Alexandra Degraeve, PhD
Postdoctoral Scholar
Medicine
School of Medicine

Publications (4)

Top publication keywords:
Kidney TransplantationGenotypeAnimalsRNA, Ribosomal, 16SCross-Sectional StudiesPilot ProjectsDose-Response Relationship, DrugDrug InteractionsTacrolimusPharmacogeneticsCytochrome P-450 CYP3AGastrointestinal MicrobiomeMembrane Transport ProteinsImmunosuppressive AgentsMice

• The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy.
  bioRxiv : the preprint server for biology 2025 Villa Soto VS, Degraeve AL, Heath CM, Orellana DA, Reilly ER, Mukherjee M, Brockert JG, Dumlao DS, Blank RB, Perlmutter N, Yu S, Ashouri J, Scher JU, Patterson AD, Turnbaugh PJ, Nayak RR
• Tacrolimus Pharmacokinetics is Associated with Gut Microbiota Diversity in Kidney Transplant Patients: Results from a Pilot Cross-Sectional Study.
  Clinical pharmacology and therapeutics 2023 Degraeve AL, Bindels LB, Haufroid V, Moudio S, Boland L, Delongie KA, Dewulf JP, Eddour DC, Mourad M, Elens L
• Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1.
  Microbiome 2023 Degraeve AL, Haufroid V, Loriot A, Gatto L, Andries V, Vereecke L, Elens L, Bindels LB
• Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives.
  Expert opinion on drug metabolism & toxicology 2020 Degraeve AL, Moudio S, Haufroid V, Chaib Eddour D, Mourad M, Bindels LB, Elens L