Allan Basbaum, PhD
Professor
Anatomy
School of Medicine

The hallmark of our work is a multidisciplinary approach to the problem, using molecular, neuroanatomical, pharmacological and behavioral analyses in wild type and genetically-modified mice, including knockouts and Cre- or reporter-expressing mice generated in our laboratory. By combining these studies with an analysis of the functional properties of molecularly-defined neurons, these studies examine the extent to which pain and itch circuits segregate or converge at the level of spinal cord interneurons and projection neurons. Also of great interest are the mechanisms through which monocytes, including peripheral macrophages and spinal cord microglia, contribute to the persistent pain following nerve injury. With a view to overcoming the neurological consequences of peripheral nerve damage, we also studied the effects of transplanting embryonic cortical GABAergic precursor cells into the spinal cord. We have demonstrated that the cells integrate synaptically and functionally into host neural circuits and can ameliorate the persistent pain and itch associated with nerve damage, effectively treating what we consider to be the "disease" of neuropathic pain. And recently using long-term calcium imaging of spinal cord and cortical neurons in awake, behaving mice we are examining the brain and spinal cord circuits and mechanisms through which pain and itch percepts are generated as well as the mechanisms through which different general anesthetics exert their analgesic action. Below are several comprehensive reviews that we have published on the topics described above.

• Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results.
  Neuroscience and biobehavioral reviews 2023 Linguiti S, Vogel JW, Sydnor VJ, Pines A, Wellman N, Basbaum A, Eickhoff CR, Eickhoff SB, Edwards RR, Larsen B, McKinstry-Wu A, Scott JC, Roalf DR, Sharma V, Strain EC, Corder G, Dworkin RH, …
• Pain and Itch Processing in Aged Mice.
  The journal of pain 2023 Braz JM, Hamel K, Craik V, Rodriguez-Rosado S, Bhardwaj K, Jewell M, Bieri G, Villeda SA, Basbaum AI
• Long-term optical imaging of the spinal cord in awake, behaving animals.
  bioRxiv : the preprint server for biology 2023 Ahanonu B, Crowther A, Kania A, Casillas MR, Basbaum A
• Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
  Cell 2023 Singh I, Seth A, Billesbølle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V, Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A,…
• Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect.
  bioRxiv : the preprint server for biology 2023 Weinrich JA, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI
• Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.
  Science (New York, N.Y.) 2022 Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, …
• TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons.
  eLife 2022 Yue WWS, Yuan L, Braz JM, Basbaum AI, Julius D
• History of Spinal Cord "Pain" Pathways Including the Pathways Not Taken.
  Frontiers in pain research (Lausanne, Switzerland) 2022 Basbaum A
• Structural imaging studies of patients with chronic pain: an anatomical likelihood estimate meta-analysis.
  Pain 2022 Henn AT, Larsen B, Frahm L, Xu A, Adebimpe A, Scott JC, Linguiti S, Sharma V, Basbaum AI, Corder G, Dworkin RH, Edwards RR, Woolf CJ, Habel U, Eickhoff SB, Eickhoff CR, Wagels L, Satterthwaite TD
• ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
  Pain 2022 Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC
• Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor.
  Journal of medicinal chemistry 2022 Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, Amabo V, O'Donnell H, Lak P, Basbaum AI, Roth BL, Shoichet BK
• Structures of the σ2 receptor enable docking for bioactive ligand discovery.
  Nature 2021 Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC
• Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.
  eLife 2021 Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI
• Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Wercberger R, Braz JM, Weinrich JA, Basbaum AI
• Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity.
  eLife 2021 Löken LS, Braz JM, Etlin A, Sadeghi M, Bernstein M, Jewell M, Steyert M, Kuhn J, Hamel K, Llewellyn-Smith IJ, Basbaum A
• TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY
• Contribution of colony-stimulating factor 1 to neuropathic pain.
  Pain reports 2021 Yu X, Basbaum A, Guan Z
• Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Braz JM, Dembo T, Charruyer A, Ghadially R, Fassett MS, Basbaum AI
• Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis.
  JAMA network open 2021 Xu A, Larsen B, Henn A, Baller EB, Scott JC, Sharma V, Adebimpe A, Basbaum AI, Corder G, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, Satterthwaite TD
• Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
  PloS one 2020 Alvaro CG, Braz JM, Bernstein M, Hamel KA, Craik V, Yamanaka H, Basbaum AI
• Convergent neural representations of experimentally-induced acute pain in healthy volunteers: A large-scale fMRI meta-analysis.
  Neuroscience and biobehavioral reviews 2020 Xu A, Larsen B, Baller EB, Scott JC, Sharma V, Adebimpe A, Basbaum AI, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, Satterthwaite TD
• Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain.
  Nature communications 2020 Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI
• Ablation of spinal cord estrogen receptor α-expressing interneurons reduces chemically induced modalities of pain and itch.
  The Journal of comparative neurology 2020 Tran M, Braz JM, Hamel K, Kuhn J, Todd AJ, Basbaum AI
• Spinal cord projection neurons: a superficial, and also deep, analysis.
  Current opinion in physiology 2019 Wercberger R, Basbaum AI
• GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness.
  Brain : a journal of neurology 2019 Juarez-Salinas DL, Braz JM, Etlin A, Gee S, Sohal V, Basbaum AI
• Mispositioned Neurokinin-1 Receptor-Expressing Neurons Underlie Heat Hyperalgesia in Disabled-1 Mutant Mice.
  eNeuro 2019 Wang X, Yvone GM, Cilluffo M, Kim AS, Basbaum AI, Phelps PE
• Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion.
  Neuron 2019 Meda KS, Patel T, Braz JM, Malik R, Turner ML, Seifikar H, Basbaum AI, Sohal VS
• Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn.
  Pain 2019 Dickie AC, Bell AM, Iwagaki N, Polgár E, Gutierrez-Mecinas M, Kelly R, Lyon H, Turnbull K, West SJ, Etlin A, Braz J, Watanabe M, Bennett DLH, Basbaum AI, Riddell JS, Todd AJ
• Primary Afferent-Derived BDNF Contributes Minimally to the Processing of Pain and Itch.
  eNeuro 2018 Dembo T, Braz JM, Hamel KA, Kuhn JA, Basbaum AI
• Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls.
  Pain reports 2018 Juarez-Salinas DL, Braz JM, Hamel KA, Basbaum AI
• Transition to chronic pain: opportunities for novel therapeutics.
  Nature reviews. Neuroscience 2018 Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH
• NaV1.1 inhibition can reduce visceral hypersensitivity.
  JCI insight 2018 Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F
• Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.
  Neuron 2018 Wang D, Tawfik VL, Corder G, Low SA, François A, Basbaum AI, Scherrer G
• Long-term, dynamic synaptic reorganization after GABAergic precursor cell transplantation into adult mouse spinal cord.
  The Journal of comparative neurology 2017 Llewellyn-Smith IJ, Basbaum AI, Bráz JM
• Chemogenetic management of neuropathic pain.
  Brain : a journal of neurology 2017 Basbaum A
• Neuronal aromatase expression in pain processing regions of the medullary and spinal cord dorsal horn.
  The Journal of comparative neurology 2017 Tran M, Kuhn JA, Bráz JM, Basbaum AI
• Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D
• Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis.
  The Journal of allergy and clinical immunology 2017 Cevikbas F, Braz JM, Wang X, Solorzano C, Sulk M, Buhl T, Steinhoff M, Basbaum AI
• Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch.
  Progress in brain research 2017 Braz JM, Etlin A, Juarez-Salinas D, Llewellyn-Smith IJ, Basbaum AI
• Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Etlin A, Bráz JM, Kuhn JA, Wang X, Hamel KA, Llewellyn-Smith IJ, Basbaum AI
• Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE.
  Experimental neurology 2016 Frezel N, Sohet F, Daneman R, Basbaum AI, Braz JM
• Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.
  Nature 2016 Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans …
• Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.
  Pain 2016 Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice ASC, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, …
• Cell transplants to treat the "disease" of neuropathic pain and itch.
  Pain 2016 Basbaum AI, Bráz JM
• Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.
  Nature neuroscience 2015 Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI
• Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli.
  PloS one 2015 Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH
• Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.
  Cell reports 2015 Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R
• Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection.
  PloS one 2015 Bráz JM, Wang F, Basbaum AI
• CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine.
  Science translational medicine 2015 Brown JD, Saeed M, Do L, Braz J, Basbaum AI, Iadarola MJ, Wilson DM, Dillon WP
• In Memoriam Jean-Marie Besson 1938-2014.
  European journal of pain (London, England) 2015 Villanueva L, Bouhassira D, Dickenson T, Basbaum A, Zimmermann M
• Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity.
  Pain 2015 Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI
• Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI
• Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch.
  The Journal of clinical investigation 2014 Braz JM, Juarez-Salinas D, Ross SE, Basbaum AI
• Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control.
  Neuron 2014 Braz J, Solorzano C, Wang X, Basbaum AI
• Interneurons from embryonic development to cell-based therapy.
  Science (New York, N.Y.) 2014 Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A
• Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn.
  Neuron 2014 Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB…
• Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn.
  Neuron 2014 Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB…
• A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.
  The Journal of allergy and clinical immunology 2013 Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M
• Identification of multisegmental nociceptive afferents that modulate locomotor circuits in the neonatal mouse spinal cord.
  The Journal of comparative neurology 2013 Mandadi S, Hong P, Tran MA, Bráz JM, Colarusso P, Basbaum AI, Whelan PJ
• TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.
  Nature neuroscience 2013 Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY
• Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.
  Neuron 2013 Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, Yamanaka H, Rice D, Basbaum AI
• Paradoxical surrogate markers of dental injury-induced pain in the mouse.
  Pain 2013 Gibbs JL, Urban R, Basbaum AI
• The modality-specific contribution of peptidergic and non-peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons.
  The Journal of physiology 2012 Zhang J, Cavanaugh DJ, Nemenov MI, Basbaum AI
• Loss of the Reelin-signaling pathway differentially disrupts heat, mechanical and chemical nociceptive processing.
  Neuroscience 2012 Wang X, Babayan AH, Basbaum AI, Phelps PE
• Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain.
  Neuron 2012 Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI
• A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain.
  Nature 2011 Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D
• Sciatic nerve transection triggers release and intercellular transfer of a genetically expressed macromolecular tracer in dorsal root ganglia.
  The Journal of comparative neurology 2011 Bráz JM, Ackerman L, Basbaum AI
• Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Cavanaugh DJ, Chesler AT, Bráz JM, Shah NM, Julius D, Basbaum AI
• Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI
• Differential TRPV1 and TRPV2 channel expression in dental pulp.
  Journal of dental research 2011 Gibbs JL, Melnyk JL, Basbaum AI
• Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity.
  Pain 2011 Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI
• Targeting pain where it resides ... In the brain.
  Science translational medicine 2011 Sharif-Naeini R, Basbaum AI
• Introducing the Biennial review of pain.
  Pain 2010 Mogil JS, Basbaum AI
• VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI
• Olfactory ensheathing glia express aquaporin 1.
  The Journal of comparative neurology 2010 Shields SD, Moore KD, Phelps PE, Basbaum AI
• Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors.
  Pain 2010 Shields SD, Cavanaugh DJ, Lee H, Anderson DJ, Basbaum AI
• Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli.
  Pain 2010 Bráz JM, Basbaum AI
• Effect of topical 0.5% morphine on postoperative pain after photorefractive keratectomy.
  Journal of refractive surgery (Thorofare, N.J. : 1995) 2010 Faktorovich EG, Basbaum AI
• Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice.
  Cephalalgia : an international journal of headache 2010 Bates EA, Nikai T, Brennan KC, Fu YH, Charles AC, Basbaum AI, Ptácek LJ, Ahn AH
• Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors.
  Nature 2009 Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH
• Cellular and molecular mechanisms of pain.
  Cell 2009 Basbaum AI, Bautista DM, Scherrer G, Julius D
• Triggering genetically-expressed transneuronal tracers by peripheral axotomy reveals convergent and segregated sensory neuron-spinal cord connectivity.
  Neuroscience 2009 Bráz JM, Basbaum AI
• TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK
• Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.
  Cell 2009 Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O'Donnell D, Kieffer BL, Basbaum AI
• Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ
• Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing.
  The Journal of comparative neurology 2009 Braz JM, Enquist LW, Basbaum AI
• TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Wang X, Ratnam J, Zou B, England PM, Basbaum AI
• Change is coming!
  Pain 2008 Basbaum AI
• Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth.
  Journal of neuroscience methods 2008 Ossovskaya VS, Dolganov G, Basbaum AI
• Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan.
  Pain 2008 Nikai T, Basbaum AI, Ahn AH
• Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI
• Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits.
  The Journal of comparative neurology 2008 Braz JM, Basbaum AI
• Contribution of the Reelin signaling pathways to nociceptive processing.
  The European journal of neuroscience 2008 Akopians AL, Babayan AH, Beffert U, Herz J, Basbaum AI, Phelps PE
• Dense transient receptor potential cation channel, vanilloid family, type 2 (TRPV2) immunoreactivity defines a subset of motoneurons in the dorsal lateral nucleus of the spinal cord, the nucleus ambiguus and the trigeminal motor nucleus in rat.
  Neuroscience 2007 Lewinter RD, Scherrer G, Basbaum AI
• 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P
• The menthol receptor TRPM8 is the principal detector of environmental cold.
  Nature 2007 Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D
• Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons.
  Pain 2007 Shields SD, Mazario J, Skinner K, Basbaum AI
• Contribution of substance P and neurokinin A to the differential injury-induced thermal and mechanical responsiveness of lamina I and V neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Mazarío J, Basbaum AI
• Spider toxins activate the capsaicin receptor to produce inflammatory pain.
  Nature 2006 Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D
• Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse.
  Pain 2006 Eckert WA, Julius D, Basbaum AI
• Reviews: topical, systematic and once again, comprehensive.
  Pain 2006 Basbaum AI
• Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Ahn AH, Basbaum AI
• Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, Kieffer BL
• Toward better pain control.
  Scientific American 2006 Basbaum AI, Julius D
• Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity.
  Journal of proteome research 2006 Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, Wang HY, Jackson SN, Zeitz P, Zeitz KP, Zolkowska D, Schepers R, Nold M, Danielson J, Gräslund A, Vukojevic V, Bakalkin G, Basbaum A, Shippenberg…
• Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord.
  Neuroscience 2006 Villeda SA, Akopians AL, Babayan AH, Basbaum AI, Phelps PE
• TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
  Cell 2006 Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D
• Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Neumann S, Skinner K, Basbaum AI
• Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor.
  Neuron 2005 Braz JM, Nassar MA, Wood JN, Basbaum AI
• A neuropeptide courier for delta-opioid receptors?
  Cell 2005 Julius D, Basbaum AI
• Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system.
  The Journal of biological chemistry 2005 Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM
• Where do triptans act in the treatment of migraine?
  Pain 2005 Ahn AH, Basbaum AI
• A new way to lose your nerve.
  Science of aging knowledge environment : SAGE KE 2004 Basbaum AI
• Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat.
  The European journal of neuroscience 2004 Sanderson Nydahl K, Skinner K, Julius D, Basbaum AI
• Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat.
  The Journal of comparative neurology 2004 Lewinter RD, Skinner K, Julius D, Basbaum AI
• Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo.
  Journal of neurophysiology 2004 Martin WJ, Cao Y, Basbaum AI
• The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain.
  Neuroscience 2004 Zeitz KP, Giese KP, Silva AJ, Basbaum AI
• [d-Ala2,N-MePhe4,Gly-ol5]enkephalin-induced internalization of the micro opioid receptor in the spinal cord of morphine tolerant rats.
  Neuroscience 2004 Trafton JA, Basbaum AI
• Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Potrebic S, Ahn AH, Skinner K, Fields HL, Basbaum AI
• Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis.
  The journal of pain 2003 Shields SD, Eckert WA, Basbaum AI
• Systemic morphine-induced release of serotonin in the rostroventral medulla is not mimicked by morphine microinjection into the periaqueductal gray.
  Journal of neurochemistry 2003 Taylor BK, Basbaum AI
• Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury.
  American journal of physiology. Gastrointestinal and liver physiology 2003 Bhatia M, Slavin J, Cao Y, Basbaum AI, Neoptolemos JP
• Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T.
  Pain 2003 Malmberg AB, Gilbert H, McCabe RT, Basbaum AI
• Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, Basbaum AI
• Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network.
  Journal of neurophysiology 2002 Telgkamp P, Cao YQ, Basbaum AI, Ramirez JM
• Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation.
  Neuron 2002 Neumann S, Bradke F, Tessier-Lavigne M, Basbaum AI
• Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions.
  Brain research 2002 Abbadie C, Lombard MC, Besson JM, Trafton JA, Basbaum AI
• The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI
• Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice.
  Pain 2001 Zeitz KP, Malmberg AB, Gilbert H, Basbaum AI
• Molecular mechanisms of nociception.
  Nature 2001 Julius D, Basbaum AI
• PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Martin WJ, Malmberg AB, Basbaum AI
• Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.
  Nature medicine 2001 Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL
• Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.
  Nature 2001 Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D
• Differential contribution of substance P and neurokinin A to spinal cord neurokinin-1 receptor signaling in the rat.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Trafton JA, Abbadie C, Basbaum AI
• Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine.
  British journal of pharmacology 2001 Malmberg AB, Hedley LR, Jasper JR, Hunter JC, Basbaum AI
• Hypoalgesia and hyperalgesia with inherited hypertension in the rat.
  American journal of physiology. Regulatory, integrative and comparative physiology 2001 Taylor BK, Roderick RE, St Lezin E, Basbaum AI
• Presynaptic regulation of spinal cord tachykinin signaling via GABA(B) but not GABA(A) receptor activation.
  Neuroscience 2001 Riley RC, Trafton JA, Chi SI, Basbaum AI
• Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Trafton JA, Abbadie C, Marek K, Basbaum AI
• Brainstem noradrenergic control of nociception is abnormal in the spontaneously hypertensive rat.
  Neuroscience letters 2000 Taylor BK, Roderick RE, Basbaum AI
• The contribution of spinal cord neurokinin-1 receptor signaling to pain.
  The journal of pain 2000 Trafton JA, Basbaum AI
• Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
  Science (New York, N.Y.) 2000 Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D
• Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats.
  Pain 2000 Taylor BK, Peterson MA, Roderick RE, Tate J, Green PG, Levine JO, Basbaum AI
• A locus and mechanism of action for associative morphine tolerance.
  Nature neuroscience 2000 Mitchell JM, Basbaum AI, Fields HL
• Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test.
  The journal of pain 2000 Taylor BK, Basbaum AI
• Pain genes?: natural variation and transgenic mutants.
  Annual review of neuroscience 2000 Mogil JS, Yu L, Basbaum AI
• Spinal opioid analgesia: how critical is the regulation of substance P signaling?
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Trafton JA, Abbadie C, Marchand S, Mantyh PW, Basbaum AI
• Hospital merger leaves clinical science intact.
  Nature 1999 Stryker MP, Basbaum A, DeFranco T, Herskowitz I, Yamamoto K
• Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Liu H, Cao Y, Basbaum AI, Mazarati AM, Sankar R, Wasterlain CG
• Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Honor P, Menning PM, Rogers SD, Nichols ML, Basbaum AI, Besson JM, Mantyh PW
• Second messengers, the substantia gelatinosa and injury-induced persistent pain.
  Pain 1999 Petersen-Zeitz KR, Basbaum AI
• Spinal cannabinoids are anti-allodynic in rats with persistent inflammation.
  Pain 1999 Martin WJ, Loo CM, Basbaum AI
• Distinct neurochemical features of acute and persistent pain.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Basbaum AI
• Pain.
  Current biology : CB 1999 Basbaum AI, Woolf CJ
• Immunohistochemical localization of GABA(B) receptors in the rat central nervous system.
  The Journal of comparative neurology 1999 Margeta-Mitrovic M, Mitrovic I, Riley RC, Jan LY, Basbaum AI
• Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing.
  Pain 1999 Martin WJ, Gupta NK, Loo CM, Rohde DS, Basbaum AI
• Neurons in the dorsal column white matter of the spinal cord: complex neuropil in an unexpected location.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Abbadie C, Skinner K, Mitrovic I, Basbaum AI
• Inflammation-induced up-regulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing.
  Neuroscience 1999 Martin WJ, Liu H, Wang H, Malmberg AB, Basbaum AI
• Spinal mechanisms of acute and persistent pain.
  Regional anesthesia and pain medicine 1999 Basbaum AI
• The contribution of capsaicin-sensitive afferents to the dorsal root ganglion sprouting of sympathetic axons after peripheral nerve injury in the rat.
  Neuroscience letters 1998 Abbadie C, Basbaum AI
• The cloned capsaicin receptor integrates multiple pain-producing stimuli.
  Neuron 1998 Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D
• Pain: nocistatin spells relief.
  Current biology : CB 1998 Martin WJ, Malmberg AB, Basbaum AI
• The effects of prior chronic stress on cardiovascular responses to acute restraint and formalin injection.
  Brain research 1998 Bhatnagar S, Dallman MF, Roderick RE, Basbaum AI, Taylor BK
• Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Rohde DS, Basbaum AI
• Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates.
  Pain 1998 Malmberg AB, Basbaum AI
• Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: endogenous corticosterone does not reduce nociception in the formalin test.
  Endocrinology 1998 Taylor BK, Akana SF, Peterson MA, Dallman MF, Basbaum AI
• Primary afferent tachykinins are required to experience moderate to intense pain.
  Nature 1998 Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI
• Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat.
  The Journal of pharmacology and experimental therapeutics 1998 Hammond DL, Wang H, Nakashima N, Basbaum AI
• Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Abbadie C, Trafton J, Liu H, Mantyh PW, Basbaum AI
• Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.
  Science (New York, N.Y.) 1997 Malmberg AB, Chen C, Tonegawa S, Basbaum AI
• Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Malmberg AB, Brandon EP, Idzerda RL, Liu H, McKnight GS, Basbaum AI
• Cholecystokinin and enkephalin in brain stem pain modulating circuits.
  Neuroreport 1997 Skinner K, Basbaum AI, Fields HL
• The contribution of supraspinal, peripheral and intrinsic spinal circuits to the pattern and magnitude of Fos-like immunoreactivity in the lumbar spinal cord of the rat withdrawing from morphine.
  Neuroscience 1997 Rohde DS, McKay WR, Chang DS, Abbadie C, Basbaum AI
• Formalin-evoked Fos expression in spinal cord is enhanced in morphine-tolerant rats.
  Brain research 1997 Rohde DS, Detweiler DJ, Basbaum AI
• Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivo.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Allen BJ, Rogers SD, Ghilardi JR, Menning PM, Kuskowski MA, Basbaum AI, Simone DA, Mantyh PW
• Transneuronal labeling of a nociceptive pathway, the spino-(trigemino-)parabrachio-amygdaloid, in the rat.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1997 Jasmin L, Burkey AR, Card JP, Basbaum AI
• The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test.
  Brain research 1997 Peterson MA, Basbaum AI, Abbadie C, Rohde DS, McKay WR, Taylor BK
• NMDA-receptor regulation of substance P release from primary afferent nociceptors.
  Nature 1997 Liu H, Mantyh PW, Basbaum AI
• Neurokinin-1 receptor-immunoreactive sympathetic preganglionic neurons: target specificity and ultrastructure.
  Neuroscience 1997 Llewellyn-Smith IJ, Martin CL, Minson JB, Pilowsky PM, Arnolda LF, Basbaum AI, Chalmers JP
• GABA-immunoreactive boutons contact identified OFF and ON cells in the nucleus raphe magnus.
  The Journal of comparative neurology 1997 Skinner K, Fields HL, Basbaum AI, Mason P
• Early nociceptive events influence the temporal profile, but not the magnitude, of the tonic response to subcutaneous formalin: effects with remifentanil.
  The Journal of pharmacology and experimental therapeutics 1997 Taylor BK, Peterson MA, Basbaum AI
• Interneurons presynaptic to rat tail-flick motoneurons as mapped by transneuronal transport of pseudorabies virus: few have long ascending collaterals.
  Neuroscience 1997 Jasmin L, Carstens E, Basbaum AI
• Contribution of sacral spinal cord neurons to the autonomic and somatic consequences of withdrawal from morphine in the rat.
