Aimee Kao, MD, PhD
Professor
Neurology
School of Medicine
Awards
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- Derek Denny Brown Young Neurological Scholar Award, American Neurological Association, 2020
- John Douglas French Founcation Endowed Professorship, University of California, San Francisco, 2020
- Glenn Award for Research in Biological Mechanisms of Aging, Glenn Foundation for Medical Research, 2018
Education & Training
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- Post-doctoral Fellowship University of California, San Francisco 2012
- Behavioral Neurology University of California, San Francisco 2005
- Neurology Residency University of California, San Francisco 2004
- Internal Medicine Internship Beth-Israel Deaconess Hospital, Harvard University 2001
- M.D., PhD College of Medicine University of Iowa 2000
- ScB Neural Sciences Brown University 1993
Websites
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- Profile at memory.ucsf.edu (memory.ucsf.edu)
- Clinical Profile at UCSF Medical Center (ucsfhealth.org)
- Kao Lab Website (kaolab.ucsf.edu)
Grants and Projects
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- Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal Proteases, NIH, 2021-2026
- Systematic profiling of lysosomes with age to improve proteostasis in Alzheimer's, NIH, 2018-2023
- Understanding cleaved granulin production, protease inhibition and effects on protein homeostasis, NIH, 2018-2022
- Understanding the molecular functions of progranulin and granulin in FTLD, NIH, 2015-2020
- Systematic profiling of lysosomes with age to improve proteostasis in Alzheimer's, NIH, 2017-2018
- Genetic Approaches to Understanding Granulin Function, NIH, 2013-2015
- Understanding Selective Neuronal Vulnerability in Parkinson's Disease, NIH, 2007-2012
Publications (47)
Top publication keywords:
Neurodegenerative DiseasesLysosomesCathepsin DFrontotemporal DementiaIntercellular Signaling Peptides and ProteinsDura MaterPeptide HydrolasesTuberous SclerosisEnzyme PrecursorsMetals, HeavyCaenorhabditis eleganstau Proteinsalpha-SynucleinCaenorhabditis elegans ProteinsFrontotemporal Lobar Degeneration
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Second international symposium on the chaperone code, 2023.
Cell stress & chaperones 2024 Buchner J, Alasady MJ, Backe SJ, Blagg BSJ, Carpenter RL, Colombo G, Gelis I, Gewirth DT, Gierasch LM, Houry WA, Johnson JL, Kang BH, Kao AW, LaPointe P, Mattoo S, McClellan AJ, Neckers LM, Prodromou … -
The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness.
Human molecular genetics 2024 Wang AL, Mambou EA, Kao AW -
Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Molecular neurodegeneration 2023 Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW -
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Molecular neurodegeneration 2023 Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW -
Tuberous sclerosis complex is associated with a novel human tauopathy.
Acta neuropathologica 2022 Hwang JL, Perloff OS, Gaus SE, Benitez C, Alquezar C, Cosme CQ, Nana AL, Vatsavayai SC, Ramos EM, Geschwind DH, Miller BL, Kao AW, Seeley WW
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Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling.
Stem cell reviews and reports 2022 Argouarch AR, Schultz N, Yang AC, Jang Y, Garcia K, Cosme CG, Corrales CI, Nana AL, Karydas AM, Spina S, Grinberg LT, Miller B, Wyss-Coray T, Abyzov A, Goodarzi H, Seeley WW, Kao AW -
Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model.
ACS chemical neuroscience 2022 Chin MY, Ang KH, Davies J, Alquezar C, Garda VG, Rooney B, Leng K, Kampmann M, Arkin MR, Kao AW -
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.
Science advances 2021 Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, Dickson DW, Yokoyama JS, Cuervo AM, Burlingame AL, Schellenberg GD, Miller TM, Miller BL,… -
Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
Molecular neurodegeneration 2021 Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW -
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH.
ACS sensors 2021 Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW -
Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation.
Frontiers in neurology 2021 Alquezar C, Arya S, Kao AW -
Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.
Frontiers in neuroscience 2020 Gururaj S, Sampognaro PJ, Argouarch AR, Kao AW -
Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia.
JAMA neurology 2020 Liu AJ, Staffaroni AM, Rojas-Martinez JC, Olney NT, Alquezar-Burillo C, Ljubenkov PA, La Joie R, Fong JC, Taylor J, Karydas A, Ramos EM, Coppola G, Boxer AL, Rabinovici GD, Miller BL, Kao AW -
Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons.
Scientific reports 2020 Alquezar C, Felix JB, McCandlish E, Buckley BT, Caparros-Lefebvre D, Karch CM, Golbe LI, Kao AW -
Protons in small spaces: Discrete simulations of vesicle acidification.
