Anat Levit, PhD
RSCH GNT PRG OFCR 4
Quantitative_Bioscience_Ins
School of Pharmacy
Publications (22)
Top publication keywords:
Computational BiologyDopamine AgonistsReceptors, G-Protein-CoupledReceptors, PeptideTasteSmall Molecule LibrariesBinding SitesStructure-Activity RelationshipReceptors, Dopamine D4LigandsModels, MolecularCrystallography, X-RayMolecular Docking SimulationStructural Homology, ProteinDrug Discovery
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Structural identification of a hotspot on CFTR for potentiation.
Science (New York, N.Y.) 2019 Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J -
Ultra-large library docking for discovering new chemotypes.
Nature 2019 Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ -
Corrigendum: Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes.
Frontiers in molecular biosciences 2018 Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY -
The Recognition of Unrelated Ligands by Identical Proteins.
ACS chemical biology 2018 Pottel J, Levit A, Korczynska M, Fischer M, Shoichet BK -
Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.
Biochimica et biophysica acta. General subjects 2018 Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M
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Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes.
Frontiers in molecular biosciences 2018 Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY -
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.
Nature 2018 Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL -
D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.
Science (New York, N.Y.) 2017 Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL -
Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Cell 2017 Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL -
Structure-based discovery of opioid analgesics with reduced side effects.
Nature 2016 Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK -
Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios.
Methods in cell biology 2015 Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY -
Predicting GPCR promiscuity using binding site features.
Journal of chemical information and modeling 2013 Levit A, Beuming T, Krilov G, Sherman W, Niv MY -
The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Levit A, Nowak S, Peters M, Wiener A, Meyerhof W, Behrens M, Niv MY -
The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Born S, Levit A, Niv MY, Meyerhof W, Behrens M -
Expression and structure/function relationships of human defensin 5.
Applied biochemistry and biotechnology 2012 Chapnik N, Levit A, Niv MY, Froy O -
Homology model-assisted elucidation of binding sites in GPCRs.
Methods in molecular biology (Clifton, N.J.) 2012 Levit A, Barak D, Behrens M, Meyerhof W, Niv MY -
Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.
PloS one 2011 Levit A, Yarnitzky T, Wiener A, Meidan R, Niv MY -
BitterDB: a database of bitter compounds.
Nucleic acids research 2011 Wiener A, Shudler M, Levit A, Niv MY -
Homology modeling of G-protein-coupled receptors with X-ray structures on the rise.
Current opinion in drug discovery & development 2010 Yarnitzky T, Levit A, Niv MY -
Induction of endothelin-2 expression by luteinizing hormone and hypoxia: possible role in bovine corpus luteum formation.
Endocrinology 2010 Klipper E, Levit A, Mastich Y, Berisha B, Schams D, Meidan R -
Stargazin involvement with bipolar disorder and response to lithium treatment.
Pharmacogenetics and genomics 2008 Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R -
A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia.
Human genetics 2006 Shifman S, Levit A, Chen ML, Chen CH, Bronstein M, Weizman A, Yakir B, Navon R, Darvasi A