Amit Sabnis, MD
Assistant Professor
Pediatrics
School of Medicine

I am a pediatric oncologist and physician-scientist with a focus on examining new therapeutic strategies for sarcomas. Whether using genetic and biochemical tools for discovery, preclinical models for target and biomarker validation, or participating in the care of patients on clinical trials, my goal is to align my research and clinical practice to improve cure rates and quality of life for these patients.

Education & Training

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  • Diversity, Equity, and Inclusion Champion Training University of California 2019
  • Fellowship Pediatric Hematology-Oncology University of California, San Francisco 2014
  • Residency Pediatrics University of California, San Francisco 2011
  • M.D. School of Medicine University of California, San Francisco 2008
  • Cert Medicine (Certificate in Biomedical Research) University of California, San Francisco 2007

Grants and Projects

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Publications (51)

Top publication keywords:
Drug Resistance, NeoplasmSoft Tissue NeoplasmsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaRhabdomyosarcomaForkhead Box Protein O1Rhabdomyosarcoma, EmbryonalNeoplasmsReceptors, Fibroblast Growth FactorLeukemia, ExperimentalProto-Oncogene Proteins p21(ras)Molecular Targeted TherapyHSP70 Heat-Shock ProteinsHematopoietic Stem CellsOncogene Proteins, FusionOsteosarcoma

