in Older Men.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2022 Orwoll ES, Blackwell T, Cummings SR, Cauley JA, Lane NE, Hoffman AR, Burghardt AJ, Evans WJ, Cawthon PM
• Augmenting Osteoporosis Imaging with Machine Learning.
  Current osteoporosis reports 2021 Pedoia V, Caliva F, Kazakia G, Burghardt AJ, Majumdar S
• Global and Spatial Compartmental Interrelationships of Bone Density, Microstructure, Geometry and Biomechanics in the Distal Radius in a Colles' Fracture Study Using HR-pQCT.
  Frontiers in endocrinology 2021 Shiraishi K, Burghardt AJ, Osaki M, Khosla S, Carballido-Gamio J
• Differences in bone mineral density and morphometry measurements by fixed versus relative offset methods in high-resolution peripheral quantitative computed tomography.
  Bone 2021 Okazaki N, Chiba K, Burghardt AJ, Kondo C, Doi M, Yokota K, Yonekura A, Tomita M, Osaki M
• HR-pQCT-based regional analysis reveals tibial spatial variability in cortical bone tissue quality in type 2 diabetic postmenopausal women with and without history of fragility fractures.
  Bone Reports 2021 Ursula Heilmeier, Courtney Pasco, Meliss Yilmaz, Andrew J. Burghardt, Gabby B. Joseph, Thomas M. Link, Galateia J. Kazakia
• Longitudinal Evolution of Bone Microarchitecture and Bone Strength in Type 2 Diabetic Postmenopausal Women With and Without History of Fragility Fractures-A 5-Year Follow-Up Study Using High Resolution Peripheral Quantitative Computed Tomography.
  Frontiers in endocrinology 2021 Heilmeier U, Joseph GB, Pasco C, Dinh N, Torabi S, Darakananda K, Youm J, Carballido-Gamio J, Burghardt AJ, Link TM, Kazakia GJ
• Reliability and Change in Erosion Measurements by High-resolution Peripheral Quantitative Computed Tomography in a Longitudinal Dataset of Rheumatoid Arthritis Patients.
  The Journal of rheumatology 2020 Finzel S, Manske SL, Barnabe CCM, Burghardt AJ, Marotte H, Scharmga A, Hauge EM, Chapurlat R, Engelke K, Li X, van Teeffelen BCJ, Conaghan PG, Stok KS
• High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease.
  Frontiers in medicine 2020 Klose-Jensen R, Tse JJ, Keller KK, Barnabe C, Burghardt AJ, Finzel S, Tam LS, Hauge EM, Stok KS, Manske SL
• Consensus approach for 3D joint space width of metacarpophalangeal joints of rheumatoid arthritis patients using high-resolution peripheral quantitative computed tomography.
  Quantitative imaging in medicine and surgery 2020 Stok KS, Burghardt AJ, Boutroy S, Peters MPH, Manske SL, Stadelmann V, Vilayphiou N, van den Bergh JP, Geusens P, Li X, Marotte H, van Rietbergen B, Boyd SK, Barnabe C, SPECTRA Collaboration
• Objective measures of moderate to vigorous physical activity are associated with higher distal limb bone strength among elderly men.
  Bone 2019 Langsetmo L, Burghardt AJ, Schousboe JT, Cawthon PM, Cauley JA, Lane NE, Orwoll ES, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Group
• HR-pQCT Measures of Bone Microarchitecture Predict Fracture: Systematic Review and Meta-Analysis.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Mikolajewicz N, Bishop N, Burghardt AJ, Folkestad L, Hall A, Kozloff KM, Lukey PT, Molloy-Bland M, Morin SN, Offiah AC, Shapiro J, van Rietbergen B, Wager K, Willie BM, Komarova SV, Glorieux FH
• THU0067 THREE-MONTH RADIOLOGICAL CHANGES IN WRIST JOINT MEASURED BY MRI AND HR-PQCT CAN PREDICT 12-MONTH CHANGES IN EROSION AND FUNCTIONAL OUTCOMES AFTER MTX AND ANTI-TNF TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A MULTI-MODALITY IMAGING STUDY.
  Poster Presentations 2019 Kenji Mamoto, Tomohiro Shimizu, Matthew Tanaka, Valentina Pedoia, Andrew Burghardt, Ursula Heilmeier, Thomas Link, Jonathan Graf, John Imboden, LI Xiaojuan
• Hip Fracture Discrimination Based on Statistical Multi-parametric Modeling (SMPM).