  Brain research 1997 Rohde DS, McKay WR, Abbadie C, Basbaum AI
• Continuous intravenous infusion of naloxone does not change behavioral, cardiovascular, or inflammatory responses to subcutaneous formalin in the rat.
  Pain 1997 Taylor BK, Peterson MA, Basbaum AI
• Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: studies with remifentanil and lidocaine.
  Pain 1997 Abbadie C, Taylor BK, Peterson MA, Basbaum AI
• Spinal cord mechanisms of opioid tolerance and dependence: Fos-like immunoreactivity increases in subpopulations of spinal cord neurons during withdrawal [corrected].
  Neuroscience 1996 Rohde DS, Detweiler DJ, Basbaum AI
• Inhibition of noxious stimulus-evoked pain behaviors and neuronal fos-like immunoreactivity in the spinal cord of the rat by supraspinal morphine.
  Pain 1996 Gogas KR, Cho HJ, Botchkina GI, Levine JD, Basbaum AI
• Differential contribution of descending controls to the antinociceptive actions of kappa and mu opioids: an analysis of formalin-evoked C-fos expression.
  The Journal of pharmacology and experimental therapeutics 1996 Gogas KR, Levine JD, Basbaum AI
• Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain.
  Neuroscience 1996 Abbadie C, Brown JL, Mantyh PW, Basbaum AI
• Exaggerated cardiovascular and behavioral nociceptive responses to subcutaneous formalin in the spontaneously hypertensive rat.
  Neuroscience letters 1995 Taylor BK, Peterson MA, Basbaum AI
• Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 Taylor BK, Peterson MA, Basbaum AI
• The development of opioid tolerance in the formalin test in the rat.
  Pain 1995 Detweiler DJ, Rohde DS, Basbaum AI
• Relationship between analgesia and extracellular morphine in brain and spinal cord in awake rats.
  Brain research 1995 Matos FF, Rollema H, Taiwo YO, Levine JD, Basbaum AI
• Neurochemical characterization of extracellular serotonin in the rostral ventromedial medulla and its modulation by noxious stimuli.
  Journal of neurochemistry 1995 Taylor BK, Basbaum AI
• Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation.
  Science (New York, N.Y.) 1995 Mantyh PW, DeMaster E, Malhotra A, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE
• Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis.
  The Journal of comparative neurology 1995 Brown JL, Liu H, Maggio JE, Vigna SR, Mantyh PW, Basbaum AI
• Insights into the development of opioid tolerance.
  Pain 1995 Basbaum AI
• Co-injection of wheat germ agglutinin-HRP and choleragenoid-HRP into the sciatic nerve of the rat blocks transganglionic transport.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995 Liu H, Llewellyn-Smith IJ, Basbaum AI
• Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Mantyh PW, Allen CJ, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE
• Differential effects of morphine on noxious stimulus-evoked fos-like immunoreactivity in subpopulations of spinoparabrachial neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1994 Jasmin L, Wang H, Tarczy-Hornoch K, Levine JD, Basbaum AI
• Role of vagal afferents and spinal pathways modulating inhibition of bradykinin-induced plasma extravasation by intrathecal nicotine.
  Journal of neurophysiology 1994 Miao FJ, Jänig W, Dallman MF, Benowitz NL, Heller PH, Basbaum AI, Levine JD
• Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Liu H, Wang H, Sheng M, Jan LY, Jan YN, Basbaum AI
• Diffuse noxious inhibitory controls reduce the expression of noxious stimulus-evoked Fos-like immunoreactivity in the superficial and deep laminae of the rat spinal cord.
  Pain 1994 Morgan MM, Gogas KR, Basbaum AI
• Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Liu H, Brown JL, Jasmin L, Maggio JE, Vigna SR, Mantyh PW, Basbaum AI
• Transneuronal spread of the pseudorabies virus after injection into the central nucleus of the amygdala in the rat.
  Gene therapy 1994 Jasmin L, Tarczy-Hornoch K, Wang H, Levine JD, Basbaum AI
• Walking evokes a distinctive pattern of Fos-like immunoreactivity in the caudal brainstem and spinal cord of the rat.
  Neuroscience 1994 Jasmin L, Gogas KR, Ahlgren SC, Levine JD, Basbaum AI
• Effects of injury discharge on the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat.
  Brain research 1993 Chi SI, Levine JD, Basbaum AI
• Peripheral and central contributions to the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat.
  Brain research 1993 Chi SI, Levine JD, Basbaum AI
• Peptides and the primary afferent nociceptor.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1993 Levine JD, Fields HL, Basbaum AI
• GABAergic regulation of noradrenergic spinal projection neurons of the A5 cell group in the rat: an electron microscopic analysis.
  The Journal of comparative neurology 1993 Kwiat GC, Liu H, Williamson AM, Basbaum AI
• Adrenal medullary modulation of the inhibition of bradykinin-induced plasma extravasation by intrathecal nicotine.
  The Journal of pharmacology and experimental therapeutics 1993 Miao FJ, Dallman MF, Benowitz NL, Basbaum AI, Levine JD
• Mechanisms of opioid-mediated antinociception: correlation of Fos expression and behavior.
  NIDA research monograph 1993 Gogas KR, Levine JD, Basbaum AI
• Chronically administered nicotine attenuates bradykinin-induced plasma extravasation and aggravates arthritis-induced joint injury in the rat.
  Neuroscience 1992 Miao FJ, Helms C, Benowitz NL, Basbaum AI, Heller PH, Levine JD
• Sensory neuropeptide interactions in the production of plasma extravasation in the rat.
  Neuroscience 1992 Green PG, Basbaum AI, Levine JD
• Sympathoadrenal contribution to nicotinic and muscarinic modulation of bradykinin-induced plasma extravasation in the knee joint of the rat.
  The Journal of pharmacology and experimental therapeutics 1992 Miao FJ, Benowitz NL, Basbaum AI, Levine JD
• Construction of a microdialysis probe with attached microinjection catheter.
  Journal of neuroscience methods 1992 Frothingham EP, Basbaum AI
• Medullary CO2 chemoreceptor neuron identification by c-fos immunocytochemistry.
