Adam Abate, PhD
Professor
Bioengineering
School of Pharmacy

The droplets are used to create micro-compartments, which can be loaded with single cells and other active materials, such as drugs, nutrients, and assay reagents. By chaining together different microdevice components, the droplets can be used as tiny "test tubes" for performing chemical and biological reactions. This allows multiple, independent reactions to take place at the rate of thousands per second, while using minuscule amounts of total reagent. Adam is using this approach for directed evolution, genetic sequencing, and cell sorting.

• Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy.
  JAMA network open 2023 Vasudevan HN, Delley C, Chen WC, Mirchia K, Pan S, Shukla P, Aabedi AA, Nguyen MP, Morshed RA, Young JS, Boreta L, Fogh SE, Nakamura JL, Theodosopoulos PV, Phillips J, Hervey-Jumper SL, Daras M, Pike …
• Viral load quantitation at the point-of-care with shaken digital droplet RT-LAMP.
  Lab on a chip 2023 Weisgerber DW, Langer K, Servellita V, Xu P, Chiu CY, Abate AR
• Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification.
  bioRxiv : the preprint server for biology 2023 Peretz CAC, Kennedy VE, Walia A, Delley CL, Koh A, Tran E, Clark IC, Hayford CE, D'Amato C, Xue Y, Fontanez KM, Roy R, Logan AC, Perl AE, Abate A, Olshen A, Smith CC
• Flow cytometric printing of double emulsions into open droplet arrays.
  Lab on a chip 2023 Zhang P, Xu L, Chen H, Abate AR
• Droplet-based microfluidics.
  Nature Reviews Methods Primers 2023 Thomas Moragues, Diana Arguijo, Thomas Beneyton, Cyrus Modavi, Karolis Simutis, Adam R. Abate, Jean-Christophe Baret, Andrew J. deMello, Douglas Densmore, Andrew D. Griffiths
• Droplet-based forward genetic screening of astrocyte-microglia cross-talk.
  Science (New York, N.Y.) 2023 Wheeler MA, Clark IC, Lee HG, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, …
• Microfluidics-free single-cell genomics with templated emulsification.
  Nature biotechnology 2023 Clark IC, Fontanez KM, Meltzer RH, Xue Y, Hayford C, May-Zhang A, D'Amato C, Osman A, Zhang JQ, Hettige P, Ishibashi JSA, Delley CL, Weisgerber DW, Replogle JM, Jost M, Phong KT, Kennedy VE, Peretz …
• HIV silencing and cell survival signatures in infected T cell reservoirs.
  Nature 2023 Clark IC, Mudvari P, Thaploo S, Smith S, Abu-Laban M, Hamouda M, Theberge M, Shah S, Ko SH, Pérez L, Bunis DG, Lee JS, Kilam D, Zakaria S, Choi S, Darko S, Henry AR, Wheeler MA, Hoh R, Butrus S, Deeks…
• Identification of astrocyte regulators by nucleic acid cytometry.
  Nature 2023 Clark IC, Wheeler MA, Lee HG, Li Z, Sanmarco LM, Thaploo S, Polonio CM, Shin SW, Scalisi G, Henry AR, Rone JM, Giovannoni F, Charabati M, Akl CF, Aleman DM, Zandee SEJ, Prat A, Douek DC, Boritz EA, …
• OP 1.2 – 00157 HIV Silencing and Cell Survival Signatures of HIV-Infected CD4 T Cell Transcriptomes under Antiretroviral Therapy (ART).
  Journal of Virus Eradication 2022 I.C. Clark, P. Mudvari, S. Thaploo, S. Smith, M. Abu-Laban, S.G. Deeks, F.J. Quintana, D.C. Douek, A.R. Abate, E.A. Boritz
• Rapid parallel generation of a fluorescently barcoded drop library from a microtiter plate using the plate-interfacing parallel encapsulation (PIPE) chip.
  Lab on a chip 2022 Zath GK, Sperling RA, Hoffman CW, Bikos DA, Abbasi R, Abate AR, Weitz DA, Chang CB
• Multiomic Single-Cell Sequencing of Mixed Phenotypic Acute Leukemia (MPAL) Reveals Complex Immunophenotypic, Transcriptional, and Genetic Heterogeneity.
  Blood 2022 Cheryl Peretz, Vanessa E. Kennedy, Anushka Walia, Cyrille Delley, Andrew Koh, Elaine Tran, Iain Clark, Corey Hayford, Yi Xue, Chris D'Amato, Kristina Fontanez, Ritu P. Roy, Adam Olshen, Aaron C. Logan…
• BIOM-02. MUTATIONAL ANALYSIS AND SINGLE CELL SEQUENCING OF MELANOMA BRAIN METASTASES REVEALS BRAF STATUS CORRELATES WITH CLINICAL OUTCOME AND DIFFERENTIAL IMMUNE POPULATIONS.
