Abby Oehler
Staff Research Associate III
Institute for Neurodegenerative Diseases
School of Medicine

Publications (29)

Top publication keywords:
Encephalopathy, Bovine SpongiformArvicolinaePoint MutationCreutzfeldt-Jakob SyndromeAmidesPrion ProteinsMice, TransgenicPrPSc ProteinsMultiple System AtrophyNeurodegenerative DiseasesPrionsalpha-SynucleinPrion DiseasesBrainGerstmann-Straussler-Scheinker Disease

• Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.
  bioRxiv : the preprint server for biology 2023 Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE
• Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.
  PLoS pathogens 2020 Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB
• Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.
  Acta neuropathologica 2019 Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB
• Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB
• Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB

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• Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB
• Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.
  JAMA neurology 2017 Woerman AL, Patel S, Kazmi SA, Oehler A, Freyman Y, Espiritu L, