Akiko Hata, PhD
Professor
Cardiovascular Research Inst
School of Medicine

Education & Training

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• Diversity, Equity and Inclusion Training University of California, San Francisco 09/2020
• Post-doc Signaling, Cell Biology Memorial Sloan-Kettering Cancer Institute 05/2000
• PhD Signaling, Virology The Rockefeller University 04/1995
• MS Molecular Biology University of Tokyo 04/1990

Grants and Projects

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• Elucidating the structural insights into the BMP receptor, NIH/NHLBI, 2023-2027
• Molecular pathogenesis of pulmonary arterial hypertension, NIH, 2021-2025
• Role of DNA damage in Pulmonary Artery Hypertension, TRDRP, 2018-2023
• Identification of a novel modulator of Pulmonary Artery Hypertension, NIH, 2016-2021
• FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease, NIH, 2017-2018
• Role of the PDGF signaling pathway in pulmonary artery hypertension, NIH, 2013-2018
• FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease, NIH, 2015-2016
• Mechanisms of TGFB Signal Transduction, NIH, 2002-2016
• Role of miRNAs in Vascular Physiology, NIH, 2009-2014
• Role of BMPRII Mutants in the Pathogenesis of Pulmonary Hypertension, NIH, 2006-2011
• Mechanisms of TGFB Signal Transduction, NIH, 2003-2010
• Elucidating the structural insights into the BMP receptor, NHLBI

Publications (68)

Top publication keywords:
Ribonuclease IIITelangiectasia, Hereditary HemorrhagicBone Morphogenetic ProteinsMicroRNAsRNA Processing, Post-TranscriptionalMuscle, Smooth, VascularBone Morphogenetic Protein 4Myocytes, Smooth MuscleSmad ProteinsTrans-ActivatorsSignal TransductionBone Morphogenetic Protein Receptors, Type IITransforming Growth Factor betaGene Expression RegulationMuscle Proteins

• Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.
  Current opinion in hematology 2019 Hata A, Lagna G
• Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
  Communications biology 2018 Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A
• Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.
  American journal of physiology. Heart and circulatory physiology 2018 Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR
• Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.
  Science signaling 2018 Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A
• Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
  Circulation 2017 Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, …
• Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.
  Nature communications 2017 Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A
• Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.
  Science signaling 2017 Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A
• Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.
  eLife 2017 Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL
• Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.
  Science signaling 2016 Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A
• Dysregulation of microRNA biogenesis machinery in cancer.
  Critical reviews in biochemistry and molecular biology 2015 Hata A, Kashima R
• Targeting BMP signalling in cardiovascular disease and anaemia.
  Nature reviews. Cardiology 2015 Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD
• Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease.
  Circulation journal : official journal of the Japanese Circulation Society 2015 Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A
• The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis.
  BMB reports 2015 Kang H, Hata A
• Dysregulation of microRNA biogenesis and gene silencing in cancer.
  Science signaling 2015 Hata A, Lieberman J
• Functions of the bone morphogenetic protein signaling pathway through microRNAs (review).
  International journal of molecular medicine 2015 Hata A, Kang H
• Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation.
  Journal of cellular biochemistry 2014 Kim S, Hata A, Kang H
• Cardiovascular applications of therapeutic ultrasound.
  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2013 Nazer B, Gerstenfeld EP, Hata A, Crum LA, Matula TJ
• Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.
  The EMBO journal 2013 Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A
• Atrial natriuretic peptide is negatively regulated by microRNA-425.
  The Journal of clinical investigation 2013 Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, …
• Role of microRNAs in lung development and pulmonary diseases.
  Pulmonary circulation 2013 Sessa R, Hata A
• Regulation of miRNA biogenesis as an integrated component of growth factor signaling.
  Current opinion in cell biology 2013 Blahna MT, Hata A
• Functions of microRNAs in cardiovascular biology and disease.
  Annual review of physiology 2012 Hata A
• Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway.
  The Journal of biological chemistry 2012 Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A
• Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.
  The Journal of biological chemistry 2012 Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G
• MicroRNA regulation of smooth muscle gene expression and phenotype.
  Current opinion in hematology 2012 Kang H, Hata A
• Smad-mediated regulation of microRNA biosynthesis.
  FEBS letters 2012 Blahna MT, Hata A
• Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.
  The Journal of biological chemistry 2011 Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A
• MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling.
  Cardiovascular research 2011 McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH
• Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation.
  Arteriosclerosis, thrombosis, and vascular biology 2011 Davis-Dusenbery BN, Wu C, Hata A
• Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.
  Molecular and cellular biology 2011 Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A
• down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4.
  The Journal of biological chemistry 2011 Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A
• Regulation of pri-miRNA Processing Through Smads.
  Advances in experimental medicine and biology 2011 Hata A, Davis BN
• Smad-mediated miRNA processing: a critical role for a conserved RNA sequence.
  RNA biology 2011 Davis-Dusenbery BN, Hata A
• The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway.
  Molecular and cellular biology 2010 Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A
• MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways.
  Genes & cancer 2010 Davis-Dusenbery BN, Hata A
• Mechanisms of control of microRNA biogenesis.
  Journal of biochemistry 2010 Davis-Dusenbery BN, Hata A
• Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.
  Molecular cell 2010 Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A
• Regulation of pri-miRNA processing through Smads.
  Advances in experimental medicine and biology 2010 Hata A, Davis BN
• Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.
  The EMBO journal 2009 Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A
• Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus.
  Cytokine & growth factor reviews 2009 Hata A, Davis BN
• Regulation of MicroRNA Biogenesis: A miRiad of mechanisms.
  Cell communication and signaling : CCS 2009 Davis BN, Hata A
• The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone.
  The Journal of biological chemistry 2009 Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A
• Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype.
  The Journal of biological chemistry 2008 Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A
• SMAD proteins control DROSHA-mediated microRNA maturation.
  Nature 2008 Davis BN, Hilyard AC, Lagna G, Hata A
• Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.
  The Journal of biological chemistry 2007 Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A
• A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.
  Molecular and cellular biology 2007 Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A
• BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.
  American journal of physiology. Lung cellular and molecular physiology 2006 Lagna G, Nguyen PH, Ni W, Hata A
• OAZ regulates bone morphogenetic protein signaling through Smad6 activation.
  The Journal of biological chemistry 2005 Ku M, Howard S, Ni W, Lagna G, Hata A
• Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors.
  Molecular and cellular biology 2005 Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A
• Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway.
  The Journal of biological chemistry 2004 Seki K, Hata A
• Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.
  Biochemical and biophysical research communications 2003 Ku MC, Stewart S, Hata A
• Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.
  Blood 2003 Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S
• Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan.
  The Journal of biological chemistry 2003 Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Kaechoong L