  Neuro-Oncology 2022 Harish Vasudevan, Cyrille Delley, Alexander Aabedi, Poojan Shukla, Minh Nguyen, Ramin A Morshed, Jacob S Young, Ben Demaree, Devan Diwanji, Shawn L Hervey-Jumper, Lauren Boreta, Shannon Fogh, Jean …
• DDDR-06. NEUROFIBROMATOSIS TUMOR SUPPRESSORS COOPERATIVELY DRIVE TUMOR DE-DIFFERENTIATION AND MEK INHIBITOR RESISTANCE IN PERIPHERAL NERVOUS SYSTEM TUMORS.
  Neuro-Oncology 2022 Harish Vasudevan, Emily Payne, Cyrille Delley, Matthew Sale, S John Liu, Sydney Lastella, Calixto-Hope Lucas, Charlotte Eaton, Tim Casey-Clyde, Stephen Magill, William Chen, Alyssa Reddy, Steve …
• Mutational Analysis and Single Cell Sequencing of Melanoma Brain Metastases.
  International Journal of Radiation Oncology • Biology • Physics 2022 H. Vasudevan, C. Delley, A. Aabedi, M.P. Nguyen, R.A. Morshed, J.S. Young, B. Demaree, D. Diwanji, S. Hervey-Jumper, L. Boreta, S.E. Fogh, J.L. Nakamura, P.V. Theodosopoulos, J. Phillips, M. Daras, K.…
• Controlled fabrication of functional liver spheroids with microfluidic flow cytometric printing.
  Biofabrication 2022 Zhang P, Li X, Chen JY, Abate AR
• G1/S restriction point coordinates phasic gene expression and cell differentiation.
  Nature communications 2022 DeVeale B, Liu L, Boileau R, Swindlehurst-Chan J, Marsh B, Freimer JW, Abate A, Blelloch R
• Polyhedral Particles with Controlled Concavity by Indentation Templating.
  Analytical chemistry 2022 Weisgerber DW, Hatori M, Li X, Abate AR
• Scalable Microbial Strain Inference in Metagenomic Data Using StrainFacts.
  Frontiers in bioinformatics 2022 Smith BJ, Li X, Shi ZJ, Abate A, Pollard KS
• Droplet-microfluidics-assisted sequencing of HIV proviruses and their integration sites in cells from people on antiretroviral therapy.
  Nature biomedical engineering 2022 Sun C, Liu L, Pérez L, Li X, Liu Y, Xu P, Boritz EA, Mullins JI, Abate AR
• Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry (Adv. Mater. 12/2022).
  Advanced Materials 2022 Linfeng Xu, Xiangpeng Li, Wenzong Li, Kai-chun Chang, Hyunjun Yang, Nannan Tao, Pengfei Zhang, Emory M. Payne, Cyrus Modavi, Jacqueline Humphries, Chia-Wei Lu, Adam R. Abate
• Dual-layered hydrogels allow complete genome recovery with nucleic acid cytometry.
  Biotechnology journal 2022 Hatori MN, Modavi C, Xu P, Weisgerber D, Abate AR
• Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry.
  Advanced materials (Deerfield Beach, Fla.) 2022 Xu L, Li X, Li W, Chang KC, Yang H, Tao N, Zhang P, Payne EM, Modavi C, Humphries J, Lu CW, Abate AR
• Robotic automation of droplet microfluidics.
  Biomicrofluidics 2022 Tran TM, Kim SC, Modavi C, Abate AR
• Characterizing cell interactions at scale with made-to-order droplet ensembles (MODEs).
  Proceedings of the National Academy of Sciences of the United States of America 2022 Madrigal JL, Schoepp NG, Xu L, Powell CS, Delley CL, Siltanen CA, Danao J, Srinivasan M, Cole RH, Abate AR
• Single-Cell Protein Profiling by Microdroplet Barcoding and Next-Generation Sequencing.
  Methods in molecular biology (Clifton, N.J.) 2022 Kim SC, Haliburton JR, Gartner ZJ, Abate AR
• The chromatin repressors EZH2 and Suv4-20h coregulate cell fate specification during hippocampal development.
  FEBS letters 2021 Chang KC, Rhodes CT, Zhang JQ, Moseley MC, Cardona SM, Huang SA, Rawls A, Lemmon VP, Berger MS, Abate AR, Lin CA
• Mapping enzyme catalysis with metabolic biosensing.
