Afsaneh Amouzegar, MD
Assistant Professor
Medicine
School of Medicine

Education & Training

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• Fellowship Medical Oncology University of Texas MD Anderson Cancer Center 2025
• Residency Internal Medicine University of Pittsburgh Medical Center 2022
• Postdoctoral Research Fellowship Immunology Schepens Research Institute, Harvard Medical School 2019
• MD Medicine Tehran University of Medical Sciences 2014

Publications (35)

Top publication keywords:
Graft RejectionMelanomaT-Lymphocytes, RegulatoryImmunity, CellularBrain NeoplasmsBone Marrow CellsImmune ToleranceCorneal TransplantationCorneal InjuriesDisease ManagementGraft SurvivalDry Eye SyndromesCorneaRadiosurgeryMyeloid Progenitor Cells

• Germline variants in cancer susceptibility genes among patients with mucosal melanoma.
  NPJ genomic medicine 2026 Amouzegar A, Wu X, Long JP, Chen GW, Wong JW, Prabhakaran S, Little L, Gumbs C, Bota N, Malke J, Simon J, Zhang J, Nagarajan P, Davies MA, Tawbi H, Amaria RN, Oliva ICG, Ikeguchi AP, Su S, Hanna EY, …
• Radiomic analysis of patient and interorgan heterogeneity in response to immunotherapies and BRAF-targeted therapy in metastatic melanoma.
  Journal for immunotherapy of cancer 2025 Tompkins AG, Gray ZN, Dadey RE, Zenkin S, Batavani N, Newman S, Amouzegar A, Ak M, Ak N, Pak TY, Peddagangireddy V, Mamindla P, Amjadzadeh M, Behr S, Goodman A, Ploucha DL, Kirkwood JM, Zarour HM, …
• Navigating the Complexities of Brain Metastases Management.
  American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2024 Amouzegar A, Haig S, Kahn AM, Tawbi HA, Jones JA, Goldberg SB
• Radiomic analysis of patient and inter-organ heterogeneity in response to immunotherapies and BRAF targeted therapy in metastatic melanoma.
  medRxiv : the preprint server for health sciences 2024 Tompkins A, Gray ZN, Dadey RE, Zenkin S, Batavani N, Newman S, Amouzegar A, Ak M, Ak N, Pak TY, Peddagangireddy V, Mamindla P, Behr S, Goodman A, Ploucha DL, Kirkwood JM, Zarour HM, Najjar YG, Davar D…
• Local and Systemic Management Options for Melanoma Brain Metastases.
  Cancer journal (Sudbury, Mass.) 2024 Amouzegar A, Tawbi HA

