Alexander Reyzelman, DPM
Associate Physician Diplomate
Orthopaedic Surgery
School of Medicine

Publications (60)

Top publication keywords:
CalcaneusLeg UlcerBiological DressingsVaricose UlcerCryopreservationAcellular DermisPlacentaDiabetic FootWound HealingAllograftsChorionLimb SalvageAmnionDebridementFoot

• A Multi-Centre, Randomised, Controlled Clinical Trial Assessing Cryopreserved Ultra-Thick Human Amniotic Membrane in the Treatment of Complex Diabetic Foot Ulcers.
  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2025 Caporusso J, Motley T, Lantis JC, Heisler S, Hicks A, Wu SC, Reyzelman A
• Efficacy of a full-thickness decellularised placental membrane allograft compared to standard of care in diabetic foot ulcers: a prospective, randomised controlled trial.
  Journal of wound care 2025 Reyzelman AM, Vayser D, Hanft JR, Cazzell S, Surprenant MS, Chiu H, Moyer PM, Ducharme S, Tovmassian G
• A Multicenter, Randomized, Controlled, Clinical Trial Evaluating a Lyopreserved Amniotic Membrane in the Treatment of Venous Leg Ulcers.
  Health science reports 2025 Dhillon Y, Levine L, Tovmassian G, Reyzelman A, Perez-Clavijo F, Wodie F, Cazzell S, Grossman A, Robinson L, Sigal F, Kirsner RS, Vartivarian M, Saunders M, Banerjee J
• Institutional toe & flow programs: How and why the teams work.
  Seminars in vascular surgery 2025 Naiem AA, Callahan RT, Reyzelman AM, Conte MS
• Efficacy and safety of autologous whole blood clot in diabetic foot ulcers: a randomised controlled trial.
  Journal of wound care 2024 Snyder R, Nouvong A, Ulloa J, Wahab N, Treadwell T, Bruwer F, Naude L, McGuire J, Reyzelman AM, Graham T, AWBC Research Team:, Lessing R, Lullove E, Ozker E, Pham HT, Pasternac M, Cohen S

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• Once daily Bromelain-based enzymatic debridement of venous leg ulcers versus gel vehicle (placebo) and non-surgical standard of care: a three-arm multicenter, double blinded, randomized controlled study.
  EClinicalMedicine 2024 Shoham Y, Snyder RJ, Katz Levy Y, David Zarbiv K, Klinger E, Kramer M, Dove CR, Avrahami R, Reyzelman A, Sigal F, Tovmassian G, Shapira E, Harats M, Perez-Clavijo F, Lantis JC, Cazzell SM, Dhillon YS,…
• Effectiveness of a Continuous Remote Temperature Monitoring Program to Reduce Foot Ulcers and Amputations: Multicenter Postmarket Registry Study.
  JMIR diabetes 2024 Shih CD, Scholten HJ, Ripp G, Srikanth K, Smith C, Ma R, Fu J, Reyzelman AM
• Open revascularization approach is associated with healing and ambulation after transmetatarsal amputation in patients with chronic limb threatening ischemia.
  Journal of vascular surgery 2022 Gomez-Sanchez C, Werlin E, Sorrentino T, El Khoury R, Lancaster E, Parks C, Goodman B, Dini M, Iannuzzi J, Reyzelman A, Conte MS, Gasper W
• Outcomes for Medicare debridement intervals receiving dehydrated human amnion/chorion membrane.
  Journal of wound care 2022 Tettelbach WH, Cazzell SM, Hubbs B, DeJong JL, Forsyth RA, Reyzelman AM
• The influence of adequate debridement and placental-derived allografts on diabetic foot ulcers.
  Journal of wound care 2022 Tettelbach WH, Cazzell SM, Hubbs B, Jong JL, Forsyth RA, Reyzelman AM
• Outcomes of Partial Calcanectomy in an Academic Limb Salvage Center: A Multicenter Review.
  The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 2022 Ravine M, Kumaravel S, Dini M, Parks C, Shader SW, Shih CD, Vartivarian M, Guo A, Reyzelman A
• Pedal arterial calcification score is associated with hemodynamic change and major amputation after infrainguinal revascularization for chronic limb-threatening ischemia.
  Journal of vascular surgery 2022 Liu IH, Wu B, Krepkiy V, El Khoury R, Ferraresi R, Reyzelman AM, Hiramoto JS, Schneider PA, Conte MS, Vartanian SM
• An Evaluation of Real-world Smart Sock-Based Temperature Monitoring Data as a Physiological Indicator of Early Diabetic Foot Injury: Case-Control Study.
