Alyssa Nylander, MD, PhD
Assistant Professor
Neurology
School of Medicine

Education & Training

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• BA Biology, Neuroscience Harvard College
• Neuroimmunology Fellowship UCSF
• Neurology Residency UCSF
• MD, PhD Medicine, Neuroscience Yale School of Medicine

Grants and Projects

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• Assessing Cognitive Overload in People with Multiple Sclerosis, NIH, 2025-2030

Publications (16)

Top publication keywords:
GeriatricsMenopauseEvoked Potentials, VisualInflammationMyelin SheathMultiple SclerosisPatient Outcome AssessmentSpeechFatigueNeurofilament ProteinsIndolesTh17 CellsRemyelinationBreast NeoplasmsMembrane Glycoproteins

• Anti-CD320 Autoantibodies and Central Nervous System Vitamin B12 Deficiency in Idiopathic Myelopathy.
  medRxiv : the preprint server for health sciences 2026 Pluvinage JV, Acero-Garces D, Greco G, Moseley CE, Sidhu S, Zorn KC, Kondapavulur S, Richie M, Douglas V, Mohan S, Neely J, Masciocchi S, Businaro P, Sarreón AG, Gifreu A, McCutcheon K, Caspar C, …
• Facial Expression Metrics as Digital Biomarkers of Neurologic Disease.
  Neurology open access 2025 Nylander A, Poole S, Hsu NS, Henderson K, Sisodia N, Wijangco J, Rowson J, Halabi C, Ostrem JL, Little S, Brown E, Staffaroni A, Bove R
• Association of Menopause With Functional Outcomes and Disease Biomarkers in Women With Multiple Sclerosis.
  Neurology 2024 Silverman HE, Bostrom A, Nylander AN, Akula A, Lazar AA, Gomez R, Santaniello A, Renschen A, Harms MM, Cooper TP, Lincoln R, Poole S, Abdelhak A, Henry RG, Oksenberg J, Hauser SL, Cree BAC, Bove R
• From "invisible" to "audible": Features extracted during simple speech tasks classify patient-reported fatigue in multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2024 Nylander A, Sisodia N, Henderson K, Wijangco J, Koshal K, Poole S, Dias M, Linz N, Tröger J, König A, Hayward-Koennecke H, Pedotti R, Brown E, Halabi C, Staffaroni A, Bove R
• Clinical outcomes after use of checkpoint inhibitor immunotherapies in people with multiple sclerosis.
  Multiple sclerosis journal - experimental, translational and clinical 2024 Nylander AN, Rowles W, Poole S, Bove R

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• Cognitive function influences cognitive-motor interference during dual task walking in multiple sclerosis.
  Multiple sclerosis and related disorders 2024 Hsu WY, Block VJ, Wijangco J, Henderson K, Nylander A, Koshal K, Poole S, Possin KL, Staffaroni AM, Bove RM
• A Closed-Loop Falls Monitoring and Prevention App for Multiple Sclerosis Clinical Practice: Human-Centered Design of the Multiple Sclerosis Falls InsightTrack.
  JMIR human factors 2024 Block VJ, Koshal K, Wijangco J, Miller N, Sara N, Henderson K, Reihm J, Gopal A, Mohan SD, Gelfand JM, Guo CY, Oommen L, Nylander A, Rowson JA, Brown E, Sanders S, Rankin K, Lyles CR, Sim I, Bove R
• Re-WRAP (Remyelination for women at risk of axonal loss and progression): A phase II randomized placebo-controlled delayed-start trial of bazedoxifene for myelin repair in multiple sclerosis.
  Contemporary clinical trials 2023 Nylander A, Anderson A, Rowles W, Hsu S, Lazar AA, Mayoral SR, Pease-Raissi SE, Green A, Bove R
• Well-being at midlife: Correlates of mental health in ambulatory menopausal women with multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2023 Morales-Rodriguez D, Anderson A, Nylander A, Hsu S, Singh J, Rowles W, Walsh CM, Braley TJ, Bove R
• Clinical course of multiple sclerosis and patient experiences during breast cancer treatment.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2023 Nylander AN, Singh J, Poole S, Anderson A, Marrie RA, Rugo H, Bove R
• Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 Infection.
  Neurology(R) neuroimmunology & neuroinflammation 2022 Peluso MJ, Sans HM, Forman CA, Nylander AN, Ho HE, Lu S, Goldberg SA, Hoh R, Tai V, Munter SE, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Martin JN, Kelly JD, Durstenfeld MS, Hsue PY, Hunt PW, …
• Podoplanin is a negative regulator of Th17 inflammation.
  JCI insight 2017 Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA
• CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment.
  Neurology 2016 Cao Y, Nylander A, Ramanan S, Goods BA, Ponath G, Zabad R, Chiang VL, Vortmeyer AO, Hafler DA, Pitt D
• B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.
  Science translational medicine 2014 Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC
• Multiple sclerosis.
  The Journal of clinical investigation 2012 Nylander A, Hafler DA
• L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA