Alan Verkman, MD, PhD
Professor
Medicine
School of Medicine

Education & Training

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• Residency Medicine Brigham & Womens Hospital
• M.D. Harvard Medical School / HST
• M.A., Ph.D. Physics Harvard University
• S.B., S.B. Physics, Biology M.I.T.
• Fellowship Nephrology University of California, San Francisco

Websites

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• Lab website (not updated) (nephrology.ucsf.edu)

Grants and Projects

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• Novel small-molecule therapies for CF, NIH, 2005-2023
• Aquaporin-4 in NMO Optic Neuritis: Pathogenesis and New Therapies, NIH, 2001-2023
• Urea transport inhibitors as a new class of diuretics, NIH, 2014-2020
• Application of Novel Optical Methods to Cell Dynamics, NIH, 1997-2019
• Mechanisms of water transport in renal epithelia, NIH, 1986-2017
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Role of airway submucosal glands in CF lung disease, NIH, 2003-2013
• CFTR inhibitors for therapy of polycystic kidney disease, NIH, 2009-2012
• Mechanisms of Water Transport in Renal Epithelia, NIH, 1986-2010
• Physiology and Molecular Biology of Lung Water Transport, NIH, 1998-2009
• Application of Novel Optical Methods to Cell Dynamics, NIH, 1997-2007
• Alterations in Airway Surface Liquid in Cystic Fibrosis, NIH, 1998-2003
• Application of Novel Optical Methods to Cell Dynamics, NIH, 1993-2002
• Mechanisms of Water Transport in Renal Epithelia, NIH, 1996-2000
• Development of Chloride-sensitive Fluorescent Indicators, NIH, 1988-1992
• CF pathogenesis mechanisms and therapies, Cystic Fibrosis Foundation
• Neuromyelitis Optica: Disease Mechanisms & New Therapies, Guthy-Jackson Charitable Foundation

Publications (691)

Top publication keywords:
Aquaporin 3Immunoglobulin GBrain EdemaAquaporin 1Neuromyelitis OpticaDiarrheaIon ChannelsChloride ChannelsWaterCystic FibrosisAquaporin 4AquaporinsCystic Fibrosis Transmembrane Conductance RegulatorChloridesCell Membrane Permeability

• Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice.
  Fluids and barriers of the CNS 2024 Tong XJ, Akdemir G, Wadhwa M, Verkman AS, Smith AJ
• Transgenic ferret models define pulmonary ionocyte diversity and function.
  Nature 2023 Yuan F, Gasser GN, Lemire E, Montoro DT, Jagadeesh K, Zhang Y, Duan Y, Ievlev V, Wells KL, Rotti PG, Shahin W, Winter M, Rosen BH, Evans I, Cai Q, Yu M, Walsh SA, Acevedo MR, Pandya DN, Akurathi V, …
• Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.
  RSC medicinal chemistry 2023 Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO, Cil O
• T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS
• Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action.
  European journal of medicinal chemistry 2023 Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS

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• Ocular Surface Ion Transport and Dry Eye Disease.
  Current ophthalmology reports 2022 Lindgren ES, Cil O, Verkman AS, Pasricha ND
• Small-molecule inhibitor of intestinal anion exchanger SLC26A3 for treatment of hyperoxaluria and nephrolithiasis.
  JCI insight 2022 Cil O, Chu T, Lee S, Haggie PM, Verkman AS
• A simple method to generate human airway epithelial organoids with externally orientated apical membranes.
  American journal of physiology. Lung cellular and molecular physiology 2022 Boecking CA, Walentek P, Zlock LT, Sun DI, Wolters PJ, Ishikawa H, Jin BJ, Haggie PM, Marshall WF, Verkman AS, Finkbeiner WE
• Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder.
  Scientific reports 2021 Tradtrantip L, Yeaman MR, Verkman AS
• Chloride transport modulators as drug candidates.
  American journal of physiology. Cell physiology 2021 Verkman AS, Galietta LJV
• Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake.
  The Journal of general physiology 2021 Smith AJ, Akdemir G, Wadhwa M, Song D, Verkman AS
• SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine.
  JCI insight 2021 Cil O, Haggie PM, Tan JT, Rivera AA, Verkman AS
• A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.
  Kidney international 2021 Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Myat Thwe P, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS
• Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas.
  JCI insight 2021 Oak AA, Chhetri PD, Rivera AA, Verkman AS, Cil O
• Targeting the complement system in neuromyelitis optica spectrum disorder.
  Expert opinion on biological therapy 2021 Asavapanumas N, Tradtrantip L, Verkman AS
• Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation.
  PloS one 2020 Nalle SC, Barreira da Silva R, Zhang H, Decker M, Chalouni C, Xu M, Posthuma G, de Mazière A, Klumperman J, Baz Morelli A, Fleire SJ, Verkman AS, Trombetta ES, Albert ML, Mellman I
• Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury.
  Nature communications 2020 Hara-Chikuma M, Tanaka M, Verkman AS, Yasui M
• Ocular Surface Potential Difference Measured in Human Subjects to Study Ocular Surface Ion Transport.
  Translational vision science & technology 2020 Pasricha ND, Smith AJ, Levin MH, Schallhorn JM, Verkman AS
• 1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants.
  European journal of medicinal chemistry 2020 Son JH, Phuan PW, Zhu JS, Lipman E, Cheung A, Tsui KY, Tantillo DJ, Verkman AS, Haggie PM, Kurth MJ
• CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation.
  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2020 Phuan PW, Haggie PM, Tan JA, Rivera AA, Finkbeiner WE, Nielson DW, Thomas MM, Janahi IA, Verkman AS
• Current and potential future applications of human stem cell models in drug development.
  The Journal of clinical investigation 2020 Donowitz M, Turner JR, Verkman AS, Zachos NC
• Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.
  The Journal of clinical investigation 2020 Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR
• Emerging therapeutic targets for neuromyelitis optica spectrum disorder.
  Expert opinion on therapeutic targets 2020 Tradtrantip L, Asavapanumas N, Verkman AS
• Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye.
  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2020 Chen X, Lee S, Zhang T, Duan T, Pasricha ND, Schallhorn JM, Levin MH, Koprivica V, Verkman AS
• Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants.
  Scientific reports 2019 Phuan PW, Tan JA, Rivera AA, Zlock L, Nielson DW, Finkbeiner WE, Haggie PM, Verkman AS
• Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders.
  Neuropharmacology 2019 Duan T, Tradtrantip L, Phuan PW, Bennett JL, Verkman AS
• Experimental animal models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress and shortcomings.
  Brain pathology (Zurich, Switzerland) 2019 Duan T, Verkman AS
• 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation.
  Journal of medicinal chemistry 2019 Lee S, Cil O, Haggie PM, Verkman AS
• Diabetes insipidus.
  Nature reviews. Disease primers 2019 Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS
• CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin-4 independent.
  The Journal of physiology 2019 Smith AJ, Verkman AS
• Rebuttal from Alex J. Smith and Alan S. Verkman.
  The Journal of physiology 2019 Smith AJ, Verkman AS
• Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.
  Scientific reports 2019 Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N
• Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS
• Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity.
  Acta neuropathologica communications 2019 Duan T, Smith AJ, Verkman AS
• Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS
• Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin).
  Bioorganic & medicinal chemistry letters 2019 Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ
• Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure.
  Acta neuropathologica communications 2019 Smith AJ, Duan T, Verkman AS
• CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica.
  Journal of neuroinflammation 2019 Tradtrantip L, Duan T, Yeaman MR, Verkman AS
• Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.
  JCI insight 2019 Duan T, Cil O, Thiagarajah JR, Verkman AS
• Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Wang W, Geng X, Lei L, Jia Y, Li Y, Zhou H, Verkman AS, Yang B
• cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity.
  Cellular and molecular gastroenterology and hepatology 2019 Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M
• Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound.
  Journal of neuropathology and experimental neurology 2019 Yao X, Adams MS, Jones PD, Diederich CJ, Verkman AS
• Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica.
  Journal of neuroinflammation 2018 Duan T, Smith AJ, Verkman AS
• SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.
  JCI insight 2018 Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS
• Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators.
  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2018 Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS
• Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells.
  Analytical chemistry 2018 Jin BJ, Lee S, Verkman AS
• Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis.
  JCI insight 2018 Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW
• Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.
  Journal of medicinal chemistry 2018 Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS
• ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.
  SLAS discovery : advancing life sciences R & D 2018 Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS
• Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica.
  Neuropharmacology 2018 Tradtrantip L, Felix CM, Spirig R, Morelli AB, Verkman AS
• The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica.
  Journal of cellular and molecular medicine 2018 Verkman AS, Yao X, Smith AJ
• The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation?
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Smith AJ, Verkman AS
• The aquaporin-4 water channel as a potential drug target in neurological disorders.
  Expert opinion on therapeutic targets 2017 Verkman AS, Smith AJ, Phuan PW, Tradtrantip L, Anderson MO
• Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders.
  Investigative ophthalmology & visual science 2017 Felix CM, Lee S, Levin MH, Verkman AS
• Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma.
  eLife 2017 Smith AJ, Yao X, Dix JA, Jin BJ, Verkman AS
• Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G.
  Acta neuropathologica communications 2017 Yao X, Verkman AS
• Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica.
  Acta neuropathologica 2017 Tradtrantip L, Yao X, Su T, Smith AJ, Verkman AS
• Mechanisms of Autoantibody-Induced Pathology.
  Frontiers in immunology 2017 Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P…
• Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).
  Journal of medicinal chemistry 2017 Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO
• Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains.
  Biochimica et biophysica acta. Biomembranes 2017 Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman AS, Mangiatordi GF, Nicolotti O
• Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury.
  Biochimica et biophysica acta. Molecular basis of disease 2017 Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman AS, Yang B
• High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.
  Journal of medicinal chemistry 2017 Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ
• Microfluidic platform for rapid measurement of transepithelial water transport.
  Lab on a chip 2017 Jin BJ, Verkman AS
• Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G.
  Acta neuropathologica communications 2017 Yao X, Verkman AS
• Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.
  Journal of medicinal chemistry 2017 Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS
• Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI
• Aquaporin-Targeted Therapeutics: State-of-the-Field.
  Advances in experimental medicine and biology 2017 Tradtrantip L, Jin BJ, Yao X, Anderson MO, Verkman AS
• Aquaporin Water Channels and Hydrocephalus.
  Pediatric neurosurgery 2016 Verkman AS, Tradtrantip L, Smith AJ, Yao X
• Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS
• Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product.
  The Journal of biological chemistry 2016 Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS
• Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism.
  The Journal of general physiology 2016 Jin BJ, Smith AJ, Verkman AS
• Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS
• Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G.
  Journal of neuroinflammation 2016 Felix CM, Levin MH, Verkman AS
• Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.
  Translational research : the journal of laboratory and clinical medicine 2016 Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS
• Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.
  Tomography (Ann Arbor, Mich.) 2016 Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB
• Aquaporin gene therapy for disorders of cholestasis?
  Hepatology (Baltimore, Md.) 2016 Tradtrantip L, Verkman AS
• Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma.
  Scientific reports 2016 Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K
• Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.
  Journal of the American Society of Nephrology : JASN 2016 Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS
• Clobetasol promotes remyelination in a mouse model of neuromyelitis optica.
  Acta neuropathologica communications 2016 Yao X, Su T, Verkman AS
• Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1.
  Molecular pharmacology 2016 Esteva-Font C, Jin BJ, Lee S, Phuan PW, Anderson MO, Verkman AS
• Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS
• Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Flores AM, Casey SD, Felix CM, Phuan PW, Verkman AS, Levin MH
• Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.
  Journal of enzyme inhibition and medicinal chemistry 2016 Piechowicz KA, Truong EC, Javed KM, Chaney RR, Wu JY, Phuan PW, Verkman AS, Anderson MO
• Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Hirt L, Fukuda AM, Ambadipudi K, Rashid F, Binder D, Verkman A, Ashwal S, Obenaus A, Badaut J
• CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.
  Cellular and molecular gastroenterology and hepatology 2016 Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS
• Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections.
  Biophysical journal 2015 Smith AJ, Verkman AS
• Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015.
  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2015 Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE
• TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D
• Droplet-based microfluidic platform for measurement of rapid erythrocyte water transport.