  Annals of biomedical engineering 2019 Carballido-Gamio J, Yu A, Wang L, Su Y, Burghardt AJ, Lang TF, Cheng X
• Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis.
  The Journal of rheumatology 2019 Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X
• Investigation of Semi-Coupled Dictionary Learning in 3-D Super Resolution HR-pQCT Imaging
  IEEE Transactions on Radiation and Plasma Medical Sciences 2018 Li Y, Sixou B, Burghardt AJ, Peyrin F
• THE ASSOCIATION BETWEEN OBJECTIVELY MEASURED PHYSICAL ACTIVITY AND BONE STRENGTH AMONG OLDER MEN.
  Innovation in Aging 2018 L Langsetmo, K Ensrud, J Cauley, P Cawthon, A Burghardt
• Accelerated Bone Loss in Older Men: Effects on Bone Microarchitecture and Strength.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2018 Cauley JA, Burghardt AJ, Harrison SL, Cawthon PM, Schwartz AV, Connor EB, Ensrud KE, Langsetmo L, Majumdar S, Orwoll E, Osteoporotic Fractures in Men (MrOS) Research Group
• Weight loss in men in late life and bone strength and microarchitecture: a prospective study.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2018 Ensrud KE, Vo TN, Burghardt AJ, Schousboe JT, Cauley JA, Taylor BC, Hoffman AR, Orwoll ES, Lane NE, Langsetmo L, Osteoporotic Fractures in Men (MrOS) Research Group
• Chapter 55 High-Resolution Imaging Techniques for Bone Quality Assessment.
  Vitamin D 2018 Andrew J. Burghardt, Roland Krug, Sharmila Majumdar
• High dairy protein intake is associated with greater bone strength parameters at the distal radius and tibia in older men: a cross-sectional study.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2017 Langsetmo L, Shikany JM, Burghardt AJ, Cawthon PM, Orwoll ES, Cauley JA, Taylor BC, Schousboe JT, Bauer DC, Vo TN, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Research Group
• Assessment of 3-month changes in bone microstructure under anti-TNFα therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT).
  Arthritis research & therapy 2017 Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X
• The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions.
  The Journal of rheumatology 2017 Stok KS, Finzel S, Burghardt AJ, Conaghan PG, Barnabe C, SPECTRA Collaboration
• OP0020 Assessment of 3-month changes in bone microstructure under anti-tnfa therapy in patients with rheumatoid arthritis using hr-pqct.
  Annals of the Rheumatic Diseases 2017 T Shimizu, HJ Choi, U Heilmeier, M Tanaka, AJ Burghardt, J Gong, N Chanchek, TM Link, J Graf, JB Imboden, X Li
• Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions.
  Bone 2017 Ghasem-Zadeh A, Burghardt A, Wang XF, Iuliano S, Bonaretti S, Bui M, Zebaze R, Seeman E
• The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2017 Bonaretti S, Majumdar S, Lang TF, Khosla S, Burghardt AJ
• Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD.
  Bone reports 2016 Okazaki N, Burghardt AJ, Chiba K, Schafer AL, Majumdar S
• Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High-resolution Peripheral Quantitative Computed Tomography.
  The Journal of rheumatology 2016 Tom S, Frayne M, Manske SL, Burghardt AJ, Stok KS, Boyd SK, Barnabe C
• Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 Heilmeier U, Hackl M, Skalicky S, Weilner S, Schroeder F, Vierlinger K, Patsch JM, Baum T, Oberbauer E, Lobach I, Burghardt AJ, Schwartz AV, Grillari J, Link TM
• Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 Bonaretti S, Vilayphiou N, Chan CM, Yu A, Nishiyama K, Liu D, Boutroy S, Ghasem-Zadeh A, Boyd SK, Chapurlat R, McKay H, Shane E, Bouxsein ML, Black DM, Majumdar S, Orwoll ES, Lang TF, Khosla S, …
• Microarchitecture and Peripheral BMD are Impaired in Postmenopausal White Women With Fracture Independently of Total Hip T-Score: An International Multicenter Study.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 Boutroy S, Khosla S, Sornay-Rendu E, Zanchetta MB, McMahon DJ, Zhang CA, Chapurlat RD, Zanchetta J, Stein EM, Bogado C, Majumdar S, Burghardt AJ, Shane E
• SAT0545 The Effect of anti-TNF Alpha Treatment on Erosion Progression in Rheumatoid Arthritis by High-Resolution Peripheral Quantitative Computed Tomography: Three-Month Data.
