Alice Chan, MD, PhD
Associate Professor
Pediatrics
School of Medicine

I'm a pediatric immunologist and rheumatologist dedicated to improving our understanding of immune regulation to advance care for patients with immune system disorders. My clinical practice is focused on diagnosing and managing patients with complex or unknown immune system disorders. My research area is focused on studying genes that regulate the immune system. We utilize CRISPR/Cas9 to generate mouse models harboring human mutations to help elucidate the molecular mechanism driving disease.

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2019
• Fellowship Allergy/Immunology University of California, San Francisco 2016
• Fellowship Pediatric Rheumatology University of California, San Francisco 2016
• Residency Pediatrics University of California, San Francisco 2011
• MD, PhD University of Texas Southwestern Medical School 2008

Publications (17)

Top publication keywords:
Antigens, CDImmune TolerancePolyendocrinopathies, AutoimmuneAutoimmunitySiblingsSevere Combined ImmunodeficiencyDelayed DiagnosisAutoimmune DiseasesZAP-70 Protein-Tyrosine KinaseArthritis, JuvenileHealth SurveysChromatin Assembly and DisassemblyMutation, MissenseT-Lymphocytes, RegulatoryMutant Proteins

• A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.
  The Journal of experimental medicine 2021 Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS
• The autoimmune targets in IPEX are dominated by gut epithelial proteins.
  The Journal of allergy and clinical immunology 2019 Eriksson D, Bacchetta R, Gunnarsson HI, Chan A, Barzaghi F, Ehl S, Hallgren Å, van Gool F, Sardh F, Lundqvist C, Laakso SM, Rönnblom A, Ekwall O, Mäkitie O, Bensing S, Husebye ES, Anderson M, Kämpe O,…
• A large CRISPR-induced bystander mutation causes immune dysregulation.
  Communications biology 2019 Simeonov DR, Brandt AJ, Chan AY, Cortez JT, Li Z, Woo JM, Lee Y, Carvalho CMB, Indart AC, Roth TL, Zou J, May AP, Lupski JR, Anderson MS, Buaas FW, Rokhsar DS, Marson A
• Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation.
  Nature 2018 Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, …
• Analysis of pulmonary features and treatment approaches in the COPA syndrome.
  ERJ open research 2018 Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK

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• Discovery of stimulation-responsive immune enhancers with CRISPR activation.
  Nature 2017 Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, …
• Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism.
  The Journal of clinical endocrinology and metabolism 2017 Li D, Streeten EA, Chan A, Lwin W, Tian L, Pellegrino da Silva R, Kim CE, Anderson MS, Hakonarson H, Levine MA
• Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders.
  The Journal of allergy and clinical immunology 2016 Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO…
• A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
  The Journal of experimental medicine 2016 Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM
• Central tolerance to self revealed by the autoimmune regulator.
  Annals of the New York Academy of Sciences 2015 Chan AY, Anderson MS
• B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Wong EB, Soni C, Chan AY, Domeier PP, Abraham T, Limaye N, Khan TN, Elias MJ, Chodisetti SB, Wakeland EK, Rahman ZS
• Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation.
  Journal of clinical immunology 2015 Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM
• Treatment of juvenile idiopathic arthritis.
  Pediatric annals 2012 Chan AY, Milojevic D
• Early vs. delayed diagnosis of severe combined immunodeficiency: a family perspective survey.
  Clinical immunology (Orlando, Fla.) 2010 Chan A, Scalchunes C, Boyle M, Puck JM
• Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAP.
  Journal of autoimmunity 2008 Jennings P, Chan A, Schwartzberg P, Wakeland EK, Yuan D
• The role of SAP and the SLAM family in autoimmunity.
  Current opinion in immunology 2006 Chan AY, Westcott JM, Mooney JM, Wakeland EK, Schatzle JD
• Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.
  Immunity 2004 Wandstrat AE, Nguyen C, Limaye N, Chan AY, Subramanian S, Tian XH, Yim YS, Pertsemlidis A, Garner HR, Morel L, Wakeland EK