  Lab on a chip 2015 Jin BJ, Esteva-Font C, Verkman AS
• Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.
  Molecular pharmacology 2015 Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS
• Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP.
  Molecular pharmacology 2015 Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS
• Secretory diarrhoea: mechanisms and emerging therapies.
  Nature reviews. Gastroenterology & hepatology 2015 Thiagarajah JR, Donowitz M, Verkman AS
• Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis.
  Nature communications 2015 Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, Verkman AS
• Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury.
  Journal of neurotrauma 2015 Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley GT, Verkman AS
• Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.
  Kidney international 2015 Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS
• Muddying the water in brain edema?
  Trends in neurosciences 2015 Smith AJ, Jin BJ, Verkman AS
• Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice.
  Glia 2015 Yao X, Smith AJ, Jin BJ, Zador Z, Manley GT, Verkman AS
• Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG.
  The Journal of biological chemistry 2015 Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman AS, Bennett JL
• Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.
  Biochimica et biophysica acta 2015 Esteva-Font C, Phuan PW, Lee S, Su T, Anderson MO, Verkman AS
• Aquaporin-1 water permeability as a novel determinant of axonal regeneration in dorsal root ganglion neurons.
  Experimental neurology 2015 Zhang H, Verkman AS
• Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Wang W, Li F, Sun Y, Lei L, Zhou H, Lei T, Xia Y, Verkman AS, Yang B
• Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors.
  MedChemComm 2015 Lee S, Esteva-Font C, Phuan PW, Anderson MO, Verkman AS
• Urea transporter proteins as targets for small-molecule diuretics.
  Nature reviews. Nephrology 2014 Esteva-Font C, Anderson MO, Verkman AS
• Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia.
  Neuroscience letters 2014 Yao X, Derugin N, Manley GT, Verkman AS
• ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.
  Bioorganic & medicinal chemistry letters 2014 Ye L, Hu B, El-Badri F, Hudson BM, Phuan PW, Verkman AS, Tantillo DJ, Kurth MJ
• Transient hyperckemia in the setting of neuromyelitis optica (NMO).
  Muscle & nerve 2014 Malik R, Lewis A, Cree BA, Ratelade J, Rossi A, Verkman AS, Bollen AW, Ralph JW
• Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model.
  PloS one 2014 Tradtrantip L, Asavapanumas N, Phuan PW, Verkman AS
• Treatment of neuromyelitis optica: state-of-the-art and emerging therapies.
  Nature reviews. Neurology 2014 Papadopoulos MC, Bennett JL, Verkman AS
• Constrained bithiazoles: small molecule correctors of defective ΔF508-CFTR protein trafficking.
  Journal of medicinal chemistry 2014 Coffman KC, Nguyen HH, Phuan PW, Hudson BM, Yu GJ, Bagdasarian AL, Montgomery D, Lodewyk MW, Yang B, Yoo CL, Verkman AS, Tantillo DJ, Kurth MJ
• Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.
  Science translational medicine 2014 Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL
• Inhibitor(s) of the classical complement pathway in mouse serum limit the utility of mice as experimental models of neuromyelitis optica.
  Molecular immunology 2014 Ratelade J, Verkman AS
• Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS
• Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury.
  Acta neuropathologica communications 2014 Asavapanumas N, Verkman AS
• Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.
  Molecular pharmacology 2014 Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS
• Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion.
  Neuroscience letters 2014 Akdemir G, Ratelade J, Asavapanumas N, Verkman AS
• Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids.
  Biomicrofluidics 2014 Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman AS
• Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59.
  Journal of autoimmunity 2014 Zhang H, Verkman AS
• Aquaporins: important but elusive drug targets.
  Nature reviews. Drug discovery 2014 Verkman AS, Anderson MO, Papadopoulos MC
• Human immunoglobulin G reduces the pathogenicity of aquaporin-4 autoantibodies in neuromyelitis optica.
  Experimental neurology 2014 Ratelade J, Smith AJ, Verkman AS
• Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy.
  PLoS neglected tropical diseases 2014 Tradtrantip L, Ko EA, Verkman AS
• Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes.
  The Journal of cell biology 2014 Smith AJ, Jin BJ, Ratelade J, Verkman AS
• Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G.
  Journal of neuroinflammation 2014 Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman AS
• Small-molecule inhibitors of urea transporters.
  Sub-cellular biochemistry 2014 Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B
• Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Esteva-Font C, Jin BJ, Verkman AS
• Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure.
  Neurobiology of disease 2013 Rama Rao KV, Verkman AS, Curtis KM, Norenberg MD
• Discovery and development of antisecretory drugs for treating diarrheal diseases.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013 Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS
• Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W
• Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG.
  Acta neuropathologica 2013 Asavapanumas N, Ratelade J, Verkman AS
• Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO.
  Brain pathology (Zurich, Switzerland) 2013 Verkman AS, Phuan PW, Asavapanumas N, Tradtrantip L
• Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman AS
• Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013 Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M
• Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds.
  Lab on a chip 2013 Jin BJ, Ko EA, Namkung W, Verkman AS
• A small molecule screen identifies selective inhibitors of urea transporter UT-A.
  Chemistry & biology 2013 Esteva-Font C, Phuan PW, Anderson MO, Verkman AS
• Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice.
  Gut 2013 Ko EA, Jin BJ, Namkung W, Ma T, Thiagarajah JR, Verkman AS
• Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica.
  Acta neuropathologica 2013 Ratelade J, Asavapanumas N, Ritchie AM, Wemlinger S, Bennett JL, Verkman AS
• Chloride channel-targeted therapy for secretory diarrheas.
  Current opinion in pharmacology 2013 Thiagarajah JR, Verkman AS
• Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses.
  Cellular microbiology 2013 Valentine CD, Zhang H, Phuan PW, Nguyen J, Verkman AS, Haggie PM
• Diffusion in the extracellular space in brain and tumors.
  Physical biology 2013 Verkman AS
• Response to "Diffusion versus convection".
  The Journal of general physiology 2013 Jin BJ, Thiagarajah JR, Verkman AS
• Cystic fibrosis transmembrane regulator correctors and potentiators.
  Cold Spring Harbor perspectives in medicine 2013 Rowe SM, Verkman AS
• Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonist.
  Molecular pharmacology 2013 Namkung W, Park J, Seo Y, Verkman AS
• Response to "When can AQP4 assist transporter-mediated K⁺ uptake?".
  The Journal of general physiology 2013 Jin BJ, Zhang H, Binder DK, Verkman AS
• C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica.
  Acta neuropathologica 2013 Phuan PW, Zhang H, Asavapanumas N, Leviten M, Rosenthal A, Tradtrantip L, Verkman AS
• Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
  Nature chemical biology 2013 Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL
• ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27.
  ACS medicinal chemistry letters 2013 Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS
• Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase.
  Molecular pharmacology 2013 Tradtrantip L, Asavapanumas N, Verkman AS
• Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica.
  The Journal of clinical investigation 2013 Zhang H, Verkman AS
• 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.
  Bioorganic & medicinal chemistry letters 2013 Liu Y, Esteva-Font C, Yao C, Phuan PW, Verkman AS, Anderson MO
• Optic neuritis in neuromyelitis optica.
  Progress in retinal and eye research 2013 Levin MH, Bennett JL, Verkman AS
• Aquaporin water channels in the nervous system.
  Nature reviews. Neuroscience 2013 Papadopoulos MC, Verkman AS
• Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs.
  The Journal of general physiology 2013 Jin BJ, Thiagarajah JR, Verkman AS
• Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01.
  British journal of pharmacology 2013 Davis AJ, Shi J, Pritchard HA, Chadha PS, Leblanc N, Vasilikostas G, Yao Z, Verkman AS, Albert AP, Greenwood IA
• Aquaporins.
  Current biology : CB 2013 Verkman AS
• Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation.
  The Journal of general physiology 2013 Jin BJ, Zhang H, Binder DK, Verkman AS
• CFTR inhibitors.
  Current pharmaceutical design 2013 Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO
• Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions.
  Neuroreport 2012 Saadoun S, Bridges LR, Verkman AS, Papadopoulos MC
• Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.
  The Journal of biological chemistry 2012 Valentine CD, Lukacs GL, Verkman AS, Haggie PM
• Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody.
  Annals of neurology 2012 Tradtrantip L, Ratelade J, Zhang H, Verkman AS
• A small-molecule screen yields idiotype-specific blockers of neuromyelitis optica immunoglobulin G binding to aquaporin-4.
  The Journal of biological chemistry 2012 Phuan PW, Anderson MO, Tradtrantip L, Zhang H, Tan J, Lam C, Bennett JL, Verkman AS
• Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly.
  Glia 2012 Rossi A, Ratelade J, Papadopoulos MC, Bennett JL, Verkman AS
• Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia.
  Molecular biology of the cell 2012 Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL
• Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake.
  The Journal of experimental medicine 2012 Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y
• CFTR inhibitors for treating diarrheal disease.
  Clinical pharmacology and therapeutics 2012 Thiagarajah JR, Verkman AS
• Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis.
  Bioorganic & medicinal chemistry 2012 Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth MJ
• Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes.
  Journal of cell science 2012 Rossi A, Moritz TJ, Ratelade J, Verkman AS
• Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B.
  Journal of medicinal chemistry 2012 Anderson MO, Zhang J, Liu Y, Yao C, Phuan PW, Verkman AS
• Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies.
  The international journal of biochemistry & cell biology 2012 Ratelade J, Verkman AS
• Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors.
  Bioorganic & medicinal chemistry 2012 Kumar S, Namkung W, Verkman AS, Sharma PK
• Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A.
  PloS one 2012 Yao Z, Namkung W, Ko EA, Park J, Tradtrantip L, Verkman AS
• Aquaporin 4 and neuromyelitis optica.
  The Lancet. Neurology 2012 Papadopoulos MC, Verkman AS
• Consequences of NMO-IgG binding to aquaporin-4 in neuromyelitis optica.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Rossi A, Ratelade J, Papadopoulos MC, Bennett JL, Verkman AS
• Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss.
  Acta neuropathologica 2012 Ratelade J, Zhang H, Saadoun S, Bennett JL, Papadopoulos MC, Verkman AS
• Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration.
  Journal of the American Society of Nephrology : JASN 2012 Yao C, Anderson MO, Zhang J, Yang B, Phuan PW, Verkman AS
• Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays.
  The Journal of biological chemistry 2012 Phuan PW, Ratelade J, Rossi A, Tradtrantip L, Verkman AS
• Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.
  Annals of neurology 2012 Saadoun S, Waters P, MacDonald C, Bell BA, Vincent A, Verkman AS, Papadopoulos MC
• Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Tradtrantip L, Zhang H, Anderson MO, Saadoun S, Phuan PW, Papadopoulos MC, Bennett JL, Verkman AS
• Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.
  Annals of neurology 2012 Tradtrantip L, Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, Verkman AS
• Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein.
  Journal of medicinal chemistry 2012 Knapp JM, Wood AB, Phuan PW, Lodewyk MW, Tantillo DJ, Verkman AS, Kurth MJ
• Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging.
  Bioorganic & medicinal chemistry letters 2012 Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth MJ
• Aquaporins in clinical medicine.
  Annual review of medicine 2012 Verkman AS
• Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimeras.
  The Journal of general physiology 2012 Baumgart F, Rossi A, Verkman AS
• Live-cell imaging of aquaporin-4 supramolecular assembly and diffusion.
  Methods in enzymology 2012 Verkman AS, Rossi A, Crane JM
• CFTR: folding, misfolding and correcting the ΔF508 conformational defect.
  Trends in molecular medicine 2011 Lukacs GL, Verkman AS
• Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice.
  Bioconjugate chemistry 2011 Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ
• Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica.
  The Journal of biological chemistry 2011 Ratelade J, Bennett JL, Verkman AS
• Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms.
  Annals of neurology 2011 Zhang H, Bennett JL, Verkman AS
• Post-Golgi supramolecular assembly of aquaporin-4 in orthogonal arrays.
  Traffic (Copenhagen, Denmark) 2011 Rossi A, Baumgart F, van Hoek AN, Verkman AS
• Intravenous neuromyelitis optica autoantibody in mice targets aquaporin-4 in peripheral organs and area postrema.
  PloS one 2011 Ratelade J, Bennett JL, Verkman AS
• Protein trafficking rates assessed by quantum dot quenching with bromocresol green.
  Traffic (Copenhagen, Denmark) 2011 Valentine CD, Verkman AS, Haggie PM
• Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Namkung W, Yao Z, Finkbeiner WE, Verkman AS
• Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease.
  Journal of medicinal chemistry 2011 Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS
• Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis.
  Molecular pharmacology 2011 Phuan PW, Yang B, Knapp JM, Wood AB, Lukacs GL, Kurth MJ, Verkman AS
• Aquaporins at a glance.
  Journal of cell science 2011 Verkman AS
• Model of aquaporin-4 supramolecular assembly in orthogonal arrays based on heterotetrameric association of M1-M23 isoforms.
  Biophysical journal 2011 Jin BJ, Rossi A, Verkman AS
• Orthogonal array formation by human aquaporin-4: examination of neuromyelitis optica-associated aquaporin-4 polymorphisms.
  Journal of neuroimmunology 2011 Crane JM, Rossi A, Gupta T, Bennett JL, Verkman AS
• Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica.
  Acta pharmacologica Sinica 2011 Verkman AS, Ratelade J, Rossi A, Zhang H, Tradtrantip L
• Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE
• T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement.
  Journal of neuroimmunology 2011 Saadoun S, Waters P, Macdonald C, Bridges LR, Bell BA, Vincent A, Verkman AS, Papadopoulos MC
• Aquaporin-4 Mz isoform: brain expression, supramolecular assembly and neuromyelitis optica antibody binding.
  Glia 2011 Rossi A, Crane JM, Verkman AS
• Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS
• Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays.
  The Journal of biological chemistry 2011 Crane JM, Lam C, Rossi A, Gupta T, Bennett JL, Verkman AS
• Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing.
  European journal of organic chemistry 2011 Carpenter RD, Verkman AS
• Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Li L, Zhang H, Varrin-Doyer M, Zamvil SS, Verkman AS
• Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia.
  The Journal of investigative dermatology 2010 Nakahigashi K, Kabashima K, Ikoma A, Verkman AS, Miyachi Y, Hara-Chikuma M
• TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
  The Journal of biological chemistry 2010 Namkung W, Phuan PW, Verkman AS
• Altered cellular localization of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency.
  Molecular and cellular neurosciences 2010 Wang D, Nykanen M, Yang N, Winlaw D, North K, Verkman AS, Owler BK
• Airway surface liquid depth imaged by surface laser reflectance microscopy.
  The Journal of general physiology 2010 Thiagarajah JR, Song Y, Derichs N, Verkman AS
• Microfiberoptic measurement of extracellular space volume in brain and tumor slices based on fluorescent dye partitioning.
  Biophysical journal 2010 Zhang H, Verkman AS
• Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Namkung W, Thiagarajah JR, Phuan PW, Verkman AS
• CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures.
  Molecular biology of the cell 2010 Namkung W, Finkbeiner WE, Verkman AS
• Protective role of aquaporin-4 water channels after contusion spinal cord injury.
  Annals of neurology 2010 Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK
• Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles.
  Journal of medicinal chemistry 2010 Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ
• Isoxazolopyrimidines as Novel ΔF508-CFTR Correctors.
  Synlett : accounts and rapid communications in synthetic organic chemistry 2010 Yu GJ, Yang B, Verkman AS, Kurth MJ
• Synthesis of a sensitive and selective potassium-sensing fluoroionophore.
  Organic letters 2010 Carpenter RD, Verkman AS
• Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage.
  Neuroscience 2010 Tait MJ, Saadoun S, Bell BA, Verkman AS, Papadopoulos MC
• Aquaporin-4 (AQP4) associations and array dynamics probed by photobleaching and single-molecule analysis of green fluorescent protein-AQP4 chimeras.
  The Journal of biological chemistry 2010 Tajima M, Crane JM, Verkman AS
• Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.
  Brain : a journal of neurology 2010 Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC
• Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells.
  The Journal of biological chemistry 2009 Crane JM, Bennett JL, Verkman AS
• Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons.
  The Journal of biological chemistry 2009 Zhang H, Verkman AS
• Reversible, temperature-dependent supramolecular assembly of aquaporin-4 orthogonal arrays in live cell membranes.
  Biophysical journal 2009 Crane JM, Verkman AS
• Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR.
  Bioorganic & medicinal chemistry letters 2009 Mills AD, Yoo C, Butler JD, Yang B, Verkman AS, Kurth MJ
• Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.
  Journal of medicinal chemistry 2009 Tradtrantip L, Sonawane ND, Namkung W, Verkman AS
• Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function.
  American journal of physiology. Lung cellular and molecular physiology 2009 Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS
• Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels.
  Molecular pharmacology 2009 Tradtrantip L, Namkung W, Verkman AS
• Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles.
  Neuroscience 2009 Crane JM, Tajima M, Verkman AS
• Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice.
  BMC neuroscience 2009 Li L, Zhang H, Verkman AS
• Aquaporins: translating bench research to human disease.
  The Journal of experimental biology 2009 Verkman AS
• In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye.
  The Journal of biological chemistry 2009 Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS
• AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology.
  Neuroscience 2009 Saadoun S, Tait MJ, Reza A, Davies DC, Bell BA, Verkman AS, Papadopoulos MC
• Sporadic obstructive hydrocephalus in Aqp4 null mice.
  Journal of neuroscience research 2009 Feng X, Papadopoulos MC, Liu J, Li L, Zhang D, Zhang H, Verkman AS, Ma T
• Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis.
  American journal of physiology. Lung cellular and molecular physiology 2009 Haggie PM, Verkman AS
• Extracellular space volume measured by two-color pulsed dye infusion with microfiberoptic fluorescence photodetection.
  Biophysical journal 2009 Magzoub M, Zhang H, Dix JA, Verkman AS
• Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models.
  Experimental eye research 2009 Ruiz-Ederra J, Verkman AS
• QUANTUM DOT SINGLE MOLECULE TRACKING REVEALS A WIDE RANGE OF DIFFUSIVE MOTIONS OF MEMBRANE TRANSPORT PROTEINS.
  Proceedings of SPIE--the International Society for Optical Engineering 2009 Crane JM, Haggie PM, Verkman AS
• Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging.
  Journal of cell science 2009 Crane JM, Verkman AS
• The expression of differentiation markers in aquaporin-3 deficient epidermis.
  Archives of dermatological research 2009 Hara-Chikuma M, Takahashi K, Chikuma S, Verkman AS, Miyachi Y
• Very high aquaporin-1 facilitated water permeability in mouse gallbladder.
  American journal of physiology. Gastrointestinal and liver physiology 2009 Li L, Zhang H, Ma T, Verkman AS
• In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency.
  Investigative ophthalmology & visual science 2009 Ruiz-Ederra J, Levin MH, Verkman AS
• Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis.
  The Journal of biological chemistry 2009 Haggie PM, Verkman AS
• Aquaporin water channels in transepithelial fluid transport.
  The journal of medical investigation : JMI 2009 Tradtrantip L, Tajima M, Li L, Verkman AS
• Knock-out models reveal new aquaporin functions.
  Handbook of experimental pharmacology 2009 Verkman AS
• Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Yang B, Zhao D, Verkman AS
• Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion.
  Molecular pharmacology 2008 Tradtrantip L, Yangthara B, Padmawar P, Morrison C, Verkman AS
• Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy.
  Journal of medicinal chemistry 2008 Yu GJ, Yoo CL, Yang B, Lodewyk MW, Meng L, El-Idreesy TT, Fettinger JC, Tantillo DJ, Verkman AS, Kurth MJ
• Evidence against involvement of aquaporin-4 in cell-cell adhesion.
  Journal of molecular biology 2008 Zhang H, Verkman AS
• Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis.
  Bioorganic & medicinal chemistry 2008 Sonawane ND, Verkman AS
• Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides.
  Chemistry & biology 2008 Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS
• Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging.
  The Journal of biological chemistry 2008 Haggie PM, Verkman AS
• Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis.
  The Biochemical journal 2008 Caci E, Caputo A, Hinzpeter A, Arous N, Fanen P, Sonawane N, Verkman AS, Ravazzolo R, Zegarra-Moran O, Galietta LJ
• Roles of aquaporin-3 in the epidermis.
  The Journal of investigative dermatology 2008 Hara-Chikuma M, Verkman AS
• Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides.
  Bioorganic & medicinal chemistry 2008 Yang B, Zhang H, Verkman AS
• Cell-based fluorescence screen for K+ channels and transporters using an extracellular triazacryptand-based K+ sensor.
  Journal of the American Chemical Society 2008 Namkung W, Padmawar P, Mills AD, Verkman AS
• Impaired olfaction in mice lacking aquaporin-4 water channels.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Lu DC, Zhang H, Zador Z, Verkman AS
• From the farm to the lab: the pig as a new model of cystic fibrosis lung disease.
  American journal of physiology. Lung cellular and molecular physiology 2008 Verkman AS
• Functions of aquaporins in the eye.
  Progress in retinal and eye research 2008 Verkman AS, Ruiz-Ederra J, Levin MH
• Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking.
  Molecular biology of the cell 2008 Crane JM, Van Hoek AN, Skach WR, Verkman AS
• Mammalian aquaporins: diverse physiological roles and potential clinical significance.
  Expert reviews in molecular medicine 2008 Verkman AS
• Random-walk model of diffusion in three dimensions in brain extracellular space: comparison with microfiberoptic photobleaching measurements.
  Biophysical journal 2008 Jin S, Zador Z, Verkman AS
• Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice.
  Seminars in nephrology 2008 Verkman AS
• Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease.
  Journal of the American Society of Nephrology : JASN 2008 Yang B, Sonawane ND, Zhao D, Somlo S, Verkman AS
• Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling.
  The Journal of biological chemistry 2008 Yang B, Zador Z, Verkman AS
• 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing.
  Bioorganic & medicinal chemistry letters 2008 Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth MJ
• Aquaporins--new players in cancer biology.
  Journal of molecular medicine (Berlin, Germany) 2008 Verkman AS, Hara-Chikuma M, Papadopoulos MC
• A cautionary note on cosmetics containing ingredients that increase aquaporin-3 expression.
  Experimental dermatology 2008 Verkman AS
• Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.
  The Journal of pharmacology and experimental therapeutics 2008 Sonawane ND, Zegarra-Moran O, Namkung W, Galietta LJ, Verkman AS
• Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice.
  Brain : a journal of neurology 2008 Saadoun S, Bell BA, Verkman AS, Papadopoulos MC
• Chloride channels as drug targets.
  Nature reviews. Drug discovery 2008 Verkman AS, Galietta LJ
• Crowding effects on diffusion in solutions and cells.
  Annual review of biophysics 2008 Dix JA, Verkman AS
• Potential utility of aquaporin modulators for therapy of brain disorders.
  Progress in brain research 2008 Papadopoulos MC, Verkman AS
• Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel.
  Molecular pharmacology 2007 De La Fuente R, Namkung W, Mills A, Verkman AS
• Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing.
  Journal of molecular medicine (Berlin, Germany) 2007 Hara-Chikuma M, Verkman AS
• Aquaporins and cell migration.
  Pflugers Archiv : European journal of physiology 2007 Papadopoulos MC, Saadoun S, Verkman AS
• Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption.
  Molecular and cellular biology 2007 Hara-Chikuma M, Verkman AS
• Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS
• Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen-induced retinopathy.
  Investigative ophthalmology & visual science 2007 Ruiz-Ederra J, Verkman AS
• Long-range nonanomalous diffusion of quantum dot-labeled aquaporin-1 water channels in the cell plasma membrane.
  Biophysical journal 2007 Crane JM, Verkman AS
• Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Magzoub M, Jin S, Verkman AS
• Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages.
  The Journal of biological chemistry 2007 Haggie PM, Verkman AS
• Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells.
  Molecular and cellular neurosciences 2007 Zhang H, Verkman AS
• Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis.
  Gut 2007 Thiagarajah JR, Zhao D, Verkman AS
• Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Müller cells.
  The Journal of biological chemistry 2007 Ruiz-Ederra J, Zhang H, Verkman AS
• Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels.
