Anatoly Urisman, MD, PhD
Associate Professor
Pathology
School of Medicine

2010-2011 Pulmonary Pathology Fellowship, UCSF 2011-2014 Research Fellow, Department of Pathology, UCSF 2015-2016 Renal Pathology Fellowship, UCSF 2014-2016 Clinical Instructor, Department of Pathology, UCSF 2016-2022 Assistant Professor, Department of Pathology, UCSF 2022-now Associate Professor, Department of Pathology, UCSF

Research interests: My research is focused on understanding regulation of cell signaling by post-translational modifications in cancer cells. Specifically, we are using targeted proteomic techniques to study phosphorylation dynamics in key signaling networks such as EGFR, RAS/ERK, and AKT/mTOR. The studies are aimed at identifying key regulatory phosphorylation sites relevant to tumor development, progression, response to targeted therapies, and development of resistance. As part of this effort, we are working on novel approaches for quantifying site-specific phosphorylation of low-abundance proteins, such as transcription factors and other nuclear targets of the intracellular signal transduction pathways.

• Non-Full House Membranous Lupus Nephritis Represents a Clinically Distinct Subset.
  Kidney360 2023 Ye J, Croom N, Troxell ML, Kambham N, Zuckerman JE, Andeen N, Dall'Era M, Hsu R, Walavalkar V, Laszik ZG, Urisman A
• The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.
  The Journal of biological chemistry 2023 Lopez J, Bonsor DA, Sale MJ, Urisman A, Mehalko JL, Cabanski-Dunning M, Castel P, Simanshu DK, McCormick F
• Case report: Short-term eculizumab use in atypical HUS associated with Lemierre's syndrome and post-infectious glomerulonephritis.
  Frontiers in medicine 2023 Sadiq S, Urisman A, Cil O
• Bilateral Lung Transplant with Recognition of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) of rhe Donor Lungs in the Immediate Postoperative Period.
  The Journal of Heart and Lung Transplantation 2023 B. Bromberger, F. McLafferty, J. Smith, B. Elicker, K. Jones, C. Mulvey, A. Urisman, A. Venado, S. Hays, J. Kukreja, B. Trinh
• COVID-19 Vaccination and New Onset Glomerular Disease: Results from the IRocGN2 International Registry.
  Kidney360 2023 Waldman M, Sinaii N, Lerma EV, Kurien AA, Jhaveri KD, Uppal NN, Wanchoo R, Avasare R, Zuckerman JE, Liew A, Gallan AJ, El-Meanawy A, Yagil Y, Lebedev L, Baskaran K, Vilayur E, Cohen A, Weerasinghe N, …
• 'Granulomatosis with polyangiitis after Pfizer vaccination': a case report.
  Therapeutic advances in rare disease 2022 Essien F, Evans J, Kyle A, Urisman A, Adams N
• Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.
  Cell host & microbe 2022 Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM
• Data-independent acquisition and quantification of extracellular matrix from human lung in chronic inflammation-associated carcinomas.
  Proteomics 2022 Bons J, Pan D, Shah S, Bai R, Chen-Tanyolac C, Wang X, Elliott DRF, Urisman A, O'Broin A, Basisty N, Rose J, Sangwan V, Camilleri-Broët S, Tankel J, Gascard P, Ferri L, Tlsty TD, Schilling B
• Correction to: Genetic and immunohistochemical profiling of small cell and large cell neuroendocrine carcinomas of the breast.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2022 Bean GR, Najjar S, Shin SJ, Hosfield EM, Caswell-Jin JL, Urisman A, Jones KD, Chen YY, Krings G
• Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer.
  The Journal of clinical investigation 2022 Nanjo S, Wu W, Karachaliou N, Blakely CM, Suzuki J, Chou YT, Ali SM, Kerr DL, Olivas VR, Shue J, Rotow J, Mayekar MK, Haderk F, Chatterjee N, Urisman A, Yeo JC, Skanderup AJ, Tan AC, Tam WL, Arrieta O…
• Abstract 3808: Spatially resolved transcriptomics of cellular architecture in EGFR-mutated lung cancer.
  Cancer Research 2022 Daniel L. Kerr, Wei Wu, Whitney Tamaki, Anatoly Urisman, Yu-Ting Chou, Philippe Gui, David M. Jablons, Trever G. Bivona, Collin M. Blakely
• Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs.
