Ahmed Abdelhak, MD
HS Clinical Instructor
Neurology
School of Medicine

Awards

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• Early Investigator Research Award, DoD - USAMRDC, 2023-2024
• Best Poster Award, ECTRIMS-ACTRIMS 2023, 2023
• Junior Investigator Award - Establishing novel blood-based biomarkers to track MS activity, Weill Institute for Neurosciences, 2021-2022
• Yearly travel grants, ECTRIMS - DGN, 2016-2022

Education & Training

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• German Neurology Board Certification Clinical Neurology German Medical Board 2022
• MS.c Neuroscience University of Bordeaux 2019
• Doctor of Medicine (PhD equivalent) Clinical Neurology University of Ulm 2017
• MD Human Medicine Ain Shams University 2010

Websites

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• ResearchGate (researchgate.net)
• Publons (publons.com)
• LinkedIn (linkedin.com)
• Google Scholar (scholar.google.com)

Grants and Projects

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• Explorative study of emerging blood biomarkers in progressive multiple sclerosis (EmBioProMS) - Phase 2, German Multiple Sclerosis Society, German Multiple Sclerosis Trust, 2021-2023
• Identification of Protein Pathways and Novel Biomarkers in Pre- and Early Clinical MS Individuals with Distinct Patterns of Autoimmunity, Congressionally Directed Medical Research Programs at the U.S. Army Medical Research and Development Command., 2023
• Explorative study of emerging blood biomarkers in progressive multiple sclerosis (EmBioProMS):, German Multiple Sclerosis Society, 2018-2022

Publications (41)

Top publication keywords:
SerumNeurofilament ProteinsIntermediate FilamentsMultiple SclerosisDisability EvaluationRetinaCerebrospinal FluidAmyotrophic Lateral SclerosisSpinal Cord DiseasesGuillain-Barre SyndromeMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingBiomarkersGlial Fibrillary Acidic ProteinRetinal Vessels

• Neurofilaments as biomarkers in neurological disorders - towards clinical application.
  Nature reviews. Neurology 2024 Khalil M, Teunissen CE, Lehmann S, Otto M, Piehl F, Ziemssen T, Bittner S, Sormani MP, Gattringer T, Abu-Rumeileh S, Thebault S, Abdelhak A, Green A, Benkert P, Kappos L, Comabella M, Tumani H, …
• Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis.
  Cell reports. Medicine 2024 Cordano C, Werneburg S, Abdelhak A, Bennett DJ, Beaudry-Richard A, Duncan GJ, Oertel FC, Boscardin WJ, Yiu HH, Jabassini N, Merritt L, Nocera S, Sin JH, Samana IP, Condor Montes SY, Ananth K, Bischof …
• Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies".
  Acta neuropathologica 2024 Oertel FC, Casillas D, Cobigo Y, Condor Montes S, Heuer HW, Chapman M, Beaudry-Richard A, Reinsberg H, Abdelhak A, Cordano C, Boeve BF, Dickerson BC, Grossman M, Huey E, Irwin DJ, Litvan I, Pantelyat …
• Serum glial fibrillary acidic protein and disability progression in progressive multiple sclerosis.
  Annals of clinical and translational neurology 2023 Abdelhak A, Antweiler K, Kowarik MC, Senel M, Havla J, Zettl UK, Kleiter I, Skripuletz T, Haarmann A, Stahmann A, Huss A, Gingele S, Krumbholz M, Benkert P, Kuhle J, Friede T, Ludolph AC, Ziemann U, …
• Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis.
  JAMA neurology 2023 Abdelhak A, Benkert P, Schaedelin S, Boscardin WJ, Cordano C, Oechtering J, Ananth K, Granziera C, Melie-Garcia L, Montes SC, Beaudry-Richard A, Achtnichts L, Oertel FC, Lalive PH, Leppert D, Müller S…

