Andrei Goga, MD, PhD
Professor
Cell and Tissue Biology
School of Dentistry

Awards

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• CDMRP Era of Hope Scholar, 2012
• Leukemia and Lymphoma Society Scholar, 2012
• American Society for Clinical Investigations, 2011
• V-Foundation Scholar, 2009
• Susan G. Komen Scholar Award, 2008
• NCI K08 Mentored-Physician Scientist Award, 2005
• HHMI Physician-Scientist Fellowship Award, 2001

Education & Training

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• Medical Oncology Fellowship School of Medicine University of California, San Francisco 2003
• M.D., Ph.D. School of Medicine University of California Los Angeles 1997
• Residency School of Medicine University of California, San Francisco

Websites

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• Tetrad Graduate program (tetrad.ucsf.edu)
• Profile at UCSF Cancer Center (cancer.ucsf.edu)
• Goga Lab (oncogenes.net)
• Clinical Profile at UCSF Medical Center (ucsfhealth.org)
• Lab Website (oncogenes.net)
• BMS Graduate program (bms.ucsf.edu)

Grants and Projects

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• Molecular and Cellular Mechanisms in Cancer, NIH, 2004-2025
• Understanding breast cancer progression as a defect in the mechanics of tissue self-organization, NIH, 2020-2025
• Uncovering Mechanisms of Regulation and Dependency on Fatty Acid Oxidation in MYC-Driven Tumors, NIH, 2018-2023
• Integrative approach to heterogeneity in breast cancer metastasis, NIH, 2016-2021
• In Vivo Metabolic Catastrophe Is Induced By Acute Oncogene Inhibition (PQ #22), NIH, 2012-2018
• Targeting the MYC Oncogene with CDK Inhibitors, NIH, 2010-2017
• CDK Inhibition in Cancer, NIH, 2005-2011

Publications (84)

Top publication keywords:
Triple Negative Breast NeoplasmsCell Transformation, NeoplasticTumor Suppressor Protein p53Liver Neoplasms, ExperimentalCDC2 Protein KinaseCyclin-Dependent Kinase 2OncogenesMicroRNAsMyeloid Cell Leukemia Sequence 1 ProteinGlutamate-Cysteine LigaseAurora Kinase BProto-Oncogene Proteins c-mycProtein Kinase InhibitorsPyruvic AcidProto-Oncogene Proteins c-pim-1

• Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment.
  Journal for immunotherapy of cancer 2024 Turpin R, Liu R, Munne PM, Peura A, Rannikko JH, Philips G, Boeckx B, Salmelin N, Hurskainen E, Suleymanova I, Aung J, Vuorinen EM, Lehtinen L, Mutka M, Kovanen PE, Niinikoski L, Meretoja TJ, Mattson …
• The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.
  PloS one 2024 Sutanto R, Neahring L, Serra Marques A, Jacobo Jacobo M, Kilinc S, Goga A, Dumont S
• An inflamed tumor cell subpopulation promotes chemotherapy resistance in triple negative breast cancer.
  Scientific reports 2024 Jacobo Jacobo M, Donnella HJ, Sobti S, Kaushik S, Goga A, Bandyopadhyay S
• The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.
  bioRxiv : the preprint server for biology 2023 Sutanto R, Neahring L, Marques AS, Kilinc S, Goga A, Dumont S
• An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
  Nature cell biology 2023 Navickas A, Asgharian H, Winkler J, Fish L, Garcia K, Markett D, Dodel M, Culbertson B, Miglani S, Joshi T, Yin K, Nguyen P, Zhang S, Stevers N, Hwang HW, Mardakheh F, Goga A, Goodarzi H