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• Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.
  bioRxiv : the preprint server for biology 2023 Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A
• Essential role of the amino-terminal region of Drosha for the Microprocessor function.
  iScience 2023 Prabhakar A, Hu S, Tang J, Ghatpande P, Lagna G, Jiang X, Hata A
• Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
  Journal of medicinal chemistry 2022 Hanke T, Mathea S, Woortman J, Salah E, Berger BT, Tumber A, Kashima R, Hata A, Kuster B, Müller S, Knapp S
• Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.
  International journal of molecular sciences 2021 Bisserier M, Katz MG, Bueno-Beti C, Brojakowska A, Zhang S, Gubara S, Kohlbrenner E, Fazal S, Fargnoli A, Dorfmuller P, Humbert M, Hata A, Goukassian DA, Sassi Y, Hadri L
• Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
  Nature communications 2021 Agnew C, Ayaz P, Kashima R, Loving HS, Ghatpande P, Kung JE, Underbakke ES, Shan Y, Shaw DE, Hata A, Jura N
• How do you mend inactive tumor suppressor mutants? You glue them!
  Cell chemical biology 2021 Hata A, Lagna G
• Control of ribosomal protein synthesis by the Microprocessor complex.
  Science signaling 2021 Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A
• Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration.
  PloS one 2020 Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD
• The role of TGF-β superfamily signaling in neurological disorders.
  Acta biochimica et biophysica Sinica 2018 Kashima R, Hata A
• TGF-β Signaling from Receptors to Smads.
  Cold Spring Harbor perspectives in biology 2016 Hata A, Chen YG
• Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-β Signaling.
  Methods in molecular biology (Clifton, N.J.) 2016 Kang H, Hata A
• Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature.
  PLoS genetics 2015 Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J
• Targeting the TGFβ signalling pathway in disease.
  Nature reviews. Drug discovery 2012 Akhurst RJ, Hata A
• A taste of TGFβ in Tuscany.
  Development (Cambridge, England) 2012 Hata A, Brivanlou AH
• ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.
  Cancer cell 2009 Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R