Adrian Erlebacher, MD, PhD
Professor
Laboratory Medicine
School of Medicine

Historically, we have focused on the immunological paradox of fetomaternal tolerance - i.e., how the fetus and placenta avoid rejection by the maternal immune system during pregnancy - with one long-term goal being the application of underlying mechanisms to the induction of antigen-specific immune tolerance in the clinical arena. We also study how uterine quiescence is established and maintained during pregnancy, as well as the immunological and epigenetic pathways that control gestation length and parturition induction. These interweaving lines of investigation have implications for the pathogenesis of preterm labor, preeclampsia, early pregnancy failure, and other disorders of maternal/fetal health.

• Paul's Fundamental Immunology
  Maternal-Fetal Immunology (Chapter 41) 2022 Gabrielle Rizzuto and Adrian Erlebacher
• CD22/Lyn-mediated suppression of trophoblast antigen-specific B cells underlies fetomaternal tolerance.
  The Journal of Immunology 2021 Gabrielle Rizzuto, Jeremy Brooks, Susan Fisher, Julie Zikherman, Adrian Erlebacher
• Chapter 8 Immunology of the decidua.
  2021 Ivan Osokine, Adrian Erlebacher
• Myometrial leukocytes.
  Current Opinion in Physiology 2020 Johan Siewiera, Adrian Erlebacher
• Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.
  The Journal of clinical investigation 2020 Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A
• H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition.
  The Journal of clinical investigation 2017 Nancy P, Siewiera J, Rizzuto G, Tagliani E, Osokine I, Manandhar P, Dolgalev I, Clementi C, Tsirigos A, Erlebacher A
• Inflammation and Autism: From Maternal Gut to Fetal Brain.
  Trends in molecular medicine 2017 Osokine I, Erlebacher A
• Baby's First Organ.
  Scientific American 2017 Erlebacher A, Fisher SJ
• Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis.
  Infection and immunity 2017 Rizzuto G, Tagliani E, Manandhar P, Erlebacher A, Bakardjiev AI
• Epigenetic regulation of decidual inflammation.
  Journal of Reproductive Immunology 2016 A. Erlebacher, J. Siewiera, P. Nancy
• Presence and Functionality of Resident Memory CD8 T Cells in the Pregnant Mouse Uterus.
  Journal of Reproductive Immunology 2016 Emiel D. Post Uiterweer, Johan Siewiera, Patrice Nancy, Adrian Erlebacher
• Presence and functionality of resident memory CD8 T cells in the pregnant mouse uterus.
  Journal of Reproductive Immunology 2016 Emiel D. Post Uiterweer, Johan Siewiera, Patrice Nancy, Adrian Erlebacher
• Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells.
  Cancer cell 2015 Blaisdell A, Crequer A, Columbus D, Daikoku T, Mittal K, Dey SK, Erlebacher A
• Immune mechanisms at the maternal-fetal interface: perspectives and challenges.
  Nature immunology 2015 PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune JM, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga K
• Neutrophil recruitment into premalignant lesions differentially influences tumor growth versus progression. (TUM4P.928).
  The Journal of Immunology 2014 Adam Blaisdell, Takiko Daikoku, Chin Siean Tay, Sudhansu Dey, Adrian Erlebacher
• 19 Leukocyte Population Dynamics and Functions at the Maternal–Fetal Interface.
  The Guide to Investigation of Mouse Pregnancy 2014 Adrian Erlebacher
• 49 Immunofluorescence and Immunohistochemistry.
  The Guide to Investigation of Mouse Pregnancy 2014 Adam Blaisdell, Adrian Erlebacher
• 53 Flow Cytometric Analysis of Myometrial and Decidual Cell Suspensions.
  The Guide to Investigation of Mouse Pregnancy 2014 Adam Blaisdell, Adrian Erlebacher
• T cell behavior at the maternal-fetal interface.
  The International journal of developmental biology 2014 Nancy P, Erlebacher A
• Cis-acting pathways selectively enforce the non-immunogenicity of shed placental antigen for maternal CD8 T cells.
  PloS one 2013 Tay CS, Tagliani E, Collins MK, Erlebacher A
• Immunology of the maternal-fetal interface.