  JMIR formative research 2022 Reyzelman AM, Shih CD, Tovmassian G, Nathan M, Ma R, Scholten HJ, Malhotra K, Armstrong DG
• Utilization of a Smart Sock for the Remote Monitoring of Patients With Peripheral Neuropathy: Cross-sectional Study of a Real-world Registry.
  JMIR formative research 2022 Scholten HJ, Shih CD, Ma R, Malhotra K, Reyzelman AM
• Multi-centre prospective randomised controlled clinical trial to evaluate a bioactive split thickness skin allograft vs standard of care in the treatment of diabetic foot ulcers.
  International wound journal 2022 Armstrong DG, Galiano RD, Orgill DP, Glat PM, Carter MJ, Di Domenico LA, Reyzelman AM, Zelen CM
• Pedal arterial calcification score is associated with the risk of major amputation in chronic limb-threatening ischemia.
  Journal of vascular surgery 2021 Liu IH, Wu B, Krepkiy V, Ferraresi R, Reyzelman AM, Hiramoto JS, Schneider PA, Conte MS, Vartanian SM
• Fetal bovine acellular dermal matrix for the closure of diabetic foot ulcers: a prospective randomised controlled trial.
  Journal of wound care 2021 Lantis JC, Snyder R, Reyzelman AM, Van Gils CC, Sigal F, Vayser D, Caporusso JM, Cazzell S, Lavery LA, PriMatrix Study Group
• A multicentre, randomised controlled clinical trial evaluating the effects of a novel autologous, heterogeneous skin construct in the treatment of Wagner one diabetic foot ulcers: Interim analysis.
  International wound journal 2021 Armstrong DG, Orgill DP, Galiano R, Glat PM, Didomenico L, Reyzelman A, Snyder R, Li WW, Carter M, Zelen CM
• A prospective, randomized, controlled, crossover study comparing three multilayered foam dressings for the management of chronic wounds.
  Journal of comparative effectiveness research 2021 Alvarez OM, Granick MS, Reyzelman A, Serena T
• Impact of the coronavirus disease 2019 pandemic on an academic vascular practice and a multidisciplinary limb preservation program.
  Journal of vascular surgery 2020 Lancaster EM, Wu B, Iannuzzi J, Oskowitz A, Gasper W, Vartanian S, Wick E, Hiramoto J, Eichler C, Lobo E, Reyzelman A, Reilly L, Sosa JA, Conte MS
• Increased Reintervention After Infrainguinal Revascularization for Chronic Limb-Threatening Ischemia in Women.
  Annals of vascular surgery 2020 Wu B, Lancaster EM, Ramirez JL, Zarkowsky DS, Reyzelman AM, Gasper WJ, Conte MS, Hiramoto JS
• A Comparative Diabetic Foot Wound Measurement Trial Using Wound Tracker Professional Versus Aranz Imaging System and Conventional Ruler Measurement.
  Clinics in podiatric medicine and surgery 2020 Reyzelman AM, McCray S, Peck LB, Allen M, Koelewyn K
• Wound Closure Outcomes Suggest Clinical Equivalency Between Lyopreserved and Cryopreserved Placental Membranes Containing Viable Cells.
  Advances in wound care 2019 Ananian CE, Davis RD, Johnson EL, Regulski MJ, Reyzelman AM, Saunders MC, Danilkovitch A
• A prospective, randomized, controlled clinical trial on the efficacy of a single-use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities.
  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2019 Kirsner R, Dove C, Reyzelman A, Vayser D, Jaimes H
• A Prospective, Single-center, Open-label Case Series Evaluating the Clinical Outcomes of Lyopreserved Placental Membrane Containing Viable Cells in the Treatment of Chronic Wounds.
  Wounds : a compendium of clinical research and practice 2019 Reyzelman AM, Vartivarian M, Danilkovitch A, Saunders MC
• Continuous Temperature-Monitoring Socks for Home Use in Patients With Diabetes: Observational Study.
  Journal of medical Internet research 2018 Reyzelman AM, Koelewyn K, Murphy M, Shen X, Yu E, Pillai R, Fu J, Scholten HJ, Ma R
• A confirmatory study on the efficacy of dehydrated human amnion/chorion membrane dHACM allograft in the management of diabetic foot ulcers: A prospective, multicentre, randomised, controlled study of 110 patients from 14 wound clinics.
