Amanda McQuade, PhD
Postdoctoral Scholar
Institute for Neurodegenerative Diseases
School of Medicine

Grants and Projects

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• Epigenetic control of microglial activation in Alzheimer?s disease via DNA methylation, NIH, 2026-2028

Publications (10)

Top publication keywords:
Lipid DropletsPluripotent Stem CellsNeuronal PlasticityNerve Tissue ProteinsExtracellular VesiclesCulture MediaInterferon-gammaMicrogliaCalcium SignalingTransgenesInduced Pluripotent Stem CellsOxidative StressNF-E2-Related Factor 2Endoplasmic ReticulumGene Silencing

• Regulators of interferon-responsive microglia uncovered by Genome-wide CRISPRi screening.
  NPJ dementia 2026 McQuade A, Castillo VC, Hagan V, Liang W, Ta T, Mishra R, Teter O, Gomes L, Gonzalez B, Teyssier N, Leng K, Kampmann M
• Transcriptional regulation of disease-relevant microglial activation programs.
  Neuron 2026 McQuade A, Mishra R, Hagan V, Liang W, Colias PJ, Castillo VC, Gonzalez B, Lubin JP, Haage V, Marshe V, Fujita M, Ta T, Gomes L, Teter O, Han X, Robichaud N, Chasins SE, Rexach JE, De Jager PL, Nuñez …
• Prevention of transgene silencing during human pluripotent stem cell differentiation.
  Cell stem cell 2026 Uenaka T, Napole A, Saha AD, Sun D, Singavarapu A, Calzada E, Chen J, Erlebach L, McQuade A, Ramos DM, Rigamonti A, Salazar L, Samelson AJ, Sedov K, Welsh NJ, Wild K, Wu Q, Arenas E, Bassett AR, …
• Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition.
  Stem cell reports 2026 Toda Robert A, McQuade A, Koppes-den Hertog SJ, Erlebach L, Kronenberg-Versteeg D, Kampmann M, Giera M, van der Kant R
• Transcriptional regulation of disease-relevant microglial activation programs.
  bioRxiv : the preprint server for biology 2025 McQuade A, Mishra R, Hagan V, Liang W, Colias PJ, Castillo VC, Lubin JP, Haage V, Marshe V, Fujita M, Gomes L, Ta T, Teter O, Chasins SE, De Jager PL, Nuñez JK, Kampmann M

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• CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning.
  Molecular psychiatry 2025 Teter OM, McQuade A, Hagan V, Liang W, Dräger NM, Sattler SM, Holmes BB, Castillo VC, Papakis V, Leng K, Boggess S, Nowakowski TJ, Wells J, Kampmann M
• CRISPRi-based screen of Autism Spectrum Disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning.
  bioRxiv : the preprint server for biology 2024 Teter OM, McQuade A, Hagan V, Liang W, Dräger NM, Sattler SM, Holmes BB, Castillo VC, Papakis V, Leng K, Boggess S, Nowakowski TJ, Wells J, Kampmann M
• ER and SOCE Ca2+ signals are not required for directed cell migration in human iPSC-derived microglia.
  Cell calcium 2024 Granzotto A, McQuade A, Chadarevian JP, Davtyan H, Sensi SL, Parker I, Blurton-Jones M, Smith IF
• Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease.
  Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Kang YJ, Hyeon SJ, McQuade A, Lim J, Baek SH, Diep YN, Do KV, Jeon Y, Jo DG, Lee CJ, Blurton-Jones M, Ryu H, Cho H
• Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.
  Journal of extracellular vesicles 2022 You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T