  Nucleic acids research 2022 Patel P, Buchanan CN, Zdradzinski MD, Sahoo PK, Kar AN, Lee SJ, Vaughn LS, Urisman A, Oses-Prieto J, Dell'Orco M, Cassidy DE, Costa ID, Miller S, Thames E, Smith TP, Burlingame AL, Perrone-Bizzozero N…
• Genetic and immunohistochemical profiling of small cell and large cell neuroendocrine carcinomas of the breast.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2022 Bean GR, Najjar S, Shin SJ, Hosfield EM, Caswell-Jin JL, Urisman A, Jones KD, Chen YY, Krings G
• Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs.
  eLife 2022 Cuevas-Navarro A, Rodriguez-Muñoz L, Grego-Bessa J, Cheng A, Rauen KA, Urisman A, McCormick F, Jimenez G, Castel P
• Immunosuppression-Induced Pulmonary Alveolar Proteinosis Following Bilateral Lung Transplantation.
  The Journal of Heart and Lung Transplantation 2022 J. Maheshwari, A. Perez, N. Kolaitis, D. Calabrese, A. Venado Estrada, J. Golden, R.J. Shah, L. Leard, M. Kleinhenz, K. Jones, A. Urisman, J. Kukreja, B. Trinh, Y. Gesthalter, J. Singer, S. Hays
• Starting off on the Right Foot: A 22-Year-Old Woman With Leg Swelling.
  Arthritis care & research 2022 Aguirre A, Urisman A, Margaretten M
• Abstract 10428: Bad Fall, Good Catch: Diagnosing a Rare Condition Presenting as Acute Coronary Syndrome.
  Circulation 2021 Leila Haghighat, Barbara Hamilton, Anatoly Urisman, Ramin Beygui, Kirsten Tolstrup
• P26.02 A Phase II Trial of Neoadjuvant Osimertinib for Surgically Resectable EGFR-Mutant Non-Small Cell Lung Cancer: Updated Results.
  Journal of Thoracic Oncology 2021 C. Blakely, A. Urisman, D. Kerr, W. Wu, B. Bacaltos, J. Rotow, M. Gubens, K. Jones, T. Bivona, S. Joo, J. Riess, D. Aisner, R. Doebele, T. Patil, E. Schenk, J. Kratz, D. Jablons
• RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F
• A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19).
  Kidney international 2021 May RM, Cassol C, Hannoudi A, Larsen CP, Lerma EV, Haun RS, Braga JR, Hassen SI, Wilson J, VanBeek C, Vankalakunti M, Barnum L, Walker PD, Bourne TD, Messias NC, Ambruzs JM, Boils CL, Sharma SS, …
• The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression.
  Current biology : CB 2021 Cuevas-Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F
• Detection of cryptogenic malignancies from metagenomic whole genome sequencing of body fluids.
  Genome medicine 2021 Gu W, Talevich E, Hsu E, Qi Z, Urisman A, Federman S, Gopez A, Arevalo S, Gottschall M, Liao L, Tung J, Chen L, Lim H, Ho C, Kasowski M, Oak J, Holmes BJ, Yeh I, Yu J, Wang L, Miller S, DeRisi JL, …
• A Distributed System Improves Inter-Observer and AI Concordance in Annotating Interstitial Fibrosis and Tubular Atrophy.
  Proceedings of SPIE--the International Society for Optical Engineering 2021 Shashiprakash AK, Lutnick B, Ginley B, Govind D, Lucarelli N, Jen KY, Rosenberg AZ, Urisman A, Walavalkar V, Zuckerman JE, Delsante M, Bissonnette MLZ, Tomaszewski JE, Manthey D, Sarder P
• Complement activation on endothelium initiates antibody-mediated acute lung injury.
  The Journal of clinical investigation 2020 Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR
• Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.
  Cell 2020 Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA…
• Abstract 3765: c-Kit mediated phosphorylation of Spred1 regulates Neurofibromin-Spred1 interaction.
  Cancer Research 2020 Claire Lorenzo, Lucy C. Young, Alexandra Tannka, Anatoly Urisman, Frank McCormick
• Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
  Cell reports 2020 Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK
• Pulmonary Embolus of Benign Liver Tissue Following Partial Hepatectomy.
  AJSP Review and Reports 2020 Calixto-Hope G. Lucas, Johannes R. Kratz, Anatoly Urisman
• Small Airway Disease: A Step Closer to Etiology-Based Classification of Bronchiolitis.
  Surgical pathology clinics 2019 Urisman A, Jones KD
• Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells.