  Annals of the Rheumatic Diseases 2016 H. Choi, U. Heilmeier, M. Tanaka, A.J. Burghardt, N. Chanchek, T.M. Link, J. Graft, J.B. Imboden, X. Li
• Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2016 Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G
• Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016 Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S
• Automatic multi-parametric quantification of the proximal femur with quantitative computed tomography.
  Quantitative imaging in medicine and surgery 2015 Carballido-Gamio J, Bonaretti S, Saeed I, Harnish R, Recker R, Burghardt AJ, Keyak JH, Harris T, Khosla S, Lang TF
• Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography.
  International journal of rheumatic diseases 2015 Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X
• Spatial distribution of intracortical porosity varies across age and sex.
  Bone 2015 Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ
• Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2015 Heilmeier U, Carpenter DR, Patsch JM, Harnish R, Joseph GB, Burghardt AJ, Baum T, Schwartz AV, Lang TF, Link TM
• Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD.
  Physics in medicine and biology 2014 Bonaretti S, Carpenter RD, Saeed I, Burghardt AJ, Yu L, Bruesewitz M, Khosla S, Lang T
• Validation of bone marrow fat quantification in the presence of trabecular bone using MRI.
  Journal of magnetic resonance imaging : JMRI 2014 Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R
• Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis.
  International journal of rheumatic diseases 2014 Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM, Li X
• Population-based local multi-parametric comparisons of HR-pQCT studies.
  Journal of Orthopaedic Translation 2014 Julio Carballido-Gamio, Serena Bonaretti, Galateia J. Kazakia, Sundeep Khosla, Thomas F. Lang, Andrew J. Burghardt
• Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats.
  Calcified tissue international 2014 Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y
• Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study.
  The Journal of rheumatology 2014 Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X
• Three-dimensional analysis of subchondral cysts in hip osteoarthritis: an ex vivo HR-pQCT study.
  Bone 2014 Chiba K, Burghardt AJ, Osaki M, Majumdar S
• Latest Developments in Computed Tomographic Imaging in Joint Disease.
  Japanese Journal of Rheumatism and Joint Surgery 2014 Ko CHIBA, ?? ??, Andrew BURGHARDT, Sharmila MAJUMDAR, ?? ?
• SAT0178 Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography (HR-PQCT): Reliability Exercise-2 (RELEX-2).
  Annals of the Rheumatic Diseases 2014 C. Barnabe, H. Marotte, A. Scharmga, S. Kraus, A. Burghardt, E.-M. Hauge, S. Boutroy, D. Toepfer, K. Engelke, R. Kocijan, J. de Jong, X. Li, K. Stok, S. Finzel
• The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT.
  Bone 2014 Kazakia GJ, Tjong W, Nirody JA, Burghardt AJ, Carballido-Gamio J, Patsch JM, Link T, Feeley BT, Ma CB
• Structural analysis of cortical porosity applied to HR-pQCT data.
  Medical physics 2014 Tjong W, Nirody J, Burghardt AJ, Carballido-Gamio J, Kazakia GJ
• Quantification of lower leg arterial calcifications by high-resolution peripheral quantitative computed tomography.
  Bone 2013 Patsch JM, Zulliger MA, Vilayphou N, Samelson EJ, Cejka D, Diarra D, Berzaczy G, Burghardt AJ, Link TM, Weber M, Loewe C
• Heterogeneity of bone microstructure in the femoral head in patients with osteoporosis: an ex vivo HR-pQCT study.
  Bone 2013 Chiba K, Burghardt AJ, Osaki M, Majumdar S
• High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group.
  Current osteoporosis reports 2013 Cheung AM, Adachi JD, Hanley DA, Kendler DL, Davison KS, Josse R, Brown JP, Ste-Marie LG, Kremer R, Erlandson MC, Dian L, Burghardt AJ, Boyd SK
• Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS).
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2013 Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM
• Multiple subchondral cyst formation has strong correlation with bone sclerosis: ex vivo HR-pQCT study.
  Osteoarthritis and Cartilage 2013 K. Chiba, A. Burghardt, M. Osaki, S. Majumdar
• Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis.
  The Journal of rheumatology 2013 Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X
• Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, Link TM
• Computational identification and quantification of trabecular microarchitecture classes by 3-D texture analysis-based clustering.
  Bone 2013 Valentinitsch A, Patsch JM, Burghardt AJ, Link TM, Majumdar S, Fischer L, Schueller-Weidekamm C, Resch H, Kainberger F, Langs G
• Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis.
