Ajay Maker, MD
Professor
Surgery
School of Medicine

Dr. Ajay V. Maker M.D. is a surgical oncologist and chief of the UCSF Division of Surgical Oncology. He is an expert in surgically treating complex gastrointestinal and hepatopancreatobiliary diseases (those affecting the liver, pancreas, gallbladder and bile ducts), as well as melanomas and sarcomas.

Maker's research aims to improve early detection of pancreas cancer and to develop new therapies for treating metastases (cancers that have spread from a primary site in the body). Under grants awarded by the Department of Defense and National Institutes of Health (NIH), he works on designing novel immunotherapies (treatments that harness the immune system to fight tumors), particularly for liver metastases from colon cancer. He is one of only a few surgeons to receive the NIH MERIT award and U.S. Army Medical Research Acquisition Activity Cancer Impact Award.

Maker earned his medical degree at Yale School of Medicine. He completed a residency in general surgery at Brigham and Women's Hospital, an affiliate of Harvard Medical School. He trained in surgical oncology at the NIH and completed postdoctoral studies in tumor immunology at the National Cancer Institute; this research included working in trials that led to the Food and Drug Administration approval of Ipilimumab as a new treatment for metastatic melanoma. He later completed a fellowship in surgical oncology at Memorial Sloan Kettering Cancer Center and then gained experience in minimally invasive surgical techniques at the University of Paris. He came to UCSF from his hometown of Chicago, where he was a tenured professor of surgery and of microbiology and immunology at the University of Illinois at Chicago.

In 2015, Maker was the European Society of Surgical Oncology's international traveling fellow and was later honored with the Society of Surgical Oncology's Clinical Investigator Award. He has published more than 170 manuscripts, abstracts and book chapters, and he lectures all over the world. He serves on the editorial boards of many surgical and scientific journals; serves on NIH study sections, which evaluate the merit of proposed research; and has held leadership positions in numerous academic and scientific societies, including program chair of the Americas Hepato-Pancreato-Biliary Association and chair of the Society of Surgical Oncology's gastrointestinal working group. He is also active in various medical societies, including the Surgical Biology Club , Western Surgical Association, American Society of Clinical Oncology and Pancreas Club. He has been named numerous times to Castle Connolly's Top Doctors and Top Doctors for Cancer lists. He is a fellow of the American College of Surgeons and Society of Surgical Oncology.

Research Interests and Funding:

Dr. Maker graduated from Brown University with honors in fine arts and biology, completing his honors thesis in the NASA-funded lab of Dr. Herman Vandenberg in tissue engineering. Thereafter, he enrolled in the Yale School of Medicine and was selected to enter the Basic Science Research Training Fellowship where he was awarded the ADA Medical Scholars Award and the AAS/Novartis Research Award for his work in the R01-funded lab of surgeon Dana Andersen on elucidating mechanisms of pancreatogenic diabetes. He completed his general surgery residency at Harvard University's Brigham and Women's Hospital and a tumor immunology post-doctorate fellowship in the laboratory of Dr. Steven Rosenberg in the Surgery Branch of the NIH/NCI, during which time he was first author on many of the initial phase I/II trials utilizing anti-CTLA4 antibodies. This work was later honored with the "most cited article" award by the Society of Surgical Oncology.

Dr. Maker went on to complete surgical oncology fellowships at the NCI and Memorial Sloan-Kettering Cancer Center, where he continued translational bench research in the Ludwig Cancer Institute, funded, in part, by an ASCO Merit Award and an NCI EDRU U01. He has focused the efforts of his research career on expanding the role of immunotherapy for gastrointestinal tumors and has aligned his clinical practice to coincide with his research interests. His NCI/NIH and DoD-funded research program has identified an immunostimulatory cytokine capable of activating and supporting the proliferation of antigen-specific T-cells to incite an anti-tumor immune response in colorectal liver metastases. This strategy is currently being investigated in combination with oncolytic viruses and immune checkpoint blockade to elicit complete tumor responses. This work has been funded over time as PI by internal funding, the Warren and Clara Cole Foundation of the ACS, the NIH through both K08 and UL1 mechanisms, the DoD (Cancer Impact Award), R37 MERIT from the NCI, and the Society of Surgical Oncology (Investigator of the Year Award).

Dr. Maker's lab also investigates novel drug combinations that stimulate immunogenic cell death and that generate anti-tumor immune responses to treat GI tumor liver metastases. As part of these studies, Dr. Maker has developed multiple unique orthotopic animal models in which to study solid organ metastases that have led to multiple federally funded collaborations, including work on the novel Oncopig porcine large animal cancer model for liver and pancreatic cancer.

Furthermore, Dr. Maker has been a leader in the international IPMN biomarkers research group, and has developed a gene signature to predict malignancy in IPMN from pancreatic cyst fluid. He houses the international IPMN cyst fluid repository, one of the largest biobanks of its kind, for which he serves as the international PI. With this collaborative, he is currently validating a single-platform biosignature to accurately predict the malignant potential of pancreatic cysts.

Finally, as a clinical surgeon with a passion for developing new laparoscopic and robotic techniques in complex surgical oncology, he has also maintained a robust clinical database from which multiple techniques papers and outcomes studies have been generated along with his residents.

• Surgical Cancer Care in Safety-Net Hospitals: a Systematic Review.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2023 Wong P, Victorino GP, Sadjadi J, Knopf K, Maker AV, Thornblade LW
• Impact of safety-net hospital burden on achievement of textbook oncologic outcomes following resection in for stage I-IV colorectal cancer.
  Journal of surgical oncology 2023 Wong P, Victorino GP, Miraflor E, Alseidi A, Maker AV, Thornblade LW
• A Machine Learning Approach to Predict Postoperative Pancreatic Fistula After Pancreaticoduodenectomy Using Only Preoperatively Known Data.
  Annals of surgical oncology 2023 Ashraf Ganjouei A, Romero-Hernandez F, Wang JJ, Casey M, Frye W, Hoffman D, Hirose K, Nakakura E, Corvera C, Maker AV, Kirkwood KS, Alseidi A, Adam MA
• ASO Visual Abstract: National Practice Patterns in Malignant Peritoneal Mesothelioma-Updates in Management and Survival.
  Annals of surgical oncology 2023 Calthorpe L, Romero-Hernandez F, Casey M, Nunez M, Conroy PC, Hirose K, Kim A, Kirkwood K, Maker AV, Corvera C, Nakakura E, Alseidi A, Adam MA
• Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance.
  Cancers 2023 Wiley MB, Bauer J, Mehrotra K, Zessner-Spitzenberg J, Kolics Z, Cheng W, Castellanos K, Nash MG, Gui X, Kone L, Maker AV, Qiao G, Reddi D, Church DN, Kerr RS, Kerr DJ, Grippo PJ, Jung B
• National Practice Patterns in Malignant Peritoneal Mesothelioma: Updates in Management and Survival.
  Annals of surgical oncology 2023 Calthorpe L, Romero-Hernandez F, Casey M, Nunez M, Conroy PC, Hirose K, Kim A, Kirkwood K, Maker AV, Corvera C, Nakakura E, Alseidi A, Adam MA
• It is not necessary to resect all mucinous cystic neoplasms of the pancreas: current guidelines do not reflect the actual risk of malignancy.
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2023 Pollini T, Marchegiani G, Facciorusso A, Balduzzi A, Biancotto M, Bassi C, Maker AV, Salvia R
• Drain Placement After Pancreatic Resection: Friend or Foe For Surgical Site Infections?
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2023 Pollini T, Wong P, Kone LB, Khoury RE, Kabir C, Maker VK, Banulescu M, Maker AV
• Hypertension Requiring Medication Use: a Silent Predictor of Poor Outcomes After Pancreaticoduodenectomy.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2023 Lin JJ, Conroy PC, Romero-Hernandez F, Yilma M, Feng J, Hirose K, Nakakura E, Maker AV, Corvera C, Kirkwood K, Alseidi A, Adam MA
• The Landmark Series: Intraductal Papillary Mucinous Neoplasms of the Pancreas-From Prevalence to Early Cancer Detection.