  Biophysical journal 2007 Jin S, Haggie PM, Verkman AS
• Small-molecule vasopressin-2 receptor antagonist identified by a g-protein coupled receptor "pathway" screen.
  Molecular pharmacology 2007 Yangthara B, Mills A, Chatsudthipong V, Tradtrantip L, Verkman AS
• Single particle tracking of complex diffusion in membranes: simulation and detection of barrier, raft, and interaction phenomena.
  The journal of physical chemistry. B 2007 Jin S, Verkman AS
• Aquaporin-4 and brain edema.
  Pediatric nephrology (Berlin, Germany) 2007 Papadopoulos MC, Verkman AS
• Role of aquaporins in lung liquid physiology.
  Respiratory physiology & neurobiology 2007 Verkman AS
• Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera.
  Gastroenterology 2007 Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS
• Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Levin MH, de la Fuente R, Verkman AS
• Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS
• Comparative efficacy of HgCl2 with candidate aquaporin-1 inhibitors DMSO, gold, TEA+ and acetazolamide.
  FEBS letters 2006 Yang B, Kim JK, Verkman AS
• Millisecond association kinetics of K+ with triazacryptand-based K+ indicators measured by fluorescence correlation spectroscopy.
  The journal of physical chemistry. B 2006 Magzoub M, Padmawar P, Dix JA, Verkman AS
• Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization.
  Investigative ophthalmology & visual science 2006 Levin MH, Verkman AS
• Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions.
  Molecular biology of the cell 2006 Haggie PM, Kim JK, Lukacs GL, Verkman AS
• Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening.
  British journal of pharmacology 2006 De La Fuente R, Sonawane ND, Arumainayagam D, Verkman AS
• Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice.
  Investigative ophthalmology & visual science 2006 Ruiz-Ederra J, Verkman AS
• CFTR inhibition mimics the cystic fibrosis inflammatory profile.
  American journal of physiology. Lung cellular and molecular physiology 2006 Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB
• Aquaporins and CFTR in ocular epithelial fluid transport.
  The Journal of membrane biology 2006 Levin MH, Verkman AS
• Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins.
  The Journal of biological chemistry 2006 Levin MH, Sullivan S, Nielson D, Yang B, Finkbeiner WE, Verkman AS
• Increased migration and metastatic potential of tumor cells expressing aquaporin water channels.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Hu J, Verkman AS
• Physiological roles of glycerol-transporting aquaporins: the aquaglyceroporins.
  Cellular and molecular life sciences : CMLS 2006 Hara-Chikuma M, Verkman AS
• Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis.
  Kidney international 2006 Ni J, Verbavatz JM, Rippe A, Boisdé I, Moulin P, Rippe B, Verkman AS, Devuyst O
• Roles of aquaporins in kidney revealed by transgenic mice.
  Seminars in nephrology 2006 Verkman AS
• Evidence against functionally significant aquaporin expression in mitochondria.
  The Journal of biological chemistry 2006 Yang B, Zhao D, Verkman AS
• Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport.
  American journal of physiology. Cell physiology 2006 Yang B, Zhao D, Solenov E, Verkman AS
• Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels.
  Glia 2006 Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley GT
• Aquaporins in endothelia.
  Kidney international 2006 Verkman AS
• Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching.
  Nature methods 2006 Thiagarajah JR, Kim JK, Magzoub M, Verkman AS
• Cardiac aquaporin expression in humans, rats, and mice.
  American journal of physiology. Heart and circulatory physiology 2006 Butler TL, Au CG, Yang B, Egan JR, Tan YM, Hardeman EC, North KN, Verkman AS, Winlaw DS
• Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis.
  Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 2006 Ripoche P, Goossens D, Devuyst O, Gane P, Colin Y, Verkman AS, Cartron JP
• Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006 Bloch O, Auguste KI, Manley GT, Verkman AS
• Three distinct roles of aquaporin-4 in brain function revealed by knockout mice.
  Biochimica et biophysica acta 2006 Verkman AS, Binder DK, Bloch O, Auguste K, Papadopoulos MC
• Fluorescence correlation spectroscopy simulations of photophysical phenomena and molecular interactions: a molecular dynamics/monte carlo approach.
  The journal of physical chemistry. B 2006 Dix JA, Hom EF, Verkman AS
• Impaired pain sensation in mice lacking Aquaporin-1 water channels.
  Biochemical and biophysical research communications 2006 Oshio K, Watanabe H, Yan D, Verkman AS, Manley GT
• Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion.
  American journal of physiology. Renal physiology 2006 Yang B, Zhao D, Qian L, Verkman AS
• CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis.
  Current pharmaceutical design 2006 Verkman AS, Lukacs GL, Galietta LJ
• Increased seizure duration in mice lacking aquaporin-4 water channels.
  Acta neurochirurgica. Supplement 2006 Binder DK, Yao X, Verkman AS, Manley GT
• Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic model.
  Investigative ophthalmology & visual science 2006 Levin MH, Kim JK, Hu J, Verkman AS
• Aquaporin-1 facilitates epithelial cell migration in kidney proximal tubule.
  Journal of the American Society of Nephrology : JASN 2005 Hara-Chikuma M, Verkman AS
• Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005 Sonawane ND, Hu J, Muanprasat C, Verkman AS
• Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion.
  Experimental eye research 2005 Ruiz-Ederra J, Verkman AS
• Involvement of aquaporin-4 in astroglial cell migration and glial scar formation.
  Journal of cell science 2005 Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS
• Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating.
  Bioorganic & medicinal chemistry letters 2005 Suen YF, Robins L, Yang B, Verkman AS, Nantz MH, Kurth MJ
• K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator.
  Nature methods 2005 Padmawar P, Yao X, Bloch O, Manley GT, Verkman AS
• Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis.
  American journal of physiology. Cell physiology 2005 Song Y, Salinas D, Nielson DW, Verkman AS
• Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess.
  Journal of neurochemistry 2005 Bloch O, Papadopoulos MC, Manley GT, Verkman AS
• Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting duct in AQP3 null mice.
  Biology of the cell 2005 Kim SW, Gresz V, Rojek A, Wang W, Verkman AS, Frøkiaer J, Nielsen S
• Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.
  American journal of physiology. Lung cellular and molecular physiology 2005 Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA
• Extracellular space diffusion in central nervous system: anisotropic diffusion measured by elliptical surface photobleaching.
  Biophysical journal 2005 Papadopoulos MC, Kim JK, Verkman AS
• Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule.
  Molecular and cellular biology 2005 Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K
• Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.
  The Journal of clinical investigation 2005 Pedemonte N, Lukacs GL, Du K, Caci E, Zegarra-Moran O, Galietta LJ, Verkman AS
• IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.
  The Journal of experimental medicine 2005 Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR
• More than just water channels: unexpected cellular roles of aquaporins.
  Journal of cell science 2005 Verkman AS
• Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice.
  American journal of physiology. Renal physiology 2005 Sohara E, Rai T, Miyazaki J, Verkman AS, Sasaki S, Uchida S
• Aquaporin-3 functions as a glycerol transporter in mammalian skin.
  Biology of the cell 2005 Hara-Chikuma M, Verkman AS
• Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.
  The Biochemical journal 2005 Schulz BL, Sloane AJ, Robinson LJ, Sebastian LT, Glanville AR, Song Y, Verkman AS, Harry JL, Packer NH, Karlsson NG
• Impaired acidification in early endosomes of ClC-5 deficient proximal tubule.
  Biochemical and biophysical research communications 2005 Hara-Chikuma M, Wang Y, Guggino SE, Guggino WB, Verkman AS
• Noninvasive early detection of brain edema in mice by near-infrared light scattering.
  Journal of neuroscience research 2005 Thiagarajah JR, Papadopoulos MC, Verkman AS
• Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption.
  Nature 2005 Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS
• Intracellular routing of plasmid DNA during non-viral gene transfer.
  Advanced drug delivery reviews 2005 Lechardeur D, Verkman AS, Lukacs GL
• CFTR-regulated chloride transport at the ocular surface in living mice measured by potential differences.
  Investigative ophthalmology & visual science 2005 Levin MH, Verkman AS
• New drug targets for cholera therapy.
  Trends in pharmacological sciences 2005 Thiagarajah JR, Verkman AS
• Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation.
  The Journal of biological chemistry 2005 Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS
• Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating.
  Molecular pharmacology 2005 Pedemonte N, Sonawane ND, Taddei A, Hu J, Zegarra-Moran O, Suen YF, Robins LI, Dicus CW, Willenbring D, Nantz MH, Kurth MJ, Galietta LJ, Verkman AS
• Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis.
  The Journal of biological chemistry 2005 Papadopoulos MC, Verkman AS
• Phenotype analysis of aquaporin-8 null mice.
  American journal of physiology. Cell physiology 2005 Yang B, Song Y, Zhao D, Verkman AS
• Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm: a new barrier for non-viral gene delivery.
  The Journal of biological chemistry 2005 Dauty E, Verkman AS
• In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents.
  Journal of pharmaceutical sciences 2005 Sonawane ND, Muanprasat C, Nagatani R, Song Y, Verkman AS
• Novel roles of aquaporins revealed by phenotype analysis of knockout mice.
  Reviews of physiology, biochemistry and pharmacology 2005 Verkman AS
• Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Papadopoulos MC, Binder DK, Verkman AS
• Submucosal gland dysfunction as a primary defect in cystic fibrosis.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS
• Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia.
  Investigative ophthalmology & visual science 2004 Da T, Verkman AS
• Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva.
  Investigative ophthalmology & visual science 2004 Levin MH, Verkman AS
• Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT
• ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.
  The Journal of biological chemistry 2004 Hara-Chikuma M, Yang B, Sonawane ND, Sasaki S, Uchida S, Verkman AS
• In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Binder DK, Papadopoulos MC, Haggie PM, Verkman AS
• Drug discovery and epithelial physiology.
  Current opinion in nephrology and hypertension 2004 Verkman AS
• Molecular crowding reduces to a similar extent the diffusion of small solutes and macromolecules: measurement by fluorescence correlation spectroscopy.
  Journal of molecular recognition : JMR 2004 Dauty E, Verkman AS
• Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.
  The Journal of general physiology 2004 Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS
• Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.
  The Journal of biological chemistry 2004 Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, Verkman AS
• CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor.
  American journal of physiology. Lung cellular and molecular physiology 2004 Salinas DB, Pedemonte N, Muanprasat C, Finkbeiner WF, Nielson DW, Verkman AS
• Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Papadopoulos MC, Manley GT, Krishna S, Verkman AS
• Fluid transport across cultured layers of corneal endothelium from aquaporin-1 null mice.
  Experimental eye research 2004 Kuang K, Yiming M, Wen Q, Li Y, Ma L, Iserovich P, Verkman AS, Fischbarg J
• A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Thiagarajah JR, Song Y, Haggie PM, Verkman AS
• Drug discovery in academia.
  American journal of physiology. Cell physiology 2004 Verkman AS
• Increased seizure threshold in mice lacking aquaporin-4 water channels.
  Neuroreport 2004 Binder DK, Oshio K, Ma T, Verkman AS, Manley GT
• Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor.
  Gastroenterology 2004 Thiagarajah JR, Broadbent T, Hsieh E, Verkman AS
• Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker.
  FEBS letters 2004 Taddei A, Folli C, Zegarra-Moran O, Fanen P, Verkman AS, Galietta LJ
• Expression of aquaporin water channels in mouse spinal cord.
  Neuroscience 2004 Oshio K, Binder DK, Yang B, Schecter S, Verkman AS, Manley GT
• Molecular mechanisms of brain tumor edema.
  Neuroscience 2004 Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS
• New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice.
  Neuroscience 2004 Manley GT, Binder DK, Papadopoulos MC, Verkman AS
• CFTR pharmacology and its role in intestinal fluid secretion.
  Current opinion in pharmacology 2003 Thiagarajah JR, Verkman AS
• Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif.
  The Journal of biological chemistry 2003 Haggie PM, Stanton BA, Verkman AS
• Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method.
  American journal of physiology. Cell physiology 2003 Solenov E, Watanabe H, Manley GT, Verkman AS
• Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways.
  The Journal of general physiology 2003 Song Y, Thiagarajah J, Verkman AS
• Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain.
