Alexandra Apple, PhD, MS
Psychologist 2
Psychiatry
Chancellor/EVC/FAS

Apple also works with individuals and groups who want to improve their mood and sleep, as well as those who aim to enhance cognitive and everyday functioning through effective compensatory and coping strategies.

One of Apple's research interests is combining neuropsychological assessments and brain imaging to better understand cognitive decline. She is also interested in how to maintain cognitive abilities and resilience during normal aging. Her long-term goal is to use neuroimaging techniques to find behavioral and cognitive interventions that can make older people's brain function more resilient.

Apple earned her doctorate in psychology at Northwestern University Feinberg School of Medicine. She completed a fellowship in neuropsychology at UCSF.

• Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment.
  Journal of the International Neuropsychological Society : JINS 2021 Asken BM, VandeVrede L, Rojas JC, Fonseca C, Staffaroni AM, Elahi FM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Boxer AL, Miller BL, Rosen HJ, Kramer JH, Casaletto KB
• Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults.
  Brain imaging and behavior 2021 Asken BM, Mantyh WG, La Joie R, Strom A, Casaletto KB, Staffaroni AM, Apple AC, Lindbergh CA, Iaccarino L, You M, Grant H, Fonseca C, Windon C, Younes K, Tanner J, Rabinovici GD, Kramer JH, Gardner RC
• Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
  Journal of Alzheimer's disease : JAD 2021 Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer …
• Worth the Wait: Delayed Recall after 1 Week Predicts Cognitive and Medial Temporal Lobe Trajectories in Older Adults.
  Journal of the International Neuropsychological Society : JINS 2020 Lindbergh CA, Walker N, La Joie R, Weiner-Light S, Staffaroni AM, Casaletto KB, Elahi F, Walters SM, You M, Cotter D, Asken B, Apple AC, Tsoy E, Neuhaus J, Fonseca C, Wolf A, Cobigo Y, Rosen H, Kramer…
• Sex-related differences in the relationship between β-amyloid and cognitive trajectories in older adults.
  Neuropsychology 2020 Lindbergh CA, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Edwards L, Tsoy E, Elahi F, Walters SM, Cotter D, You M, Apple AC, Asken B, Neuhaus J, Rexach JE, Wojta KJ, Rabinovici G, Kramer JH, …
• Longitudinal fMRI task reveals neural plasticity in default mode network with disrupted executive-default coupling and selective attention after traumatic brain injury.
  Brain imaging and behavior 2020 Wu SJ, Jenkins LM, Apple AC, Petersen J, Xiao F, Wang L, Yang FG
• Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
  Journal of Alzheimer's disease : JAD 2020 Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer …
• Sleep talking and primary progressive aphasia: case study and autopsy findings in a patient with logopenic primary progressive aphasia and dementia with Lewy bodies.
  BMJ case reports 2019 Apple AC, Mao Q, Bigio E, Bonakdarpour B
• In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies.
  Neurobiology of aging 2018 Hanko V, Apple AC, Alpert KI, Warren KN, Schneider JA, Arfanakis K, Bennett DA, Wang L
• Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy.
  NeuroImage. Clinical 2018 Apple AC, Schroeder MP, Ryals AJ, Wagner LI, Cella D, Shih PA, Reilly J, Penedo FJ, Voss JL, Wang L
• Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes.
  Neuropsychologia 2017 Possin KL, Kim H, Geschwind MD, Moskowitz T, Johnson ET, Sha SJ, Apple A, Xu D, Miller BL, Finkbeiner S, Hess CP, Kramer JH
• Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns.
  NeuroImage. Clinical 2017 Apple AC, Ryals AJ, Alpert KI, Wagner LI, Shih PA, Dokucu M, Cella D, Penedo FJ, Voss JL, Wang L
• Reduced prefrontal activation during working and long-term memory tasks and impaired patient-reported cognition among cancer survivors postchemotherapy compared with healthy controls.
  Cancer 2015 Wang L, Apple AC, Schroeder MP, Ryals AJ, Voss JL, Gitelman D, Sweet JJ, Butt ZA, Cella D, Wagner LI
• Executive functions in premanifest Huntington's disease.
  Movement disorders : official journal of the Movement Disorder Society 2013 You SC, Geschwind MD, Sha SJ, Apple A, Satris G, Wood KA, Johnson ET, Gooblar J, Feuerstein JS, Finkbeiner S, Kang GA, Miller BL, Hess CP, Kramer JH, Possin KL