  Annals of surgical oncology 2023 Pollini T, Wong P, Maker AV
• Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States.
  Cancers 2022 Calthorpe L, Romero-Hernandez F, Miller P, Conroy PC, Hirose K, Kim A, Kirkwood K, Nakakura E, Corvera C, Maker AV, Alseidi A, Adam MA
• Hand-Assisted Versus Pure Minimally-Invasive Distal Pancreatectomy: Is There a Downside to Lending a Hand?
  World journal of surgery 2022 Miller PN, Romero-Hernandez F, Conroy P, Calthorpe L, Yilma M, Mohamedaly S, Kelly YM, Feng J, Hirose K, Kirkwood K, Maker AV, Corvera C, Nakakura E, Alseidi A, Adam MA
• Minimally Invasive Distal Pancreatectomy Techniques: A Contemporary Analysis Exploring Trends, Similarities, and Differences to Open Surgery.
  Cancers 2022 Romero-Hernandez F, Mohamedaly S, Miller P, Rodriguez N, Calthorpe L, Conroy PC, Ganjouei AA, Hirose K, Maker AV, Nakakura E, Corvera C, Kirkwood KS, Alseidi A, Adam MA
• The tumour immune microenvironment and microbiome of pancreatic intraductal papillary mucinous neoplasms.
  The lancet. Gastroenterology & hepatology 2022 Pollini T, Adsay V, Capurso G, Dal Molin M, Esposito I, Hruban R, Luchini C, Maggino L, Matthaei H, Marchegiani G, Scarpa A, Wood LD, Bassi C, Salvia R, Mino-Kenudson M, Maker AV
• Diagnostic laparoscopy is underutilized in the staging of gastric adenocarcinoma regardless of hospital type: An US safety net collaborative analysis.
  Journal of surgical oncology 2022 Leder Macek AJ, Wang A, Turgeon MK, Lee RM, Russell MC, Porembka MR, Alterio R, Ju M, Kronenfeld J, Goel N, Datta J, Maker AV, Fernandez M, Richter H, Berman RS, Correa-Gallego C, Lee AY
• Physical exam reveals etiology of liver and pancreatic tumors.
  Surgery 2022 Kone LB, Maker AV
• Langer's arch: An anatomic variant complicating axillary node dissection.
  Surgery 2022 Baskin AS, Wang K, Maker AV
• Robotic Surgery for Biliary Tract Cancer.
  Cancers 2022 Kone LB, Bystrom PV, Maker AV
• LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer.
  Oncogene 2022 Qiao G, Kone LB, Phillips EH, Lee SS, Brown GE, Khetani SR, Thakur A, Lum LG, Prabhakar BS, Maker AV
• Clinical Presentation Patterns and Survival Outcomes of Hispanic Patients With Gastric Cancer.
  The Journal of surgical research 2021 Vitiello GA, Hani L, Wang A, Porembka MR, Alterio R, Ju M, Turgeon MK, Lee RM, Russell MC, Kronenfeld J, Goel N, Datta J, Maker AV, Fernandez M, Richter H, Correa-Gallego C, Berman RS, Lee AY
• Attrition during neoadjuvant chemotherapy for gastric adenocarcinoma is associated with decreased survival: A United States Safety-Net Collaborative analysis.
  Journal of surgical oncology 2021 Kronenfeld JP, Collier AL, Turgeon MK, Ju M, Alterio R, Wang A, Fernandez M, Porembka MR, Richter H, Lee AY, Russell MC, Merchant NB, Maker AV, Datta J
• The Evolution of Cancer Immunotherapy.
  Vaccines 2021 Khan M, Maker AV, Jain S
• Is there a difference in utilization of a perioperative treatment approach for gastric cancer between safety net hospitals and tertiary referral centers?
  Journal of surgical oncology 2021 Turgeon MK, Lee RM, Keilson JM, Ju MR, Porembka MR, Alterio RE, Kronenfeld J, Datta J, Goel N, Wang A, Lee AY, Fernandez M, Richter H, Maker AV, Maithel SK, Russell MC
• Race and Gender Differences in Awareness of Colorectal Cancer Screening Tests and Guidelines Among Recently Diagnosed Colon Cancer Patients in an Urban Setting.
  Journal of cancer education : the official journal of the American Association for Cancer Education 2021 Carnahan LR, Jones L, Brewer KC, Watts EA, Peterson CE, Ferrans CE, Cipriano-Steffens T, Polite B, Maker AV, Chowdhery R, Molina Y, Rauscher GH
• Combining On-Table Embolization with Immediate Resection to Safely Excise Giant Hepatic Hemangiomas.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2021 Maker AV, Al Rameni D, Prabhakar N
• Combination Immunotherapy With LIGHT and Interleukin-2 Increases CD8 Central Memory T-Cells In Vivo.
  The Journal of surgical research 2021 Fernandez MF, Qiao G, Tulla K, Prabhakar BS, Maker AV
• ASO Author Reflections: How Can We Improve the Postoperative Experience for Our Pancreatic Cancer Patients? A Practical Technique to Optimize Pain Control After Major Abdominal Surgery.
  Annals of surgical oncology 2020 Maker AV
• Surgeon-Placed Continuous Wound Infusion Pain Catheters Markedly Decrease Narcotic Use and Improve Outcomes After Pancreatic Tumor Resection.
  Annals of surgical oncology 2020 Kone LB, Kunda NM, Tran TB, Maker AV
• Epidural Analgesia Is Associated with Prolonged Length of Stay After Open HPB Surgery in Over 27,000 Patients.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2020 Kone LB, Maker VK, Banulescu M, Maker AV
• Perioperative Broad-spectrum Antibiotics are Associated With Decreased Surgical Site Infections Compared to 1st-3rd Generation Cephalosporins After Open Pancreaticoduodenectomy in Patients With Jaundice or a Biliary Stent.
  Annals of surgery 2020 Kone LB, Torres C, Banulescu M, Maker VK, Maker AV
• Should Drains Suck? A Propensity Score Analysis of Closed-Suction Versus Closed-Gravity Drainage After Pancreatectomy.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2020 Kone LB, Maker VK, Banulescu M, Maker AV
• Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice.
  Cancer gene therapy 2020 Dai S, Lv Y, Xu W, Yang Y, Liu C, Dong X, Zhang H, Prabhakar BS, Maker AV, Seth P, Wang H
• Management of Cancer Surgery Cases During the COVID-19 Pandemic: Considerations.
  Annals of surgical oncology 2020 Bartlett DL, Howe JR, Chang G, Crago A, Hogg M, Karakousis G, Levine E, Maker A, Mamounas E, McGuire K, Merchant N, Shibata D, Sohn V, Solorzano C, Turaga K, White R, Yang A, Yoon S, Society of …
• A propensity score analysis of over 12,000 pancreaticojejunal anastomoses after pancreaticoduodenectomy: does technique impact the clinically relevant fistula rate?
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2020 Kone LB, Maker VK, Banulescu M, Maker AV
• MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.
  Endocrine-related cancer 2019 Saini S, Sripada L, Tulla K, Qiao G, Kunda N, Maker AV, Prabhakar BS
• Cyst Fluid Biosignature to Predict Intraductal Papillary Mucinous Neoplasms of the Pancreas with High Malignant Potential.
  Journal of the American College of Surgeons 2019 Maker AV, Hu V, Kadkol SS, Hong L, Brugge W, Winter J, Yeo CJ, Hackert T, Büchler M, Lawlor RT, Salvia R, Scarpa A, Bassi C, Green S
• Loss of MADD expression inhibits cellular growth and metastasis in anaplastic thyroid cancer.
  Cell death & disease 2019 Saini S, Sripada L, Tulla K, Kumar P, Yue F, Kunda N, Maker AV, Prabhakar BS
• Impact of Immunotherapy after Resection of Pancreatic Cancer.
  Journal of the American College of Surgeons 2019 Tran TB, Maker VK, Maker AV
• Molecular aberrations and signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer.
  Biochimica et biophysica acta. Reviews on cancer 2018 Saini S, Maker AV, Burman KD, Prabhakar BS
• Management of asymptomatic, well-differentiated PNETs: results of the Delphi consensus process of the Americas Hepato-Pancreato-Biliary Association.
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2018 Mansour JC, Chavin K, Morris-Stiff G, Warner SG, Cardona K, Fong ZV, Maker A, Libutti SK, Warren R, St Hill C, Celinski S, Newell P, Ly QP, Howe J, Coburn N
• Does attending a Delphi consensus conference impact surgeon attitudes? Survey results from the Americas HepatoPancreatoBiliary Association consensus conference on small asymptomatic pancreatic neuroendocrine tumors.
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2018 Maker AV, Tran TB, Coburn N, Fong ZV, Cardona K, Newell P, Morris-Stiff G, Chavin K, Mansour J, members of the AHPBA Research Committee Consensus Conference
• Therapeutic advances in anaplastic thyroid cancer: a current perspective.
  Molecular cancer 2018 Saini S, Tulla K, Maker AV, Burman KD, Prabhakar BS
• ASO Author Reflections: Improving Identification of Intraductal Papillary Mucinous Neoplasm Patients at Risk-Current Status and the Role of IPMN Molecular Biomarkers.
  Annals of surgical oncology 2018 Maker AV
• Identification of a Novel OX40L+ Dendritic Cell Subset That Selectively Expands Regulatory T cells.
  Scientific reports 2018 Marinelarena A, Bhattacharya P, Kumar P, Maker AV, Prabhakar BS
• KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs.
  Scientific reports 2018 Principe DR, Overgaard NH, Park AJ, Diaz AM, Torres C, McKinney R, Dorman MJ, Castellanos K, Schwind R, Dawson DW, Rana A, Maker A, Munshi HG, Rund LA, Grippo PJ, Schook LB
• Vaccination With Mitoxantrone-Treated Primary Colon Cancer Cells Enhances Tumor-Infiltrating Lymphocytes and Clinical Responses in Colorectal Liver Metastases.
  The Journal of surgical research 2018 Qin J, Kunda NM, Qiao G, Tulla K, Prabhakar BS, Maker AV
• Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation.
  Cellular & molecular immunology 2018 Kumar P, Marinelarena A, Raghunathan D, Ragothaman VK, Saini S, Bhattacharya P, Fan J, Epstein AL, Maker AV, Prabhakar BS
• What is the Incidence of Malignancy in Resected Intraductal Papillary Mucinous Neoplasms? An Analysis of Over 100 US Institutions in a Single Year.
  Annals of surgical oncology 2018 Khoury RE, Kabir C, Maker VK, Banulescu M, Wasserman M, Maker AV
• Do Drains Contribute to Pancreatic Fistulae? Analysis of over 5000 Pancreatectomy Patients.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2018 El Khoury R, Kabir C, Maker VK, Banulescu M, Wasserman M, Maker AV
• Can we better predict the biologic behavior of incidental IPMN? A comprehensive analysis of molecular diagnostics and biomarkers in intraductal papillary mucinous neoplasms of the pancreas.
  Langenbeck's archives of surgery 2017 Tulla KA, Maker AV
• Port-Site Resection in the Surgical Management of Incidental Gallbladder Cancer: A Still Inconclusive Question: A Reply.
  Annals of surgical oncology 2017 Maker AV, Jarnagin WR
• Examining racial disparities in colon cancer clinical delay in the Colon Cancer Patterns of Care in Chicago study.
  Annals of epidemiology 2017 Jones LA, Ferrans CE, Polite BN, Brewer KC, Maker AV, Pauls HA, Rauscher GH
• The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform.