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• Patient-reported outcome parameters and disability worsening in progressive multiple sclerosis.
  Multiple sclerosis and related disorders 2023 Abdelhak A, Antweiler K, Kowarik MC, Senel M, Havla J, Zettl UK, Kleiter I, Hoshi MM, Skripuletz T, Haarmann A, Stahmann A, Huss A, Gingele S, Krumbholz M, Selge C, Friede T, Ludolph AC, Overell J, …
• Serum biomarker levels predict disability progression in patients with primary progressive multiple sclerosis.
  Journal of neurology, neurosurgery, and psychiatry 2023 Fissolo N, Benkert P, Sastre-Garriga J, Mongay-Ochoa N, Vilaseca-Jolonch A, Llufriu S, Blanco Y, Hegen H, Berek K, Perez-Miralles F, Rejdak K, Villar LM, Monreal E, Alvarez-Lafuente R, Soylu OK, …
• Remyelination protects neurons from DLK-mediated neurodegeneration.
  bioRxiv : the preprint server for biology 2023 Duncan GJ, Ingram SD, Emberley K, Hill J, Cordano C, Abdelhak A, McCane M, Jabassini N, Ananth K, Ferrara SJ, Stedelin B, Sivyer B, Aicher SA, Scanlan T, Watkins TA, Mishra A, Nelson J, Green AJ, …
• Serum neurofilament light chain reference database for individual application in paediatric care: a retrospective modelling and validation study.
  The Lancet. Neurology 2023 Abdelhak A, Petermeier F, Benkert P, Schädelin S, Oechtering J, Maleska Maceski A, Kabesch M, Geis T, Laub O, Leipold G, Gobbi C, Zecca C, Green A, Tumani H, Willemse E, Wiendl H, Granziera C, Kappos …
• Editorial: CSF and blood biomarkers in COVID-19 and other neuroinfectious diseases.
  Frontiers in neurology 2023 Foschi M, Abu-Rumeileh S, Massa F, Cordano C, Abdelhak A
• Challenges and Opportunities for the Promising Biomarker Blood Neurofilament Light Chain.
  JAMA neurology 2023 Abdelhak A, Kuhle J, Green AJ
• A Predictive Autoantibody Signature in Multiple Sclerosis.
  medRxiv : the preprint server for health sciences 2023 Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Tubati A, Gomez R, Fouassier C, Gerungan C, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, …
• Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis.
  Journal of neurology 2023 Abdelhak A, Barba L, Romoli M, Benkert P, Conversi F, D'Anna L, Masvekar RR, Bielekova B, Prudencio M, Petrucelli L, Meschia JF, Erben Y, Furlan R, De Lorenzo R, Mandelli A, Sutter R, Hert L, Epple V,…
• Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort.
  Neurology(R) neuroimmunology & neuroinflammation 2023 Oertel FC, Krämer J, Motamedi S, Keihani A, Zimmermann HG, Dimitriou NG, Condor-Montes S, Bereuter C, Cordano C, Abdelhak A, Trip A, Aktas O, Meuth SG, Wiendl H, Ruprecht K, Bellmann-Strobl J, Paul F,…
• Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis.
  JAMA neurology 2023 Meier S, Willemse EAJ, Schaedelin S, Oechtering J, Lorscheider J, Melie-Garcia L, Cagol A, Barakovic M, Galbusera R, Subramaniam S, Barro C, Abdelhak A, Thebault S, Achtnichts L, Lalive P, Müller S, …
• The multifaceted role of neurofilament light chain protein in non-primary neurological diseases.
  Brain : a journal of neurology 2023 Abu-Rumeileh S, Abdelhak A, Foschi M, D'Anna L, Russo M, Steinacker P, Kuhle J, Tumani H, Blennow K, Otto M
• Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Primary Progressive Multiple Sclerosis and Hereditary Spastic Paraplegia Type 4.
  International journal of molecular sciences 2022 Kessler C, Ruschil C, Abdelhak A, Wilke C, Maleska A, Kuhle J, Krumbholz M, Kowarik MC, Schüle R
• Differences in Age-related Retinal and Cortical Atrophy Rates in Multiple Sclerosis.
  Neurology 2022 Cordano C, Nourbakhsh B, Yiu HH, Papinutto N, Caverzasi E, Abdelhak A, Oertel FC, Beaudry-Richard A, Santaniello A, Sacco S, Bennett DJ, Gomez A, Sigurdson CJ, Hauser SL, Magliozzi R, Cree BAC, Henry …
• Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease.
  Biomedicines 2022 Huss A, Abdelhak A, Mayer B, Tumani H, Müller HP, Althaus K, Kassubek J, Otto M, Ludolph AC, Yilmazer-Hanke D, Neugebauer H
• Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2022 Abdelhak A, Solomon I, Montes SC, Saias A, Cordano C, Asken B, Fonseca C, Oertel FC, Arfanakis K, Staffaroni AM, Kramer JH, Geschwind M, Miller BL, Elahi FM, Green AJ
• Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis.
  Journal of neurology, neurosurgery, and psychiatry 2022 Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, …
• Reply to "Interpretation of Longitudinal Changes of the Inner Nuclear Layer in MS".
