Abul Abbas, MBBS
Professor
Pathology
School of Medicine
Awards
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- Fellow, American Academy of Arts and Sciences, 2009
- Rous-Whipple Award, American Society of Investigative Pathology, 2008
- Outstanding Lecture Series, UCSF, 2008
- Member, Institute of Medicine, National Academy of Sciences, 2002
- Outstanding Lecture Series, UCSF, 2002
- Faculty Prize for Excellence in Teaching, Harvard Medical School, 1994
- Warner-Lambert/Parke-Davis Award, American Society of Investigative Pathology, 1987
Websites
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- Dr. Abbas’ Elsevier Author's (elsevierauthors.com)
Grants and Projects
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- FOCIS 2014 - 2018: The 14th through 18th Annual Meetings of the Federation of Cli, NIH, 2009-2019
- Autoimmunity Center of Excellence, NIH, 2003-2015
- Interleukin-2 and autoimmune disease, NIH, 2007-2013
- Immune Tolerance and Autoimmunity, NIH, 1900-2012
- Immunodeficiency and Autoimmunity, NIH, 2005-2011
- 13th International Congress of Immunology, NIH, 2007-2008
- Regulation of Lymphocyte Apoptosis, NIH, 1998-2006
- Memory T Cell Development, NIH, 2000-2005
- Function and Activation of Helper T Lymphocytes, NIH, 1987-2004
- Cellular and Molecular Mechanisms of Autoimmunity, NIH, 1993-2002
- Mechanisms in the Genration of Protective Immunity, NIH, 1995-2000
- Regulatory Mechanisms in Antibody Production, NIH, 1986-1996
- Function and Activation of Helper T Lymphocytes, NIH, 1987-1993
- Pathology B Study Section, NIH, 1986-1991
- Virus Transformed Hapten-specific B Lymphocyte Lines, NIH, 1987-1988
- Virus Transformed Hapten-specific B Lymphocyte Lines, NIH, 1985-1986
- Regulatory Mechanisms in Antibody Production, NIH, 1985-1986
Publications (73)
Top publication keywords:
Immune ToleranceAutoimmunityCTLA-4 AntigenT-Lymphocyte SubsetsT-Lymphocytes, RegulatoryReceptors, Interleukin-2Autoimmune DiseasesMice, Inbred BALB CInterleukin-2Th1 CellsAutoantigensT-LymphocytesCD4-Positive T-LymphocytesImmunologic MemoryLymphocyte Activation
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Chance and Opportunity: A Personal Story.
Annual review of pathology 2024 Abbas AK -
Cutting Edge: Tissue Antigen Expression Levels Fine-Tune T Cell Differentiation Decisions In Vivo.
Journal of immunology (Baltimore, Md. : 1950) 2020 Pinheiro DF, Szenes-Nagy AB, Maurano MM, Lietzenmayer M, Klicznik MM, Holly R, Kirchmeier D, Kitzmueller S, Achatz-Straussberger G, Rosenblum MD, Thalhamer J, Abbas AK, Gratz IK -
The Surprising Story of IL-2: From Experimental Models to Clinical Application.
The American journal of pathology 2020 Abbas AK -
Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair.
Immunity 2019 Mathur AN, Zirak B, Boothby IC, Tan M, Cohen JN, Mauro TM, Mehta P, Lowe MM, Abbas AK, Ali N, Rosenblum MD -
HARNESSING THE IMMUNE RESPONSE: BASIC PRINCIPLES AND THERAPEUTIC APPLICATIONS.
Transactions of the American Clinical and Climatological Association 2019 Abbas AK
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Revisiting IL-2: Biology and therapeutic prospects.
Science immunology 2018 Abbas AK, Trotta E, R Simeonov D, Marson A, Bluestone JA -
Skin-Resident T Cells Drive Dermal Dendritic Cell Migration in Response to Tissue Self-Antigen.
Journal of immunology (Baltimore, Md. : 1950) 2018 Ali N, Zirak B, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD -
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.
Frontiers in immunology 2018 Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, … -
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
Cell 2017 Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, … -
Promoting immunology: The future is here.
