Adam Litterman, PhD
Assistant Professor
Biochemistry and Biophysics
School of Medicine

Education & Training

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• Postdoc Immunology University of California San Francisco 2018
• PhD Microbiology Immunology and Cancer Biology University of Minnesota 2014
• BA Molecular Biology Princeton University 2007

Publications (16)

Top publication keywords:
Immunologic MemoryGene ExpressionLymphocytes, Tumor-InfiltratingConserved SequenceImmunotherapy, AdoptiveCancer VaccinesAntineoplastic Agents, AlkylatingCD8-Positive T-Lymphocytes3' Untranslated RegionsGenes, ReporterCytotoxicity, ImmunologicGene Expression RegulationNeoplasms, ExperimentalBase CompositionAdaptive Immunity

• Compact CRISPR genetic screens enabled by improved guide RNA library cloning.
  Genome biology 2024 Heo SJ, Enriquez LD, Federman S, Chang AY, Mace R, Shevade K, Nguyen P, Litterman AJ, Shafer S, Przybyla L, Chow ED
• GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins.
  Genome biology 2023 Zhu WS, Litterman AJ, Sekhon HS, Kageyama R, Arce MM, Taylor KE, Zhao W, Criswell LA, Zaitlen N, Erle DJ, Ansel KM
• Non-viral precision T cell receptor replacement for personalized cell therapy.
  Nature 2022 Foy SP, Jacoby K, Bota DA, Hunter T, Pan Z, Stawiski E, Ma Y, Lu W, Peng S, Wang CL, Yuen B, Dalmas O, Heeringa K, Sennino B, Conroy A, Bethune MT, Mende I, White W, Kukreja M, Gunturu S, Humphrey E, …
• MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.
  The Journal of experimental medicine 2021 Wigton EJ, Mikami Y, McMonigle RJ, Castellanos CA, Wade-Vallance AK, Zhou SK, Kageyama R, Litterman A, Roy S, Kitamura D, Dykhuizen EC, Allen CDC, Hu H, O'Shea JJ, Ansel KM
• RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery.
  Cell reports 2019 Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW

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• miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
  Cell reports 2019 Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, …
• A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.
  Genome research 2019 Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM
• Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses.
  PloS one 2015 Renner DN, Jin F, Litterman AJ, Balgeman AJ, Hanson LM, Gamez JD, Chae M, Carlson BL, Sarkaria JN, Parney IF, Ohlfest JR, Pirko I, Pavelko KD, Johnson AJ
• Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy.
  Cancer immunology research 2014 Litterman AJ, Zellmer DM, LaRue RS, Jameson SC, Largaespada DA
• Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination.
  Oncoimmunology 2013 Litterman AJ, Dudek AZ, Largaespada DA
• Minicircle DNA is superior to plasmid DNA in eliciting antigen-specific CD8+ T-cell responses.
  Molecular therapy : the journal of the American Society of Gene Therapy 2013 Dietz WM, Skinner NE, Hamilton SE, Jund MD, Heitfeld SM, Litterman AJ, Hwu P, Chen ZY, Salazar AM, Ohlfest JR, Blazar BR, Pennell CA, Osborn MJ
• Profound impairment of adaptive immune responses by alkylating chemotherapy.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Litterman AJ, Zellmer DM, Grinnen KL, Hunt MA, Dudek AZ, Salazar AM, Ohlfest JR
• Vaccine injection site matters: qualitative and quantitative defects in CD8 T cells primed as a function of proximity to the tumor in a murine glioma model.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Ohlfest JR, Andersen BM, Litterman AJ, Xia J, Pennell CA, Swier LE, Salazar AM, Olin MR
• Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma.
  PloS one 2012 Yancovitz M, Litterman A, Yoon J, Ng E, Shapiro RL, Berman RS, Pavlick AC, Darvishian F, Christos P, Mazumdar M, Osman I, Polsky D
• Oxygen is a master regulator of the immunogenicity of primary human glioma cells.
  Cancer research 2011 Olin MR, Andersen BM, Litterman AJ, Grogan PT, Sarver AL, Robertson PT, Liang X, Chen W, Parney IF, Hunt MA, Blazar BR, Ohlfest JR
• FTC presentation by Alfred Litterman to the metropolitan Washington section of the American College of Dentists.
  District of Columbia Dental Society journal. District of Columbia Dental Society 1977 Litterman A