  Journal of applied physiology (Bethesda, Md. : 1985) 1992 Sato M, Severinghaus JW, Basbaum AI
• Simultaneous measurement of extracellular morphine and serotonin in brain tissue and CSF by microdialysis in awake rats.
  Journal of neurochemistry 1992 Matos FF, Rollema H, Basbaum AI
• Ultrastructural evidence for GABA-mediated disinhibitory circuits in the spinal cord of the cat.
  Neuroscience letters 1992 Liu H, Llewellyn-Smith IJ, Pilowsky P, Basbaum AI
• Do opioids evoke the release of serotonin in the spinal cord? An in vivo microdialysis study of the regulation of extracellular serotonin in the rat.
  Pain 1992 Matos FF, Rollema H, Brown JL, Basbaum AI
• Morphine or U-50,488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat.
  The Journal of comparative neurology 1992 Hammond DL, Presley R, Gogas KR, Basbaum AI
• Opioid regulation of nociceptive and neuropathic pain.
  Clinical neuropharmacology 1992 Basbaum AI
• The origin of brainstem noradrenergic and serotonergic projections to the spinal cord dorsal horn in the rat.
  Somatosensory & motor research 1992 Kwiat GC, Basbaum AI
• The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study.
  Pain 1991 Basbaum AI, Gautron M, Jazat F, Mayes M, Guilbaud G
• Opiate analgesia. How central is a peripheral target?
  The New England journal of medicine 1991 Basbaum AI, Levine JD
• Sympathetic neuron factors involved in bradykinin-induced plasma extravasation in the rat.
  Brain research 1991 Lee A, Coderre TJ, Basbaum AI, Levine JD
• Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Green PG, Basbaum AI, Helms C, Levine JD
• The contribution of the nervous system to inflammation and inflammatory disease.
  Canadian journal of physiology and pharmacology 1991 Basbaum AI, Levine JD
• High-dose epinephrine acts at alpha 2-adrenoceptors to suppress experimental arthritis.
  Brain research 1991 Coderre TJ, Basbaum AI, Helms C, Levine JD
• GABAergic circuitry in the rostral ventral medulla of the rat and its relationship to descending antinociceptive controls.
  The Journal of comparative neurology 1991 Cho HJ, Basbaum AI
• Collateralization of periaqueductal gray neurons to forebrain or diencephalon and to the medullary nucleus raphe magnus in the rat.
  Neuroscience 1991 Reichling DB, Basbaum AI
• Increasing sympathetic nerve terminal-dependent plasma extravasation correlates with decreased arthritic joint injury in rats.
  Neuroscience 1991 Coderre TJ, Chan AK, Helms C, Basbaum AI, Levine JD
• Neutrophils contribute to sympathetic nerve terminal-dependent plasma extravasation in the knee joint of the rat.
  Neuroscience 1991 Bjerknes L, Coderre TJ, Green PG, Basbaum AI, Levine JD
• The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: correlation of nociceptive behavior and c-fos expression.
  Neuroscience 1991 Gogas KR, Presley RW, Levine JD, Basbaum AI
• Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphe magnus.
  The Journal of comparative neurology 1990 Reichling DB, Basbaum AI
• Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: II. Electron microscopic immunocytochemical evidence of GABAergic control over the projection from the periaqueductal gray to the nucleus raphe magnus in the rat.
  The Journal of comparative neurology 1990 Reichling DB, Basbaum AI
• Denervation-induced inflammation in the rat.
  Neuroscience letters 1990 Levine JD, Coderre TJ, White DM, Finkbeiner WE, Basbaum AI
• Characterization of monoamine release in the lateral hypothalamus of awake, freely moving rats using in vivo microdialysis.
  Brain research 1990 Matos FF, Rollema H, Basbaum AI
• Organization of tyrosine hydroxylase- and serotonin-immunoreactive brainstem neurons with axon collaterals to the periaqueductal gray and the spinal cord in the rat.
  Brain research 1990 Kwiat GC, Basbaum AI
• Neural influences on synovial mast cell density in rat.
  Journal of neuroscience research 1990 Levine JD, Coderre TJ, Covinsky K, Basbaum AI
• The 15-lipoxygenase product, 8R,15S-diHETE, stereospecifically sensitizes C-fiber mechanoheat nociceptors in hairy skin of rat.
  Journal of neurophysiology 1990 White DM, Basbaum AI, Goetzl EJ, Levine JD
• Neurogenic mechanism for symmetrical arthritis.
  Lancet (London, England) 1990 Levine JD, Basbaum AI
• Deafferentation in the rat increases mechanical nociceptive threshold in the innervated limbs.
  Brain research 1990 Kayser V, Basbaum AI, Guilbaud G
• Epinephrine exacerbates arthritis by an action at presynaptic B2-adrenoceptors.
  Neuroscience 1990 Coderre TJ, Basbaum AI, Dallman MF, Helms C, Levine JD
• Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1990 Presley RW, Menétrey D, Levine JD, Basbaum AI
• A rapid and simple silver enhancement procedure for ultrastructural localization of the retrograde tracer WGAapoHRP-Au and its use in double-label studies with post-embedding immunocytochemistry.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989 Basbaum AI
• Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation.
  The Journal of comparative neurology 1989 Menétrey D, Gannon A, Levine JD, Basbaum AI
• Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents.
  Journal of neurophysiology 1989 Coderre TJ, Basbaum AI, Levine JD
• Effect of deafferentation on the levels of uric acid in the spinal cord of the rat.
  Neuroscience letters 1989 Weil-Fugazza J, Godefroy F, Basbaum AI
• Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor.
  The Journal of pharmacology and experimental therapeutics 1989 Taiwo YO, Basbaum AI, Perry F, Levine JD
• Ultrastructural analysis of dynorphin B-immunoreactive cells and terminals in the superficial dorsal horn of the deafferented spinal cord of the rat.
  The Journal of comparative neurology 1989 Cho HJ, Basbaum AI
• Arborization of single axons of the spinal dorsolateral funiculus to the contralateral superficial dorsal horn.
