Alfred Kuo, MD, PhD
Professor
Orthopaedic Surgery
School of Medicine

Dr. Kuo practices orthopaedic surgery, teaches, and performs research at the San Francisco Veterans Affairs Medical Center. His clinical focus is total joint replacement. He is interested in creating new treatments for orthopedic disorders as well as improving the outcomes of orthopaedic treatments. He holds leadership positions locally, regionally, and nationally within the Department of Veterans Affairs.

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2019
• M.D. Medicine University of California, San Francisco 2000
• Ph.D. Graduate Division (Medicine) University of California, San Francisco 1997

Grants and Projects

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• Development and Validation of a Risk Calculator for Total Joint Replacement, NIH, 2015-2020

Publications (40)

Top publication keywords:
Osteoarthritis, HipVeteransArthroplasty, Replacement, HipBone CementsEpisode of CareBone NailsAnesthetics, LocalProsthesis-Related InfectionsNanofibersCartilage, ArticularPain, PostoperativeOsteoarthritis, KneeChondrocytesMinimal Clinically Important DifferenceArthroplasty, Replacement, Knee

• A Tool to Estimate Risk of 30-day Mortality and Complications After Hip Fracture Surgery: Accurate Enough for Some but Not All Purposes? A Study From the ACS-NSQIP Database.
  Clinical orthopaedics and related research 2022 Harris AHS, Trickey AW, Eddington HS, Seib CD, Kamal RN, Kuo AC, Ding Q, Giori NJ
• What Factors Lead to Racial Disparities in Outcomes After Total Knee Arthroplasty?
  Journal of racial and ethnic health disparities 2021 Hu DA, Hu JB, Lee A, Rubenstein WJ, Hwang KM, Ibrahim SA, Kuo AC
• Hepatitis C infection and complication rates after total shoulder arthroplasty in United States veterans.
  JSES international 2021 Su F, Cogan CJ, Bendich I, Zhang N, Whooley MA, Kuo AC
• Antibiotic-Laden Bone Cement Use and Revision Risk After Primary Total Knee Arthroplasty in U.S. Veterans.
  The Journal of bone and joint surgery. American volume 2020 Bendich I, Zhang N, Barry JJ, Ward DT, Whooley MA, Kuo AC
• Can Machine Learning Methods Produce Accurate and Easy-to-Use Preoperative Prediction Models of One-Year Improvements in Pain and Functioning After Knee Arthroplasty?
  The Journal of arthroplasty 2020 Harris AHS, Kuo AC, Bowe TR, Manfredi L, Lalani NF, Giori NJ