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  • Abstract 1759: Integrative longitudinal genomic analysis of therapy-resistant and metastatic pediatric cancers.
    Cancer Research 2024 Henry J. Martell, Avanthi T. Shah, Alex G. Lee, Stanley G. Leung, Soo-Jin Cho, María Pons Ventura, Ana Golla, Amanda E. Marinoff, Elizabeth P. Young, Bogdan Tanasa, Inge Behroozfard, Heng-Yi Liu, Aviv…
  • Abstract 2862: Evolution of clinically relevant variants in advanced pediatric sarcomas.
    Cancer Research 2024 Hannah Y. Comeau, Lorena Lazo De La Vega, Alanna J. Church, Luke D. Maese, Navin Pinto, Margaret E. Macy, Mark A. Applebaum, Amit J. Sabnis, AeRang Kim, Susan I. Colace, Filemon Dela Cruz, Steven G. …
  • The essential chaperone DNAJC17 activates HSP70 to coordinate RNA splicing and G2-M progression.
    bioRxiv : the preprint server for biology 2023 Allegakoen DV, Kwong K, Morales J, Bivona TG, Sabnis AJ
  • Clinical Targeted Next-Generation Panel Sequencing Reveals MYC Amplification Is a Poor Prognostic Factor in Osteosarcoma.
    JCO precision oncology 2023 Marinoff AE, Spurr LF, Fong C, Li YY, Forrest SJ, Ward A, Doan D, Corson L, Mauguen A, Pinto N, Maese L, Colace S, Macy ME, Kim A, Sabnis AJ, Applebaum MA, Laetsch TW, Glade-Bender J, Weiser DA, …
  • Rare FGFR Oncogenic Alterations in Sequenced Pediatric Solid and Brain Tumors Suggest FGFR Is a Relevant Molecular Target in Childhood Cancer.
    JCO precision oncology 2022 Lazo De La Vega L, Comeau H, Sallan S, Al-Ibraheemi A, Gupta H, Li YY, Tsai HK, Kang W, Ward A, Church AJ, Kim A, Pinto NR, Macy ME, Maese LD, Sabnis AJ, Cherniack AD, Lindeman NI, Anderson ME, Cooney…
  • Abstract A015: Biochemical and preclinical anti-tumor activity of a bi-steric mTORC1-selective inhibitor in fusion positive rhabdomyosarcoma.
    Clinical Cancer Research 2022 Jacqueline Morales, Kristen Kwong, W. Clay Gustafson, Amit J. Sabnis
  • Addition of chemo-immunotherapy to standard induction chemotherapy for high-risk neuroblastoma.
    Journal of Clinical Oncology 2022 Karen S. Fernandez, Amit J. Sabnis, Ruetima Titapiwatanakun, Katherine Baker, Wendy Tcheng
  • Ulixertinib in patients with tumors with MAPK pathway alterations: Results from NCI-COG Pediatric MATCH trial Arm J (APEC1621J).
    Journal of Clinical Oncology 2022 Kieuhoa Tran Vo, Amit J. Sabnis, Paul M. Williams, Sinchita Roy-Chowdhuri, David R. Patton, Brent Coffey, Joel M. Reid, Jin Piao, Lauren Saguilig, Todd Allen Alonzo, Stacey L. Berg, Alok Jaju, …
  • Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor.
    JCO precision oncology 2021 Schienda J, Church AJ, Corson LB, Decker B, Clinton CM, Manning DK, Imamovic-Tuco A, Reidy D, Strand GR, Applebaum MA, Bagatell R, DuBois SG, Glade-Bender JL, Kang W, Kim A, Laetsch TW, Macy ME, Maese…
  • Clinical characteristics and outcomes of infants compared with children diagnosed with rhabdomyosarcoma: Analysis of surveillance, epidemiology and end results data from 2000 to 2016.
    Cancer reports (Hoboken, N.J.) 2021 Rees HD, Hills NK, Sabnis AJ, Tulpule AB, Shimotake TK, Goldsby RE
  • Clinical impact of molecular tumor profiling in pediatric, adolescent, and young adult patients with extra-cranial solid malignancies: An interim report from the GAIN/iCat2 study.
    Journal of Clinical Oncology 2021 Alanna J. Church, Laura Corson, Pei-Chi Kao, Alma Imamovic-Tuco, Wenjun Kang, Navin R. Pinto, Luke Maese, Theodore Willis Laetsch, AeRang Kim, Susan Colace, Margaret E Macy, Mark A. Applebaum, …
  • HGG-01. ENTRECTINIB IN RECURRENT OR REFRACTORY SOLID TUMORS INCLUDING PRIMARY CNS TUMORS: UPDATED DATA IN CHILDREN AND ADOLESCENTS.
    Neuro-Oncology 2020 Giles Robinson, Ami Desai, Ellen Basu, Jennifer Foster, Karen Gauvain, Amit Sabnis, Suzanne Shusterman, Margaret Macy, Luke Mease, Janet Yoon, Thomas Cash, Mohamed Abdelbaki, Kellie Nazemi, Christine …
  • Clinical Benefit and Tolerability of Crenolanib in Children with Relapsed Acute Myeloid Leukemia Harboring Treatment Resistant FLT3 ITD and Variant FLT3 TKD Mutations Treated on Compassionate Access.
    Blood 2020 Katherine Tarlock, Soheil Meshinchi, Jeffrey E. Rubnitz, Seth E. Karol, Barbara Spitzer, Amit J. Sabnis, Asif Pathan, Boo Messahel
