Alan Baik, MD
Assistant Professor
Medicine
School of Medicine

Cancer patients are at increased risk of cardiovascular disease, and this can be further exacerbated by their cancer-directed therapies, which can cause a myriad of cardiovascular problems, such as cardiomyopathy, heart failure, arrhythmias, hypertension, pericardial disease, valvular disease, and metabolic syndrome. I work closely with oncologists and other providers in a multidisciplinary team to optimize the cardiovascular care of cancer patients.

I am also a physician-scientist with a research focus on how cells, tissues, and organisms respond and adapt to low oxygen (hypoxia) and high oxygen (hyperoxia) states. I am studying novel ways cells and tissues respond to states of low oxygen and why high oxygen is toxic at the cellular and systemic levels.

• Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.
  Molecular cell 2023 Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH
• Editorial commentary: Immune checkpoint inhibitors and the cardiovascular system: Reflecting on the past and looking towards the future.
  Trends in cardiovascular medicine 2022 Baik AH
• Hypoxia signaling and oxygen metabolism in cardio-oncology.
  Journal of molecular and cellular cardiology 2022 Baik AH
• Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review.
  JAMA cardiology 2021 Lehmann LH, Cautela J, Palaskas N, Baik AH, Meijers WC, Allenbach Y, Alexandre J, Rassaf T, Müller OJ, Aras M, Asnani AH, Deswal A, Laufer-Perl M, Thuny F, Kerneis M, Hayek SS, Ederhy S, Salem JE, …
• Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies.
  Circulation research 2021 Baik AH, Oluwole OO, Johnson DB, Shah N, Salem JE, Tsai KK, Moslehi JJ
• Preclinical Models of Cancer Therapy-Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association.
  Circulation research 2021 Asnani A, Moslehi JJ, Adhikari BB, Baik AH, Beyer AM, de Boer RA, Ghigo A, Grumbach IM, Jain S, Zhu H, American Heart Association Council on Basic Cardiovascular Sciences; Cardio-Oncology Science …
• Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors.
  Clinical science (London, England : 1979) 2021 Baik AH, Tsai KK, Oh DY, Aras MA
• Abstract 14843: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Associated Myocarditis.
  Circulation 2020 John R Power, Joachim Alexandre, Arrush Choudhary, benay ozbay, Nicolas L Palaskas, Lorenz H Lehmann, Daniel Finke, Jennifer Cautela, Franck Thuny, Yuichi Tamura, Salim S Hayek, Tariq U Azam, Aarti …
• Abstract 15365: Natural History of Immune Checkpoint Inhibitor Associated Myocarditis With Preserved Ejection Fraction.
  Circulation 2020 Joseph Nowatzke, John R Power, Wouter C Meijers, Olusola Orimoloye, Charlotte Fenioux, Yuichi Tamura, Jennifer Cautela, Lorenz H Lehmann, Daniel Finke, Salim Hayek, Tariq U Azam, Aarti Asnani, Tyler …
• Turning the Oxygen Dial: Balancing the Highs and Lows.
  Trends in cell biology 2020 Baik AH, Jain IH
• EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.
  Cell 2016 Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG
• EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.
  Cell 2016 Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG
• ACUTE HYPOXIA-INDUCIBLE FACTOR EGLN1 INACTIVATION PROTECTS AGAINST ISCHEMIA-REPERFUSION INJURY BY REGULATION OF GLUCOSE OXIDATION AND REACTIVE OXYGEN SPECIES GENERATION.
  Journal of the American College of Cardiology 2013 Alan Baik, Ben Olenchock, Javid Moslehi, William G. Kaelin
• Genetic subdivision of chemosynthetic endosymbionts of Solemya velum along the Southern New England coast.
  Applied and environmental microbiology 2009 Stewart FJ, Baik AH, Cavanaugh CM