  International wound journal 2018 Tettelbach W, Cazzell S, Reyzelman AM, Sigal F, Caporusso JM, Agnew PS
• Randomized Controlled Trial of Micronized Dehydrated Human Amnion/Chorion Membrane (dHACM) Injection Compared to Placebo for the Treatment of Plantar Fasciitis.
  Foot & ankle international 2018 Cazzell S, Stewart J, Agnew PS, Senatore J, Walters J, Murdoch D, Reyzelman A, Miller SD
• Human placental membrane as a wound cover for chronic diabetic foot ulcers: a prospective, postmarket, CLOSURE study.
  Journal of wound care 2018 Pacaccio DJ, Cazzell SM, Halperin GJ, Kasper MA, Neutel JM, O'Carroll BD, Reyzelman AM
• A multicentre randomised controlled trial evaluating the efficacy of dehydrated human amnion/chorion membrane (EpiFix® ) allograft for the treatment of venous leg ulcers.
  International wound journal 2017 Bianchi C, Cazzell S, Vayser D, Reyzelman AM, Dosluoglu H, Tovmassian G, EpiFix VLU Study Group
• Determinants of midterm functional outcomes, wound healing, and resources used in a hospital-based limb preservation program.
  Journal of vascular surgery 2017 Ramanan B, Ahmed A, Wu B, Causey MW, Gasper WJ, Vartanian SM, Reyzelman AM, Hiramoto JS, Conte MS
• A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator.
  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2017 Cazzell S, Vayser D, Pham H, Walters J, Reyzelman A, Samsell B, Dorsch K, Moore M
• Feasibility and Efficacy of a Smart Mat Technology to Predict Development of Diabetic Plantar Ulcers.
  Diabetes care 2017 Frykberg RG, Gordon IL, Reyzelman AM, Cazzell SM, Fitzgerald RH, Rothenberg GM, Bloom JD, Petersen BJ, Linders DR, Nouvong A, Najafi B
• A Prospective, Randomized, Blinded, Controlled Trial Comparing Transdermal Continuous Oxygen Delivery to Moist Wound Therapy for the Treatment of Diabetic Foot Ulcers.
  Ostomy/wound management 2017 Driver VR, Reyzelman A, Kawalec J, French M
• Evaluation of tissue engineering products for the management of neuropathic diabetic foot ulcers: an interim analysis.
  Journal of wound care 2016 Frykberg RG, Cazzell SM, Arroyo-Rivera J, Tallis A, Reyzelman AM, Saba F, Warren L, Stouch BC, Gilbert TW
• Society for Vascular Surgery limb stage and patient risk correlate with outcomes in an amputation prevention program.
  Journal of vascular surgery 2016 Causey MW, Ahmed A, Wu B, Gasper WJ, Reyzelman A, Vartanian SM, Hiramoto JS, Conte MS
• A Prospective, Randomized, Multicenter, Controlled Evaluation of the Use of Dehydrated Amniotic Membrane Allograft Compared to Standard of Care for the Closure of Chronic Diabetic Foot Ulcer.
  Wounds : a compendium of clinical research and practice 2016 Snyder RJ, Shimozaki K, Tallis A, Kerzner M, Reyzelman A, Lintzeris D, Bell D, Rutan RL, Rosenblum B
• Initial Report on the Use of In-Office Cone Beam Computed Tomography for Early Diagnosis of Osteomyelitis in Diabetic Patients.
  Journal of the American Podiatric Medical Association 2016 Shih CD, Bazarov I, Harrington T, Vartivarian M, Reyzelman AM
• Healing Rates in a Multicenter Assessment of a Sterile, Room Temperature, Acellular Dermal Matrix Versus Conventional Care Wound Management and an Active Comparator in the Treatment of Full-Thickness Diabetic Foot Ulcers.
  Eplasty 2016 Walters J, Cazzell S, Pham H, Vayser D, Reyzelman A
• A clinical trial of Integra Template for diabetic foot ulcer treatment.
  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2015 Driver VR, Lavery LA, Reyzelman AM, Dutra TG, Dove CR, Kotsis SV, Kim HM, Chung KC
• Evidence of Intensive Autolytic Debridement With a Self-Adaptive Wound Dressing.
  Wounds : a compendium of clinical research and practice 2015 Reyzelman AM, Vartivarian M
• Human acellular dermal wound matrix for treatment of DFU: literature review and analysis.
  Journal of wound care 2015 Reyzelman AM, Bazarov I
• A Multicenter Randomized Controlled Trial Comparing Treatment of Venous Leg Ulcers Using Mechanically Versus Electrically Powered Negative Pressure Wound Therapy.