Science immunology 2016 Colmone AC, Sallusto F, Abbas AK -
Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.
Journal of immunology (Baltimore, Md. : 1950) 2016 Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD -
Regulatory T cell memory.
Nature reviews. Immunology 2015 Rosenblum MD, Way SS, Abbas AK -
A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.
Immunity 2015 Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD -
Mechanisms of human autoimmunity.
The Journal of clinical investigation 2015 Rosenblum MD, Remedios KA, Abbas AK -
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases.
Nature reviews. Immunology 2015 Klatzmann D, Abbas AK -
Memory regulatory T cells reside in human skin.
The Journal of clinical investigation 2014 Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, … -
Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.
Journal of immunology (Baltimore, Md. : 1950) 2014 Gratz IK, Rosenblum MD, Maurano MM, Paw JS, Truong HA, Marshak-Rothstein A, Abbas AK -
Regulatory T cells: recommendations to simplify the nomenclature.
Nature immunology 2013 Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF -
Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.
Journal of immunology (Baltimore, Md. : 1950) 2013 Gratz IK, Truong HA, Yang SH, Maurano MM, Lee K, Abbas AK, Rosenblum MD -
The life of regulatory T cells.
Annals of the New York Academy of Sciences 2013 Gratz IK, Rosenblum MD, Abbas AK -
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2012 Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H -
A resource for the conditional ablation of microRNAs in the mouse.
Cell reports 2012 Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus… -
Treating human autoimmunity: current practice and future prospects.
Science translational medicine 2012 Rosenblum MD, Gratz IK, Paw JS, Abbas AK -
Response to self antigen imprints regulatory memory in tissues.
Nature 2011 Rosenblum MD, Gratz IK, Paw JS, Lee K, Marshak-Rothstein A, Abbas AK -
A network of regulatory pathways in lepromatous leprosy.
Clinical immunology (Orlando, Fla.) 2011 Abbas AK -
Opposing functions of IL-2 and IL-7 in the regulation of immune responses.
Cytokine 2011 Katzman SD, Hoyer KK, Dooms H, Gratz IK, Rosenblum MD, Paw JS, Isakson SH, Abbas AK -
Differential requirements for Th1 and Th17 responses to a systemic self-antigen.
Journal of immunology (Baltimore, Md. : 1950) 2011 Katzman SD, Gallo E, Hoyer KK, Abbas AK -
Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells.
Immunity 2011 Villarino AV, Katzman SD, Gallo E, Miller O, Jiang S, McManus MT, Abbas AK -
Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2010 Barron L, Dooms H, Hoyer KK, Kuswanto W, Hofmann J, O'Gorman WE, Abbas AK -
STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2010 Villarino AV, Gallo E, Abbas AK -
Duration of antigen receptor signaling determines T-cell tolerance or activation.
Proceedings of the National Academy of Sciences of the United States of America 2010 Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK -
Revisiting the role of IL-2 in autoimmunity.
European journal of immunology 2010 Dooms H, Abbas AK -
Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009 Caretto D, Katzman SD, Villarino AV, Gallo E, Abbas AK -
The initial phase of an immune response functions to activate regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009 O'Gorman WE, Dooms H, Thorne SH, Kuswanto WF, Simonds EF, Krutzik PO, Nolan GP, Abbas AK -
Balance of Th1 and Th17 effector and peripheral regulatory T cells.
Microbes and infection 2009 Lohr J, Knoechel B, Caretto D, Abbas AK -
Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2009 Schmidt EM, Wang CJ, Ryan GA, Clough LE, Qureshi OS, Goodall M, Abbas AK, Sharpe AH, Sansom DM, Walker LS -
Interleukin-2 in the development and control of inflammatory disease.
Immunological reviews 2008 Hoyer KK, Dooms H, Barron L, Abbas AK -
Distinct roles of helper T-cell subsets in a systemic autoimmune disease.
Blood 2008 Hoyer KK, Kuswanto WF, Gallo E, Abbas AK -
Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2008 Barron L, Knoechel B, Lohr J, Abbas AK -
Pillars article: antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. 1984.