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• Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice.
  Transplantation 2022 Nakao T, Inomata T, Blanco T, Musayeva A, Tahvildari M, Amouzegar A, Yin J, Chauhan SK, Chen Y, Dana R
• Next-Generation Immunotherapy Approaches in Melanoma.
  Current oncology reports 2021 Buchanan T, Amouzegar A, Luke JJ
• STING Agonists as Cancer Therapeutics.
  Cancers 2021 Amouzegar A, Chelvanambi M, Filderman JN, Storkus WJ, Luke JJ
• Restoration of Regulatory T-Cell Function in Dry Eye Disease by Antagonizing Substance P/Neurokinin-1 Receptor.
  The American journal of pathology 2020 Taketani Y, Marmalidou A, Dohlman TH, Singh RB, Amouzegar A, Chauhan SK, Chen Y, Dana R
• The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease.
  Mucosal immunology 2020 Chen Y, Shao C, Fan NW, Nakao T, Amouzegar A, Chauhan SK, Dana R
• Regulatory T cells promote corneal endothelial cell survival following transplantation via interleukin-10.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019 Coco G, Foulsham W, Nakao T, Yin J, Amouzegar A, Taketani Y, Chauhan SK, Dana R
• Neurokinin-1 Receptor Antagonism Ameliorates Dry Eye Disease by Inhibiting Antigen-Presenting Cell Maturation and T Helper 17 Cell Activation.
  The American journal of pathology 2019 Yu M, Lee SM, Lee H, Amouzegar A, Nakao T, Chen Y, Dana R
• The therapeutic application of mesenchymal stem cells at the ocular surface.
  The ocular surface 2019 Sahu A, Foulsham W, Amouzegar A, Mittal SK, Chauhan SK
• Local Delivery of Regulatory T Cells Promotes Corneal Allograft Survival.
  Transplantation 2019 Shao C, Chen Y, Nakao T, Amouzegar A, Yin J, Tahvildari M, Lužnik Z, Chauhan SK, Dana R
• Peripheral Blood or Bone Marrow Stem Cells? Practical Considerations in Hematopoietic Stem Cell Transplantation.
  Transfusion medicine reviews 2018 Amouzegar A, Dey BR, Spitzer TR
• Regulatory T cell modulation of cytokine and cellular networks in corneal graft rejection.
  Current ophthalmology reports 2018 Tahvildari M, Inomata T, Amouzegar A, Dana R
• Mast cells contribute to the induction of ocular mucosal alloimmunity.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Li M, Mittal SK, Foulsham W, Amouzegar A, Sahu SK, Chauhan SK
• Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival.
  The American journal of pathology 2018 Satitpitakul V, Sun Z, Suri K, Amouzegar A, Katikireddy KR, Jurkunas UV, Kheirkhah A, Dana R
• The immunoregulatory role of corneal epithelium-derived thrombospondin-1 in dry eye disease.
  The ocular surface 2018 Tan X, Chen Y, Foulsham W, Amouzegar A, Inomata T, Liu Y, Chauhan SK, Dana R
• Mesenchymal Stromal Cells Inhibit Neutrophil Effector Functions in a Murine Model of Ocular Inflammation.
  Investigative ophthalmology & visual science 2018 Mittal SK, Mashaghi A, Amouzegar A, Li M, Foulsham W, Sahu SK, Chauhan SK
• Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation.
  Cellular and molecular life sciences : CMLS 2018 Tahvildari M, Amouzegar A, Foulsham W, Dana R
• Corneal Tissue From Dry Eye Donors Leads to Enhanced Graft Rejection.
  Cornea 2018 Inomata T, Hua J, Nakao T, Shiang T, Chiang H, Amouzegar A, Dana R
• Interleukin-6 neutralization prolongs corneal allograft survival.
  Current trends in immunology 2018 Kodati S, Chauhan SK, Chen Y, Emami-Naeini P, Omoto M, Dohlman TH, Stevenson W, Amouzegar A, Tummala G, Saban DR, Dana R
• When Clarity Is Crucial: Regulating Ocular Surface Immunity.
  Trends in immunology 2017 Foulsham W, Coco G, Amouzegar A, Chauhan SK, Dana R
• Kinetics of Corneal Antigen Presenting Cells in Experimental Dry Eye Disease.
  BMJ open ophthalmology 2017 Lee HS, Amouzegar A, Dana R
• Review: The function of regulatory T cells at the ocular surface.
  The ocular surface 2017 Foulsham W, Marmalidou A, Amouzegar A, Coco G, Chen Y, Dana R
• Hepatocyte Growth Factor Suppresses Inflammation and Promotes Epithelium Repair in Corneal Injury.
  Molecular therapy : the journal of the American Society of Gene Therapy 2017 Omoto M, Suri K, Amouzegar A, Li M, Katikireddy KR, Mittal SK, Chauhan SK
• Effector and Regulatory T Cell Trafficking in Corneal Allograft Rejection.
  Mediators of inflammation 2017 Amouzegar A, Chauhan SK
• Mesenchymal Stem Cells Modulate Differentiation of Myeloid Progenitor Cells During Inflammation.
  Stem cells (Dayton, Ohio) 2017 Amouzegar A, Mittal SK, Sahu A, Sahu SK, Chauhan SK
• Restoration of Corneal Transparency by Mesenchymal Stem Cells.
  Stem cell reports 2016 Mittal SK, Omoto M, Amouzegar A, Sahu A, Rezazadeh A, Katikireddy KR, Shah DI, Sahu SK, Chauhan SK
• Alloimmunity and Tolerance in Corneal Transplantation.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Amouzegar A, Chauhan SK, Dana R
• Correlation of major components of ocular astigmatism in myopic patients.
  Contact lens & anterior eye : the journal of the British Contact Lens Association 2015 Mohammadpour M, Heidari Z, Khabazkhoob M, Amouzegar A, Hashemi H
• Comparison of Lotrafilcon B and Balafilcon A silicone hydrogel bandage contact lenses in reducing pain and discomfort after photorefractive keratectomy: A contralateral eye study.
  Contact lens & anterior eye : the journal of the British Contact Lens Association 2015 Mohammadpour M, Amouzegar A, Hashemi H, Jabbarvand M, Kordbacheh H, Rahimi F, Hashemian MN
• 5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide.
  Epilepsy research 2012 Payandemehr B, Bahremand A, Rahimian R, Ziai P, Amouzegar A, Sharifzadeh M, Dehpour AR
• Additive anticonvulsant effects of agmatine and lithium chloride on pentylenetetrazole-induced clonic seizure in mice: involvement of α₂-adrenoceptor.
  European journal of pharmacology 2011 Bahremand A, Ziai P, Payandemehr B, Rahimian R, Amouzegar A, Khezrian M, Montaser-Kouhsari L, Meibodi MA, Ebrahimi A, Ghasemi A, Ghasemi M, Dehpour AR