Amelia Deitchman, PharmD, PhD
Assistant Professor
Clinical Pharmacy
School of Pharmacy

Education & Training

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• T32 Clinical Pharmacology Fellowship University of California, San Francisco 01/2020
• PhD Pharmaceutical Sciences University of Florida 12/2017
• PharmD University of Florida 05/2013

Interests

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• computational modeling
• pharmacokinetics
• pharmacometrics
• protein binding
• HIV
• infectious disease
• tuberculosis
• PK/PD
• clinical pharmacology

Grants and Projects

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• Clinical Pharmacology Approaches towards Accelerating HIV Cure Initiatives, NIH, 2021-2026

Publications (29)

Top publication keywords:
Precision MedicineAnti-Bacterial AgentsDrug DesignCritical IllnessPharmacokineticsAnti-Infective AgentsPalivizumabRespiratory Syncytial Virus InfectionsChelating AgentsPharmaceutical PreparationsHIV-1MicrodialysisHIV SeropositivityMinocyclineHIV Infections

• The breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of Long COVID symptoms.
  Journal of medical virology 2023 Buck AM, Deitchman AN, Takahashi S, Lu S, Goldberg SA, Bodansky A, Kung A, Hoh R, Williams MC, Kerbleski M, Maison DP, Deveau TM, Munter SE, Lombardo J, Wrin T, Petropoulos CJ, Durstenfeld MS, Hsue PY…
• A long-term fulvestrant eluting implant is safe, non-toxic, and reduces the risk of breast cancer in in vivo models.
  Research square 2023 Thomas S, Roche E, Desai P, Pawlowska N, Bauer D, Gingrich D, Hsu E, Deitchman AN, Aweeka F, Munster PN
• Translational predictions of phase 2a first-in-patient efficacy studies for antituberculosis drugs.
  The European respiratory journal 2023 Ernest JP, Goh JJN, Strydom N, Wang Q, van Wijk RC, Zhang N, Deitchman A, Nuermberger E, Savic RM
• Challenges in HIV-1 Latent Reservoir and Target Cell Quantification in CAR-T Cell and Other Lentiviral Gene Modifying HIV Cure Strategies.
  Viruses 2023 Buck AM, Deveau TM, Henrich TJ, Deitchman AN
• The Breadth of the Neutralizing Antibody Response to Original SARS-CoV-2 Infection is Linked to the Presence of Long COVID Symptoms.
  medRxiv : the preprint server for health sciences 2023 Buck AM, Deitchman AN, Takahashi S, Lu S, Goldberg SA, Hoh R, Williams MC, Kerbleski M, Deveau TM, Munter SE, Lombardo J, Wrin T, Petropoulos CJ, Durstenfeld MS, Hsue PY, Kelly JD, Greenhouse B, …