  • Outcomes of Elderly Patients with Soft Tissue Sarcoma of the Extremities.
    International Journal of Radiation Oncology • Biology • Physics 2020 J. Chew, S.A. Lloyd, R.A. Okimoto, A. Sabnis, E. Nakakura, C. Corvera, M.N. Zimel, A.E. Horvai, S.J. Cho, R.L. Wustrack, A.R. Gottschalk, R.J. O'Donnell, T.M. Jahan, S.E. Braunstein
  • Germline MUTYH Mutation in a Pediatric Cancer Survivor Developing a Secondary Malignancy.
    Journal of pediatric hematology/oncology 2020 Lavergne V, Sabnis A, Tupule A, Davidson PR, Kline C, Matthay K, Nicolaides T, Goldsby R, Braunstein S, Fogh SE, Sneed PK, Menzel P, Nakamura A, DuBois SG, Haas-Kogan DA, Nakamura JL
  • Abstract A06: The added value of examining germline variants in a precision cancer therapy study.
    Cancer Research 2020 Jaclyn Schienda, Catherine M. Clinton, Laura B. Corson, Alma Imamovic-Tuco, Navin Pinto, Luke Maese, Theodore W. Laetsch, AeRang Kim, Susan I. Vear, Margaret E. Macy, Mark A. Applebaum, Rochelle …
  • Abstract A27: An apoptosis-based screen for targeted agents in rhabdomyosarcoma reveals potential combination therapies.
    Cancer Research 2020 Amit J. Sabnis, Steven Chen, Carolina Morales, Benjamin S. Braun
  • Abstract A59: Sequencing identifies diagnostically relevant alterations in pediatric solid tumor patients.
    Cancer Research 2020 Alanna J. Church, Laura B. Corson, Alma Imamovic-Tuco, Gianna R. Strand, Dierdre Reidy, Duong Doan, Robert S. Pinches, Mark A. Applebaum, Rochelle Bagatell, Brian D. Crompton, Steven G. DuBois, Julia …
  • Abstract B13: Leveraging cloud-based computational resources for gene fusion discovery with potential clinical implications for pediatric solid tumor patients.
    Cancer Research 2020 Alma Imamovic, Alanna J. Church, Laura B. Corson, Deirdre Reidy, Navin Pinto, Luke Maese, Theodore W. Laetsch, AeRang Kim, Susan I. Vear, Margaret E. Macy, Mark A. Applebaum, Rochelle Bagatell, Amit J…
  • Updated entrectinib data in children and adolescents with recurrent or refractory solid tumors, including primary CNS tumors.
    Journal of Clinical Oncology 2020 Ami Vijay Desai, Giles W. Robinson, Ellen M. Basu, Jennifer Foster, Karen Gauvain, Amit Sabnis, Suzanne Shusterman, Margaret E Macy, Luke Maese, Janet Yoon, Thomas Cash, Mohamed Abdelbaki, Kellie …
  • PDCT-13. ENTRECTINIB IN CHILDREN AND ADOLESCENTS WITH RECURRENT OR REFRACTORY SOLID TUMORS INCLUDING PRIMARY CNS TUMORS.
    Neuro-Oncology 2019 Giles Robinson, Ami Desai, Karen Gauvain, Ellen Basu, Kathleen Dorris, Luke Maese, Amit Sabnis, Jennifer Foster, Suzanne Shusterman, Janet Yoon, Brian Weiss, Mohamed Abdelbaki, Mufiza Farid-Kapadia, …
  • Use of three-dimensional printing and intraoperative navigation in the surgical resection of metastatic acetabular osteosarcoma.
    BMJ case reports 2019 Heunis JC, Cheah JW, Sabnis AJ, Wustrack RL
  • Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
    Cell reports 2019 Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, …
  • Abstract 2664: Differential activation of the integrated stress response correlates with anti-tumor activity of imipridones ONC201 and ONC206 in pediatric sarcomas.
    Molecular and Cellular Biology / Genetics 2019 David V. Allegakoen, Rohinton S. Tarapore, Joshua E. Allen, Amit J. Sabnis, Trever G. Bivona
  • Abstract 3104: A high prevalence of chromosomal translocations as drivers in high-risk pediatric solid cancers.
    Cancer Research 2019 Laura B. Corson, Alma Imamovic-Tuco, Gianna R. Strand, Deirdre Reidy, Duong Doan, Mark A. Applebaum, Rochelle Bagatell, Brian D. Crompton, Steven G. DuBois, Julia L. Glade Bender, AeRang Kim, Theodore…
  • Abstract 3656: The mTOR-activating GATOR2 complex is essential in PAX3-FOXO1- positive rhabdomyosarcoma.
    Tumor Biology 2019 Amit J. Sabnis, David V. Allegakoen, Trever G. Bivona
  • Abstract 4268: Protein folding pathway modulation upon Hsp70 inhibition in cancer cells.
    Molecular and Cellular Biology / Genetics 2019 Sara Sannino, Christopher J. Guerriero, Amit J. Sabnis, Jeffrey J. Bridsky