Journal of immunology (Baltimore, Md. : 1950) 2007 Rock KL, Benacerraf B, Abbas AK -
Role of T cells in a murine model of Escherichia coli sepsis.
European journal of immunology 2007 van Schaik SM, Abbas AK -
Targeting T cell-specific costimulators and growth factors in a model of autoimmune hemolytic anemia.
Journal of immunology (Baltimore, Md. : 1950) 2007 Hoyer KK, Wolslegel K, Dooms H, Abbas AK -
Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2007 Bour-Jordan H, Salomon BL, Thompson HL, Santos R, Abbas AK, Bluestone JA -
Balancing autoaggressive and protective T cell responses.
Journal of autoimmunity 2007 Abbas AK, Lohr J, Knoechel B -
Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells.
The Journal of experimental medicine 2007 Dooms H, Wolslegel K, Lin P, Abbas AK -
Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease.
The Journal of experimental medicine 2006 Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK -
T-cell costimulation--biology, therapeutic potential, and challenges.
The New England journal of medicine 2006 Sharpe AH, Abbas AK -
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
The Journal of clinical investigation 2006 Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA -
Regulatory T cells in the periphery.
Immunological reviews 2006 Lohr J, Knoechel B, Abbas AK -
Control of CD4+ T-cell memory by cytokines and costimulators.
Immunological reviews 2006 Dooms H, Abbas AK -
Functional and molecular comparison of anergic and regulatory T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006 Knoechel B, Lohr J, Zhu S, Wong L, Hu D, Ausubel L, Abbas AK -
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
The Journal of experimental medicine 2005 Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK -
B7-independent inhibition of T cells by CTLA-4.
Journal of immunology (Baltimore, Md. : 1950) 2005 Chikuma S, Abbas AK, Bluestone JA -
The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2005 Knoechel B, Lohr J, Kahn E, Abbas AK -
Paths to understanding the genetic basis of autoimmune disease.
Nature 2005 Rioux JD, Abbas AK -
T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens.
Immunological reviews 2005 Lohr J, Knoechel B, Nagabhushanam V, Abbas AK -
Dendritic cells giveth and taketh away.
Nature immunology 2005 Abbas AK, Sharpe AH -
T cell tolerance and autoimmunity.
Autoimmunity reviews 2004 Abbas AK, Lohr J, Knoechel B, Nagabhushanam V -
Role of B7 in T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2004 Lohr J, Knoechel B, Kahn EC, Abbas AK -
CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion.
Journal of immunology (Baltimore, Md. : 1950) 2004 Sarween N, Chodos A, Raykundalia C, Khan M, Abbas AK, Walker LS -
Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen.
The Journal of experimental medicine 2004 Eggena MP, Walker LS, Nagabhushanam V, Barron L, Chodos A, Abbas AK -
CD28 signals in the immature immunological synapse.
Journal of immunology (Baltimore, Md. : 1950) 2004 Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas AK, Krummel MF -
IL-2 induces a competitive survival advantage in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004 Dooms H, Kahn E, Knoechel B, Abbas AK -
Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.
Nature immunology 2004 Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK -
Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo.
The Journal of experimental medicine 2003 Walker LS, Chodos A, Eggena M, Dooms H, Abbas AK -
The activation of lymphocytes is in their CARMA.
Immunity 2003 Abbas AK, Sen R -
The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens.
Nature immunology 2003 Lohr J, Knoechel B, Jiang S, Sharpe AH, Abbas AK -
The control of T cell activation vs. tolerance.
Autoimmunity reviews 2003 Abbas AK -
Natural versus adaptive regulatory T cells.
Nature reviews. Immunology 2003 Bluestone JA, Abbas AK -
Functional tolerance is maintained despite proliferation of CD4 T cells after encounter with tissue-derived antigen.
Developmental immunology 2002 Ausubel LJ, Chodos A, Bekarian N, Abbas AK, Walker LS -
The enemy within: keeping self-reactive T cells at bay in the periphery.
Nature reviews. Immunology 2002 Walker LS, Abbas AK -
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines.
Nature immunology 2001 Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A -
Immunology: improving on nature in the twenty-first century.
Cell 2000 Abbas AK, Janeway CA