  Brain research 1989 Cho HJ, Basbaum AI
• Distribution of glycine receptor immunoreactivity in the spinal cord of the rat: cytochemical evidence for a differential glycinergic control of lamina I and V nociceptive neurons.
  The Journal of comparative neurology 1988 Basbaum AI
• Leukotriene B4 decreases the mechanical and thermal thresholds of C-fiber nociceptors in the hairy skin of the rat.
  Journal of neurophysiology 1988 Martin HA, Basbaum AI, Goetzl EJ, Levine JD
• Beta 2-adrenergic mechanisms in experimental arthritis.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Levine JD, Coderre TJ, Helms C, Basbaum AI
• Use of serotonin immunocytochemistry as a marker of injury severity after experimental spinal trauma in rats.
  Brain research 1988 Faden AI, Gannon A, Basbaum AI
• The effect of gold, an antirheumatic therapy, on substance P levels in rat peripheral nerve.
  Neuroscience letters 1988 Levine JD, Moskowitz MA, Basbaum AI
• An ultrastructural study of the projections from the midbrain periaqueductal gray to spinally projecting, serotonin-immunoreactive neurons of the medullary nucleus raphe magnus in the rat.
  Brain research 1988 Lakos S, Basbaum AI
• Increased staining of immunoreactive dynorphin cell bodies in the deafferented spinal cord of the rat.
  Neuroscience letters 1988 Cho HJ, Basbaum AI
• Anatomical introduction to analgesia: correlation of activity of neurons of the superficial dorsal horn with pain and analgesia.
  Acta anaesthesiologica Belgica 1988 Basbaum AI
• Anatomy, physiology and pharmacology of the periaqueductal gray contribution to antinociceptive controls.
  Progress in brain research 1988 Reichling DB, Kwiat GC, Basbaum AI
• The fiber caliber of 5-HT immunoreactive axons in the dorsolateral funiculus of the spinal cord of the rat and cat.
  Somatosensory research 1988 Basbaum AI, Zahs K, Lord B, Lakos S
• Autoradiographic evidence of serotonin1 binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord.
  Neuroscience letters 1987 Daval G, Vergé D, Basbaum AI, Bourgoin S, Hamon M
• The distribution of substance P-, enkephalin- and dynorphin-immunoreactive neurons in the medulla of the rat and their contribution to bulbospinal pathways.
  Neuroscience 1987 Menetrey D, Basbaum AI
• A new microdissection technique for regional biochemical analysis of the rat spinal cord: serotonin, norepinephrine, dopamine and uric acid.
  Brain research 1987 Basbaum AI, Godefroy F, Weil-Fugazza J
• Contribution of the nervous system to the pathophysiology of rheumatoid arthritis and other polyarthritides.
  Rheumatic diseases clinics of North America 1987 Levine JD, Goetzl EJ, Basbaum AI
• Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs.
  Neuroscience 1987 Martin HA, Basbaum AI, Kwiat GC, Goetzl EJ, Levine JD
• Wheat germ agglutinin-apoHRP gold: a new retrograde tracer for light- and electron-microscopic single- and double-label studies.
  The Journal of comparative neurology 1987 Basbaum AI, Menetrey D
• Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Mochly-Rosen D, Basbaum AI, Koshland DE
• Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation.
  The Journal of comparative neurology 1987 Menétrey D, Basbaum AI
• Cytochemical studies of the neural circuitry underlying pain and pain control.
  Acta neurochirurgica. Supplementum 1987 Basbaum AI
• Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: anatomical and subcellular distribution.
  Brain research bulletin 1987 Doble A, Malgouris C, Daniel M, Daniel N, Imbault F, Basbaum A, Uzan A, Guérémy C, Le Fur G
• Clinical response to regional intravenous guanethidine in patients with rheumatoid arthritis.
  The Journal of rheumatology 1986 Levine JD, Fye K, Heller P, Basbaum AI, Whiting-O'Keefe Q
• Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1986 Levine JD, Dardick SJ, Roizen MF, Helms C, Basbaum AI
• Bulbospinal projections in the primate: a light and electron microscopic study of a pain modulating system.
  The Journal of comparative neurology 1986 Basbaum AI, Ralston DD, Ralston HJ
• Benzidine dihydrochloride as a chromogen for single- and double-label light and electron microscopic immunocytochemical studies.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1986 Lakos S, Basbaum AI
• The contribution of pain to disability in experimentally induced arthritis.
  Arthritis and rheumatism 1986 Dardick SJ, Basbaum AI, Levine JD
• The neurotoxic effect of gold sodium thiomalate on the peripheral nerves of the rat. Insights into the antiinflammatory actions of gold therapy.
  Arthritis and rheumatism 1986 Levine JD, Goldstine J, Mayes M, Moskowitz MA, Basbaum AI
• Immunoreactive dynorphin B in sacral primary afferent fibers of the cat.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1986 Basbaum AI, Cruz L, Weber E
• Immunoreactive glutamic acid decarboxylase in the trigeminal nucleus caudalis of the cat: a light- and electron-microscopic analysis.
  Somatosensory research 1986 Basbaum AI, Glazer EJ, Oertel W
• Identification of Aplysia neurons containing immunoreactive FMRFamide.
  Neuropeptides 1985 Brown RO, Gusman D, Basbaum AI, Mayeri E
• Multiple opioid peptides and the modulation of pain: immunohistochemical analysis of dynorphin and enkephalin in the trigeminal nucleus caudalis and spinal cord of the cat.
  The Journal of comparative neurology 1985 Cruz L, Basbaum AI
• The contribution of neurogenic inflammation in experimental arthritis.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Levine JD, Moskowitz MA, Basbaum AI
• Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis.
  The Journal of rheumatology 1985 Levine JD, Collier DH, Basbaum AI, Moskowitz MA, Helms CA
• Reflex neurogenic inflammation. I. Contribution of the peripheral nervous system to spatially remote inflammatory responses that follow injury.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1985 Levine JD, Dardick SJ, Basbaum AI, Scipio E
• Immunoreactive pro-enkephalin and prodynorphin products are differentially distributed within the nucleus of the solitary tract of the rat.
  The Journal of comparative neurology 1984 Lee HS, Basbaum AI
• Intraneuronal substance P contributes to the severity of experimental arthritis.