  Bioorganic & medicinal chemistry 2003 Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH
• Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes.
  The Journal of biological chemistry 2003 Sonawane ND, Szoka FC, Verkman AS
• 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators.
  Bioorganic & medicinal chemistry letters 2003 Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth MJ
• Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.
  The Journal of biological chemistry 2003 Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS
• Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Hara M, Verkman AS
• Increased expression of H+-ATPase in inner medullary collecting duct of aquaporin-1-deficient mice.
  American journal of physiology. Renal physiology 2003 Kim YH, Kim J, Verkman AS, Madsen KM
• Determinants of [Cl-] in recycling and late endosomes and Golgi complex measured using fluorescent ligands.
  The Journal of cell biology 2003 Sonawane ND, Verkman AS
• CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds.
  American journal of physiology. Lung cellular and molecular physiology 2003 Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ
• Role of aquaporin water channels in eye function.
  Experimental eye research 2003 Verkman AS
• Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production.
  Acta neurochirurgica. Supplement 2003 Oshio K, Song Y, Verkman AS, Manley GT
• Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema.
  Acta neurochirurgica. Supplement 2003 Oshio K, Binder DK, Bollen A, Verkman AS, Berger MS, Manley GT
• Diffusion in cells measured by fluorescence recovery after photobleaching.
  Methods in enzymology 2003 Verkman AS
• Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease.
  American journal of physiology. Cell physiology 2003 Verkman AS, Song Y, Thiagarajah JR
• Lung edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways.
  Journal of applied physiology (Bethesda, Md. : 1985) 2002 Borok Z, Verkman AS
• Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.
  The Journal of clinical investigation 2002 Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS
• Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier.
  Journal of applied physiology (Bethesda, Md. : 1985) 2002 Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS
• Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo. Evidence for restricted mobility of a multienzyme complex.
  The Journal of biological chemistry 2002 Haggie PM, Verkman AS
• High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening.
  The Journal of biological chemistry 2002 Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS
• Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes.
  The Journal of biological chemistry 2002 Yang B, Verkman AS
• Analysis of coupled bimolecular reaction kinetics and diffusion by two-color fluorescence correlation spectroscopy: enhanced resolution of kinetics by resonance energy transfer.
  Biophysical journal 2002 Hom EF, Verkman AS
• Does aquaporin-1 pass gas? An opposing view.
  The Journal of physiology 2002 Verkman AS
• Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney.
  The Journal of physiology 2002 Fang X, Yang B, Matthay MA, Verkman AS
• Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production.
  The Journal of general physiology 2002 Zhang D, Vetrivel L, Verkman AS
• Aquaporin water channels and endothelial cell function.
  Journal of anatomy 2002 Verkman AS
• Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice.
  The Journal of physiology 2002 Song Y, Sonawane N, Verkman AS
• Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling.
  The Journal of biological chemistry 2002 Thiagarajah JR, Verkman AS
• Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3.
  The Journal of biological chemistry 2002 Ma T, Hara M, Sougrat R, Verbavatz JM, Verkman AS
• Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras.
  The Journal of biological chemistry 2002 Haggie PM, Stanton BA, Verkman AS
• Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channels.
  Investigative ophthalmology & visual science 2002 Li J, Patil RV, Verkman AS
• Novel role for CFTR in fluid absorption from the distal airspaces of the lung.
  The Journal of general physiology 2002 Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA
• Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice.
  Journal of neuroscience methods 2002 Solenov EI, Vetrivel L, Oshio K, Manley GT, Verkman AS
• Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B.
  The Journal of biological chemistry 2002 Yang B, Bankir L, Gillespie A, Epstein CJ, Verkman AS
• Fluorescent indicator methods to assay functional CFTR expression in cells.
  Methods in molecular medicine 2002 Verkman AS, Jayaraman S
• Physiological importance of aquaporin water channels.
  Annals of medicine 2002 Verkman AS
• Renal concentrating and diluting function in deficiency of specific aquaporin genes.
  Experimental nephrology 2002 Verkman AS
• Solute and macromolecule diffusion in cellular aqueous compartments.
  Trends in biochemical sciences 2002 Verkman AS
• Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification.
  The Journal of biological chemistry 2001 Sonawane ND, Thiagarajah JR, Verkman AS
• In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colon.
  American journal of physiology. Cell physiology 2001 Thiagarajah JR, Jayaraman S, Naftalin RJ, Verkman AS
• Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Zhou Q, Clarke L, Nie R, Carnes K, Lai LW, Lien YH, Verkman A, Lubahn D, Fisher JS, Katzenellenbogen BS, Hess RA
• Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea.
  American journal of physiology. Cell physiology 2001 Jayaraman S, Song Y, Verkman AS
• Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists.
  American journal of physiology. Cell physiology 2001 Galietta LV, Jayaraman S, Verkman AS
• Applications of aquaporin inhibitors.
  Drug news & perspectives 2001 Verkman AS
• Lung disease in cystic fibrosis: is airway surface liquid composition abnormal?
  American journal of physiology. Lung cellular and molecular physiology 2001 Verkman AS
• HCO3- transport in relation to mucus secretion from submucosal glands.
  JOP : Journal of the pancreas 2001 Joo NS, Krouse ME, Wu JV, Saenz Y, Jayaraman S, Verkman AS, Wine JJ
• Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na(+)] and pH but elevated viscosity.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Jayaraman S, Joo NS, Reitz B, Wine JJ, Verkman AS
• Green fluorescent protein-based halide indicators with improved chloride and iodide affinities.
  FEBS letters 2001 Galietta LJ, Haggie PM, Verkman AS
• Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration.
  The Journal of general physiology 2001 Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS
• Airway surface liquid osmolality measured using fluorophore-encapsulated liposomes.
  The Journal of general physiology 2001 Jayaraman S, Song Y, Verkman AS
• Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus.
  The Journal of biological chemistry 2001 Levin MH, Haggie PM, Vetrivel L, Verkman AS
• Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.
  The Journal of biological chemistry 2001 Galietta LJ, Springsteel MF, Eda M, Niedzinski EJ, By K, Haddadin MJ, Kurth MJ, Nantz MH, Verkman AS
• Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH.
  The Journal of clinical investigation 2001 Jayaraman S, Song Y, Vetrivel L, Shankar L, Verkman AS
• Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3.
  The Journal of biological chemistry 2001 Yang B, Ma T, Verkman AS
• Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels.
  American journal of physiology. Cell physiology 2001 Ma T, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman AS
• Role of aquaporin water channels in pleural fluid dynamics.
  American journal of physiology. Cell physiology 2000 Song Y, Yang B, Matthay MA, Ma T, Verkman AS
• Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4.
  The Journal of biological chemistry 2000 Foster W, Helm A, Turnbull I, Gulati H, Yang B, Verkman AS, Skach WR
• Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus.
  The Journal of biological chemistry 2000 Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS
• Physiological importance of aquaporins: lessons from knockout mice.
  Current opinion in nephrology and hypertension 2000 Verkman AS
• Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum.
  Molecular biology of the cell 2000 Lu Y, Turnbull IR, Bragin A, Carveth K, Verkman AS, Skach WR
• Colon water transport in transgenic mice lacking aquaporin-4 water channels.
  American journal of physiology. Gastrointestinal and liver physiology 2000 Wang KS, Ma T, Filiz F, Verkman AS, Bastidas JA
• Gastric acid secretion in aquaporin-4 knockout mice.
  American journal of physiology. Gastrointestinal and liver physiology 2000 Wang KS, Komar AR, Ma T, Filiz F, McLeroy J, Hoda K, Verkman AS, Bastidas JA
• Analysis of organ physiology in transgenic mice.
  American journal of physiology. Cell physiology 2000 Rao S, Verkman AS
• Mesoscopic surfactant organization and membrane protein crystallization.
  Protein science : a publication of the Protein Society 2000 Wiener MC, Verkman AS, Stroud RM, van Hoek AN
• Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice.
  The Journal of physiology 2000 Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS
• Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice.
  American journal of physiology. Renal physiology 2000 Vallon V, Verkman AS, Schnermann J
• Skeletal muscle function and water permeability in aquaporin-4 deficient mice.
  American journal of physiology. Cell physiology 2000 Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS
• Quenching mechanism of quinolinium-type chloride-sensitive fluorescent indicators.
  Biophysical chemistry 2000 Jayaraman S, Verkman AS
• Aquaporin water channels and lung physiology.
  American journal of physiology. Lung cellular and molecular physiology 2000 Verkman AS, Matthay MA, Song Y
• Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5.
  Experimental eye research 2000 Moore M, Ma T, Yang B, Verkman AS
• Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS
• Mechanism and cellular applications of a green fluorescent protein-based halide sensor.
  The Journal of biological chemistry 2000 Jayaraman S, Haggie P, Wachter RM, Remington SJ, Verkman AS
• Altered gravity downregulates aquaporin-1 protein expression in choroid plexus.
  Journal of applied physiology (Bethesda, Md. : 1985) 2000 Masseguin C, Corcoran M, Carcenac C, Daunton NG, Güell A, Verkman AS, Gabrion J
• Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery.
  Human gene therapy 2000 Yang B, Ma T, Dong JY, Verkman AS
• Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice.
  Experimental physiology 2000 Verkman AS, Yang B, Song Y, Manley GT, Ma T
• Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.
  Nature medicine 2000 Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS
• Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney.
  American journal of physiology. Renal physiology 2000 van Hoek AN, Ma T, Yang B, Verkman AS, Brown D
• cAMP regulated membrane diffusion of a green fluorescent protein-aquaporin 2 chimera.
  Biophysical journal 2000 Umenishi F, Verbavatz JM, Verkman AS
• Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes.
  The Journal of biological chemistry 2000 Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS
• Size-dependent DNA mobility in cytoplasm and nucleus.
  The Journal of biological chemistry 2000 Lukacs GL, Haggie P, Seksek O, Lechardeur D, Freedman N, Verkman AS
• Water permeability measurement in living cells and complex tissues.
  The Journal of membrane biology 2000 Verkman AS
• Lung fluid transport in aquaporin-5 knockout mice.
  The Journal of clinical investigation 2000 Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS
• Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta.
  The Journal of clinical investigation 2000 Pallone TL, Edwards A, Ma T, Silldorff EP, Verkman AS
• Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method.
  The Journal of general physiology 2000 Song Y, Ma T, Matthay MA, Verkman AS
• Structure and function of aquaporin water channels.
  American journal of physiology. Renal physiology 2000 Verkman AS, Mitra AK
• Misfolding of mutant aquaporin-2 water channels in nephrogenic diabetes insipidus.
  The Journal of biological chemistry 1999 Tamarappoo BK, Yang B, Verkman AS
• Long-wavelength iodide-sensitive fluorescent indicators for measurement of functional CFTR expression in cells.
  The American journal of physiology 1999 Jayaraman S, Teitler L, Skalski B, Verkman AS
• Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels.
  The Journal of biological chemistry 1999 Ma T, Song Y, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS
• Aquaporin water channels in gastrointestinal physiology.
  The Journal of physiology 1999 Ma T, Verkman AS
• Diffusion of green fluorescent protein in the aqueous-phase lumen of endoplasmic reticulum.
  Biophysical journal 1999 Dayel MJ, Hom EF, Verkman AS
• Lessons on renal physiology from transgenic mice lacking aquaporin water channels.
  Journal of the American Society of Nephrology : JASN 1999 Verkman AS
• Fluorescent chloride indicators to assess the efficacy of CFTR cDNA delivery.
  Human gene therapy 1999 Mansoura MK, Biwersi J, Ashlock MA, Verkman AS
• cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus.
  Genomics 1999 Yang B, Ma T, Xu Z, Verkman AS
• Receptor-mediated targeting of fluorescent probes in living cells.
  The Journal of biological chemistry 1999 Farinas J, Verkman AS
• Synthesis and characterization of dual-wavelength Cl--sensitive fluorescent indicators for ratio imaging.
  The American journal of physiology 1999 Jayaraman S, Biwersi J, Verkman AS
• Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice.
  The Journal of clinical investigation 1999 Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS
• Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice.
  The Journal of clinical investigation 1999 Chou CL, Knepper MA, Hoek AN, Brown D, Yang B, Ma T, Verkman AS
• Green fluorescent protein as a probe to study intracellular solute diffusion.