  Advances in wound care 2015 Marston WA, Armstrong DG, Reyzelman AM, Kirsner RS
• Outcomes of neuroischemic wounds treated by a multidisciplinary amputation prevention service.
  Annals of vascular surgery 2015 Vartanian SM, Robinson KD, Ofili K, Eichler CM, Hiramoto JS, Reyzelman AM, Conte MS
• Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial.
  Diabetic medicine : a journal of the British Diabetic Association 2014 Armstrong DG, Hanft JR, Driver VR, Smith AP, Lazaro-Martinez JL, Reyzelman AM, Furst GJ, Vayser DJ, Cervantes HL, Snyder RJ, Moore MF, May PE, Nelson JL, Baggs GE, Voss AC, Diabetic Foot Nutrition …
• Initial clinical assessment of a novel multifunctional topical ointment for difficult-to-heal wounds: a case series.
  Advances in skin & wound care 2012 Reyzelman AM, Bazarov I
• NorLeu3-A(1-7) stimulation of diabetic foot ulcer healing: results of a randomized, parallel-group, double-blind, placebo-controlled phase 2 clinical trial.
  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2012 Balingit PP, Armstrong DG, Reyzelman AM, Bolton L, Verco SJ, Rodgers KE, Nigh KA, diZerega GS
• Comparative effectiveness of mechanically and electrically powered negative pressure wound therapy devices: a multicenter randomized controlled trial.
  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2012 Armstrong DG, Marston WA, Reyzelman AM, Kirsner RS
• Topical application of a gentamicin-collagen sponge combined with systemic antibiotic therapy for the treatment of diabetic foot infections of moderate severity: a randomized, controlled, multicenter clinical trial.
  Journal of the American Podiatric Medical Association 2012 Lipsky BA, Kuss M, Edmonds M, Reyzelman A, Sigal F
• Initial clinical assessment of a novel wound management system: a case series.
  Advances in skin & wound care 2011 Reyzelman AM, Vayser D, Tam SW, Dove C
• Comparison of negative pressure wound therapy with an ultraportable mechanically powered device vs. traditional electrically powered device for the treatment of chronic lower extremity ulcers: a multicenter randomized-controlled trial.
  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2011 Armstrong DG, Marston WA, Reyzelman AM, Kirsner RS
• Clinical effectiveness of an acellular dermal regenerative tissue matrix compared to standard wound management in healing diabetic foot ulcers: a prospective, randomised, multicentre study.
  International wound journal 2009 Reyzelman A, Crews RT, Moore JC, Moore L, Mukker JS, Offutt S, Tallis A, Turner WB, Vayser D, Winters C, Armstrong DG
• A randomised controlled 8-week crossover clinical evaluation of the 3M Coban 2 Layer Compression System versus Profore to evaluate the product performance in patients with venous leg ulcers.
  International wound journal 2008 Moffatt CJ, Edwards L, Collier M, Treadwell T, Miller M, Shafer L, Sibbald G, Brassard A, McIntosh A, Reyzelman A, Price P, Kraus SM, Walters SA, Harding K
• The role of revascularization in transmetatarsal amputations.
  Journal of the American Podiatric Medical Association 2001 La Fontaine J, Reyzelman A, Rothenberg G, Husain K, Harkless LB
• Are antibiotics necessary in the treatment of locally infected ingrown toenails?
  Archives of family medicine 2000 Reyzelman AM, Trombello KA, Vayser DJ, Armstrong DG, Harkless LB
• The increased prevalence of severe necrotizing infections caused by non-group A streptococci.
  Journal of the American Podiatric Medical Association 1999 Reyzelman AM, Lipsky BA, Hadi SA, Harkless LB, Armstrong DG
• Limb salvage with Chopart's amputation and tendon balancing.
  Journal of the American Podiatric Medical Association 1999 Reyzelman AM, Hadi S, Armstrong DG
• Emergence of non-group A streptococcal necrotizing diabetic foot infections.
  Journal of the American Podiatric Medical Association 1998 Reyzelman AM, Armstrong DG, Vayser DJ, Hadi SA, Harkless LB, Hussain SK
• Central pain syndrome with manifestations in the foot.
  Journal of the American Podiatric Medical Association 1998 Reyzelman AM, Lomba MR, Vayser DJ, Day RD, Burnett OE
• Vancomycin-resistant enterococci osteomyelitis in the foot. A case report.
  Journal of the American Podiatric Medical Association 1997 Reyzelman AM, Van Gils CC, Hardin TC, Vayser DJ, Harkless LB