  Frontiers in oncology 2017 Schachtschneider KM, Schwind RM, Newson J, Kinachtchouk N, Rizko M, Mendoza-Elias N, Grippo P, Principe DR, Park A, Overgaard NH, Jungersen G, Garcia KD, Maker AV, Rund LA, Ozer H, Gaba RC, Schook LB
• PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells.
  Scientific reports 2017 Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Bhattacharya P, Sun Z, Epstein AL, Maker AV, Prabhakar BS
• Perioperative management of endocrine insufficiency after total pancreatectomy for neoplasia.
  Langenbeck's archives of surgery 2017 Maker AV, Sheikh R, Bhagia V, Diabetes Control and Complications Trial (DCCT) Research Group
• A Technique to Define Extrahepatic Biliary Anatomy Using Robotic Near-Infrared Fluorescent Cholangiography.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2017 Maker AV, Kunda N
• Targeting cancer with tumor-specific therapeutic strategies-metabolic reprogramming beyond the Warburg effect.
  Translational cancer research 2017 Grippo P, Maker AV
• Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis.
  Oncotarget 2017 Aung LHH, Li R, Prabhakar BS, Maker AV, Li P
• Utilization and impact of adjuvant chemotherapy among patients with resected stage II colon cancer: a multi-institutional analysis.
  The Journal of surgical research 2017 Ejaz A, Casadaban L, Maker AV
• LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases.
  Cancer research 2017 Qiao G, Qin J, Kunda N, Calata JF, Mahmud DL, Gann P, Fu YX, Rosenberg SA, Prabhakar BS, Maker AV
• Isolated Pancreatic Uncinate Duct IPMN.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2017 Maker AV, Maker VK
• Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death.
  Cell death & disease 2017 Qin J, Kunda N, Qiao G, Calata JF, Pardiwala K, Prabhakar BS, Maker AV
• Can Colon Cancer Recurrence and Metastases Be Determined After Surgical Resection Using a Gene Expression Signature?
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Casadaban L, Maker AV
• Gene-expression profiling to predict responsiveness to immunotherapy.
  Cancer gene therapy 2016 Jamieson NB, Maker AV
• Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.
  Cell death discovery 2016 Carr RM, Qiao G, Qin J, Jayaraman S, Prabhakar BS, Maker AV
• Adjuvant chemotherapy is associated with improved survival in patients with stage II colon cancer.
  Cancer 2016 Casadaban L, Rauscher G, Aklilu M, Villenes D, Freels S, Maker AV
• Techniques to perform robotic left adrenalectomy in the obese patient.
  Surgical endoscopy 2016 Maker AV, Maker VK
• Hepatectomy After Yttrium-90 (Y90) Radioembolization-Induced Liver Fibrosis.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2016 Maker AV, August C, Maker VK, Weisenberg E
• A Minimally Invasive Technique to Obtain Optimal Tumor Margins in Anatomically Confined Locations Using a Contoured Stapler.
  Annals of surgical oncology 2015 Maker AV, Valbuena V, Maker VK
• Precise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment-Evidence to turn on the LIGHT.
  Oncoimmunology 2015 Maker AV
• The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses.
  Journal of clinical & cellular immunology 2015 Maker AV, Prabhakar B, Pardiwala K
• Techniques to perform a laparoscopic right adrenalectomy for metastases abutting the liver, renal vein, and posterior vena cava.
  Surgical endoscopy 2015 Maker AV, Carr R
• Symptomatic Massive Splenomegaly in Persistent Polyclonal B-cell Lymphocytosis Requiring Splenectomy.
  Open journal of clinical & medical case reports 2015 Bhagwandin SB, Weisenberg ES, Ozer H, Maker AV
• Tailoring GIST therapy—biology is still king.
  JAMA surgery 2015 Maker AV
• Essential roles of FoxM1 in Ras-induced liver cancer progression and in cancer cells with stem cell features.
