Alexandra Lee, PhD, MSPH
Assistant Professor
Medicine
School of Medicine

Her work seeks to clarify the risks of hypoglycemia and hyperglycemia in older adults, including the how these dysglycemic events may increase the risk of other geriatric outcomes, including falls, cognitive decline, functional impairment, and behavioral symptoms of dementia.

Prior to joining faculty at UCSF, Dr. Lee completed a post-doctoral fellowship in aging research with the UCSF Division of Geriatrics. She received her PhD in Epidemiology from Johns Hopkins Bloomberg School of Public Health, her MSPH in Epidemiology from Rollins School of Public Health at Emory University, and her BA from Amherst College.

• New psychotropic medication use among Medicare beneficiaries with dementia after hospital discharge.
  Journal of the American Geriatrics Society 2022 Growdon ME, Gan S, Yaffe K, Lee AK, Anderson TS, Muench U, Boscardin WJ, Steinman MA
• Fingerstick glucose monitoring by cognitive impairment status in Veterans Affairs nursing home residents with diabetes.
  Journal of the American Geriatrics Society 2022 Nguyen B, Deardorff WJ, Shi Y, Jing B, Lee AK, Lee SJ
• A comprehensive prognostic tool for older adults: Predicting death, ADL disability, and walking disability simultaneously.
  Journal of the American Geriatrics Society 2022 Lee AK, Diaz-Ramirez LG, Boscardin WJ, Smith AK, Lee SJ
• Do functional status and Medicare claims data improve the predictive accuracy of an electronic health record mortality index? Findings from a national Veterans Affairs cohort.
  BMC geriatrics 2022 Deardorff WJ, Jing B, Jeon SY, Boscardin WJ, Lee AK, Fung KZ, Lee SJ
• Comparing Machine Learning to Regression Methods for Mortality Prediction Using Veterans Affairs Electronic Health Record Clinical Data.
  Medical care 2022 Jing B, Boscardin WJ, Deardorff WJ, Jeon SY, Lee AK, Donovan AL, Lee SJ
• Intensification of Diabetes Medications at Hospital Discharge and Clinical Outcomes in Older Adults in the Veterans Administration Health System.
  JAMA network open 2021 Anderson TS, Lee AK, Jing B, Lee S, Herzig SJ, Boscardin WJ, Fung K, Rizzo A, Steinman MA
• Predicting Life Expectancy to Target Cancer Screening Using Electronic Health Record Clinical Data.
  Journal of general internal medicine 2021 Lee AK, Jing B, Jeon SY, Boscardin WJ, Lee SJ
• Biomarkers of Kidney Tubule Health, CKD Progression, and Acute Kidney Injury in SPRINT (Systolic Blood Pressure Intervention Trial) Participants.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 Bullen AL, Katz R, Jotwani V, Garimella PS, Lee AK, Estrella MM, Shlipak MG, Ix JH
• Association of Urine Biomarkers of Kidney Tubule Injury and Dysfunction With Frailty Index and Cognitive Function in Persons With CKD in SPRINT.
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 Miller LM, Rifkin D, Lee AK, Kurella Tamura M, Pajewski NM, Weiner DE, Al-Rousan T, Shlipak M, Ix JH
• FGF23, Frailty, and Falls in SPRINT.
  Journal of the American Geriatrics Society 2020 Jovanovich A, Ginsberg C, You Z, Katz R, Ambrosius WT, Berlowitz D, Cheung AK, Cho M, Lee AK, Punzi H, Rehman S, Roumie C, Supiano MA, Wright CB, Shlipak M, Ix JH, Chonchol M
• Severe Hypoglycemia, Cardiac Structure and Function, and Risk of Cardiovascular Events Among Older Adults With Diabetes.
  Diabetes care 2020 Echouffo-Tcheugui JB, Daya N, Lee AK, Tang O, Ndumele CE, Windham BG, Shah AM, Selvin E
• Associations of 1,5-Anhydroglucitol and 2-Hour Glucose with Major Clinical Outcomes in the Atherosclerosis Risk in Communities (ARIC) Study.
  The journal of applied laboratory medicine 2020 Warren B, Lee AK, Ballantyne CM, Hoogeveen RC, Pankow JS, Grams ME, Köttgen A, Selvin E
• Fingerstick Glucose Monitoring in Veterans Affairs Nursing Home Residents with Diabetes Mellitus.
  Journal of the American Geriatrics Society 2020 Jeon SY, Shi Y, Lee AK, Hunt L, Lipska K, Boscardin J, Lee S
• Improving the American Diabetes Association Framework for individualizing treatment in older adults: evaluating life expectancy.
  BMJ open diabetes research & care 2020 Lee AK, Steinman MA, Lee SJ
• Severe Hypoglycemia and Risk of Falls in Type 2 Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study.
  Diabetes care 2020 Lee AK, Juraschek SP, Windham BG, Lee CJ, Sharrett AR, Coresh J, Selvin E
• The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE.
  The Journal of clinical endocrinology and metabolism 2020 Lee AK, Woodward M, Wang D, Ohkuma T, Warren B, Sharrett AR, Williams B, Marre M, Hamet P, Harrap S, Mcevoy JW, Chalmers J, Selvin E
• Cancer Survivorship and Subclinical Myocardial Damage.
  American journal of epidemiology 2019 Florido R, Lee AK, McEvoy JW, Hoogeveen RC, Koton S, Vitolins MZ, Shenoy C, Russell SD, Blumenthal RS, Ndumele CE, Ballantyne CM, Joshu CE, Platz EA, Selvin E
• Markers of kidney tubule function and risk of cardiovascular disease events and mortality in the SPRINT trial.