  Nature communications 2021 Xu L, Chang KC, Payne EM, Modavi C, Liu L, Palmer CM, Tao N, Alper HS, Kennedy RT, Cornett DS, Abate AR
• CSIG-01. EPIGENETIC REPROGRAMMING DRIVES MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) DE-DIFFERENTIATION AND TREATMENT RESISTANCE.
  Neuro-Oncology 2021 Harish Vasudevan, Sydney Lastella, Matthew Sale, Timothy Casey-Clyde, Benjamin Demaree, Cyrille Delley, Calixto Lucas, Stephen Magill, John Liu, William Chen, Steve Braunstein, Alyssa Reddy, Arie …
• Change can be SCARI.
  Nature chemical biology 2021 Modavi C, Abate A
• Accurate Bulk Quantitation of Droplet Digital Polymerase Chain Reaction.
  Analytical chemistry 2021 Sun C, Liu L, Vasudevan HN, Chang KC, Abate AR
• Modular barcode beads for microfluidic single cell genomics.
  Scientific reports 2021 Delley CL, Abate AR
• Sequencing Ultrarare Targets with Compound Nucleic Acid Cytometry.
  Analytical chemistry 2021 Sun C, Chang KC, Abate AR
• Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.
  The Journal of experimental medicine 2021 Le Coz C, Nguyen DN, Su C, Nolan BE, Albrecht AV, Xhani S, Sun D, Demaree B, Pillarisetti P, Khanna C, Wright F, Chen PA, Yoon S, Stiegler AL, Maurer K, Garifallou JP, Rymaszewski A, Kroft SH, Olson …
• Barcoded viral tracing of single-cell interactions in central nervous system inflammation.
  Science (New York, N.Y.) 2021 Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, …
• Precision ejection of microfluidic droplets into air with a superhydrophobic outlet.
  Lab on a chip 2021 Zhang P, Chang KC, Abate AR
• Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR
• Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia.
  Nature communications 2021 Demaree B, Delley CL, Vasudevan HN, Peretz CAC, Ruff D, Smith CC, Abate AR
• Particle Templated Emulsification enables Microfluidic-Free Droplet Assays.
  Journal of Visualized Experiments 2021 Daniel W. Weisgerber, Makiko N. Hatori, Adam R. Abate
• Particle Templated Emulsification enables Microfluidic-Free Droplet Assays.
  Journal of visualized experiments : JoVE 2021 Weisgerber DW, Hatori MN, Abate AR
• Simple, Affordable, and Modular Patterning of Cells using DNA.
  Journal of visualized experiments : JoVE 2021 Cabral KA, Patterson DM, Scheideler OJ, Cole R, Abate AR, Schaffer DV, Sohn LL, Gartner ZJ
• Simple, Affordable, and Modular Patterning of Cells using DNA.
  Journal of Visualized Experiments 2021 Katelyn A. Cabral, David M. Patterson, Olivia J. Scheideler, Russell Cole, Adam R. Abate, David V. Schaffer, Lydia L. Sohn, Zev J. Gartner
• High diversity droplet microfluidic libraries generated with a commercial liquid spotter.
  Scientific reports 2021 Zhang JQ, Siltanen CA, Dolatmoradi A, Sun C, Chang KC, Cole RH, Gartner ZJ, Abate AR
• Accurate bulk quantitation of droplet digital PCR.
  bioRxiv : the preprint server for biology 2021 Sun C, Liu L, Vasudevan HN, Chang KC, Abate AR
• Digital droplet PCR accurately quantifies SARS-CoV-2 viral load from crude lysate without nucleic acid purification.
  Scientific reports 2021 Vasudevan HN, Xu P, Servellita V, Miller S, Liu L, Gopez A, Chiu CY, Abate AR
• Networks of High Aspect Ratio Particles to Direct Colloidal Assembly Dynamics and Cellular Interactions.
  Advanced functional materials 2020 Finbloom JA, Demaree B, Abate AR, Desai TA
• High-Definition Single-Cell Printing: Cell-by-Cell Fabrication of Biological Structures.
  Advanced materials (Deerfield Beach, Fla.) 2020 Zhang P, Abate AR
• Single-cell mutation analysis of clonal evolution in myeloid malignancies.
  Nature 2020 Miles LA, Bowman RL, Merlinsky TR, Csete IS, Ooi AT, Durruthy-Durruthy R, Bowman M, Famulare C, Patel MA, Mendez P, Ainali C, Demaree B, Delley CL, Abate AR, Manivannan M, Sahu S, Goldberg AD, Bolton …
• Targeted Single-Cell RNA and DNA Sequencing With Fluorescence-Activated Droplet Merger.