  Annual review of immunology 2013 Erlebacher A
• [Epigenetic repression of chemokine expression at the maternal-fetal interface as a mechanism of feto-maternal tolerance].
  Medecine sciences : M/S 2012 Nancy P, Erlebacher A
• Mechanisms of T cell tolerance towards the allogeneic fetus.
  Nature reviews. Immunology 2012 Erlebacher A
• Fetal programming and environmental exposures: implications for prenatal care and preterm birth.
  Annals of the New York Academy of Sciences 2012 Schug TT, Erlebacher A, Leibowitz S, Ma L, Muglia LJ, Rando OJ, Rogers JM, Romero R, vom Saal FS, Wise DL
• Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface.
  Science (New York, N.Y.) 2012 Nancy P, Tagliani E, Tay CS, Asp P, Levy DE, Erlebacher A
• Dendritic cell function at the maternal-fetal interface.
  Expert review of clinical immunology 2011 Tagliani E, Erlebacher A
• Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1.
  The Journal of experimental medicine 2011 Tagliani E, Shi C, Nancy P, Tay CS, Pamer EG, Erlebacher A
• miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.
  Cancer cell 2011 Gaziel-Sovran A, Segura MF, Di Micco R, Collins MK, Hanniford D, Vega-Saenz de Miera E, Rakus JF, Dankert JF, Shang S, Kerbel RS, Bhardwaj N, Shao Y, Darvishian F, Zavadil J, Erlebacher A, Mahal LK, …
• Strangers no more: uterine NK cell recognition of the placenta in mice.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Erlebacher A
• Acquisition and presentation of follicular dendritic cell-bound antigen by lymph node-resident dendritic cells.
  The Journal of experimental medicine 2010 McCloskey ML, Curotto de Lafaille MA, Carroll MC, Erlebacher A
• Regulation of CD8 T cell responses by follicular dendritic cell-bound antigen (98.17).
  The Journal of Immunology 2010 Adrian Erlebacher, Maria Curotto de Lafaille, Juan Lafaille, Michael Carroll, Megan McCloskey
• Immune surveillance of the maternal/fetal interface: controversies and implications.
  Trends in endocrinology and metabolism: TEM 2010 Erlebacher A
• Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice.
  The Journal of clinical investigation 2009 Collins MK, Tay CS, Erlebacher A
• Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.
  The Journal of clinical investigation 2007 Erlebacher A, Vencato D, Price KA, Zhang D, Glimcher LH
• Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
  Journal of Clinical Investigation 2006 K. Red-Horse, J. Rivera, A. Schanz, Y. Zhou, V. Winn, M. Kapidzic, E. Maltepe, K. Okazaki, R. Kochman, K. C. Vo, L. Giudice, A. Erlebacher, J. M. McCune, C. A. Stoddart, S. J. Fisher
• Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
  The Journal of clinical investigation 2006 Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ
• Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells.
  Journal of leukocyte biology 2005 Tayade C, Fang Y, Black GP, V A P, Erlebacher A, Croy BA
• National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development.
  American journal of obstetrics and gynecology 2004 Thadani PV, Strauss JF, Dey SK, Anderson VM, Audus KL, Coats KS, Cross JC, Erlebacher A, Ganapathy V, Linzer DI, Miller RK, Novak DA, Rapaka RS, Sadovsky Y, Salafia CM, Soares M, Unadkat J
• Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin.
  Developmental biology 2004 Erlebacher A, Price KA, Glimcher LH
• Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system.
  The Journal of clinical investigation 2004 Erlebacher A, Zhang D, Parlow AF, Glimcher LH
• Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Erlebacher A, Lukens AK, Glimcher LH
• Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass.
  Development (Cambridge, England) 1999 Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R
• Osteoblastic responses to TGF-beta during bone remodeling.
  Molecular biology of the cell 1998 Erlebacher A, Filvaroff EH, Ye JQ, Derynck R
• Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.
  The Journal of cell biology 1996 Erlebacher A, Derynck R
• Toward a molecular understanding of skeletal development.
  Cell 1995 Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R
• THE ROLE OF TGF-ß FAMILY MEMBERS IN MESENCHYMAL DIFFERENTIATION.
  Pediatric Research 1993 Rik Derynck, Ellen Filvaroff, Adrian Erlebacher, Stephen Gitelman