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• Social Determinants of Health and Patient-Reported Outcomes Following Total Hip and Knee Arthroplasty in Veterans.
  The Journal of arthroplasty 2020 Rubenstein WJ, Harris AHS, Hwang KM, Giori NJ, Kuo AC
• Comparing Methods to Determine the Minimal Clinically Important Differences in Patient-Reported Outcome Measures for Veterans Undergoing Elective Total Hip or Knee Arthroplasty in Veterans Health Administration Hospitals.
  JAMA surgery 2020 Kuo AC, Giori NJ, Bowe TR, Manfredi L, Lalani NF, Nordin DA, Harris AHS
• Comparison of Periarticular Infiltration and Combination Delivery of Local Anesthetics for Reducing Pain and Opioid Consumption after Total Knee Arthroplasty.
  The journal of knee surgery 2020 Ward DT, Grotkopp E, Detch RC, Kim HT, Kuo AC
• Does Implant Choice Affect the Episode Cost of Pertrochanteric Hip Fracture for US Veterans?
  Journal of orthopaedic trauma 2019 Patterson JT, Takemoto SK, Shearer DW, Kuo AC
• Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.
  Bone research 2019 Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T
• Preoperative Treatment of Hepatitis C Is Associated With Lower Prosthetic Joint Infection Rates in US Veterans.
  The Journal of arthroplasty 2019 Bendich I, Takemoto S, Patterson JT, Monto A, Barber TC, Kuo AC
• Can Machine Learning Methods Produce Accurate and Easy-to-use Prediction Models of 30-day Complications and Mortality After Knee or Hip Arthroplasty?
  Clinical orthopaedics and related research 2019 Harris AHS, Kuo AC, Weng Y, Trickey AW, Bowe T, Giori NJ
• Freedom From Opioids After Total Knee Arthroplasty.
  The Journal of arthroplasty 2019 Kuo AC, Raghunathan K, Lartigue AM, Bryan WE, Pepin MJ, Takemoto S, Wallace AW
• Repurposing Human Osteoarthritic Cartilage as a Bone Graft Substitute in an Athymic Rat Posterolateral Spinal Fusion Model.
  International journal of spine surgery 2018 Dang ABC, Hong H, Lee K, Luan T, Reddy S, Kuo AC
• Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty.
  Regional anesthesia and pain medicine 2018 Hsia HL, Takemoto S, van de Ven T, Pyati S, Buchheit T, Ray N, Wellman S, Kuo A, Wallace A, Raghunathan K
• American Joint Replacement Registry Risk Calculator Does Not Predict 90-day Mortality in Veterans Undergoing Total Joint Replacement.
  Clinical orthopaedics and related research 2018 Harris AHS, Kuo AC, Bozic KJ, Lau E, Bowe T, Gupta S, Giori NJ
• Prediction Models for 30-Day Mortality and Complications After Total Knee and Hip Arthroplasties for Veteran Health Administration Patients With Osteoarthritis.
  The Journal of arthroplasty 2017 Harris AH, Kuo AC, Bowe T, Gupta S, Nordin D, Giori NJ
• A Simple Method Associated With Reduced Opioid Consumption After Total Knee Arthroplasty.
  The Journal of arthroplasty 2017 Kuo AC, Grotkopp E
• The Effects of Topical Vancomycin on Mesenchymal Stem Cells: More May Not Be Better.
  International journal of spine surgery 2017 Chu S, Chen N, Dang ABC, Kuo AC, Dang ABC
• Preoperative Anemia Independently Predicts 30-Day Complications After Aseptic and Septic Revision Total Joint Arthroplasty.
  The Journal of arthroplasty 2017 Lu M, Sing DC, Kuo AC, Hansen EN
• Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.
  Tissue engineering. Part A 2016 Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC
• Costs and Complications of Short Versus Long Cephalomedullary Nailing of OTA 31-A2 Proximal Femur Fractures in U.S. Veterans.
  Journal of orthopaedic trauma 2016 Krigbaum H, Takemoto S, Kim HT, Kuo AC
• Complications of Morbid Obesity in Total Joint Arthroplasty: Risk Stratification Based on BMI.
  The Journal of arthroplasty 2015 Ward DT, Metz LN, Horst PK, Kim HT, Kuo AC
• Trophic stimulation of articular chondrocytes by late-passage mesenchymal stem cells in coculture.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 Wang M, Rahnama R, Cheng T, Grotkopp E, Jacobs L, Limburg S, Kim HT, Kuo AC
• Mid-term outcomes in HIV-positive patients after primary total hip or knee arthroplasty.
  The Journal of arthroplasty 2013 Lin CA, Takemoto S, Kandemir U, Kuo AC
• Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor.
  Tissue engineering. Part A 2013 Jin J, Limburg S, Joshi SK, Landman R, Park M, Zhang Q, Kim HT, Kuo AC
• Comorbidities and perioperative complications in HIV-positive patients undergoing primary total hip and knee arthroplasty.
  The Journal of bone and joint surgery. American volume 2013 Lin CA, Kuo AC, Takemoto S
• Cytotoxicity of local anesthetics on human mesenchymal stem cells.
  The Journal of bone and joint surgery. American volume 2013 Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC
• Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model.
  Regenerative medicine 2012 Jin J, Park M, Rengarajan A, Zhang Q, Limburg S, Joshi SK, Patel S, Kim HT, Kuo AC
• Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis.
  Biochemical and biophysical research communications 2012 Cheng T, Yang C, Weber N, Kim HT, Kuo AC
• Inducible immortality in hTERT-human mesenchymal stem cells.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012 Piper SL, Wang M, Yamamoto A, Malek F, Luu A, Kuo AC, Kim HT
• Comparison of gene expression patterns in articular cartilage and dedifferentiated articular chondrocytes.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2011 Cheng T, Maddox NC, Wong AW, Rahnama R, Kuo AC
• Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy.
  Osteoarthritis and cartilage 2011 Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T
• In situ Materials Characterization using the Tissue Diagnostic Instrument.
  Polymer testing 2010 Tang SY, Mathews P, Randall C, Yurtsev E, Fields K, Wong A, Kuo A, Alliston T, Hansma P
• The tissue diagnostic instrument.
  The Review of scientific instruments 2009 Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, …
• Total hip arthroplasty in rapidly destructive osteoarthritis of the hip: a case series.
  HSS journal : the musculoskeletal journal of Hospital for Special Surgery 2009 Kuo A, Ezzet KA, Patil S, Colwell CW
• Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair.
  Osteoarthritis and cartilage 2006 Kuo AC, Rodrigo JJ, Reddi AH, Curtiss S, Grotkopp E, Chiu M
• Knee fusion using dual platings with the locking compression plate.
  The Journal of arthroplasty 2005 Kuo AC, Meehan JP, Lee M
• Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55.
  The EMBO journal 2000 Kuo A, Zhong C, Lane WS, Derynck R
• Association of the transmembrane TGF-alpha precursor with a protein kinase complex.
  The Journal of cell biology 1994 Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R