  Analytical chemistry 2020 Clark IC, Delley CL, Sun C, Thakur R, Stott SL, Thaploo S, Li Z, Quintana FJ, Abate AR
• Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
  Nature communications 2020 Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, …
• Digital droplet PCR accurately quantifies SARS-CoV-2 viral load from crude lysate without nucleic acid purification.
  medRxiv : the preprint server for health sciences 2020 Vasudevan H, Xu P, Servellita V, Miller S, Liu L, Gopez A, Chiu CY, Abate AR
• Microfluidic particle zipper enables controlled loading of droplets with distinct particle types.
  Lab on a chip 2020 Delley CL, Abate AR
• High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing.
  Journal of Visualized Experiments 2020 Jesse Q. Zhang, Kai-Chun Chang, Leqian Liu, Zev J. Gartner, Adam R. Abate
• High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing.
  Journal of visualized experiments : JoVE 2020 Zhang JQ, Chang KC, Liu L, Gartner ZJ, Abate AR
• Microfluidic automated plasmid library enrichment for biosynthetic gene cluster discovery.
  Nucleic acids research 2020 Xu P, Modavi C, Demaree B, Twigg F, Liang B, Sun C, Zhang W, Abate AR
• Linked optical and gene expression profiling of single cells at high-throughput.
  Genome biology 2020 Zhang JQ, Siltanen CA, Liu L, Chang KC, Gartner ZJ, Abate AR
• Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.
  Cell reports 2020 Liu SJ, Magill ST, Vasudevan HN, Hilz S, Villanueva-Meyer JE, Lastella S, Daggubati V, Spatz J, Choudhury A, Orr BA, Demaree B, Seo K, Ferris SP, Abate AR, Oberheim Bush NA, Bollen AW, McDermott MW, …
• Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets.
  ACS nano 2019 Kim JH, Kim SC, Kline MA, Grzincic EM, Tresca BW, Cardiel J, Karbaschi M, Dehigaspitiya DC, Chen Y, Udumula V, Jian T, Murray DJ, Yun L, Connolly MD, Liu J, Ren G, Chen CL, Kirshenbaum K, Abate AR, …
• OP 1.3 Single-cell transcriptome sequencing of latently-infected cells ex vivo using PCR-activated cell sorting (PACS).
  Journal of virus eradication 2019 E. Boritz, I. Clark, A. Abate, F. Quintana, S. Deeks, D. Douek
• Combined Single-Cell DNA Genotyping and Protein Quantification (DAb-seq) in Acute Myeloid Leukemias Reveals Distinct Immunophenotypic Subsets Among Pathogenic Clones.
  Blood 2019 Benjamin Demaree, Cyrille Delley, Cheryl Peretz, Harish Vasudevan, David Ruff, Aik Ooi, Catherine C. Smith, Adam Abate
• TMOD-27. A NEURAL CREST CELL SUBPOPULATION UNDERLIES INTRATUMOR HETEROGENEITY IN MENINGIOMA.
  Neuro-Oncology 2019 Stephen Magill, Harish Vasudevan, Kyounghee Seo, S John Liu, Stephanie Hilz, Javier Villanueva-Meyer, Abrar Choudhury, Benjamin Demaree, Daniel Lim, Steve Braunstein, Nancy Ann Oberheim-Bush, Erik …
• Uniform, Large-Area, Highly Ordered Peptoid Monolayer and Bilayer Films for Sensing Applications.
  Langmuir : the ACS journal of surfaces and colloids 2019 Murray DJ, Kim JH, Grzincic EM, Kim SC, Abate AR, Zuckermann RN
• Human intestinal spheroids cultured using Sacrificial Micromolding as a model system for studying drug transport.
  Scientific reports 2019 Samy KE, Levy ES, Phong K, Demaree B, Abate AR, Desai TA
• Abstract 3527: Combined high-throughput DNA genotyping and protein quantification in single cancer cells.
  Molecular and Cellular Biology / Genetics 2019 Benjamin Demaree, Cyrille Delley, David Ruff, Sebastian Treusch, Dennis Eastburn, Keith Jones, Adam Abate
• HIGH-RESOLUTION CLONAL ANALYSIS OF TUMORS WITH SIMULTANEOUS SINGLE-CELL DNA SEQUENCING AND CELL SURFACE PHENOTYPING.
