Hunter Shain, PhD
Associate Professor
Dermatology
School of Medicine

Education & Training

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• Ph.D. Cancer Biology Stanford University 04/2012
• B.S. Biochemistry University of Illinois 05/2006
• Postdoctoral Fellow University of California San Francisco

Interests

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• Dermatology
• Single-cell
• Melanoma
• Cutaneous squamous cell carcinoma
• Genomics
• Skin Cancer
• Genetics

Websites

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• @@ShainLab on Twitter (twitter.com)
• Publications (scholar.google.com)
• Shain Lab (shainlab.ucsf.edu)

Publications (41)

Top publication keywords:
ExomeNevus, PigmentedHealthMelanocytesMAP Kinase Signaling SystemCell Transformation, NeoplasticEvolution, MolecularGenomicsMutationSkin NeoplasmsUltraviolet RaysMelanomaFormaldehydeCarcinogenesisNeoplasms, Second Primary

• The genetic evolution of metastatic uveal melanoma.
  Nature genetics 2019 Shain AH, Bagger MM, Yu R, Chang D, Liu S, Vemula S, Weier JF, Wadt K, Heegaard S, Bastian BC, Kiilgaard JF
• Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution.
  Cancer cell 2018 Shain AH, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC
• From melanocytes to melanomas.
  Nature reviews. Cancer 2016 Shain AH, Bastian BC
• The Genetic Evolution of Melanoma from Precursor Lesions.
  The New England journal of medicine 2015 Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC
• Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
  Nature genetics 2015 Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, …
• The spectrum of SWI/SNF mutations, ubiquitous in human cancers.
  PloS one 2013 Shain AH, Pollack JR
• Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M, Maitra A, Pollack JR

