Amanda Paulson, PhD
Specialist
Pharmaceutical Chemistry
School of Pharmacy

Education & Training

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• Ph.D. Biomedical Sciences University of California, San Francisco 06/2019
• B.S. Cell & Molecular Biology University of Michigan 05/2009

Interests

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• machine learning
• tumor cell population dynamics
• drug discovery
• epithelial mesenchymal transition
• data science
• education
• cell cell interactions
• cancer

Websites

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• Github (github.com)

Publications (7)

Top publication keywords:
Breast NeoplasmsPTEN PhosphohydrolaseNeoplastic Stem CellsBreastSuppressor of Cytokine Signaling ProteinsCarcinoma, Intraductal, NoninfiltratingReceptor, ErbB-3ras ProteinsTriple Negative Breast NeoplasmsProto-Oncogene Proteins c-metGene Knockdown TechniquesInterleukin-6Receptor, ErbB-2Proto-Oncogene Proteins c-aktDrug Resistance, Neoplasm

• Generative Molecular Design and Experimental Validation of Selective Histamine H1 Inhibitors
  bioRxiv 2023 Kevin S. McLoughlin, Da Shi, Jeffrey E. Mast, John Bucci, John P. Williams, W. Derek Jones, Derrick Miyao, Luke Nam, Heather L. Osswald, Lev Zegelman, Jonathan Allen, Brian J. Bennion, Amanda K. …
• SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model.
  Oncogene 2014 Kim G, Ouzounova M, Quraishi AA, Davis A, Tawakkol N, Clouthier SG, Malik F, Paulson AK, D'Angelo RC, Korkaya S, Baker TL, Esen ES, Prat A, Liu S, Kleer CG, Thomas DG, Wicha MS, Korkaya H
• MET and ERBB2 are coexpressed in ERBB2+ breast cancer and contribute to innate resistance.
  Molecular cancer research : MCR 2013 Paulson AK, Linklater ES, Berghuis BD, App CA, Oostendorp LD, Paulson JE, Pettinga JE, Melnik MK, Vande Woude GF, Graveel CR
• Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis.
  Cell reports 2012 Liu JS, Farlow JT, Paulson AK, Labarge MA, Gartner ZJ
• Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.
  Molecular cell 2012 Korkaya H, Kim GI, Davis A, Malik F, Henry NL, Ithimakin S, Quraishi AA, Tawakkol N, D'Angelo R, Paulson AK, Chung S, Luther T, Paholak HJ, Liu S, Hassan KA, Zen Q, Clouthier SG, Wicha MS
• Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.
  PLoS biology 2009 Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS
• HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion.
  Oncogene 2008 Korkaya H, Paulson A, Iovino F, Wicha MS