  Journal of cellular and molecular medicine 2019 Miao J, Kyoyama H, Liu L, Chan G, Wang Y, Urisman A, Yang YL, Liu S, Xu Z, Bin H, Li H, Jablons DM, You L
• P1.14-58 A Phase II Study to Evaluate Neoadjuvant Osimertinib for Surgically Resectable, EGFR-Mutant Non-Small Cell Lung Cancer.
  Journal of Thoracic Oncology 2019 J. Rotow, A. Urisman, C. Mccoach, T. Jahan, T. Bivona, K. Jones, A. Gupta, H. Do, J. Riess, D. Aisner, R. Doebele, D. Jablons, J. Kratz, C. Blakely
• Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Wang VE, Xue JY, Frederick DT, Cao Y, Lin E, Wilson C, Urisman A, Carbone DP, Flaherty KT, Bernards R, Lito P, Settleman J, McCormick F
• Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model.
  Oncology reports 2019 Hsu PC, Tian B, Yang YL, Wang YC, Liu S, Urisman A, Yang CT, Xu Z, Jablons DM, You L
• A 36-Year-Old Man With Renal Failure, Fever, and Hypocomplementemia.
  Arthritis care & research 2019 DeQuattro K, Urisman A, Margaretten M
• RIT1 oncoproteins escape LZTR1-mediated proteolysis.
  Science (New York, N.Y.) 2019 Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F
• Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates.
  Protein science : a publication of the Protein Society 2019 Wong AW, Urisman A, Burlingame AL, Shokat KM
• Pathologic Complete Response to Neoadjuvant Crizotinib in a Lung Adenocarcinoma Patient With a MET Exon 14 Skipping Mutation.
  Clinical lung cancer 2018 Rotow JK, Woodard GA, Urisman A, McCoach CE, Bivona TG, Elicker BM, Jablons DM, Blakely CM
• Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
  Mucosal immunology 2018 Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR
• Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration.
  Nature communications 2018 Sahoo PK, Lee SJ, Jaiswal PB, Alber S, Kar AN, Miller-Randolph S, Taylor EE, Smith T, Singh B, Ho TS, Urisman A, Chand S, Pena EA, Burlingame AL, Woolf CJ, Fainzilber M, English AW, Twiss JL
• Abstract 5520: Oncogenic RTK signaling inhibits Spred1/NF1 to sustain constitutive Ras/MAPK signaling.
  Molecular and Cellular Biology / Genetics 2018 Evan Markegard, Ellen L. Mercado, Pau Castel, Jillian Silva, Jacqueline Galeas, Kathy Li, Anatoly Urisman, Frank McCormick
• Surgical Management of Pulmonary Mucormycosis in Third-Trimester Pregnancy.
  The Thoracic and cardiovascular surgeon reports 2018 Ramirez JL, Urisman A, Kukreja J, Kratz JR
• Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model.
  Journal of cellular and molecular medicine 2018 Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, Urisman A, Yang CT, Jablons DM, You L
• Locally translated mTOR controls axonal local translation in nerve injury.
  Science (New York, N.Y.) 2018 Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RB, Koppel I, Twiss JL, Burlingame …
• Revealing nascent proteomics in signaling pathways and cell differentiation.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL
• Chapter 12 Histopathologic Approach to the Surgical Lung Biopsy in Interstitial Lung Disease.
  Interstitial Lung Disease 2018 Kirk D. Jones, Anatoly Urisman
• Checkpoint inhibitor is active against large cell neuroendocrine carcinoma with high tumor mutation burden.
  Journal for immunotherapy of cancer 2017 Wang VE, Urisman A, Albacker L, Ali S, Miller V, Aggarwal R, Jablons D
• Abstract 1370: EGFR-mediated Spred1 phosphorylation inhibits NF1 to sustain constitutive Ras/MAPK signaling.
  Molecular and Cellular Biology, Genetics 2017 Evan Markegard, Ellen L. Mercado, Jillian M. Silva, Jacqueline Galeas, Marena I. Trinidad, Anatoly Urisman, Frank McCormick
• A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases.
  The oncologist 2017 Wang VE, Young L, Ali S, Miller VA, Urisman A, Wolfe J, Bivona TG, Damato B, Fogh S, Bergsland EK
• Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis.
  Chest 2017 Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL
• The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia.
  Thorax 2017 Brownell R, Moua T, Henry TS, Elicker BM, White D, Vittinghoff E, Jones KD, Urisman A, Aravena C, Johannson KA, Golden JA, King TE, Wolters PJ, Collard HR, Ley B
• Infection-Associated Thrombotic Microangiopathy.
