Abhijit Satpati, PhD
Postdoctoral Scholar
Neurology
School of Medicine
Dr. Satpati received his Master of Science (Zoology) and Ph.D. (Zoology) degrees from Bangalore University, India. His Ph.D.
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thesis was on the neuroprotective potential of endurance exercise and grape seed polyphenols, emphasizing the role of oxidative stress-associated changes in the expression of the muscarinic cholinergic receptor (m1) across different subfields of the hippocampus and medial prefrontal cortex in aging rats. He is particularly interested to understand the molecular mechanisms associated with selective neuronal vulnerability. In 2019 he joined the Department of Biomedical Sciences at the University of North Dakota as a post-doctoral fellow. He identified Group A Streptococcus infection mediated peripheral inflammation-induced reactive astrogliosis in the hippocampus and cerebral cortex is HLA-II and sex-dependent. He joined the Grinberg Lab in 2021 and is utilizing the quantitative stereology method to study the changes in wake-promoting histaminergic neurons in progressive Alzheimer’s disease and other neurodegenerative disorders.
Education & Training
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- Ph.D Zoology Bangalore University 04/2019
- Master of Science Zoology Bangalore University 07/2009
Interests
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- Neurodegeneration
- neuronal-astrocyte interaction
- progressive AD
- Sleep and Exercise physiology
Publications (9)
Top publication keywords:
MiceHumansMacrophagesMice, Inbred C57BLBrainBiomarkersZincGram-Negative Bacterial InfectionsAlzheimer DiseaseDisease ProgressionAnimalsInflammasomesCaspases
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The wake and sleep-modulating neurons of the lateral hypothalamic area demonstrate a differential pattern of degeneration in Alzheimer's disease.
bioRxiv : the preprint server for biology 2024 Satpati A, Soloviev AV, Pereira FL, Mladinov M, Larsen E, Leite REP, Suemoto CK, Rodriguez RD, Paes VR, Walsh C, Spina S, Seeley WW, Pasqualucci CA, Filho WJ, Neylan TC, Grinberg LT -
Histaminergic neurotransmission in aging and Alzheimer's disease: A review of therapeutic opportunities and gaps.
Alzheimer's & dementia (New York, N. Y.) 2023 Satpati A, Neylan T, Grinberg LT -
Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgàs N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hämmerer D, Leiman M, Counts SE, Shine JM, … -
Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.
Frontiers in immunology 2021 Chowdhury D, Gardner JC, Satpati A, Nookala S, Mukundan S, Porollo A, Landero Figueroa JA, Subramanian Vignesh K -
Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat
Methods in Molecular Biology. Clinical and Preclinical Models for Maximizing Healthspan. (Ed) Paul C. Guest 2020 S Asha Devi, S Abhijit
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Grape seed proanthocyanidin extract and swimming training enhances neuronal number in dorso-medial prefrontal cortex in middle-aged male rats by alleviating oxidative stress
Journal of Functional Foods 2019 S. Abhijit, Sunil Jamuna Tripathi, B.S. Shankaranarayana Rao, S. Asha Devi -
Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle-aged rats
Experimental Gerontology 2017 S. Abhijit, Sunil Jamuna Tripathi, Bhagya V., Shankaranarayana Rao B.S., Muthangi V. Subramanyam, S. Asha Devi -
Grape Seed Proanthocyanidin and Swimming Exercise Protects Against Cognitive Decline: A Study on M1 Acetylcholine Receptors in Aging Male Rat Brain
Neurochemical Research 2017 Satpati Abhijit, Muthangi V. V. Subramanyam, Sambe Asha Devi -
Oxidative Stress and the Brain: An Insight into Cognitive Aging
Topics in Biomedical Gerontology. (Eds) Rath, P., Sharma, R., Prasad, S. 2016 Sambe Asha Devi, Abhijit Satpati