  HemaSphere 2019 D. Eastburn, C. Delley, B. Demaree, D. Dhingra, P. Mendez, D. Ruff, A. Abate
• High throughput gene expression profiling of yeast colonies with microgel-culture Drop-seq.
  Lab on a chip 2019 Liu L, Dalal CK, Heineike BM, Abate AR
• Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage.
  Nature immunology 2019 Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M
• Direct quantification of EGFR variant allele frequency in cell-free DNA using a microfluidic-free digital droplet PCR assay.
  Methods in cell biology 2018 Demaree B, Weisgerber D, Dolatmoradi A, Hatori M, Abate AR
• Microfluidic bead encapsulation above 20 kHz with triggered drop formation.
  Lab on a chip 2018 Clark IC, Abate AR
• Particle-Templated Emulsification for Microfluidics-Free Digital Biology.
  Analytical chemistry 2018 Hatori MN, Kim SC, Abate AR
• An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing.
  Journal of Visualized Experiments 2018 Benjamin Demaree, Daniel Weisgerber, Freeman Lan, Adam R. Abate
• An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing.
  Journal of visualized experiments : JoVE 2018 Demaree B, Weisgerber D, Lan F, Abate AR
• An Oil-Free Picodrop Bioassay Platform for Synthetic Biology.
  Scientific reports 2018 Siltanen CA, Cole RH, Poust S, Chao L, Tyerman J, Kaufmann-Malaga B, Ubersax J, Gartner ZJ, Abate AR
• A comparative analysis of single cell and droplet-based FACS for improving production phenotypes: Riboflavin overproduction in Yarrowia lipolytica.
  Metabolic engineering 2018 Wagner JM, Liu L, Yuan SF, Venkataraman MV, Abate AR, Alper HS
• Concentric electrodes improve microfluidic droplet sorting.
  Lab on a chip 2018 Clark IC, Thakur R, Abate AR
• Combined aptamer and transcriptome sequencing of single cells.
  Scientific reports 2018 Delley CL, Liu L, Sarhan MF, Abate AR
• Single-Cell RT-PCR in Microfluidic Droplets with Integrated Chemical Lysis.
  Analytical chemistry 2018 Kim SC, Clark IC, Shahi P, Abate AR
• Bulk double emulsification for flow cytometric analysis of microfluidic droplets.
  The Analyst 2017 Sukovich DJ, Kim SC, Ahmed N, Abate AR
• PP1.1 Whole genome sequencing of single HIV provirus and its proviral integration site for the study of HIV latency.
  Journal of virus eradication 2017 C. Sun, J. Mullins, A. Abate
• Cell-free extract based optimization of biomolecular circuits with droplet microfluidics.
  Lab on a chip 2017 Hori Y, Kantak C, Murray RM, Abate AR
• RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes.
  Nature communications 2017 Abatemarco J, Sarhan MF, Wagner JM, Lin JL, Liu L, Hassouneh W, Yuan SF, Alper HS, Abate AR
• Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Cole RH, Tang SY, Siltanen CA, Shahi P, Zhang JQ, Poust S, Gartner ZJ, Abate AR
• Rapid, chemical-free breaking of microfluidic emulsions with a hand-held antistatic gun.
  Biomicrofluidics 2017 Karbaschi M, Shahi P, Abate AR
• Measurement of copy number variation in single cancer cells using rapid-emulsification digital droplet MDA.
  Microsystems & nanoengineering 2017 Kim SC, Premasekharan G, Clark IC, Gemeda HB, Paris PL, Abate AR
• Finding a helix in a haystack: nucleic acid cytometry with droplet microfluidics.
  Lab on a chip 2017 Clark IC, Abate AR
• Single-cell genome sequencing at ultra-high-throughput with microfluidic droplet barcoding.
  Nature biotechnology 2017 Lan F, Demaree B, Ahmed N, Abate AR
• Efficient extraction of oil from droplet microfluidic emulsions.
  Biomicrofluidics 2017 Haliburton JR, Kim SC, Clark IC, Sperling RA, Weitz DA, Abate AR
• Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding.
  Scientific reports 2017 Shahi P, Kim SC, Haliburton JR, Gartner ZJ, Abate AR
• Genetic interaction mapping with microfluidic-based single cell sequencing.
  PloS one 2017 Haliburton JR, Shao W, Deutschbauer A, Arkin A, Abate AR
• Sequence specific sorting of DNA molecules with FACS using 3dPCR.
  Scientific reports 2017 Sukovich DJ, Lance ST, Abate AR
• Rapid Encapsulation of Cell and Polymer Solutions with Bubble-Triggered Droplet Generation.