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• A single-cell atlas of IL-23 inhibition in cutaneous psoriasis distinguishes clinical response.
  Science immunology 2024 Wu D, Hailer AA, Wang S, Yuan M, Chan J, El Kurdi A, Han D, Ali H, D'Angio B, Mayer A, Rahim M, Kondo A, Klufas D, Kim E, Shain AH, Choi J, Bhutani T, Simpson G, Grekin RC, Ricardo-Gonzalez R, Purdom …
• A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma.
  Cell 2024 Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Vanwynsberghe L, Nowosad A, Roda N, Makhzami S, Bervoets G, Maciel LF, Pulido-Vicuña CA, Pollaris L, Seurinck R, Zhao F, Flem-Karlsen K, …
• STmut: a framework for visualizing somatic alterations in spatial transcriptomics data of cancer.
  Genome biology 2023 Chen L, Chang D, Tandukar B, Deivendran D, Pozniak J, Cruz-Pacheco N, Cho RJ, Cheng J, Yeh I, Marine C, Bastian BC, Ji AL, Shain AH
• The genetic evolution of acral melanoma.
  bioRxiv : the preprint server for biology 2023 Wang M, Fukushima S, Sheen YS, Ramelyte E, Pacheco NC, Shi C, Liu S, Banik I, Aquino JD, Acosta MS, Levesque M, Dummer R, Liau JY, Chu CY, Shain AH, Yeh I, Bastian BC
• Melanoma Genomics: Shifting Focus from Inter- to Intrapatient Variation.
  Cancer discovery 2023 Shain AH
• Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes.
  Genome medicine 2022 Wang M, Banik I, Shain AH, Yeh I, Bastian BC
• Hepatocellular neoplasms with loss of liver fatty acid binding protein: Clinicopathologic features and molecular profiling.
  Human pathology 2022 Joseph NM, Blank A, Shain AH, Gill RM, Umetsu SE, Shafizadeh N, Torbenson MS, Kakar S
• BRAFV600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB.
  eLife 2021 McNeal AS, Belote RL, Zeng H, Urquijo M, Barker K, Torres R, Curtin M, Shain AH, Andtbacka RH, Holmen S, Lum DH, McCalmont TH, VanBrocklin MW, Grossman D, Wei ML, Lang UE, Judson-Torres RL
• The landscape of driver mutations in cutaneous squamous cell carcinoma.
  NPJ genomic medicine 2021 Chang D, Shain AH
• Two Trajectories to Melanoma on the Hands and Feet.
  JAMA dermatology 2021 Shain AH
• UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma.
  Life science alliance 2021 Bowman RL, Hennessey RC, Weiss TJ, Tallman DA, Crawford ER, Murphy BM, Webb A, Zhang S, La Perle KM, Burd CJ, Levine RL, Shain AH, Burd CE
• Publisher Correction: The genomic landscapes of individual melanocytes from human skin.
  Nature 2021 Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH
• The genomic landscapes of individual melanocytes from human skin.
  Nature 2020 Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH
• Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma.
  Nature communications 2020 Cao W, Lee H, Wu W, Zaman A, McCorkle S, Yan M, Chen J, Xing Q, Sinnott-Armstrong N, Xu H, Sailani MR, Tang W, Cui Y, Liu J, Guan H, Lv P, Sun X, Sun L, Han P, Lou Y, Chang J, Wang J, Gao Y, Guo J, …
• Author Correction: From melanocytes to melanomas.
  Nature reviews. Cancer 2020 Shain AH, Bastian BC
• Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses.
  Cell reports 2019 Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC
• The Evolution of Melanoma - Moving beyond Binary Models of Genetic Progression.
  The Journal of investigative dermatology 2019 Zeng H, Judson-Torres RL, Shain AH
• Targeted Genomic Profiling of Acral Melanoma.
  Journal of the National Cancer Institute 2019 Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM
• MicroRNA Ratios Distinguish Melanomas from Nevi.
  The Journal of investigative dermatology 2019 Torres R, Lang UE, Hejna M, Shelton SJ, Joseph NM, Shain AH, Yeh I, Wei ML, Oldham MC, Bastian BC, Judson-Torres RL
• Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma.
  The Journal of pathology 2019 Joseph NM, Tsokos CG, Umetsu SE, Shain AH, Kelley RK, Onodera C, Bowman S, Talevich E, Ferrell LD, Kakar S, Krings G
• The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
  Pigment cell & melanoma research 2018 Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E,…
• Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation.
  Cancer cell 2018 Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL
• Filling the gaps in the genomic catalogue of melanoma subtypes.
  Pigment cell & melanoma research 2017 Shain AH, Bastian BC
• Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi.
  Nature communications 2017 Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A
• Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.
  Science (New York, N.Y.) 2017 Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D
• NTRK3 kinase fusions in Spitz tumours.
  The Journal of pathology 2016 Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC
• CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing.
  PLoS computational biology 2016 Talevich E, Shain AH, Botton T, Bastian BC
• The Genetic Evolution of Melanoma.
  The New England journal of medicine 2016 Shain AH, Bastian BC
• Activating MET kinase rearrangements in melanoma and Spitz tumours.
  Nature communications 2015 Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC
• Integrative genomic and functional profiling of the pancreatic cancer genome.
  BMC genomics 2013 Shain AH, Salari K, Giacomini CP, Pollack JR
• Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types.
  PLoS genetics 2013 Giacomini CP, Sun S, Varma S, Shain AH, Giacomini MM, Balagtas J, Sweeney RT, Lai E, Del Vecchio CA, Forster AD, Clarke N, Montgomery KD, Zhu S, Wong AJ, van de Rijn M, West RB, Pollack JR
• Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma.
  Cancer research 2012 Del Vecchio CA, Jensen KC, Nitta RT, Shain AH, Giacomini CP, Wong AJ
• SMURF1 amplification promotes invasiveness in pancreatic cancer.
  PloS one 2011 Kwei KA, Shain AH, Bair R, Montgomery K, Karikari CA, van de Rijn M, Hidalgo M, Maitra A, Bashyam MD, Pollack JR
• Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Tseng WW, Winer D, Kenkel JA, Choi O, Shain AH, Pollack JR, French R, Lowy AM, Engleman EG