  European heart journal 2019 Garimella PS, Lee AK, Ambrosius WT, Bhatt U, Cheung AK, Chonchol M, Craven T, Hawfield AT, Jotwani V, Killeen A, Punzi H, Sarnak MJ, Wall BM, Ix JH, Shlipak MG
• Distinct Dimensions of Kidney Health and Risk of Cardiovascular Disease, Heart Failure, and Mortality.
  Hypertension (Dallas, Tex. : 1979) 2019 Lee AK, Katz R, Jotwani V, Garimella PS, Ambrosius WT, Cheung AK, Gren LH, Neyra JA, Punzi H, Raphael KL, Shlipak MG, Ix JH
• Number and Characteristics of US Adults Meeting Prediabetes Criteria for Diabetes Prevention Programs: NHANES 2007-2016.
  Journal of general internal medicine 2019 Lee AK, Warren B, Liu C, Foti K, Selvin E
• The SPRINT trial suggests that markers of tubule cell function in the urine associate with risk of subsequent acute kidney injury while injury markers elevate after the injury.
  Kidney international 2019 Bullen AL, Katz R, Lee AK, Anderson CAM, Cheung AK, Garimella PS, Jotwani V, Haley WE, Ishani A, Lash JP, Neyra JA, Punzi H, Rastogi A, Riessen E, Malhotra R, Parikh CR, Rocco MV, Wall BM, Bhatt UY, …
• Relation of Isolated Systolic Hypertension and Pulse Pressure to High-Sensitivity Cardiac Troponin-T and N-Terminal pro-B-Type Natriuretic Peptide in Older Adults (from the Atherosclerosis Risk in Communities Study).
  The American journal of cardiology 2019 Madan N, Lee AK, Matsushita K, Hoogeveen RC, Ballantyne CM, Selvin E, McEvoy JW
• Urinary Biomarkers of Tubular Damage Are Associated with Mortality but Not Cardiovascular Risk among Systolic Blood Pressure Intervention Trial Participants with Chronic Kidney Disease.
  American journal of nephrology 2019 Jotwani VK, Lee AK, Estrella MM, Katz R, Garimella PS, Malhotra R, Rifkin DE, Ambrosius W, Freedman BI, Cheung AK, Raphael KL, Drawz P, Neyra JA, Oparil S, Punzi H, Shlipak MG, Ix JH, for the SPRINT …
• Association between white matter hyperintensities, cortical volumes, and late-onset epilepsy.
  Neurology 2019 Johnson EL, Krauss GL, Lee AK, Schneider ALC, Kucharska-Newton AM, Huang J, Jack CR, Gottesman RF
• Association Between Midlife Risk Factors and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study.
  JAMA neurology 2018 Johnson EL, Krauss GL, Lee AK, Schneider ALC, Dearborn JL, Kucharska-Newton AM, Huang J, Alonso A, Gottesman RF
• Diagnostic Performance of 1,5-Anhydroglucitol Compared to 2-H Glucose in the Atherosclerosis Risk in Communities Study.
  Clinical chemistry 2018 Warren B, Lee AK, Ballantyne CM, Hoogeveen RC, Pankow JS, Grams M, Köttgen A, Selvin E
• Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study.
  Diabetologia 2018 Lee AK, Rawlings AM, Lee CJ, Gross AL, Huang ES, Sharrett AR, Coresh J, Selvin E
• Identifying Trends in Undiagnosed Diabetes in U.S. Adults.
  Annals of internal medicine 2018 Selvin E, Wang D, Lee AK, Coresh J, Bergenstal RM
• Diabetes and Trajectories of Estimated Glomerular Filtration Rate: A Prospective Cohort Analysis of the Atherosclerosis Risk in Communities Study.
  Diabetes care 2018 Warren B, Rebholz CM, Sang Y, Lee AK, Coresh J, Selvin E, Grams ME
• The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes.
  Diabetes care 2017 Lee AK, Warren B, Lee CJ, McEvoy JW, Matsushita K, Huang ES, Sharrett AR, Coresh J, Selvin E
• Identifying Trends in Undiagnosed Diabetes in U.S. Adults by Using a Confirmatory Definition: A Cross-sectional Study.
  Annals of internal medicine 2017 Selvin E, Wang D, Lee AK, Bergenstal RM, Coresh J
• Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study.
  Diabetes care 2017 Lee AK, Lee CJ, Huang ES, Sharrett AR, Coresh J, Selvin E
• Increases in Biomarkers of Hyperglycemia With Age in the Atherosclerosis Risk in Communities (ARIC) Study.
  Diabetes care 2017 Warren B, Rawlings AM, Lee AK, Grams M, Coresh J, Selvin E
• Severe Hypoglycemia and Elevated High-Sensitivity Cardiac Troponin T in Older Adults With Diabetes: The ARIC Study.
  Journal of the American College of Cardiology 2016 Lee AK, McEvoy JW, Hoogeveen RC, Ballantyne CM, Selvin E
• Sugars and adiposity: the long-term effects of consuming added and naturally occurring sugars in foods and in beverages.
  Obesity science & practice 2015 Lee AK, Chowdhury R, Welsh JA
• Automated Telephone Self-Management Support for Diabetes in a Low-Income Health Plan: A Health Care Utilization and Cost Analysis.
  Population health management 2015 Quan J, Lee AK, Handley MA, Ratanawongsa N, Sarkar U, Tseng S, Schillinger D
• Sodium content in packaged foods by census division in the United States, 2009.
  Preventing chronic disease 2015 Lee AK, Schieb LJ, Yuan K, Maalouf J, Gillespie C, Cogswell ME
• Consumption of less than 10% of total energy from added sugars is associated with increasing HDL in females during adolescence: a longitudinal analysis.
  Journal of the American Heart Association 2014 Lee AK, Binongo JN, Chowdhury R, Stein AD, Gazmararian JA, Vos MB, Welsh JA