Aliza Ehrlich, PhD
Assistant Professor
Psychiatry
School of Medicine

Psychiatric disorders are believed to in part arise from dysregulation of neuromodulators and therefore the study of GPCR regulation is key to developing new therapies. Additionally, my research focuses on the role of GPCR activation at distinct membrane domains such as the primary cilium and how compartmentalization of receptor signaling impacts psychiatric disorders.

• Oxycodone-Mediated Activation of the Mu Opioid Receptor Reduces Whole Brain Functional Connectivity in Mice.
  ACS pharmacology & translational science 2019 Nasseef MT, Singh JP, Ehrlich AT, McNicholas M, Park DW, Ma W, Kulkarni P, Kieffer BL, Darcq E
• Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.
  iScience 2019 Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL
• Current strategies toward safer mu opioid receptor drugs for pain management.
  Expert opinion on therapeutic targets 2019 Ehrlich AT, Kieffer BL, Darcq E
• Recommending buprenorphine for pain management.
  Pain management 2018 Ehrlich AT, Darcq E
• Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research.
  Communications biology 2018 Ehrlich AT, Maroteaux G, Robe A, Venteo L, Nasseef MT, van Kempen LC, Mechawar N, Turecki G, Darcq E, Kieffer BL
• Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.
  Biological psychiatry 2018 Ben Hamida S, Mendonça-Netto S, Arefin TM, Nasseef MT, Boulos LJ, McNicholas M, Ehrlich AT, Clarke E, Moquin L, Gratton A, Darcq E, Harsan LA, Maldonado R, Kieffer BL
• Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.
  Brain structure & function 2017 Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL
• Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice.
  Brain connectivity 2017 Arefin TM, Mechling AE, Meirsman AC, Bienert T, Hübner NS, Lee HL, Ben Hamida S, Ehrlich A, Roquet D, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA
• Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice.
  Molecular psychiatry 2017 Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawa A, Narumiya S, Furuyashiki T
• Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Mechling AE, Arefin T, Lee HL, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ, Rosa-Neto P, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA
• Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
  Molecular pharmacology 2013 Ehrlich AT, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S