Adam Numis, MD
Associate Professor
Neurology
School of Medicine

His research includes evaluating the connection between inflammation and epilepsy. His work attempts to understand how inflammatory markers in the blood could help predict which patients might respond best to a particular antiseizure medications, in particular for a severe type of epilepsy termed infantile spasms. Additionally, his work seeks to understand the role inflammation and genetics may play in epilepsy development in certain at-risk populations, including children with neonatal encephalopathy, traumatic brain injuries, and stroke.

Dr. Numis received his medical degree from Harvard Medical School. He completed a residency in pediatrics at Boston Children's Hospital, a residency in child neurology at UCSF, and fellowships in clinical neurophysiology and epilepsy at the University of California, Los Angeles.

To make an appointment with Dr. Numis in the Pediatric Center of Excellence, ask your child's pediatrician to fax a referral to (415) 353-2400 or call (855) 722-8273. Learn more at: https://about.ucsfbenioffchildrens.org/schedule

• Responsive Neurostimulation in Drug-Resistant Pediatric Epilepsy: Findings From the Epilepsy Surgery Subgroup of the Pediatric Epilepsy Research Consortium.
  Pediatric neurology 2023 Singh RK, Eschbach K, Samanta D, Perry MS, Liu G, Alexander AL, Wong-Kisiel L, Ostendorf A, Tatachar P, Reddy SB, McCormack MJ, Manuel CM, Gonzalez-Giraldo E, Numis AL, Wolf S, Karia S, Karakas C, …
• Proceedings of the 14th International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring.
  Journal of neonatal-perinatal medicine 2023 Abramsky R, Acun C, Alt J, Aly H, Arad N, Baak LM, Bakalar D, Balasingham T, Bammler T, Benders MJNL, Benitez D, Boni E, Boylan G, Campbell E, Castri P, Chandrashekar P, Chavez-Valdez R, Chen M, …
• Risk of seizures in neonates with hypoxic-ischemic encephalopathy receiving hypothermia plus erythropoietin or placebo.
  Pediatric research 2022 Glass HC, Wusthoff CJ, Comstock BA, Numis AL, Gonzalez FF, Maitre N, Massey SL, Mayock DE, Mietzsch U, Natarajan N, Sokol GM, Bonifacio SL, Van Meurs KP, Thomas C, Ahmad KA, Heagerty PJ, Juul SE, Wu …
• Seizure Burden, EEG, and Outcome in Neonates With Acute Intracranial Infections: A Prospective Multicenter Cohort Study.
  Pediatric neurology 2022 Mehta N, Shellhaas RA, McCulloch CE, Chang T, Wusthoff CJ, Abend NS, Lemmon ME, Chu CJ, Massey SL, Franck LS, Thomas C, Soul JS, Rogers E, Numis A, Glass HC
• Inequities in Therapy for Infantile Spasms: A Call to Action.
  Annals of neurology 2022 Baumer FM, Mytinger JR, Neville K, Briscoe Abath C, Gutierrez CA, Numis AL, Harini C, He Z, Hussain SA, Berg AT, Chu CJ, Gaillard WD, Loddenkemper T, Pasupuleti A, Samanta D, Singh RK, Singhal NS, …
• Neonatal Seizure Management: What Is Timely Treatment and Does It Influence Neurodevelopment?
  The Journal of pediatrics 2021 Numis AL, Shellhaas RA
• Disorders of Neuronal Migration/Organization Convey the Highest Risk of Neonatal Onset Epilepsy Compared With Other Congenital Brain Malformations.
  Pediatric neurology 2021 Simmons R, Martinez AB, Barkovich J, Numis AL, Cilio MR, Glenn OA, Gano D, Rogers EE, Glass HC
• Early-life epilepsy after acute symptomatic neonatal seizures: A prospective multicenter study.
  Epilepsia 2021 Shellhaas RA, Wusthoff CJ, Numis AL, Chu CJ, Massey SL, Abend NS, Soul JS, Chang T, Lemmon ME, Thomas C, McNamara NA, Guillet R, Franck LS, Sturza J, McCulloch CE, Glass HC
• Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures.
  JAMA neurology 2021 Glass HC, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Lemmon M, Thomas C, Numis AL, Guillet R, Sturza J, McNamara NA, Rogers EE, Franck LS, McCulloch CE, Shellhaas RA
• Neonatal presentation of genetic epilepsies: Early differentiation from acute provoked seizures.
  Epilepsia 2021 Cornet MC, Morabito V, Lederer D, Glass HC, Ferrao Santos S, Numis AL, Ferriero DM, Sands TT, Cilio MR
• Seizure and Interictal Electroencephalographic (EEG) Changes with Cannabinoid Concentrate Use.
  The American journal of case reports 2021 Kahan MD, Breithaupt A, Nash K, Numis AL
• Whole-exome sequencing with targeted analysis and epilepsy after acute symptomatic neonatal seizures.
  Pediatric research 2021 Numis AL, da Gente G, Sherr EH, Glass HC
• Comparison of multiplex cytokine assays in a pediatric cohort with epilepsy.
  Heliyon 2021 Numis AL, Fox CH, Lowenstein DJ, Norris PJ, Di Germanio C
• Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology.
  Epilepsy & behavior : E&B 2020 Hussain SA, Heesch J, Weng J, Rajaraman RR, Numis AL, Sankar R
• De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism.
  American journal of human genetics 2020 Guillen Sacoto MJ, Tchasovnikarova IA, Torti E, Forster C, Andrew EH, Anselm I, Baranano KW, Briere LC, Cohen JS, Craigen WJ, Cytrynbaum C, Ekhilevitch N, Elrick MJ, Fatemi A, Fraser JL, Gallagher RC,…
• ECI biocommentary november 2019.
  Pediatric research 2019 Numis A
• Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy.
  Pediatric research 2019 Numis AL, Foster-Barber A, Deng X, Rogers EE, Barkovich AJ, Ferriero DM, Glass HC
• Clinical spectrum of STX1B-related epileptic disorders.
  Neurology 2019 Wolking S, May P, Mei D, Møller RS, Balestrini S, Helbig KL, Altuzarra CD, Chatron N, Kaiwar C, Stöhr K, Widdess-Walsh P, Mendelsohn BA, Numis A, Cilio MR, Van Paesschen W, Svendsen LL, Oates S, …
• Lack of response to quinidine in KCNT1-related neonatal epilepsy.
  Epilepsia 2018 Numis AL, Nair U, Datta AN, Sands TT, Oldham MS, Patel A, Li M, Gazina E, Petrou S, Cilio MR
• Outcomes After Acute Symptomatic Seizures in Children Admitted to a Neonatal Neurocritical Care Service.
  Pediatric neurology 2018 Glass HC, Numis AL, Gano D, Bali V, Rogers EE
• Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy.
  Epilepsy & behavior case reports 2018 Singhal NS, Numis AL, Lee MB, Chang EF, Sullivan JE, Auguste KI, Rao VR
• Population-based study of ischemic stroke risk after trauma in children and young adults.
  Neurology 2017 Fox CK, Hills NK, Vinson DR, Numis AL, Dicker RA, Sidney S, Fullerton HJ
• AR2, a novel automatic artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software.
  F1000Research 2017 Weiss SA, Asadi-Pooya AA, Vangala S, Moy S, Wyeth DH, Orosz I, Gibbs M, Schrader L, Lerner J, Cheng CK, Chang E, Rajaraman R, Keselman I, Churchman P, Bower-Baca C, Numis AL, Ho MG, Rao L, Bhat A, …
• WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities.
  Epilepsia 2016 Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A
• Cerebral palsy research funding from the National Institutes of Health, 2001 to 2013.
  Developmental medicine and child neurology 2015 Wu YW, Mehravari AS, Numis AL, Gross P
• Early and effective treatment of KCNQ2 encephalopathy.
  Epilepsia 2015 Pisano T, Numis AL, Heavin SB, Weckhuysen S, Angriman M, Suls A, Podesta B, Thibert RL, Shapiro KA, Guerrini R, Scheffer IE, Marini C, Cilio MR
• Arterial ischemic stroke in children: risk factors and etiologies.
  Current neurology and neuroscience reports 2014 Numis AL, Fox CK
• KCNQ2 encephalopathy: delineation of the electroclinical phenotype and treatment response.
  Neurology 2013 Numis AL, Angriman M, Sullivan JE, Lewis AJ, Striano P, Nabbout R, Cilio MR
• Intraoperative rerupture during surgical treatment of aneurysmal subarachnoid hemorrhage is not associated with an increased risk of vasospasm.
  Journal of neurosurgery 2013 Sheth SA, Hausrath D, Numis AL, Lawton MT, Josephson SA
• Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and follow-up in tuberous sclerosis complex.
  Journal of computer assisted tomography 2012 Muzykewicz DA, Black ME, Muse V, Numis AL, Rajagopal J, Thiele EA, Sharma A
• The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms.
  Epilepsy research 2011 Numis AL, Yellen MB, Chu-Shore CJ, Pfeifer HH, Thiele EA
• Identification of risk factors for autism spectrum disorders in tuberous sclerosis complex.
  Neurology 2011 Numis AL, Major P, Montenegro MA, Muzykewicz DA, Pulsifer MB, Thiele EA
• Characterizing sleep disorders of adults with tuberous sclerosis complex: a questionnaire-based study and review.
  Epilepsy & behavior : E&B 2010 van Eeghen AM, Numis AI, Staley BA, Therrien SE, Thibert RL, Thiele EA
• TSC1 and TSC2 mutations in patients with lymphangioleiomyomatosis and tuberous sclerosis complex.
  Journal of medical genetics 2009 Muzykewicz DA, Sharma A, Muse V, Numis AL, Rajagopal J, Thiele EA
• Role of mutational analysis in diagnosis of tuberous sclerosis complex.
  Clinical genetics 2009 Vail EA, Rakowski SK, Numis AL, Thiele EA
• The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP).
  Molecular pharmacology 2004 Numis AL, Unger EL, Sheridan DL, Chisnell AC, Andrews AM
• Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1.
  Neurobiology of disease 2004 Szapacs ME, Numis AL, Andrews AM