  Bone 2012 Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt AJ, Majumdar S
• Microstructure analysis of subchondral trabecular bone in hip osteoarthritis - ex-vivo HR-pQCT study -.
  Osteoarthritis and Cartilage 2012 K. Chiba, A. Burghardt, S. Majumdar
• The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure.
  Medical physics 2012 Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S
• Vascular patterning and permeability in prostate cancer models with differing osteogenic properties.
  NMR in biomedicine 2011 Dafni H, Burghardt AJ, Majumdar S, Navone NM, Ronen SM
• Noninvasive imaging of bone microarchitecture.
  Annals of the New York Academy of Sciences 2011 Patsch JM, Burghardt AJ, Kazakia G, Majumdar S
• Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis.
  Magnetic resonance imaging 2011 Pinney JR, Taylor C, Doan R, Burghardt AJ, Li X, Kim HT, Benjamin Ma C, Majumdar S
• Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture.
  Bone 2011 Pialat JB, Burghardt AJ, Sode M, Link TM, Majumdar S
• Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?
  Journal of magnetic resonance imaging : JMRI 2011 Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM
• Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment.
  PloS one 2011 Jobke B, Burghardt AJ, Muche B, Hahn M, Semler J, Amling M, Majumdar S, Busse B
• Morphology of the human vertebral endplate.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2011 Rodriguez AG, Rodriguez-Soto AE, Burghardt AJ, Berven S, Majumdar S, Lotz JC
• High-resolution computed tomography for clinical imaging of bone microarchitecture.
  Clinical orthopaedics and related research 2011 Burghardt AJ, Link TM, Majumdar S
• Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study.
  Journal of magnetic resonance imaging : JMRI 2011 Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S
• Teriparatide in bisphosphonate-resistant osteoporosis: microarchitectural changes and clinical results after 6 and 18 months.
  Calcified tissue international 2011 Jobke B, Muche B, Burghardt AJ, Semler J, Link TM, Majumdar S
• Vitamin D, 3rd Edition, Feldman, Pike, and Adams
  Chapter 50: High-Resolution Imaging Techniques for Bone Quality Assessment 2011 Burghardt AJ, Krug R, Majumdar S
• Age-related differences in cortico-trabecular connectivity and load transfer in the distal radius measured in vivo by HR-pQCT.
  Bone 2011 A.J. Burghardt, G.J. Kazakia?, T.M. Link, S. Majumdar
• Longitudinal in vivo HR-pQCT assessment of the influence of non-weight bearing on bone quality.
  Bone 2011 W. Tjong, M. Sode, A. Burghardt, S. Majumdar, B. Feeley, B. Ma, G. Kazakia
• Human disc nucleus properties and vertebral endplate permeability.
  Spine 2011 Rodriguez AG, Slichter CK, Acosta FL, Rodriguez-Soto AE, Burghardt AJ, Majumdar S, Lotz JC
• Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibia.
  Bone 2011 Sode M, Burghardt AJ, Pialat JB, Link TM, Majumdar S
• Chapter 50 High-Resolution Imaging Techniques for Bone Quality Assessment.
  Vitamin D 2011 Andrew J. Burghardt, Roland Krug, Sharmila Majumdar
• Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD.
  Journal of biomechanics 2010 Kazakia GJ, Burghardt AJ, Link TM, Majumdar S
• Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women.
  Bone 2010 Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S
• High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus.
  The Journal of clinical endocrinology and metabolism 2010 Burghardt AJ, Issever AS, Schwartz AV, Davis KA, Masharani U, Majumdar S, Link TM
• A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S
• Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT.
  Bone 2010 Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK
• Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S
• High-resolution imaging techniques for the assessment of osteoporosis.
  Radiologic clinics of North America 2010 Krug R, Burghardt AJ, Majumdar S, Link TM
• Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia.
  Bone 2010 Sode M, Burghardt AJ, Kazakia GJ, Link TM, Majumdar S
• Contribution of the intra-specimen variations in tissue mineralization to PTH- and raloxifene-induced changes in stiffness of rat vertebrae.
  Bone 2009 Easley SK, Jekir MG, Burghardt AJ, Li M, Keaveny TM
• Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats.
  Bone 2009 Shahnazari M, Yao W, Dai W, Wang B, Ionova-Martin SS, Ritchie RO, Heeren D, Burghardt AJ, Nicolella DP, Kimiecik MG, Lane NE
• Trabecular bone structure analysis in the osteoporotic spine using a clinical in vivo setup for 64-slice MDCT imaging: comparison to microCT imaging and microFE modeling.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 Issever AS, Link TM, Kentenich M, Rogalla P, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Diederichs G
• Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard.