  Journal of hepatology 2015 Kopanja D, Pandey A, Kiefer M, Wang Z, Chandan N, Carr JR, Franks R, Yu DY, Guzman G, Maker A, Raychaudhuri P
• Simultaneous Occurrence of Glandular and Neuroendocrine Components in Lymph Node Metastasis of Gastric MANEC.
  International journal of surgical pathology 2015 August C, Maker AV, Weisenberg E
• Closure of Melanoma Defects on the Sole of the Foot Using Glaborous Skin: The End of the Flap?
  Annals of surgical oncology 2015 Maker AV, Iteld L
• Operative management of portal annular pancreas during pancreaticoduodenectomy.
  Surgery 2015 Pardiwala KH, Maker AV
• Genetic evidence that intratumoral T-cell proliferation and activation are associated with recurrence and survival in patients with resected colorectal liver metastases.
  Cancer immunology research 2015 Maker AV, Ito H, Mo Q, Weisenberg E, Qin LX, Turcotte S, Maithel S, Shia J, Blumgart L, Fong Y, Jarnagin WR, DeMatteo RP, D'Angelica MI
• Cyst fluid biomarkers for intraductal papillary mucinous neoplasms of the pancreas: a critical review from the international expert meeting on pancreatic branch-duct-intraductal papillary mucinous neoplasms.
  Journal of the American College of Surgeons 2014 Maker AV, Carrara S, Jamieson NB, Pelaez-Luna M, Lennon AM, Dal Molin M, Scarpa A, Frulloni L, Brugge WR
• Appendicitis secondary to metastatic melanoma: review of the National Institutes of Health experience.
  JAMA surgery 2014 Kitano M, Maker AV, Lanier BJ, Danforth DN, Kammula US
• Calcifying fibrous tumor of the small intestine associated with Castleman-like lymphadenopathy.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014 Valladolid G, Weisenberg E, Sundaresan R, Maker AV
• Dedifferentiated gastrointestinal stromal tumor arising de novo from the small intestine.
  Pathology, research and practice 2014 Choi JJ, Sinada-Bottros L, Maker AV, Weisenberg E
• IG20/MADD plays a critical role in glucose-induced insulin secretion.
  Diabetes 2013 Li LC, Wang Y, Carr R, Haddad CS, Li Z, Qian L, Oberholzer J, Maker AV, Wang Q, Prabhakar BS
• Gene expression profiles accurately predict outcome following liver resection in patients with metastatic colorectal cancer.
  PloS one 2013 Ito H, Mo Q, Qin LX, Viale A, Maithel SK, Maker AV, Shia J, Kingham P, Allen P, DeMatteo RP, Fong Y, Jarnagin WR, D'Angelica M
• Benign adrenal hemangiomas may mimic metastases on PET.
  Clinical nuclear medicine 2013 Calata JF, Sukerkar AN, August CZ, Maker AV
• Management of patients with abdominal malignancy after remote jejunoileal bypass: surgical considerations decades later.
  Journal of the American College of Surgeons 2013 Kaminski JP, Maker VK, Maker AV
• A technique for laparoendoscopic resection of posterior fundic gastric GISTs without need for a gastrotomy.
  Annals of surgical oncology 2013 Maker AV
• Survival after resection of cutaneous adnexal carcinomas with eccrine differentiation: risk factors and trends in outcomes.
  Journal of surgical oncology 2013 Avraham JB, Villines D, Maker VK, August C, Maker AV
• Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases.
  Journal of translational medicine 2013 Qin JZ, Upadhyay V, Prabhakar B, Maker AV
• MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells.
  PloS one 2013 Turner A, Li LC, Pilli T, Qian L, Wiley EL, Setty S, Christov K, Ganesh L, Maker AV, Li P, Kanteti P, Das Gupta TK, Prabhakar BS
• Primary hepatic lymphoma presenting as an isolated solitary hepatic cyst.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012 Valladolid G, Adams LL, Weisenberg E, Maker VK, Maker AV
• Can we predict which residents are going to pass/fail the oral boards?