  Methods in enzymology 1999 Verkman AS
• Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice.
  The American journal of physiology 1999 Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS
• Role of aquaporin water channels in kidney and lung.
  The American journal of the medical sciences 1998 Verkman AS
• Vasopressin regulated trafficking of a green fluorescent protein-aquaporin 2 chimera in LLC-PK1 cells.
  Histochemistry and cell biology 1998 Gustafson CE, Levine S, Katsura T, McLaughlin M, Aleixo MD, Tamarappoo BK, Verkman AS, Brown D
• Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, Verkman AS
• A mouse model to test the in vivo efficacy of chemical chaperones.
  Journal of pharmacological and toxicological methods 1998 Bai C, Biwersi J, Verkman AS, Matthay MA
• Analysis of fluorophore diffusion by continuous distributions of diffusion coefficients: application to photobleaching measurements of multicomponent and anomalous diffusion.
  Biophysical journal 1998 Periasamy N, Verkman AS
• Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.
  American journal of respiratory cell and molecular biology 1998 Ma T, Yang B, Matthay MA, Verkman AS
• Isolation and functional analysis of alternative promoters in the human aquaporin-4 water channel gene.
  Genomics 1998 Umenishi F, Verkman AS
• Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones.
  The Journal of clinical investigation 1998 Tamarappoo BK, Verkman AS
• Monte Carlo analysis of obstructed diffusion in three dimensions: application to molecular diffusion in organelles.
  Biophysical journal 1998 Olveczky BP, Verkman AS
• Urea transporter UT3 functions as an efficient water channel. Direct evidence for a common water/urea pathway.
  The Journal of biological chemistry 1998 Yang B, Verkman AS
• High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method.
  Biophysical journal 1998 Carter EP, Olveczky BP, Matthay MA, Verkman AS
• Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS
• Green fluorescent protein as a noninvasive intracellular pH indicator.
  Biophysical journal 1998 Kneen M, Farinas J, Li Y, Verkman AS
• Expression and characterization of the NBD1-R domain region of CFTR: evidence for subunit-subunit interactions.
  Biochemistry 1998 Neville DC, Rozanas CR, Tulk BM, Townsend RR, Verkman AS
• Rapid diffusion of green fluorescent protein in the mitochondrial matrix.
  The Journal of cell biology 1998 Partikian A, Olveczky B, Swaminathan R, Li Y, Verkman AS
• Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels.
  The Journal of biological chemistry 1998 Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS
• Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice.
  The American journal of physiology 1998 Chou CL, Ma T, Yang B, Knepper MA, Verkman AS
• Isolation of the human aquaporin-1 promoter and functional characterization in human erythroleukemia cell lines.
  Genomics 1998 Umenishi F, Verkman AS
• Reconstitution of a regulated transepithelial water pathway in cells transfected with AQP2 and an AQP1/AQP2 hybrid containing the AQP2-C terminus.
  The Journal of membrane biology 1998 Toriano R, Ford P, Rivarola V, Tamarappoo BK, Verkman AS, Parisi M
• Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart.
  Biochemical and biophysical research communications 1997 Ma T, Yang B, Verkman AS
• Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4.
  Journal of cell science 1997 Verbavatz JM, Ma T, Gobin R, Verkman AS
• Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry.
  Protein science : a publication of the Protein Society 1997 Neville DC, Rozanas CR, Price EM, Gruis DB, Verkman AS, Townsend RR
• Mapping fluorophore distributions in three dimensions by quantitative multiple angle-total internal reflection fluorescence microscopy.
  Biophysical journal 1997 Olveczky BP, Periasamy N, Verkman AS
• Identification and characterization of aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response.
  Human molecular genetics 1997 Canfield MC, Tamarappoo BK, Moses AM, Verkman AS, Holtzman EJ
• Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung.
  The Journal of clinical investigation 1997 Carter EP, Umenishi F, Matthay MA, Verkman AS
• Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.
  The Journal of clinical investigation 1997 Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS
• Plasma membrane water permeability of cultured cells and epithelia measured by light microscopy with spatial filtering.
  The Journal of general physiology 1997 Farinas J, Kneen M, Moore M, Verkman AS
• Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13.
  Genomics 1997 Ma T, Yang B, Umenishi F, Verkman AS
• Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus.
  The Journal of cell biology 1997 Seksek O, Biwersi J, Verkman AS
• Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes.
  The Journal of biological chemistry 1997 Yang B, Verkman AS
• Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4.
  Biochemistry 1997 Yang B, van Hoek AN, Verkman AS
• Three-dimensional organization of a human water channel.
  Nature 1997 Cheng A, van Hoek AN, Yeager M, Verkman AS, Mitra AK
• Photobleaching recovery and anisotropy decay of green fluorescent protein GFP-S65T in solution and cells: cytoplasmic viscosity probed by green fluorescent protein translational and rotational diffusion.
  Biophysical journal 1997 Swaminathan R, Hoang CP, Verkman AS
• Aquaporins and ion conductance.
  Science (New York, N.Y.) 1997 Verkman AS, Yang B
• Cell volume and plasma membrane osmotic water permeability in epithelial cell layers measured by interferometry.
  Biophysical journal 1996 Farinas J, Verkman AS
• Distance between Cys-201 in erythrocyte band 3 and the bilayer measured by single-photon radioluminescence.
  Biophysical journal 1996 Thevenin BJ, Bicknese SE, Park J, Verkman AS, Shohet SB
• Sharp increase in rat lung water channel expression in the perinatal period.
  American journal of respiratory cell and molecular biology 1996 Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS
• cDNA cloning of a functional water channel from toad urinary bladder epithelium.
  The American journal of physiology 1996 Ma T, Yang B, Verkman AS
• Cystic fibrosis transmembrane conductance regulator activation stimulates endosome fusion in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Biwersi J, Emans N, Verkman AS
• Identification of protein kinase A phosphorylation sites on NBD1 and R domains of CFTR using electrospray mass spectrometry with selective phosphate ion monitoring.
  Protein science : a publication of the Protein Society 1996 Townsend RR, Lipniunas PH, Tulk BM, Verkman AS
• Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method.
  The Journal of general physiology 1996 Carter EP, Matthay MA, Farinas J, Verkman AS
• Cytoplasmic viscosity near the cell plasma membrane: translational diffusion of a small fluorescent solute measured by total internal reflection-fluorescence photobleaching recovery.
  Biophysical journal 1996 Swaminathan R, Bicknese S, Periasamy N, Verkman AS
• cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13.
  Genomics 1996 Ma T, Yang B, Kuo WL, Verkman AS
• Real-time fluorescence measurement of cell-free endosome fusion: regulation by second messengers.
  Biophysical journal 1996 Emans N, Verkman AS
• Evidence against defective trans-Golgi acidification in cystic fibrosis.
  The Journal of biological chemistry 1996 Seksek O, Biwersi J, Verkman AS
• Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein.
  Cell stress & chaperones 1996 Brown CR, Hong-Brown LQ, Biwersi J, Verkman AS, Welch WJ
• Quantitative analysis of aquaporin mRNA expression in rat tissues by RNase protection assay.
  DNA and cell biology 1996 Umenishi F, Verkman AS, Gropper MA
• Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel.
  Genomics 1996 Ma T, Yang B, Verkman AS
• Salt and water transport across alveolar and distal airway epithelia in the adult lung.
  The American journal of physiology 1996 Matthay MA, Folkesson HG, Verkman AS
• Construction and performance of a photobleaching recovery apparatus with microsecond time resolution.
  Biophysical chemistry 1996 Kao HP, Verkman AS
• Reversible photobleaching of fluorescein conjugates in air-saturated viscous solutions: singlet and triplet state quenching by tryptophan.
  Photochemistry and photobiology 1996 Periasamy N, Bicknese S, Verkman AS
• The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells.
  The Journal of biological chemistry 1996 Yang B, Brown D, Verkman AS
• Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport.
  The Journal of clinical investigation 1996 Folkesson HG, Matthay MA, Frigeri A, Verkman AS
• Selected cysteine point mutations confer mercurial sensitivity to the mercurial-insensitive water channel MIWC/AQP-4.
  Biochemistry 1996 Shi LB, Verkman AS
• Water transport across mammalian cell membranes.
  The American journal of physiology 1996 Verkman AS, van Hoek AN, Ma T, Frigeri A, Skach WR, Mitra A, Tamarappoo BK, Farinas J
• Optical methods to measure membrane transport processes.
  The Journal of membrane biology 1995 Verkman AS
• Structure and function of kidney water channels.
  Kidney international 1995 Verkman AS, Shi LB, Frigeri A, Hasegawa H, Farinas J, Mitra A, Skach W, Brown D, Van Hoek AN, Ma T
• cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.
  The Journal of biological chemistry 1995 Yang B, Ma T, Verkman AS
• Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues.
  Journal of cell science 1995 Frigeri A, Gropper MA, Umenishi F, Kawashima M, Brown D, Verkman AS
• The CHIP28 water channel visualized in ice by electron crystallography.
  Nature structural biology 1995 Mitra AK, van Hoek AN, Wiener MC, Verkman AS, Yeager M
• Anisotropy decay measurement of segmental dynamics of the anion binding domain in erythrocyte band 3.
  Biochemistry 1995 Bicknese S, Rossi M, Thevenin B, Shohet SB, Verkman AS
• Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Katsura T, Verbavatz JM, Farinas J, Ma T, Ausiello DA, Verkman AS, Brown D
• Imaging of endosome fusion in BHK fibroblasts based on a novel fluorimetric avidin-biotin binding assay.
  Biophysical journal 1995 Emans N, Biwersi J, Verkman AS
• Distinct biogenesis mechanisms for the water channels MIWC and CHIP28 at the endoplasmic reticulum.
  Biochemistry 1995 Shi LB, Skach WR, Ma T, Verkman AS
• Cellular distribution of the aquaporins: a family of water channel proteins.
  Histochemistry and cell biology 1995 Brown D, Katsura T, Kawashima M, Verkman AS, Sabolic I
• Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Frigeri A, Gropper MA, Turck CW, Verkman AS
• Detection of water proximity to tryptophan residues in proteins by single photon radioluminescence.
  Biophysical chemistry 1995 Bicknese S, Zimet D, Park J, van Hoek AN, Shohet SB, Verkman AS
• Calculation of resonance energy transfer in crowded biological membranes.
  Biophysical journal 1995 Zimet DB, Thevenin BJ, Verkman AS, Shohet SB, Abney JR
• Cell volume measured by total internal reflection microfluorimetry: application to water and solute transport in cells transfected with water channel homologs.
  Biophysical journal 1995 Farinas J, Simanek V, Verkman AS
• Direct measurement of trans-Golgi pH in living cells and regulation by second messengers.
  The Journal of biological chemistry 1995 Seksek O, Biwersi J, Verkman AS
• Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels.
  Biochemistry 1995 van Hoek AN, Wiener MC, Verbavatz JM, Brown D, Lipniunas PH, Townsend RR, Verkman AS
• Projection structure of the CHIP28 water channel in lipid bilayer membranes at 12-A resolution.
  Biochemistry 1994 Mitra AK, Yeager M, van Hoek AN, Wiener MC, Verkman AS
• A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells.
  The American journal of physiology 1994 Valenti G, Verbavatz JM, Sabolic I, Ausiello DA, Verkman AS, Brown D
• Tracking of single fluorescent particles in three dimensions: use of cylindrical optics to encode particle position.
  Biophysical journal 1994 Kao HP, Verkman AS
• Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter.
  The Journal of biological chemistry 1994 Ma T, Frigeri A, Hasegawa H, Verkman AS
• Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS
• Long-wavelength chloride-sensitive fluorescent indicators.
  Analytical biochemistry 1994 Biwersi J, Tulk B, Verkman AS
• Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum.
  The Journal of cell biology 1994 Skach WR, Shi LB, Calayag MC, Frigeri A, Lingappa VR, Verkman AS
• Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers.
  The Journal of biological chemistry 1994 Shi LB, Skach WR, Verkman AS
• A 28 kDa sarcolemmal antigen in kidney principal cell basolateral membranes: relationship to orthogonal arrays and MIP26.