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• Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
  Nature communications 2022 Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, …
• Deep whole genome sequencing identifies recurrent genomic alterations in commonly used breast cancer cell lines and patient-derived xenograft models.
  Breast cancer research : BCR 2022 Deng N, Minoche A, Harvey K, Li M, Winkler J, Goga A, Swarbrick A
• Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
  Nature microbiology 2022 Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh…
• Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
  Nature communications 2022 Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, …
• Biomarkers for Cyclin-Dependent Kinase 4/6 Inhibitors in the Treatment of Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced/Metastatic Breast Cancer: Translation to Clinical Practice.
  JCO precision oncology 2022 Bui TBV, Burgering BMT, Goga A, Rugo HS, van 't Veer LJ
• Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
  Nature chemical biology 2022 Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA
• NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.
  Translational oncology 2021 Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA
• Evaluation of disseminated tumor cells and circulating tumor cells in patients with breast cancer receiving adjuvant zoledronic acid.
  NPJ breast cancer 2021 Vidula N, Greenberg S, Petrillo L, Hwang J, Melisko M, Goga A, Moasser M, Magbanua M, Park JW, Rugo HS
• Oncogene-regulated release of extracellular vesicles.
  Developmental cell 2021 Kilinc S, Paisner R, Camarda R, Gupta S, Momcilovic O, Kohnz RA, Avsaroglu B, L'Etoile ND, Perera RM, Nomura DK, Goga A
• In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.
  Cancers 2021 Madonna MC, Duer JE, Lee JV, Williams J, Avsaroglu B, Zhu C, Deutsch R, Wang R, Crouch BT, Hirschey MD, Goga A, Ramanujam N
• MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.
  Journal of hepatology 2020 Komoll RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, Sharma AD, Goga A, Ott M, Balakrishnan A
• MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities.
  Cell reports 2020 Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A
• Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.
  Nature medicine 2018 Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, …
• Cancer cells exploit an orphan RNA to drive metastatic progression.
  Nature medicine 2018 Fish L, Zhang S, Yu JX, Culbertson B, Zhou AY, Goga A, Goodarzi H
• microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.
  Gastroenterology 2018 Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A,…
• Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.
  Nature chemical biology 2018 Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S
• Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.
  Nature communications 2018 Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K
• New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.
  Trends in cancer 2018 Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM
• Comprehensive analysis of normal adjacent to tumor transcriptomes.
  Nature communications 2017 Aran D, Camarda R, Odegaard J, Paik H, Oskotsky B, Krings G, Goga A, Sirota M, Butte AJ
• Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.
  Magnetic resonance imaging 2017 Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB
• In vivo Reprogramming of Cancer Metabolism by MYC.
  Frontiers in cell and developmental biology 2017 Camarda R, Williams J, Goga A
• Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z
• MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.
  EMBO reports 2017 Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A
• Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.
  Magnetic resonance imaging 2017 Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB
• PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.
  Nature medicine 2016 Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo …
• Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.
  ACS chemical biology 2016 Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK
• GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.
  Cell chemical biology 2016 Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK
• Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.
  Nature medicine 2016 Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A
• Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
  Current biology : CB 2015 Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA
• Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors.
  Human molecular genetics 2015 Caswell JL, Camarda R, Zhou AY, Huntsman S, Hu D, Brenner SE, Zaitlen N, Goga A, Ziv E
• Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells.
  Nature 2015 Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z
• Biogenesis, delivery, and function of extracellular RNA.
  Journal of extracellular vesicles 2015 Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, …
• Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
  PLoS genetics 2015 Evason KJ, Francisco MT, Juric V, Balakrishnan S, Lopez Pazmino Mdel P, Gordan JD, Kakar S, Spitsbergen J, Goga A, Stainier DY
• Direct and indirect targeting of MYC to treat acute myeloid leukemia.
  Cancer chemotherapy and pharmacology 2015 Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC
• Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.
  ACS chemical biology 2015 Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK
• CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
  Stem cell reports 2015 Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A
• Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.
  Cancer discovery 2014 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat …
• Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.