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• Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative.
  Frontiers in immunology 2023 Bonilla H, Peluso MJ, Rodgers K, Aberg JA, Patterson TF, Tamburro R, Baizer L, Goldman JD, Rouphael N, Deitchman A, Fine J, Fontelo P, Kim AY, Shaw G, Stratford J, Ceger P, Costantine MM, Fisher L, O'…
• Chronic viral coinfections differentially affect the likelihood of developing long COVID.
  The Journal of clinical investigation 2023 Peluso MJ, Deveau TM, Munter SE, Ryder D, Buck A, Beck-Engeser G, Chan F, Lu S, Goldberg SA, Hoh R, Tai V, Torres L, Iyer NS, Deswal M, Ngo LH, Buitrago M, Rodriguez A, Chen JY, Yee BC, Chenna A, …
• Translational predictions of phase 2a first-in-patient efficacy studies for antituberculosis drugs.
  bioRxiv : the preprint server for biology 2023 Ernest JP, Ni Goh JJ, Strydom N, Wang Q, van Wijk RC, Zhang N, Deitchman A, Nuermberger E, Savic RM
• Evaluating the effect of atorvastatin exposure and vitamin D levels on lipid outcomes in people with HIV-1 with suppressed HIV-1 RNA and LDL cholesterol <130 mg/dL.
  HIV medicine 2022 Rahman F, Brates I, Aweeka F, Bosch RJ, Deitchman A, Nixon D, Aberg JA
• Female Genital Fibroblasts Diminish the In Vitro Efficacy of PrEP against HIV.
  Viruses 2022 George AF, McGregor M, Gingrich D, Neidleman J, Marquez RS, Young KC, Thanigaivelan KL, Greene WC, Tien PC, Deitchman AN, Spitzer TL, Roan NR
• First-in-human immunoPET imaging of HIV-1 infection using 89Zr-labeled VRC01 broadly neutralizing antibody.
  Nature communications 2022 Beckford-Vera DR, Flavell RR, Seo Y, Martinez-Ortiz E, Aslam M, Thanh C, Fehrman E, Pardons M, Kumar S, Deitchman AN, Ravanfar V, Schulte B, Wu IK, Pan T, Reeves JD, Nixon CC, Iyer NS, Torres L, …
• Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms.
  Cell reports 2021 Peluso MJ, Deitchman AN, Torres L, Iyer NS, Munter SE, Nixon CC, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman EA, Spinelli MA, Gandhi M, Trinh L,…
• Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease.
  Open forum infectious diseases 2021 Peluso MJ, Munter SE, Lynch KL, Yun C, Torres L, Iyer NS, Donatelli J, Ryan L, Deitchman AN, Deeks SG, Rutishauser RL, Henrich TJ
• Pharmacodynamic Correlates of Linezolid Activity and Toxicity in Murine Models of Tuberculosis.
  The Journal of infectious diseases 2021 Bigelow KM, Deitchman AN, Li SY, Barnes-Boyle K, Tyagi S, Soni H, Dooley KE, Savic RM, Nuermberger EL
• Abnormal Levels of Some Biomarkers of Immune Activation Despite Very Early Treatment of Human Immunodeficiency Virus.
  The Journal of infectious diseases 2021 Schnittman SR, Deitchman AN, Beck-Engeser G, Ahn H, York VA, Hartig H, Hecht FM, Martin JN, Deeks SG, Aweeka FT, Hunt PW
• Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19.
  medRxiv : the preprint server for health sciences 2021 Peluso MJ, Deitchman AN, Torres L, Iyer NS, Nixon CC, Munter SE, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman E, Spinelli MA, Gandhi M, Trinh L, …
• Methotrexate Decreases Tenofovir Exposure in Antiretroviral-Suppressed Individuals Living With HIV.
  Journal of acquired immune deficiency syndromes (1999) 2020 Gingrich D, Deitchman AN, Kantor A, Huang L, Stein JH, Currier JS, Hsue PY, Ribaudo HJ, Aweeka FT, ACTG 5314 Protocol Team
• Supporting Precision Dosing in Drug Labeling.
  Clinical pharmacology and therapeutics 2020 Neely M, Onufrak N, Scheetz MH, Avedissian S, Lakota E, Deitchman AN, Gonzalez D
• Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Henrich TJ, Schreiner C, Cameron C, Hogan LE, Richardson B, Rutishauser RL, Deitchman AN, Chu S, Rogers R, Thanh C, Gibson EA, Zarinsefat A, Bakkour S, Aweeka F, Busch MP, Liegler T, Baker C, Milush J…
• The Risk of Treating Populations Instead of Patients.
  CPT: pharmacometrics & systems pharmacology 2019 Deitchman AN
• Nonlinear Protein Binding: Not What You Think.
  Journal of pharmaceutical sciences 2018 Deitchman AN, Singh RSP, Derendorf H
• Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).
  Circulation. Genomic and precision medicine 2018 McDonough CW, Magvanjav O, Sá ACC, El Rouby NM, Dave C, Deitchman AN, Kawaguchi-Suzuki M, Mei W, Shen Y, Singh RSP, Solayman M, Bailey KR, Boerwinkle E, Chapman AB, Gums JG, Webb A, Scherer SE, Sadee …
• Enhanced in vitro activity of tigecycline in the presence of chelating agents.
  International journal of antimicrobial agents 2018 Deitchman AN, Singh RSP, Rand KH, Derendorf H
• A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding.
  International journal of antimicrobial agents 2017 Singh RSP, Mukker JK, Drescher SK, Deitchman AN, Derendorf H
• Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization.
  The AAPS journal 2016 Deitchman AN, Heinrichs MT, Khaowroongrueng V, Jadhav SB, Derendorf H
• Ceftobiprole medocaril (BAL-5788) for the treatment of complicated skin infections.
  Expert review of anti-infective therapy 2016 Deitchman A, de Jong D, Barbour A, Derendorf H
• Role of Divalent Metal Ions in Atypical Nonlinear Plasma Protein Binding Behavior of Tigecycline.
  Journal of pharmaceutical sciences 2016 Singh RSP, Mukker JK, Deitchman AN, Drescher SK, Derendorf H
• Measuring drug distribution in the critically ill patient.
  Advanced drug delivery reviews 2014 Deitchman AN, Derendorf H
• Relevance of Liver Failure for Anti-Infective Agents: From Pharmacokinetic Alterations to Dosage Adjustments.
  Therapeutic advances in infectious disease 2014 B?dingen FV, Gonzalez D, Tucker AN, Derendorf H