  Annals of neurology 2022 Cordano C, Yiu HH, Abdelhak A, Beaudry-Richard A, Oertel FC, Green AJ
• Blood GFAP as an emerging biomarker in brain and spinal cord disorders.
  Nature reviews. Neurology 2022 Abdelhak A, Foschi M, Abu-Rumeileh S, Yue JK, D'Anna L, Huss A, Oeckl P, Ludolph AC, Kuhle J, Petzold A, Manley GT, Green AJ, Otto M, Tumani H
• Diagnostic and Prognostic Blood Biomarkers in Transient Ischemic Attack and Minor Ischemic Stroke: An Up-To-Date Narrative Review.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2022 Foschi M, Padroni M, Abu-Rumeileh S, Abdelhak A, Russo M, D'Anna L, Guarino M
• Ongoing challenges in unravelling the association between COVID-19 and Guillain-Barré syndrome.
  Brain : a journal of neurology 2021 Foschi M, D'Anna L, Abdelhak A, Mayer B, Tumani H, Otto M, Abu-Rumeileh S
• Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis.
  Cells 2020 Robinson T, Abdelhak A, Bose T, Meinl E, Otto M, Zettl UK, Dersch R, Tumani H, Rauer S, Huss A
• Longitudinal Serum Neurofilament Levels of Multiple Sclerosis Patients Before and After Treatment with First-Line Immunomodulatory Therapies.
  Biomedicines 2020 Huss A, Senel M, Abdelhak A, Mayer B, Kassubek J, Ludolph AC, Otto M, Tumani H
• Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases.
  Journal of neurology 2020 Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M
• Differential effects of disease modifying drugs on peripheral blood B cell subsets: A cross sectional study in multiple sclerosis patients treated with interferon-β, glatiramer acetate, dimethyl fumarate, fingolimod or natalizumab.
  PloS one 2020 Kemmerer CL, Pernpeintner V, Ruschil C, Abdelhak A, Scholl M, Ziemann U, Krumbholz M, Hemmer B, Kowarik MC
• A Score Based on NfL and Glial Markers May Differentiate Between Relapsing-Remitting and Progressive MS Course.
  Frontiers in neurology 2020 Huss A, Otto M, Senel M, Ludolph AC, Abdelhak A, Tumani H
• Explorative study of emerging blood biomarkers in progressive multiple sclerosis (EmBioProMS): Design of a prospective observational multicentre pilot study.
  Contemporary clinical trials communications 2020 Abdelhak A, Huss A, Stahmann A, Senel M, Krumbholz M, Kowarik MC, Havla J, Kümpfel T, Kleiter I, Wüstinger I, Zettl UK, Schwartz M, Roesler R, Friede T, Ludolph AC, Ziemann U, Tumani H
• Optical coherence tomography-based assessment of retinal vascular pathology in cerebral small vessel disease.
  Neurological research and practice 2020 Abdelhak A, Huss A, Brück A, Sebert U, Mayer B, Müller HP, Tumani H, Otto M, Yilmazer-Hanke D, Ludolph AC, Kassubek J, Pinkhardt E, Neugebauer H
• Author Correction: Serum GFAP as a biomarker for disease severity in multiple sclerosis.
  Scientific reports 2019 Abdelhak A, Huss A, Kassubek J, Tumani H, Otto M
• Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker?
  Frontiers in neurology 2019 Abdelhak A, Hottenrott T, Morenas-Rodríguez E, Suárez-Calvet M, Zettl UK, Haass C, Meuth SG, Rauer S, Otto M, Tumani H, Huss A
• Serum GFAP as a biomarker for disease severity in multiple sclerosis.
  Scientific reports 2018 Abdelhak A, Huss A, Kassubek J, Tumani H, Otto M
• Intrathecal immunoglobulin M production: A promising high-risk marker in clinically isolated syndrome patients.
  Annals of neurology 2018 Huss A, Abdelhak A, Halbgebauer S, Mayer B, Senel M, Otto M, Tumani H
• MOG-IgG in primary and secondary chronic progressive multiple sclerosis: a multicenter study of 200 patients and review of the literature.
  Journal of neuroinflammation 2018 Jarius S, Ruprecht K, Stellmann JP, Huss A, Ayzenberg I, Willing A, Trebst C, Pawlitzki M, Abdelhak A, Grüter T, Leypoldt F, Haas J, Kleiter I, Tumani H, Fechner K, Reindl M, Paul F, Wildemann B
• In vivo assessment of retinal vessel pathology in amyotrophic lateral sclerosis.
  Journal of neurology 2018 Abdelhak A, Hübers A, Böhm K, Ludolph AC, Kassubek J, Pinkhardt EH
• CSF profile in primary progressive multiple sclerosis: Re-exploring the basics.
  PloS one 2017 Abdelhak A, Hottenrott T, Mayer C, Hintereder G, Zettl UK, Stich O, Tumani H
• Primary Progressive Multiple Sclerosis: Putting Together the Puzzle.
  Frontiers in neurology 2017 Abdelhak A, Weber MS, Tumani H
• Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?
  International journal of molecular sciences 2015 Abdelhak A, Junker A, Brettschneider J, Kassubek J, Ludolph AC, Otto M, Tumani H