  Journal of cell science 1994 Verbavatz JM, Van Hoek AN, Ma T, Sabolic I, Valenti G, Ellisman MH, Ausiello DA, Verkman AS, Brown D
• Extrarenal tissue distribution of CHIP28 water channels by in situ hybridization and antibody staining.
  The American journal of physiology 1994 Hasegawa H, Lian SC, Finkbeiner WE, Verkman AS
• Segmental dynamics of the cytoplasmic domain of erythrocyte band 3 determined by time-resolved fluorescence anisotropy: sensitivity to pH and ligand binding.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Thevenin BJ, Periasamy N, Shohet SB, Verkman AS
• Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.
  The Journal of biological chemistry 1994 Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS
• Expression, functional analysis, and in situ hybridization of a cloned rat kidney collecting duct water channel.
  The American journal of physiology 1994 Ma T, Hasegawa H, Skach WR, Frigeri A, Verkman AS
• Functional CFTR in endosomal compartment of CFTR-expressing fibroblasts and T84 cells.
  The American journal of physiology 1994 Biwersi J, Verkman AS
• Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels.
  Biochemical and biophysical research communications 1993 Ma T, Frigeri A, Skach W, Verkman AS
• Nonpolar environment of tryptophans in erythrocyte water channel CHIP28 determined by fluorescence quenching.
  Biochemistry 1993 Farinas J, Van Hoek AN, Shi LB, Erickson C, Verkman AS
• Secondary structure analysis of purified functional CHIP28 water channels by CD and FTIR spectroscopy.
  Biochemistry 1993 Van Hoek AN, Wiener M, Bicknese S, Miercke L, Biwersi J, Verkman AS
• Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study.
  The Journal of cell biology 1993 Verbavatz JM, Brown D, Sabolic I, Valenti G, Ausiello DA, Van Hoek AN, Ma T, Verkman AS
• Localization and functional analysis of CHIP28k water channels in stably transfected Chinese hamster ovary cells.
  The Journal of biological chemistry 1993 Ma T, Frigeri A, Tsai ST, Verbavatz JM, Verkman AS
• Cytoplasmic viscosity near the cell plasma membrane: measurement by evanescent field frequency-domain microfluorimetry.
  Biophysical journal 1993 Bicknese S, Periasamy N, Shohet SB, Verkman AS
• Functional expression of cAMP-dependent and independent urea transporters in Xenopus oocytes.
  The American journal of physiology 1993 Hasegawa H, Verkman AS
• A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k.
  Biochemistry 1993 Zhang R, van Hoek AN, Biwersi J, Verkman AS
• Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28.
  The Journal of cell biology 1993 Zhang R, Skach W, Hasegawa H, van Hoek AN, Verkman AS
• Determinants of the translational mobility of a small solute in cell cytoplasm.
  The Journal of cell biology 1993 Kao HP, Abney JR, Verkman AS
• Tissue-specific expression of mRNA encoding rat kidney water channel CHIP28k by in situ hybridization.
  The American journal of physiology 1993 Hasegawa H, Zhang R, Dohrman A, Verkman AS
• Localization of the CHIP28 water channel in rat kidney.
  The American journal of physiology 1992 Sabolic I, Valenti G, Verbavatz JM, Van Hoek AN, Verkman AS, Ausiello DA, Brown D
• A multifunctional aqueous channel formed by CFTR.
  Science (New York, N.Y.) 1992 Hasegawa H, Skach W, Baker O, Calayag MC, Lingappa V, Verkman AS
• Single photon radioluminescence. I. Theory and spectroscopic properties.
  Biophysical journal 1992 Bicknese S, Shahrokh Z, Shohet SB, Verkman AS
• Single photon radioluminescence. II. Signal detection and biological applications.
  Biophysical journal 1992 Shahrokh Z, Bicknese S, Shohet SB, Verkman AS
• Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping ATPase.
  The Journal of cell biology 1992 Sabolic I, Wuarin F, Shi LB, Verkman AS, Ausiello DA, Gluck S, Brown D
• Organic osmolytes increase cytoplasmic viscosity in kidney cells.
  The American journal of physiology 1992 Periasamy N, Kao HP, Fushimi K, Verkman AS
• Second messengers regulate endosomal acidification in Swiss 3T3 fibroblasts.
  The Journal of cell biology 1992 Zen K, Biwersi J, Periasamy N, Verkman AS
• Functional reconstitution of the isolated erythrocyte water channel CHIP28.
  The Journal of biological chemistry 1992 van Hoek AN, Verkman AS
• Optical measurement of osmotic water transport in cultured cells. Role of glucose transporters.
  The Journal of general physiology 1992 Echevarria M, Verkman AS
• Subtraction of background fluorescence in multiharmonic frequency-domain fluorimetry.
  Analytical biochemistry 1992 Periasamy N, Verkman AS
• Calcium-dependent regulation of Cl secretion in tracheal epithelium.
  The American journal of physiology 1992 Hartmann T, Kondo M, Mochizuki H, Verkman AS, Widdicombe JH
• Protein kinase A dependent membrane protein phosphorylation and chloride conductance in endosomal vesicles from kidney cortex.
  Biochemistry 1992 Reenstra WW, Sabolic I, Bae HR, Verkman AS
• Proteinases inhibit H(+)-ATPase and Na+/H+ exchange but not water transport in apical and endosomal membranes from rat proximal tubule.
  Biochimica et biophysica acta 1992 Sabolic I, Shi LB, Brown D, Ausiello DA, Verkman AS
• Construction and performance of a rapid scan monochromator for multiwavelength fluorimetry.
  Analytical biochemistry 1992 Hartmann T, Verkman AS
• Hormonal regulation of Cl transport in polar airway epithelia measured by a fluorescent indicator.
  The American journal of physiology 1992 Verkman AS, Chao AC, Hartmann T
• Synthesis of cell-impermeable Cl-sensitive fluorescent indicators with improved sensitivity and optical properties.
  The American journal of physiology 1992 Biwersi J, Farah N, Wang YX, Ketcham R, Verkman AS
• Water channels in cell membranes.
  Annual review of physiology 1992 Verkman AS
• Picosecond rotation of small polar fluorophores in the cytosol of sea urchin eggs.
  Biochemistry 1991 Periasamy N, Armijo M, Verkman AS
• Evidence from oocyte expression that the erythrocyte water channel is distinct from band 3 and the glucose transporter.
  The Journal of clinical investigation 1991 Zhang R, Alper SL, Thorens B, Verkman AS
• Cell-permeable fluorescent indicator for cytosolic chloride.
  Biochemistry 1991 Biwersi J, Verkman AS
• Solvent drag measurement of transcellular and basolateral membrane NaCl reflection coefficient in kidney proximal tubule.
  The Journal of general physiology 1991 Shi LB, Fushimi K, Verkman AS
• Transcellular water flow modulates water channel exocytosis and endocytosis in kidney collecting tubule.
  The Journal of clinical investigation 1991 Kuwahara M, Shi LB, Marumo F, Verkman AS
• Transport mechanisms in kidney proximal tubule examined using chloride-sensitive fluorescent indicators.
  Kidney international. Supplement 1991 Verkman AS, Shi LB, Bae HR, Fushimi K
• Distance between skeletal protein 4.1 and the erythrocyte membrane bilayer measured by resonance energy transfer.
  The Journal of biological chemistry 1991 Shahrokh Z, Verkman AS, Shohet SB
• Heterogeneity in ATP-dependent acidification in endocytic vesicles from kidney proximal tubule. Measurement of pH in individual endocytic vesicles in a cell-free system.
  Biophysical journal 1991 Shi LB, Fushimi K, Bae HR, Verkman AS
• Construction and evaluation of a frequency-domain epifluorescence microscope for lifetime and anisotropy decay measurements in subcellular domains.
  Biophysical chemistry 1991 Verkman AS, Armijo M, Fushimi K
• Functional water channels and proton pumps are in separate populations of endocytic vesicles in toad bladder granular cells.
  Biochemistry 1991 Wang YX, Shi LB, Verkman AS
• High channel-mediated water permeability in rabbit erythrocytes: characterization in native cells and expression in Xenopus oocytes.
  Biochemistry 1991 Tsai ST, Zhang RB, Verkman AS
• Low viscosity in the aqueous domain of cell cytoplasm measured by picosecond polarization microfluorimetry.
  The Journal of cell biology 1991 Fushimi K, Verkman AS
• Relationship between vasopressin-sensitive water transport and plasma membrane fluidity in kidney collecting tubule.
  The American journal of physiology 1991 Fushimi K, Verkman AS
• Water and urea permeability properties of Xenopus oocytes: expression of mRNA from toad urinary bladder.
  The American journal of physiology 1991 Zhang RB, Verkman AS
• Protein kinase A regulates chloride conductance in endocytic vesicles from proximal tubule.
  Nature 1990 Bae HR, Verkman AS
• Endocytosis of water channels in rat kidney: cell specificity and correlation with in vivo antidiuresis.
  The American journal of physiology 1990 Lencer WI, Brown D, Ausiello DA, Verkman AS
• Regulation of the formation and water permeability of endosomes from toad bladder granular cells.
  The Journal of general physiology 1990 Shi LB, Wang YX, Verkman AS
• Expression of mRNA coding for kidney and red cell water channels in Xenopus oocytes.
  The Journal of biological chemistry 1990 Zhang RB, Logee KA, Verkman AS
• Development and biological applications of chloride-sensitive fluorescent indicators.
  The American journal of physiology 1990 Verkman AS
• Urea transport in freshly isolated and cultured cells from rat inner medullary collecting duct.
  The Journal of membrane biology 1990 Zhang RB, Verkman AS
• Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase.
  The Journal of cell biology 1990 Lencer WI, Verkman AS, Arnaout MA, Ausiello DA, Brown D
• Model of ion transport regulation in chloride-secreting airway epithelial cells. Integrated description of electrical, chemical, and fluorescence measurements.
  Biophysical journal 1990 Hartmann T, Verkman AS
• Water, proton, and urea transport in toad bladder endosomes that contain the vasopressin-sensitive water channel.
  The Journal of general physiology 1990 Shi LB, Brown D, Verkman AS
• Fibre optic sensor for the detection of potassium using fluorescence energy transfer.
  The Analyst 1990 Roe JN, Szoka FC, Verkman AS
• [Characterization of proton pump and osmotic water transport in endocytic vesicles from rat kidney proximal tubule].
  Sheng li xue bao : [Acta physiologica Sinica] 1990 Shi LB, Ye RG, Lencer WI, Verkman AS
• Pyrene eximer mapping in cultured fibroblasts by ratio imaging and time-resolved microscopy.
  Biochemistry 1990 Dix JA, Verkman AS
• Cell membrane fluidity in the intact kidney proximal tubule measured by orientation-independent fluorescence anisotropy imaging.
  Biophysical journal 1990 Fushimi K, Dix JA, Verkman AS
• Chloride conductive and cotransport mechanisms in cultures of canine tracheal epithelial cells measured by an entrapped fluorescent indicator.
  The Journal of membrane biology 1990 Chao AC, Widdicombe JH, Verkman AS
• FITC-dextran as a probe for endosome function and localization in kidney.
  The American journal of physiology 1990 Lencer WI, Weyer P, Verkman AS, Ausiello DA, Brown D
• Mapping of fluorescence anisotropy in living cells by ratio imaging. Application to cytoplasmic viscosity.
  Biophysical journal 1990 Dix JA, Verkman AS
• The cellular action of antidiuretic hormone.
  Methods in enzymology 1990 Brown D, Verkman A, Skorecki K, Ausiello D
• Functional water channels are present in clathrin-coated vesicles from bovine kidney but not from brain.
  The Journal of biological chemistry 1989 Verkman AS, Weyer P, Brown D, Ausiello DA
• Fluorescence measurement of chloride transport in monolayer cultured cells. Mechanisms of chloride transport in fibroblasts.
  Biophysical journal 1989 Chao AC, Dix JA, Sellers MC, Verkman AS
• Very high water permeability in vasopressin-induced endocytic vesicles from toad urinary bladder.
  The Journal of general physiology 1989 Shi LB, Verkman AS
• Mechanisms and regulation of water permeability in renal epithelia.