  Macromolecular Chemistry and Physics 2017 Zihao Yan, Iain C. Clark, Adam R. Abate
• PCR-activated cell sorting as a general, cultivation-free method for high-throughput identification and enrichment of virus hosts.
  Journal of virological methods 2016 Lim SW, Lance ST, Stedman KM, Abate AR
• Peering below the diffraction limit: robust and specific sorting of viruses with flow cytometry.
  Virology journal 2016 Lance ST, Sukovich DJ, Stedman KM, Abate AR
• Operation of Droplet-Microfluidic Devices with a Lab Centrifuge.
  Micromachines 2016 Ahmed N, Sukovich D, Abate AR
• Droplet barcoding for massively parallel single-molecule deep sequencing.
  Nature communications 2016 Lan F, Haliburton JR, Yuan A, Abate AR
• Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers.
  Journal of visualized experiments : JoVE 2016 Cole RH, Gartner ZJ, Abate AR
• Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers.
  Journal of Visualized Experiments 2016 Russell H. Cole, Zev J. Gartner, Adam R. Abate
• Electrical lysis of cells for detergent-free droplet assays.
  Biomicrofluidics 2016 de Lange N, Tran TM, Abate AR
• Double Emulsion Generation Using a Polydimethylsiloxane (PDMS) Co-axial Flow Focus Device.
  Journal of visualized experiments : JoVE 2015 Cole RH, Tran TM, Abate AR
• Enhanced sequencing coverage with digital droplet multiple displacement amplification.
  Nucleic acids research 2015 Sidore AM, Lan F, Lim SW, Abate AR
• Patterning microfluidic device wettability with spatially-controlled plasma oxidation.
  Lab on a chip 2015 Kim SC, Sukovich DJ, Abate AR
• Compact and modular multicolour fluorescence detector for droplet microfluidics.
  Lab on a chip 2015 Cole RH, de Lange N, Gartner ZJ, Abate AR
• Dissecting enzyme function with microfluidic-based deep mutational scanning.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Romero PA, Tran TM, Abate AR
• Microfluidic droplet enrichment for targeted sequencing.
  Nucleic acids research 2015 Eastburn DJ, Huang Y, Pellegrino M, Sciambi A, Ptácek LJ, Abate AR
• PCR-activated cell sorting for cultivation-free enrichment and sequencing of rare microbes.
  PloS one 2015 Lim SW, Tran TM, Abate AR
• Accurate microfluidic sorting of droplets at 30 kHz.
  Lab on a chip 2015 Sciambi A, Abate AR
• Rapid modulation of droplet composition with pincer microvalves.
  Lab on a chip 2015 Ochs CJ, Abate AR
• Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.
  Blood 2014 Stieglitz E, Troup CB, Gelston LC, Haliburton J, Chow ED, Yu KB, Akutagawa J, Taylor-Weiner AN, Liu YL, Wang YD, Beckman K, Emanuel PD, Braun BS, Abate A, Gerbing RB, Alonzo TA, Loh ML
• Identification and genetic analysis of cancer cells with PCR-activated cell sorting.
  Nucleic acids research 2014 Eastburn DJ, Sciambi A, Abate AR
• Picoinjection of microfluidic drops without metal electrodes.
  Journal of visualized experiments : JoVE 2014 O'Donovan B, Tran T, Sciambi A, Abate A
• Generating electric fields in PDMS microfluidic devices with salt water electrodes.
  Lab on a chip 2014 Sciambi A, Abate AR
• Coaxial flow focusing in poly(dimethylsiloxane) microfluidic devices.
  Biomicrofluidics 2014 Tran TM, Cater S, Abate AR
• DNA sequence analysis with droplet-based microfluidics.
  Lab on a chip 2013 Abate AR, Hung T, Sperling RA, Mary P, Rotem A, Agresti JJ, Weiner MA, Weitz DA
• Ultrahigh-throughput sorting of microfluidic drops with flow cytometry.
  Lab on a chip 2013 Lim SW, Abate AR
• Ultrahigh-throughput Mammalian single-cell reverse-transcriptase polymerase chain reaction in microfluidic drops.
  Analytical chemistry 2013 Eastburn DJ, Sciambi A, Abate AR
• Adding reagent to droplets with controlled rupture of encapsulated double emulsions.
  Biomicrofluidics 2013 Sciambi A, Abate AR
• Picoinjection enables digital detection of RNA with droplet rt-PCR.
  PloS one 2013 Eastburn DJ, Sciambi A, Abate AR
• Block-and-break generation of microdroplets with fixed volume.