  Bacterial Infections and the Kidney 2017 Anatoly Urisman, Zoltan G. Laszik
• An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases.
  Molecular & cellular proteomics : MCP 2016 Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL
• Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma.
  Molecular & cellular proteomics : MCP 2016 Doll S, Urisman A, Oses-Prieto JA, Arnott D, Burlingame AL
• Abstract 1874: Oncogenic EGFR signaling inhibits the Spred1-NF1 interaction to sustain constitutive Ras signaling.
  Molecular and Cellular Biology, Genetics 2016 Evan Markegard, Ellen L. Mercado, Jacqueline Galeas, Marena I. Trinidad, Anatoly Urisman, Frank McCormick.
• Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
  Neuron 2016 Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ
• Macrophage-Dependent Regeneration of Pulmonary Epithelia Requires Trefoil Factor 2 for Wnt Expression.
  The Journal of Immunology 2016 Li-Yin Hung, Debasish Sen, Taylor K. Oniskey, Wildaliz Nieves, Anatoly Urisman, Matthew F Krummel, DeBroski R Herbert
• Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.
  Cancer research 2015 Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F
• Pulmonary pathology in connective tissue disease.
  Seminars in respiratory and critical care medicine 2014 Urisman A, Jones KD
• Global cellular response to chemotherapy-induced apoptosis.
  eLife 2013 Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA
• Large-Airway Lymphocytic Bronchitis Predicts Bronchiolitis Obliterans Syndrome.
  The Journal of Heart and Lung Transplantation 2013 J.R. Greenland, K.D. Jones, S.R. Hays, J.A. Golden, A. Urisman, N.P. Jewell, G.H. Caughey, N.N. Trivedi
• Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome.
  American journal of respiratory and critical care medicine 2012 Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN
• Pathology Case Reviews
  Pulmonary Crystal-Storing Histiocytosis: Two Cases and Review of the Literature 2012 Urisman, Anatoly MD, PhD; Jones, Kirk D. MD
• In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.
  PloS one 2012 Lee D, Das Gupta J, Gaughan C, Steffen I, Tang N, Luk KC, Qiu X, Urisman A, Fischer N, Molinaro R, Broz M, Schochetman G, Klein EA, Ganem D, Derisi JL, Simmons G, Hackett J, Silverman RH, Chiu CY
• Rapidly progressive pulmonary venoocclusive disease in young women taking oral contraceptives.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2012 Urisman A, Leard LE, Nathan M, Elicker BM, Hoopes C, Kukreja J, Jones KD
• The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases.
  Journal of pediatric surgery 2012 Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC
• Histopathologic approach to the surgical lung biopsy in interstitial lung disease.
  Clinics in chest medicine 2012 Jones KD, Urisman A
• Pulmonary Crystal-Storing Histiocytosis.
  AJSP Review and Reports 2012 Anatoly Urisman, Kirk D. Jones
• Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children.
  The Journal of pediatrics 2008 Chiu CY, Urisman A, Greenhow TL, Rouskin S, Yagi S, Schnurr D, Wright C, Drew WL, Wang D, Weintrub PS, Derisi JL, Ganem D
• Diagnostic Techniques: Microarrays.
  Encyclopedia of Virology 2008 K. Fischer, A. Urisman, J. DeRisi
• Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006 Chiu CY, Rouskin S, Koshy A, Urisman A, Fischer K, Yagi S, Schnurr D, Eckburg PB, Tompkins LS, Blackburn BG, Merker JD, Patterson BK, Ganem D, DeRisi JL
• 239: Identification of a Novel Retrovirus in Prostate Tumors of Patients Homozygous for the R462Q Mutation in the HPC1 Gene.
  The Journal of Urology 2006 Eric A. Klein, Anatoly Urisman, Ross Molinaro, Nicole Fischer, Sarah Plummer, Graham Casey, Don Ganem, Joseph Dirisi, Robert Silverman
• Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
  PLoS pathogens 2006 Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL
• E-Predict: a computational strategy for species identification based on observed DNA microarray hybridization patterns.
  Genome biology 2005 Urisman A, Fischer KF, Chiu CY, Kistler AL, Beck S, Wang D, DeRisi JL
• Viral discovery and sequence recovery using DNA microarrays.
  PLoS biology 2003 Wang D, Urisman A, Liu YT, Springer M, Ksiazek TG, Erdman DD, Mardis ER, Hickenbotham M, Magrini V, Eldred J, Latreille JP, Wilson RK, Ganem D, DeRisi JL