Amit Amit Prabhakar, PhD
Specialist
Cardiovascular Research Inst
School of Medicine

Websites

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• Posts on X @Prabhakar_Ami (X.com)

Publications (23)

Top publication keywords:
Blood Coagulation DisordersEndothelin-1Bone Morphogenetic Protein Receptors, Type IIArterial PressureGene-Environment InteractionNLR Family, Pyrin Domain-Containing 3 ProteinVenous ThromboembolismPulmonary Veno-Occlusive DiseaseAltitudeHypoxiaVenous ThrombosisThromboplastinRNA, Long NoncodingThrombomodulinBlood Coagulation

• GDF15 is a putative biomarker for distinguishing pulmonary veno-occlusive disease and pulmonary arterial hypertension.
  The Journal of clinical investigation 2025 Prabhakar A, De Bie EM, DesJardin JT, Ghatpande P, Gräf S, Howard LS, Wort SJ, Church C, Kiely DG, Sumpena E, Aung T, Carter S, Kukreja J, Hays S, Greenland JR, Singer JP, Wax M, Wolters PJ, Simon MA,…
• Pulmonary veno-occlusive disease: Insights from animal models.
  Vascular pharmacology 2025 Hata A, Gur B, Kalra J, Prabhakar A
• Essential role of protein kinase R in the pathogenesis of pulmonary veno-occlusive disease.
  JCI insight 2025 Prabhakar A, Kumar R, Wadhwa M, Barpanda A, Lyons J, Gowda A, Gupta S, Arvind A, Ghatpande P, Wiita AP, Graham BB, Lagna G, Hata A
• Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.
  The Journal of clinical investigation 2025 Kumar R, Nolan K, Kassa B, Chanana N, Palmo T, Sharma K, Singh K, Mickael C, Fonseca Balladares D, Nilsson J, Prabhakar A, Mishra A, Lee MH, Sanders L, Kumar S, Molofsky AB, Stenmark KR, Sheppard D, …
• Reply to the letter to the editor entitled "Bridging the species divide: The limits of rat models in capturing human PVOD mechanisms" by Perros F. et al.
  Pulmonary circulation 2024 Prabhakar A, Kumar R, Wadhwa M, Tuder RM, Morrell NW, Graham BB, Lagna G, Hata A

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• Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease.
  JCI insight 2024 Prabhakar A, Wadhwa M, Kumar R, Ghatpande P, Gandjeva A, Tuder RM, Graham BB, Lagna G, Hata A
• Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.
  Nature cardiovascular research 2024 Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A
• Essential role of the amino-terminal region of Drosha for the Microprocessor function.
  iScience 2023 Prabhakar A, Hu S, Tang J, Ghatpande P, Lagna G, Jiang X, Hata A
• Epidemiology and pathophysiology of vascular thrombosis in acclimatized lowlanders at high altitude: A prospective longitudinal study.
  The Lancet regional health. Southeast Asia 2022 Nair V, Singh S, Ashraf MZ, Yanamandra U, Sharma V, Prabhakar A, Ahmad R, Chatterjee T, Behera V, Guleria V, Patrikar S, Gupta S, Vishnoi MG, Kalshetty K, Sharma P, Bajaj N, Khaling TD, Wankhede TS, …
• Aberrant promoter hypermethylation regulates thrombomodulin in high altitude induced deep vein thrombosis.
  Thrombosis research 2022 Vijay A, Jha PK, Parveen S, Goel S, Prabhakar A, Sharma S, Kumar B, Chatterjee T, Bajaj N, Nair V, Sharma M, Ashraf MZ
• Transcriptome Profiling Reveals the Endogenous Sponging Role of LINC00659 and UST-AS1 in High-Altitude Induced Thrombosis.
  Thrombosis and haemostasis 2021 Jha PK, Vijay A, Prabhakar A, Chatterjee T, Nair V, Bajaj N, Kumar B, Sharma M, Ashraf MZ
• Control of ribosomal protein synthesis by the Microprocessor complex.
  Science signaling 2021 Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A
• Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains.
  Blood advances 2019 Prabhakar A, Chatterjee T, Bajaj N, Tyagi T, Sahu A, Gupta N, Kumari B, Nair V, Kumar B, Ashraf MZ
• Complement activation sustains neuroinflammation and deteriorates adult neurogenesis and spatial memory impairment in rat hippocampus following sleep deprivation.
  Brain, behavior, and immunity 2019 Wadhwa M, Prabhakar A, Anand JP, Ray K, Prasad D, Kumar B, Panjwani U
• Activation of platelets and inflammatory cytokines in male participants of an Indian Antarctic expedition
  Polar Science 2019 BrijBhushan, A.Prabhakar, A.P.Yadav, M.Z.Ashraf, S.B.Sigh, L.Ganju
• Genome-Wide Expression Analysis Suggests Hypoxia-Triggered Hyper-Coagulation Leading to Venous Thrombosis at High Altitude.
  Thrombosis and haemostasis 2018 Jha PK, Sahu A, Prabhakar A, Tyagi T, Chatterjee T, Arvind P, Nair J, Gupta N, Kumari B, Nair V, Bajaj N, Shanker J, Sharma M, Kumar B, Ashraf MZ
• Glucose-6-phosphate dehydrogenase is critical for suppression of cardiac hypertrophy by H2S.
  Cell death discovery 2018 Chhabra A, Mishra S, Kumar G, Gupta A, Keshri GK, Bharti B, Meena RN, Prabhakar AK, Singh DK, Bhargava K, Sharma M
• MicroRNA-145 Impedes Thrombus Formation via Targeting Tissue Factor in Venous Thrombosis.
  EBioMedicine 2017 Sahu A, Jha PK, Prabhakar A, Singh HD, Gupta N, Chatterjee T, Tyagi T, Sharma S, Kumari B, Singh S, Nair V, Goel S, Ashraf MZ
• Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation.
  Journal of neuroinflammation 2017 Wadhwa M, Prabhakar A, Ray K, Roy K, Kumari P, Jha PK, Kishore K, Kumar S, Panjwani U
• Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Gupta N, Sahu A, Prabhakar A, Chatterjee T, Tyagi T, Kumari B, Khan N, Nair V, Bajaj N, Sharma M, Ashraf MZ
• Endothelin-1 Gene Polymorphism and Its Level Predict the Risk of Venous Thromboembolism in Male Indian Population.
  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2016 Kumari B, Prabhakar A, Sahu A, Chatterjee T, Tyagi T, Gupta N, Nair V, Ashraf MZ
• Ebselen a Seleno-organic Molecule Inhibits Alteration in the Biological Responses in Hypoxic Human Alveolar Lung Epithelial Cells
  Microbiology Research Journal International 2015 Kushwah, N., Prabhakar, A., Prasad, D., Ravi, K., Singh, S., & Khan, N.
• A Novel Role of Protein Disulfide Isomerase in Calpain Regulated Hypoxia Induced Prothrombotic Phenotype
  Blood 2014 Tarun Tyagi, Amit Prabhakar, Shantanu Sengupta and Mohammad Z Ashraf