PLoS computational biology 2019 Singh A, Marcoline FV, Veshaguri S, Kao AW, Bruchez M, Mindell JA, Stamou D, Grabe M -
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Stem cell reports 2019 Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, … -
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.
NPJ aging and mechanisms of disease 2019 Tezil T, Chamoli M, Ng CP, Simon RP, Butler VJ, Jung M, Andersen J, Kao AW, Verdin E -
Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.
PLoS genetics 2019 Butler VJ, Gao F, Corrales CI, Cortopassi WA, Caballero B, Vohra M, Ashrafi K, Cuervo AM, Jacobson MP, Coppola G, Kao AW -
Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro.
Biochemistry 2019 Butler VJ, Cortopassi WA, Gururaj S, Wang AL, Pierce OM, Jacobson MP, Kao AW -
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.
Human molecular genetics 2019 Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi K, Mandelkow… -
Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH.
Journal of molecular biology 2019 Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW -
Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.
Human molecular genetics 2018 Yuan SH, Hiramatsu N, Liu Q, Sun XV, Lenh D, Chan P, Chiang K, Koo EH, Kao AW, Litvan I, Lin JH -
Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex.
Scientific reports 2018 Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, … -
The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response.
Methods in molecular biology (Clifton, N.J.) 2018 Hsu TY, Butler VJ, Kao AW -
Clinicopathological correlations in behavioural variant frontotemporal dementia.
Brain : a journal of neurology 2017 Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel… -
Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia.
Acta neuropathologica 2017 Olney NT, Alquezar C, Ramos EM, Nana AL, Fong JC, Karydas AM, Taylor JB, Stephens ML, Argouarch AR, Van Berlo VA, Dokuru DR, Sherr EH, Jicha GA, Dillon WP, Desikan RS, De May M, Seeley WW, Coppola G, … -
Progranulin, lysosomal regulation and neurodegenerative disease.
Nature reviews. Neuroscience 2017 Kao AW, McKay A, Singh PP, Brunet A, Huang EJ -
Animal models of dementia.
The Behavioral Neurology of Dementia 2017 Erik D. Roberson, Aimee W. Kao -
MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.
Alzheimer's & dementia (Amsterdam, Netherlands) 2016 Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH -
The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Salazar DA, Butler VJ, Argouarch AR, Hsu TY, Mason A, Nakamura A, McCurdy H, Cox D, Ng R, Pan G, Seeley WW, Miller BL, Kao AW -
A shift to organismal stress resistance in programmed cell death mutants.
PLoS genetics 2013 Judy ME, Nakamura A, Huang A, Grant H, McCurdy H, Weiberth KF, Gao F, Coppola G, Kenyon C, Kao AW -
The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012 Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M… -
Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012 Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, … -
A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
Proceedings of the National Academy of Sciences of the United States of America 2011 Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C -
Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy.
Alzheimer disease and associated disorders 2009 Kao AW, Racine CA, Quitania LC, Kramer JH, Christine CW, Miller BL -
Animal models of dementia.
The Behavioral Neurology of Dementia 2009 Erik D. Roberson, Aimee W. Kao -
Chemokine receptors, neural progenitor cells, and the AIDS dementia complex.
The Journal of infectious diseases 2004 Kao AW, Price RW -
Functional comparison of the role of dynamin 2 splice variants on GLUT-4 endocytosis in 3T3L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2000 Kao AW, Yang C, Pessin JE -
Dynamin is required for recombinant adeno-associated virus type 2 infection.
Journal of virology 1999 Duan D, Li Q, Kao AW, Yue Y, Pessin JE, Engelhardt JF -
Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4.
The Journal of biological chemistry 1999 Kao AW, Noda Y, Johnson JH, Pessin JE, Saltiel AR -
The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism.
The Journal of biological chemistry 1999 Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE, Birnbaum MJ -
Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling.
The Journal of biological chemistry 1998 Kao AW, Ceresa BP, Santeler SR, Pessin JE -
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways.
Molecular and cellular biology 1998 Ceresa BP, Kao AW, Santeler SR, Pessin JE -
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.
The Journal of biological chemistry 1997 Okada S, Kao AW, Ceresa BP, Blaikie P, Margolis B, Pessin JE -
Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways.
Endocrinology 1997 Kao AW, Waters SB, Okada S, Pessin JE -
Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation.
The Journal of biological chemistry 1996 Waters SB, Chen D, Kao AW, Okada S, Holt KH, Pessin JE -
Evidence for myosin motors on organelles in squid axoplasm.
Proceedings of the National Academy of Sciences of the United States of America 1993 Bearer EL, DeGiorgis JA, Bodner RA, Kao AW, Reese TS