  Science (New York, N.Y.) 1984 Levine JD, Clark R, Devor M, Helms C, Moskowitz MA, Basbaum AI
• Colocalization of immunoreactive proenkephalin and prodynorphin products in medullary neurons of the rat.
  Neuropeptides 1984 Guthrie J, Basbaum AI
• Radioimmunocytochemistry using a tritiated goat anti-rabbit second antibody.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1984 Glazer EJ, Ramachandran J, Basbaum AI
• Axons which take up [3H]serotonin are presynaptic to enkephalin immunoreactive neurons in cat dorsal horn.
  Brain research 1984 Glazer EJ, Basbaum AI
• Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.
  Annual review of neuroscience 1984 Basbaum AI, Fields HL
• The fine structure of the caudal periaqueductal gray of the cat: morphology and synaptic organization of normal and immunoreactive enkephalin-labeled profiles.
  Brain research 1983 Moss MS, Basbaum AI
• Opioid neurons and pain modulation: an ultrastructural analysis of enkephalin in cat superficial dorsal horn.
  Neuroscience 1983 Glazer EJ, Basbaum AI
• The peptidergic organization of the cat periaqueductal gray. II. The distribution of immunoreactive substance P and vasoactive intestinal polypeptide.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1983 Moss MS, Basbaum AI
• The peptidergic organization of the cat periaqueductal gray. I. The distribution of immunoreactive enkephalin-containing neurons and terminals.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1983 Moss MS, Glazer EJ, Basbaum AI
• Immunoreactive vasoactive intestinal polypeptide is concentrated in the sacral spinal cord: a possible marker for pelvic visceral afferent fibers.
  Somatosensory research 1983 Basbaum AI, Glazer EJ
• Simultaneous ultrastructural localization of tritiated serotonin and immunoreactive peptides.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1982 Basbaum AI, Glazer EJ, Lord BA
• Afferent and efferent connections of the rat tail flick reflex (a model used to analyze pain control mechanisms).
  The Journal of comparative neurology 1982 Grossman ML, Basbaum AI, Fields HL
• Afferent connections of the rostral medulla of the cat: a neural substrate for midbrain-medullary interactions in the modulation of pain.
  The Journal of comparative neurology 1981 Abols IA, Basbaum AI
• Immunohistochemical localization of leucine-enkephalin in the spinal cord of the cat: enkephalin-containing marginal neurons and pain modulation.
  The Journal of comparative neurology 1981 Glazer EJ, Basbaum AI
• Descending control of pain transmission: possible serotonergic-enkephalinergic interactions.
  Advances in experimental medicine and biology 1981 Basbaum AI
• Enkephalin-immunoreactive perikarya in the cat raphe dorsalis.
  Neuroscience letters 1981 Moss MS, Glazer EJ, Basbaum AI
• Serotonin neurons in nucleus raphe dorsalis and paragigantocellularis of the cat contain enkephalin.
  Journal de physiologie 1981 Glazer EJ, Steinbusch H, Verhofstad A, Basbaum AI
• Leucine enkephalin: localization in and axoplasmic transport by sacral parasympathetic preganglionic neurons.
  Science (New York, N.Y.) 1980 Glazer EJ, Basbaum AI
• Dissociation of supraspinal and spinal actions of morphine: a quantitative evaluation.
  Brain research 1980 Barton C, Basbaum AI, Fields HL
• The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation.
  The Journal of comparative neurology 1979 Basbaum AI, Fields HL
• The posterior pretectal nucleus: evidence for a direct projection to the inferior olive of the cat.
  Neuroscience letters 1979 Abols IA, Basbaum AI
• Differential origins of spinothalamic tract projections to medial and lateral thalamus in the rat.
  The Journal of comparative neurology 1979 Giesler GJ, Menétrey D, Basbaum AI
• Intradendritic recordings from hippocampal neurons.
  Proceedings of the National Academy of Sciences of the United States of America 1979 Wong RK, Prince DA, Basbaum AI
• Endogenous pain control mechanisms: review and hypothesis.
  Annals of neurology 1978 Basbaum AI, Fields HL
• Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems.
  The Journal of comparative neurology 1978 Basbaum AI, Clanton CH, Fields HL
• Brainstem control of spinal pain-transmission neurons.
  Annual review of physiology 1978 Fields HL, Basbaum AI
• Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons.
  Brain research 1977 Fields HL, Basbaum AI, Clanton CH, Anderson SD
• Response of medullary raphe neurons to peripheral stimulation and to systemic opiates.
  Brain research 1977 Anderson SD, Basbaum AI, Fields HL
• Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions.
  Pain 1977 Basbaum AI, Marley NJE, O'Keefe J, Clanton CH
• Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway.
  Proceedings of the National Academy of Sciences of the United States of America 1976 Basbaum AI, Clanton CH, Fields HL
• Chronic changes in the response of cells in adult cat dorsal horn following partial deafferentation: the appearance of responding cells in a previously non-responsive region.
  Brain research 1976 Basbaum AI, Wall PD
• Restructuring of the somatotopic map and appearance of abnormal neuronal activity in the gracile nucleus after partial deafferentation.
  Experimental neurology 1976 Millar J, Basbaum AI, Wall PD
• Nucleus raphe magnus: a common mediator of opiate- and stimulus-produced analgesia.
  Transactions of the American Neurological Association 1976 Fields HL, Anderson SD, Clanton CH, Basbaum AI
• Topography of the projection of the body surface of the cat to cuneate and gracile nuclei.
  Experimental neurology 1975 Millar J, Basbaum AI
• Ongoing activity in peripheral nerve: injury discharge.
  Experimental neurology 1974 Wall PD, Waxman S, Basbaum AI
• Effects of central lesions on disorders produced by multiple dorsal rhizotomy in rats.
  Experimental neurology 1974 Basbaum AI
• Conduction of the effects of noxious stimulation by short-fiber multisynaptic systems of the spinal cord in the rat.
  Experimental neurology 1973 Basbaum AI
• Projections of cervicothoracic dorsal roots to the cuneate nucleus of the rat, with observations on cellular "bricks".
  The Journal of comparative neurology 1973 Basbaum AI, Hand PJ