  The American journal of physiology 1989 Verkman AS
• Pre-steady-state analysis of the turn-on and turn-off of water permeability in the kidney collecting tubule.
  The Journal of membrane biology 1989 Kuwahara M, Verkman AS
• Mechanism of acridine orange interaction with phospholipids and proteins in renal microvillus vesicles.
  Biophysical chemistry 1989 Holmberg EG, Verkman AS, Dix JA
• Optical measurement of aqueous potassium concentration by a hydrophobic indicator in lipid vesicles.
  Biophysical chemistry 1989 Roe JN, Szoka FC, Verkman AS
• Fluorescence depolarization of cis- and trans-parinaric acids in artificial and red cell membranes resolved by a double hindered rotational model.
  Biochemistry 1989 Calafut TM, Dix JA, Verkman AS
• NaCl reflection coefficients in proximal tubule apical and basolateral membrane vesicles. Measurement by induced osmosis and solvent drag.
  Biophysical journal 1989 Pearce D, Verkman AS
• Quantitative fluorescence measurement of chloride transport mechanisms in phospholipid vesicles.
  Biochemistry 1989 Verkman AS, Takla R, Sefton B, Basbaum C, Widdicombe JH
• Functional colocalization of water channels and proton pumps in endosomes from kidney proximal tubule.
  The Journal of general physiology 1989 Ye RG, Shi LB, Lencer WI, Verkman AS
• Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications.
  Analytical biochemistry 1989 Verkman AS, Sellers MC, Chao AC, Leung T, Ketcham R
• Simultaneous optical measurement of osmotic and diffusional water permeability in cells and liposomes.
  Biochemistry 1989 Ye RG, Verkman AS
• Chloride transport across placental microvillous membranes measured by fluorescence.
  The American journal of physiology 1988 Illsley NP, Glaubensklee C, Davis B, Verkman AS
• Macromolecule entrapment in human placental microvillous membrane vesicles.
  Analytical biochemistry 1988 Illsley NP, Goodman JG, Verkman AS, Davis B
• Direct fluorescence measurement of diffusional water permeability in the vasopressin-sensitive kidney collecting tubule.
  Biophysical journal 1988 Kuwahara M, Verkman AS
• Osmotic gradient dependence of osmotic water permeability in rabbit proximal convoluted tubule.
  The Journal of membrane biology 1988 Berry CA, Verkman AS
• Rapid development of vasopressin-induced hydroosmosis in kidney collecting tubules measured by a new fluorescence technique.
  Biophysical journal 1988 Kuwahara M, Berry CA, Verkman AS
• Chloride transport in apical membrane vesicles from bovine tracheal epithelium: characterization using a fluorescent indicator.
  The Journal of membrane biology 1988 Fong P, Illsley NP, Widdicombe JH, Verkman AS
• Very low osmotic water permeability and membrane fluidity in isolated toad bladder granules.
  The Journal of membrane biology 1988 Verkman AS, Masur SK
• Rapid fluorescence assay of glucose and neutral solute transport using an entrapped volume indicator.
  Analytical biochemistry 1988 Kim YK, Illsley NP, Verkman AS
• Membrane water and solute permeability determined quantitatively by self-quenching of an entrapped fluorophore.
  Biochemistry 1988 Chen PY, Pearce D, Verkman AS
• Estimation of intracellular chloride activity in isolated perfused rabbit proximal convoluted tubules using a fluorescent indicator.
  Biophysical journal 1988 Krapf R, Berry CA, Verkman AS
• Endosomes from kidney collecting tubule cells contain the vasopressin-sensitive water channel.
  Nature 1988 Verkman AS, Lencer WI, Brown D, Ausiello DA
• Lipid-phase structure in epithelial cell membranes: comparison of renal brush border and basolateral membranes.
  Biochemistry 1988 Illsley NP, Lin HY, Verkman AS
• Structure-activity relationships of chloride-sensitive fluorescent indicators for biological application.
  Analytical biochemistry 1988 Krapf R, Illsley NP, Tseng HC, Verkman AS
• Sodium-dependent chloride transport in basolateral membrane vesicles isolated from rabbit proximal tubule.
  Biochemistry 1988 Chen PY, Verkman AS
• Renal brush-border chloride transport mechanisms characterized using a fluorescent indicator.
  The American journal of physiology 1988 Chen PY, Illsley NP, Verkman AS
• Vasopressin-sensitive adenylate cyclase: subunit interactions assessed by target analysis and computer modelling.
  Kidney international. Supplement 1987 Ausiello DA, Verkman AS, Skorecki KL
• Passive H+/OH- permeability in epithelial brush border membranes.
  Journal of bioenergetics and biomembranes 1987 Verkman AS
• Mechanism and kinetics of merocyanine 540 binding to phospholipid membranes.
  Biochemistry 1987 Verkman AS
• Human platelet diffusional water permeability measured by nuclear magnetic resonance.
  The American journal of physiology 1987 Wong KR, Verkman AS
• Non-electrolyte transport across renal proximal tubule cell membranes measured by tracer efflux and light scattering.
  Pflugers Archiv : European journal of physiology 1987 Chen PY, Verkman AS
• Proton nuclear magnetic resonance measurement of diffusional water permeability in suspended renal proximal tubules.
  Biophysical journal 1987 Verkman AS, Wong KR
• Kinetic transport model for cellular regulation of pH and solute concentration in the renal proximal tubule.
  Biophysical journal 1987 Verkman AS, Alpern RJ
• Membrane chloride transport measured using a chloride-sensitive fluorescent probe.
  Biochemistry 1987 Illsley NP, Verkman AS
• Vasopressin signaling in kidney cells.
  Kidney international 1987 Ausiello DA, Skorecki KL, Verkman AS, Bonventre JV
• Cross talk between stimulatory and inhibitory guanosine 5'-triphosphate binding proteins: role in activation and desensitization of the adenylate cyclase response to vasopressin.
  Biochemistry 1987 Skorecki KL, Verkman AS, Ausiello DA
• Lipid domain structure correlated with membrane protein function in placental microvillus vesicles.
  Biochemistry 1987 Illsley NP, Lin HY, Verkman AS
• Evidence for water channels in renal proximal tubule cell membranes.
  The Journal of membrane biology 1987 Meyer MM, Verkman AS
• Renal basolateral membrane anion transporter characterized by a fluorescent disulfonic stilbene.
  The Journal of membrane biology 1987 Chen PY, Verkman AS
• Mechanism of coupling between Cl- and OH- transport in renal brush-border membranes.
  Biochimica et biophysica acta 1986 Ives HE, Chen PY, Verkman AS
• Localization of cyanine dye binding to brush-border membranes by quenching of n-(9-anthroyloxy) fatty acid probes.
  Biochimica et biophysica acta 1986 Cabrini G, Verkman AS
• External anions regulate stilbene-sensitive proton transport in placental brush border vesicles.
  Biochemistry 1986 Cabrini G, Illsley NP, Verkman AS
• Human platelet osmotic water and nonelectrolyte transport.
  The American journal of physiology 1986 Meyer MM, Verkman AS
• Target molecular weights for red cell band 3 stilbene and mercurial binding sites.
  The American journal of physiology 1986 Verkman AS, Skorecki KL, Jung CY, Ausiello DA
• Mechanisms of nonhormonal activation of adenylate cyclase based on target analysis.
  Biochemistry 1986 Verkman AS, Ausiello DA, Jung CY, Skorecki KL
• Anomalous driving force for renal brush border H+/OH-transport characterized by using 6-carboxyfluorescein.
  Biochemistry 1986 Verkman AS, Ives HE
• Water permeability and fluidity of renal basolateral membranes.
  The American journal of physiology 1986 Verkman AS, Ives HE
• Water and nonelectrolyte permeability in brain synaptosomes isolated from normal and uremic rats.
  The American journal of physiology 1986 Verkman AS, Fraser CL
• Binding of chloride and a disulfonic stilbene transport inhibitor to red cell band 3.
  The Journal of membrane biology 1986 Dix JA, Verkman AS, Solomon AK
• Evidence for vasopressin activation of adenylate cyclase by subunit dissociation.
  The American journal of physiology 1986 Skorecki KL, Verkman AS, Jung CY, Ausiello DA
• Mechanism of interaction of the cyanine dye diS-C3-(5) with renal brush-border vesicles.
  The Journal of membrane biology 1986 Cabrini G, Verkman AS
• Potential-sensitive response mechanism of diS-C3-(5) in biological membranes.
  The Journal of membrane biology 1986 Cabrini G, Verkman AS
• Quenching of red cell tryptophan fluorescence by mercurial compounds.
  Membrane biochemistry 1986 Verkman AS, Lukacovic MF, Tinklepaugh MS, Dix JA
• Radiation inactivation of multimeric enzymes: application to subunit interactions of adenylate cyclase.
  The American journal of physiology 1986 Verkman AS, Skorecki KL, Ausiello DA
• Serial permeability barriers to water transport in human placental vesicles.
  The Journal of membrane biology 1986 Illsley NP, Verkman AS
• Vasopressin receptor-adenylate cyclase interactions. Studies in an intact cultured renal epithelial cell line (LLC-PK1).
  Mineral and electrolyte metabolism 1986 Skorecki KL, Verkman AS, Ausiello DA
• Target analysis studies of red cell water and urea transport.
  Biochimica et biophysica acta 1985 Dix JA, Ausiello DA, Jung CY, Verkman AS
• Temperature-jump studies of merocyanine 540 relaxation kinetics in lipid bilayer membranes.
  Biochemistry 1985 Verkman AS, Frosch MP
• Effects of membrane fluidizing agents on renal brush border proton permeability.
  The American journal of physiology 1985 Ives HE, Verkman AS
• Radiation inactivation studies of renal brush border water and urea transport.
  The American journal of physiology 1985 Verkman AS, Dix JA, Seifter JL, Skorecki KL, Jung CY, Ausiello DA
• n-Alkanols and halothane inhibit red cell anion transport and increase band 3 conformational change rate.
  Biochemistry 1985 Forman SA, Verkman AS, Dix JA, Solomon AK
• Water and urea transport in renal microvillus membrane vesicles.
  The American journal of physiology 1985 Verkman AS, Dix JA, Seifter JL
• Specific interaction of the water transport inhibitor, pCMBS, with band 3 in red blood cell membranes.
  Biochimica et biophysica acta 1984 Lukacovic MF, Verkman AS, Dix JA, Solomon AK
• Effect of unstirred layers on binding and reaction kinetics at a membrane surface.
  Analytical biochemistry 1984 Verkman AS, Dix JA
• Radiation inactivation of oligomeric enzyme systems: theoretical considerations.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Verkman AS, Skorecki K, Ausiello DA
• Anion transport inhibitor binding to band 3 in red blood cell membranes.
  The Journal of general physiology 1983 Verkman AS, Dix JA, Solomon AK
• The aqueous pore in the red cell membrane: band 3 as a channel for anions, cations, nonelectrolytes, and water.
  Annals of the New York Academy of Sciences 1983 Solomon AK, Chasan B, Dix JA, Lukacovic MF, Toon MR, Verkman AS
• A stepwise mechanism for the permeation of phloretin through a lipid bilayer.
  The Journal of general physiology 1982 Verkman AS, Solomon AK
• Interaction of phloretin with the anion transport protein of the red blood cell membrane.
  Biochimica et biophysica acta 1982 Forman SA, Verkman AS, Dix JA, Solomon AK
• A simple stopped-flow temperature-jump apparatus.
  Analytical biochemistry 1981 Verkman AS, Dix JA, Pandiscio AA
• The quenching of an intramembrane fluorescent probe. A method to study the binding and permeation of phloretin through bilayers.
  Biochimica et biophysica acta 1980 Verkman AS
• Kinetics of phloretin binding to phosphatidylcholine vesicle membranes.
  The Journal of general physiology 1980 Verkman AS, Solomon AK
• An improved temperature-jump apparatus.
  Analytical biochemistry 1980 Verkman AS, Pandiscio AA, Jennings M, Solomon AK
• Human erythrocyte anion exchange site characterised using a fluorescent probe.
  Nature 1979 Dix JA, Verkman AS, Solomon AK, Cantley LC