  Biomicrofluidics 2013 van Steijn V, Korczyk PM, Derzsi L, Abate AR, Weitz DA, Garstecki P
• From tubes to drops: droplet-based microfluidics for ultrahigh-throughput biology.
  Journal of Physics D 2013 T M Tran, F Lan, C S Thompson, A R Abate
• Adhesive-based bonding technique for PDMS microfluidic devices.
  Lab on a chip 2013 Thompson CS, Abate AR
• Flow focusing geometry generates droplets through a plug and squeeze mechanism.
  Lab on a chip 2012 Romero PA, Abate AR
• Drop formation in non-planar microfluidic devices.
  Lab on a chip 2012 Rotem A, Abate AR, Utada AS, Van Steijn V, Weitz DA
• Electrode-free picoinjection of microfluidic drops.
  Lab on a chip 2012 O'Donovan B, Eastburn DJ, Abate AR
• Microfluidic synthesis of advanced microparticles for encapsulation and controlled release.
  Lab on a chip 2012 Duncanson WJ, Lin T, Abate AR, Seiffert S, Shah RK, Weitz DA
• Experimental validation of plugging during drop formation in a T-junction.
  Lab on a chip 2012 Abate AR, Mary P, van Steijn V, Weitz DA
• High throughput production of single core double emulsions in a parallelized microfluidic device.
  Lab on a chip 2012 Romanowsky MB, Abate AR, Rotem A, Holtze C, Weitz DA
• Measuring the elastic modulus of microgels using microdrops.
  Soft Matter 2012 Adam R. Abate, Lloyd Han, Lihua Jin, Zhigang Suo, David A. Weitz
• Non-coalescence of oppositely charged droplets in pH-sensitive emulsions.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Liu T, Seiffert S, Thiele J, Abate AR, Weitz DA, Richtering W
• Efficient encapsulation with plug-triggered drop formation.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2011 Abate AR, Rotem A, Thiele J, Weitz DA
• Observation of spatial propagation of amyloid assembly from single nuclei.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Knowles TP, White DA, Abate AR, Agresti JJ, Cohen SI, Sperling RA, De Genst EJ, Dobson CM, Weitz DA
• Early development drug formulation on a chip: fabrication of nanoparticles using a microfluidic spray dryer.
  Lab on a chip 2011 Thiele J, Windbergs M, Abate AR, Trebbin M, Shum HC, Förster S, Weitz DA
• On-chip background noise reduction for cell-based assays in droplets.
  Lab on a chip 2011 Mary P, Chen A, Chen I, Abate AR, Weitz DA
• Faster multiple emulsification with drop splitting.
  Lab on a chip 2011 Abate AR, Weitz DA
• Controlling droplet incubation using close-packed plug flow.
  Biomicrofluidics 2011 Mary P, Abate AR, Agresti JJ, Weitz DA
• Air-bubble-triggered drop formation in microfluidics.
  Lab on a chip 2011 Abate AR, Weitz DA
• Syringe-vacuum microfluidics: A portable technique to create monodisperse emulsions.
  Biomicrofluidics 2011 Abate AR, Weitz DA
• Synthesis of monodisperse microparticles from non-Newtonian polymer solutions with microfluidic devices.
  Advanced materials (Deerfield Beach, Fla.) 2011 Abate AR, Kutsovsky M, Seiffert S, Windbergs M, Pinto LF, Rotem A, Utada AS, Weitz DA
• One-step formation of multiple emulsions in microfluidics.
  Lab on a chip 2010 Abate AR, Thiele J, Weitz DA
• High-throughput injection with microfluidics using picoinjectors.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Abate AR, Hung T, Mary P, Agresti JJ, Weitz DA
• Fabrication of polymersomes using double-emulsion templates in glass-coated stamped microfluidic devices.
  Small (Weinheim an der Bergstrasse, Germany) 2010 Thiele J, Abate AR, Shum HC, Bachtler S, Förster S, Weitz DA
• Patterning microfluidic device wettability using flow confinement.
  Lab on a chip 2010 Abate AR, Thiele J, Weinhart M, Weitz DA
• Microfluidic sorting with high-speed single-layer membrane valves.
  Applied Physics Letters 2010 Adam R. Abate, Jeremy J. Agresti, David A. Weitz
• Smart microgel capsules from macromolecular precursors.
  Journal of the American Chemical Society 2010 Seiffert S, Thiele J, Abate AR, Weitz DA
• Functional patterning of PDMS microfluidic devices using integrated chemo-masks.