  • Phase 1/1B trial to assess the activity of entrectinib in children and adolescents with recurrent or refractory solid tumors including central nervous system (CNS) tumors.
    Journal of Clinical Oncology 2019 Giles W. Robinson, Amar J. Gajjar, Karen Marie Gauvain, Ellen M. Basu, Margaret E Macy, Luke Devon Maese, Amit J. Sabnis, Jennifer Haunani Foster, Suzanne Shusterman, Janet Yoon, Brian D. Weiss, …
  • Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology.
    Trends in molecular medicine 2019 Sabnis AJ, Bivona TG
  • Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells.
    Journal of cell science 2018 Sannino S, Guerriero CJ, Sabnis AJ, Stolz DB, Wallace CT, Wipf P, Watkins SC, Bivona TG, Brodsky JL
  • Abstract 2325: Protein homeostasis adaptation to Hsp70 inhibition in cancer.
    Molecular and Cellular Biology / Genetics 2018 Sara Sannino, Christopher J. Guerriero, Amit J. Sabnis, Trever G. Bivona, Jeffrey L. Brodsky
  • Phase 1 study of entrectinib (RXDX-101), a TRK, ROS1, and ALK inhibitor, in children, adolescents, and young adults with recurrent or refractory solid tumors.
    Journal of Clinical Oncology 2018 Ami Vijay Desai, Garrett M. Brodeur, Jennifer Foster, Stacey L. Berg, Ellen M. Basu, Suzanne Shusterman, Amit J. Sabnis, Margaret Macy, Janet Yoon, Karen Gauvain, Vanessa Esquibel, Edna Chow Maneval, …
  • EWSR1-NFATC2 gene fusion in a soft tissue tumor with epithelioid round cell morphology and abundant stroma: a case report and review of the literature.
    Human pathology 2018 Cohen JN, Sabnis AJ, Krings G, Cho SJ, Horvai AE, Davis JL
  • Reducing Second Gram-Negative Antibiotic Therapy on Pediatric Oncology and Hematopoietic Stem Cell Transplantation Services.
    Infection control and hospital epidemiology 2017 Wattier RL, Levy ER, Sabnis AJ, Dvorak CC, Auerbach AD
  • Abstract CT030: STARTRK-NG: A phase 1/1b study of entrectinib in children and adolescents with advanced solid tumors and primary CNS tumors, with or without TRK, ROS1, or ALK fusions.
    Clinical Trials 2017 Ami V. Desai, Garrett M. Brodeur, Jennifer Foster, Suzanne Shusterman, Amit J. Sabnis, Magaret Macy, Cynthia Wetmore, Ellen Basu, Zachary Hornby, Vanessa Esquibel, Edna Chow Maneval, Pratik S. Multani…
  • HSP70 dependence in rhabdomyosarcoma: Seed or soil?
    Cell cycle (Georgetown, Tex.) 2016 Sabnis AJ, Bivona TG
  • RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
    Nature medicine 2015 Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M, Aisner DL, Vaishnavi A, Ou SH, Collisson EA, …
  • The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
    Nature genetics 2015 Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, Ramirez JL, Torres JM, Buttitta F, Rudin CM, Collisson …
  • Neurologic Emergencies.
    Supportive Care in Pediatric Oncology 2015 Amit Sabnis, Jonathan L. Finlay, Sabine Mueller
  • Activating mutations cluster in the "molecular brake" regions of protein kinases and do not associate with conserved or catalytic residues.
    Human mutation 2014 Molina-Vila MA, Nabau-Moretó N, Tornador C, Sabnis AJ, Rosell R, Estivill X, Bivona TG, Marino-Buslje C
  • FGFR fusions in the driver's seat.
    Cancer discovery 2013 Sabnis AJ, Bivona TG
  • JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.
    Cancer cell 2009 Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E
  • Oncogenic Kras initiates leukemia in hematopoietic stem cells.
    PLoS biology 2009 Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS
  • Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
    Nature genetics 2008 McGowan KA, Li JZ, Park CY, Beaudry V, Tabor HK, Sabnis AJ, Zhang W, Fuchs H, de Angelis MH, Myers RM, Attardi LD, Barsh GS
  • Leukemogenic K-RasG12D Induces Cell Cycle Entry and Clonal Dominance in Hematopoietic Stem Cells.
    Blood 2007 Amit J. Sabnis, Laurene S. Cheung, Kevin Shannon, Benjamin S. Braun
  • Multiparameter Flow Cytometric Analysis Reveals Aberrant Phosphorylation of a Network of Effector Molecules in Defined Populations of Kras Mutant Bone Marrow.
    Blood 2005 Margaret E.M. Van Meter, Ernesto Diaz-Flores, Joehleen A. Archard, Nikesh Kotecha, Amit J. Sabnis, Jonathan M. Irish, Garry P. Nolan, Kevin M. Shannon, Benjamin S. Braun