  European radiology 2009 Issever AS, Link TM, Kentenich M, Rogalla P, Burghardt AJ, Kazakia GJ, Majumdar S, Diederichs G
• Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography.
  Bone 2009 Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S
• Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2009 Burghardt AJ, Kazakia GJ, Link TM, Majumdar S
• Assessment of trabecular bone structure of the calcaneus using multi-detector CT: correlation with microCT and biomechanical testing.
  Bone 2009 Diederichs G, Link TM, Kentenich M, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Rogalla P, Issever AS
• Feasibility of measuring trabecular bone structure of the proximal femur using 64-slice multidetector computed tomography in a clinical setting.
  Calcified tissue international 2008 Diederichs G, Link T, Marie K, Huber M, Rogalla P, Burghardt A, Majumdar S, Issever A
• Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography.
  Calcified tissue international 2008 Burghardt AJ, Kazakia GJ, Laib A, Majumdar S
• Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements.
  Medical physics 2008 Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S
• In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S
• In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T.
  Journal of magnetic resonance imaging : JMRI 2008 Krug R, Carballido-Gamio J, Banerjee S, Burghardt AJ, Link TM, Majumdar S
• Resolution dependence of the non-metric trabecular structure indices.
  Bone 2007 Sode M, Burghardt AJ, Nissenson RA, Majumdar S
• Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.
  Endocrinology 2007 Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA
• Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2007 Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S
• The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography.
  Calcified tissue international 2007 Davis KA, Burghardt AJ, Link TM, Majumdar S
• IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD
• A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone.
  Annals of biomedical engineering 2007 Burghardt AJ, Kazakia GJ, Majumdar S
• Analysis of trabecular bone structure with multidetector spiral computed tomography in a simulated soft-tissue environment.
  Calcified tissue international 2007 Bauer JS, Link TM, Burghardt A, Henning TD, Mueller D, Majumdar S, Prevrhal S
• Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.
  Journal of applied physiology (Bethesda, Md. : 1985) 2007 Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP
• Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements.
  Magnetic resonance imaging 2006 Krug R, Carballido-Gamio J, Burghardt AJ, Haase S, Sedat JW, Moss WC, Majumdar S
• Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy.
  Bone 2006 Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S
• Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I.
  The Journal of endocrinology 2006 Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD
• Fourier Transform Infrared Imaging of focal lesions in human osteoarthritic cartilage.
  European cells & materials 2005 David-Vaudey E, Burghardt A, Keshari K, Brouchet A, Ries M, Majumdar S
• Trabecular architecture of lumbar vertebral pedicle.
  Spine 2005 Inceoglu S, Burghardt A, Akbay A, Majumdar S, McLain RF
• Quantification of trabecular bone structure using magnetic resonance imaging at 3 Tesla--calibration studies using microcomputed tomography as a standard of reference.
  Calcified tissue international 2005 Sell CA, Masi JN, Burghardt A, Newitt D, Link TM, Majumdar S
• Wavelet Based Characterization of Vertebral Trabecular Bone Structure from MR Images of Specimen at 3 Tesla Compared to MicroCT Measurements.
  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2005 Krug R, Carballido-Gamio J, Burghardt A, Haase S, Sedat J, Moss W, Majumdar S
• Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG
• Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Cao JJ, Singleton PA, Majumdar S, Boudignon B, Burghardt A, Kurimoto P, Wronski TJ, Bourguignon LY, Halloran BP
• Contribution of inter-site variations in architecture to trabecular bone apparent yield strains.
  Journal of biomechanics 2004 Morgan EF, Bayraktar HH, Yeh OC, Majumdar S, Burghardt A, Keaveny TM
• Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure.
  European radiology 2004 Majumdar S, Issever AS, Burghardt A, Lotz J, Arfelli F, Rigon L, Heitner G, Menk RH
• The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC
• Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae.
  Spine 2003 Issever AS, Walsh A, Lu Y, Burghardt A, Lotz JC, Majumdar S
• MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003 Patel V, Issever AS, Burghardt A, Laib A, Ries M, Majumdar S
• Changes in bone structure and mass with advancing age in the male C57BL/6J mouse.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002 Halloran BP, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S
• Sensitivity of damage predictions to tissue level yield properties and apparent loading conditions.
  Journal of biomechanics 2001 Niebur GL, Yuen JC, Burghardt AJ, Keaveny TM