  Lab on a chip 2010 Romanowsky MB, Heymann M, Abate AR, Krummel AT, Fraden S, Weitz DA
• Ultrahigh-throughput screening in drop-based microfluidics for directed evolution.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Agresti JJ, Antipov E, Abate AR, Ahn K, Rowat AC, Baret JC, Marquez M, Klibanov AM, Griffiths AD, Weitz DA
• High-throughput fluorescence detection using an integrated zone-plate array.
  Lab on a chip 2010 Schonbrun E, Abate AR, Steinvurzel PE, Weitz DA, Crozier KB
• Droplet microfluidics for fabrication of non-spherical particles.
  Macromolecular rapid communications 2009 Shum HC, Abate AR, Lee D, Studart AR, Wang B, Chen CH, Thiele J, Shah RK, Krummel A, Weitz DA
• Multiple emulsions: Small 18/2009.
  Small 2009 A. R. Abate, D. A. Weitz
• High-order multiple emulsions formed in poly(dimethylsiloxane) microfluidics.
  Small (Weinheim an der Bergstrasse, Germany) 2009 Abate AR, Weitz DA
• Magnetic Hydrogel Particles: Microfluidic Assembly of Magnetic Hydrogel Particles with Uniformly Anisotropic Structure (Adv. Mater. 31/2009).
  Advanced Materials 2009 Chia-Hung Chen, Adam R. Abate, Daeyeon Lee, Eugene M. Terentjev, David A. Weitz
• Microfluidic Assembly of Magnetic Hydrogel Particles with Uniformly Anisotropic Structure.
  Advanced Materials 2009 Chia-Hung Chen, Adam R. Abate, Daeyeon Lee, Eugene M. Terentjev, David A. Weitz
• Impact of inlet channel geometry on microfluidic drop formation.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2009 Abate AR, Poitzsch A, Hwang Y, Lee J, Czerwinska J, Weitz DA
• A multi-color fast-switching microfluidic droplet dye laser.
  Lab on a chip 2009 Tang SK, Li Z, Abate AR, Agresti JJ, Weitz DA, Psaltis D, Whitesides GM
• Beating Poisson encapsulation statistics using close-packed ordering.
  Lab on a chip 2009 Abate AR, Chen CH, Agresti JJ, Weitz DA
• Surface acoustic wave (SAW) directed droplet flow in microfluidics for PDMS devices.
  Lab on a chip 2009 Franke T, Abate AR, Weitz DA, Wixforth A
• Janus particles templated from double emulsion droplets generated using microfluidics.
  Langmuir : the ACS journal of surfaces and colloids 2009 Chen CH, Shah RK, Abate AR, Weitz DA
• Valve-based flow focusing for drop formation.
  Applied Physics Letters 2009 Adam R. Abate, Mark B. Romanowsky, Jeremy J. Agresti, David A. Weitz
• Effective temperatures and activated dynamics for a two-dimensional air-driven granular system on two approaches to jamming.
  Physical review letters 2008 Abate AR, Durian DJ
• Photoreactive coating for high-contrast spatial patterning of microfluidic device wettability.
  Lab on a chip 2008 Abate AR, Krummel AT, Lee D, Marquez M, Holtze C, Weitz DA
• Single-layer membrane valves for elastomeric microfluidic devices.
  Applied Physics Letters 2008 A. R. Abate, D. A. Weitz
• Glass coating for PDMS microfluidic channels by sol-gel methods.
  Lab on a chip 2008 Abate AR, Lee D, Do T, Holtze C, Weitz DA
• Avalanche statistics and time-resolved grain dynamics for a driven heap.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2007 Abate AR, Katsuragi H, Durian DJ
• Spatially heterogeneous dynamics in a granular system near jamming.
  Chaos (Woodbury, N.Y.) 2007 Abate AR, Durian DJ
• Topological persistence and dynamical heterogeneities near jamming.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2007 Abate AR, Durian DJ
• Approach to jamming in an air-fluidized granular bed.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2006 Abate AR, Durian DJ
• Partition of energy for air-fluidized grains.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2005 Abate AR, Durian DJ
• Penetration depth for shallow impact cratering.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2005 Ambroso MA, Santore CR, Abate AR, Durian DJ
• Statistical characterization of the forces on spheres in an upflow of air.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2005 Ojha RP, Abate AR, Durian DJ
• Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.
  Life sciences 1998 Abate A, Schröder H
• Aspirin protects endothelial cells from oxidative stress--possible synergism with vitamin E.
  FEBS letters 1997 Podhaisky HP, Abate A, Polte T, Oberle S, Schröder H
• Photoactivation of the nitric oxide donor SIN-1.
  FEBS letters 1997 Ullrich T, Oberle S, Abate A, Schröder H