  Journal of surgical education 2012 Maker VK, Zahedi MM, Villines D, Maker AV
• Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases.
  Annals of surgical oncology 2012 Katz SC, Bamboat ZM, Maker AV, Shia J, Pillarisetty VG, Yopp AC, Hedvat CV, Gonen M, Jarnagin WR, Fong Y, D'Angelica MI, DeMatteo RP
• Malignant masquerade of xanthogranulomatous cholecystitis on intraoperative ultrasound of the liver.
  Journal of surgical oncology 2012 Maker AV, Maker VK
• Video: totally laparoscopic left lateral segmentectomy for hepatic malignancies: a modified technique.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2011 Maker AV, Jamal W, Gayet B
• Is port site resection necessary in the surgical management of gallbladder cancer?
  Annals of surgical oncology 2011 Maker AV, Butte JM, Oxenberg J, Kuk D, Gonen M, Fong Y, Dematteo RP, D'Angelica MI, Allen PJ, Jarnagin WR
• Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells.
  American journal of obstetrics and gynecology 2011 Li LC, Jayaram S, Ganesh L, Qian L, Rotmensch J, Maker AV, Prabhakar BS
• Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Maker AV, Katabi N, Qin LX, Klimstra DS, Schattner M, Brennan MF, Jarnagin WR, Allen PJ
• Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas.
  Annals of surgical oncology 2010 Maker AV, Katabi N, Gonen M, DeMatteo RP, D'Angelica MI, Fong Y, Jarnagin WR, Brennan MF, Allen PJ
• Randomized clinical trials in pancreatic adenocarcinoma.
  Surgical oncology clinics of North America 2010 Rudloff U, Maker AV, Brennan MF, Allen PJ
• Novel presentation of a familial pancreatic cancer syndrome.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008 Maker AV, Warth JA, Zinner MJ
• Cytology from pancreatic cysts has marginal utility in surgical decision-making.
  Annals of surgical oncology 2008 Maker AV, Lee LS, Raut CP, Clancy TE, Swanson RS
• Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma.
  Journal of immunotherapy (Hagerstown, Md. : 1997) 2006 Maker AV, Yang JC, Sherry RM, Topalian SL, Kammula US, Royal RE, Hughes M, Yellin MJ, Haworth LR, Levy C, Allen T, Mavroukakis SA, Attia P, Rosenberg SA
• Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2.
  Journal of immunotherapy (Hagerstown, Md. : 1997) 2006 Attia P, Powell DJ, Maker AV, Kreitman RJ, Pastan I, Rosenberg SA
• Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Maker AV, Attia P, Rosenberg SA
• Images in cardiothoracic surgery. Active malignant pleural effusion captured through the thoracoscope.
  The Annals of thoracic surgery 2005 Maker AV, Nguyen DM
• Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma.
  Journal of immunotherapy (Hagerstown, Md. : 1997) 2005 Attia P, Maker AV, Haworth LR, Rogers-Freezer L, Rosenberg SA
• Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study.
  Annals of surgical oncology 2005 Maker AV, Phan GQ, Attia P, Yang JC, Sherry RM, Topalian SL, Kammula US, Royal RE, Haworth LR, Levy C, Kleiner D, Mavroukakis SA, Yellin M, Rosenberg SA
• Loss of S100 antigenicity in metastatic melanoma.
  Human pathology 2005 Aisner DL, Maker A, Rosenberg SA, Berman DM
• Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, Yang JC, Sherry RM, Topalian SL, Kammula US, Royal RE, Restifo NP, Haworth LR, Levy C, Mavroukakis SA, Nichol G, Yellin MJ, Rosenberg SA
• Rapid acute amiodarone-induced hepatotoxicity in a burn patient.
  The Journal of burn care & rehabilitation 2005 Maker AV, Orgill DP
• Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane.
  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2005 Eisenberg ML, Maker AV, Slezak LA, Nathan JD, Sritharan KC, Jena BP, Geibel JP, Andersen DK