  Blood 2014 Hoellein A, Fallahi M, Schoeffmann S, Steidle S, Schaub FX, Rudelius M, Laitinen I, Nilsson L, Goga A, Peschel C, Nilsson JA, Cleveland JL, Keller U
• Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness.
  ACS chemical biology 2014 Benjamin DI, Louie SM, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng SW, Nomura DK
• Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014 Chien AJ, Munster PN, Melisko ME, Rugo HS, Park JW, Goga A, Auerback G, Khanafshar E, Ordovas K, Koch KM, Moasser MM
• Taking on challenging targets: making MYC druggable.
  American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2014 Horiuchi D, Anderton B, Goga A
• Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
  Cancer discovery 2013 Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, …
• MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer.
  Hepatology (Baltimore, Md.) 2013 Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, Goga A
• A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
  eLife 2013 Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L
• Endogenous nuclear RNAi mediates behavioral adaptation to odor.
  Cell 2013 Juang BT, Gu C, Starnes L, Palladino F, Goga A, Kennedy S, L'Etoile ND
• Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.
  Magnetic resonance in medicine 2013 Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB
• HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells.
  The Biochemical journal 2012 Amin DN, Sergina N, Lim L, Goga A, Moasser MM
• IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
  Science (New York, N.Y.) 2012 Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA
• Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW
• Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A
• MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
  The Journal of experimental medicine 2012 Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A
• Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.
  Magnetic resonance imaging 2011 von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB
• 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.
  Cell metabolism 2011 Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A
• Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
  Molecular cell 2011 Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP
• Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.
  Science translational medicine 2011 Chow EK, Zhang XQ, Chen M, Lam R, Robinson E, Huang H, Schaffer D, Osawa E, Goga A, Ho D
• Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models.
  Journal of magnetic resonance imaging : JMRI 2011 von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB
• miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
  Nature medicine 2010 Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, …
• Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Yang D, Liu H, Goga A, Kim S, Yuneva M, Bishop JM
• Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.
  Blood 2010 den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, Hoellein A, Kremer M, Graf N, Scheerer M, Hall MA, Goga A, von Bubnoff N, Duyster J, Peschel C, Cleveland JL, Nilsson JA, Keller U
• Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Lee JI, O'Halloran DM, Eastham-Anderson J, Juang BT, Kaye JA, Scott Hamilton O, Lesch B, Goga A, L'Etoile ND
• 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer.
  Magnetic resonance in medicine 2010 Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB
• Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.
  The Journal of biological chemistry 2009 Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT
• A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons.
  Neuron 2009 Kaye JA, Rose NC, Goldsworthy B, Goga A, L'Etoile ND
• Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.
  Cancer cell 2008 Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S,…
• Anti-oncomir suppression of tumor phenotypes.
  Molecular interventions 2007 Goga A, Benz C
• Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.
  Nature medicine 2007 Goga A, Yang D, Tward AD, Morgan DO, Bishop JM
• Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b.
  The Journal of biological chemistry 2006 Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC
• RNA interference (RNAi) with RNase III-prepared siRNAs.
  Methods in molecular biology (Clifton, N.J.) 2004 Yang D, Goga A, Bishop JM
• Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM
• A functional screen for regulators of the c-Abl protein tyrosine kinase.
  Leukemia 1997 Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G
• Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia.
  Molecular and cellular biology 1996 Golub TR, Goga A, Barker GF, Afar DE, McLaughlin J, Bohlander SK, Rowley JD, Witte ON, Gilliland DG
• Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe.
  Oncogene 1996 Walkenhorst J, Goga A, Witte ON, Superti-Furga G
• Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene.
  Cell 1995 Goga A, McLaughlin J, Afar DE, Saffran DC, Witte ON
• p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.
  Oncogene 1995 Goga A, Liu X, Hambuch TM, Senechal K, Major E, Berk AJ, Witte ON, Sawyers CL
• Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Cohen L, Mohr R, Chen YY, Huang M, Kato R, Dorin D, Tamanoi F, Goga A, Afar D, Rosenberg N
• Differential complementation of Bcr-Abl point mutants with c-Myc.
  Science (New York, N.Y.) 1994 Afar DE, Goga A, McLaughlin J, Witte ON, Sawyers CL
• The nuclear tyrosine kinase c-Abl negatively regulates cell growth.
  Cell 1994 Sawyers CL, McLaughlin J, Goga A, Havlik M, Witte O
• Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL.
  Cold Spring Harbor symposia on quantitative biology 1994 Afar DE, Goga A, Cohen L, Sawyers CL, McLaughlin J, Mohr RN, Witte ON
• Oncogenic activation of c-ABL by mutation within its last exon.
  Molecular and cellular biology 1993 Goga A, McLaughlin J, Pendergast AM, Parmar K, Muller A, Rosenberg N, Witte ON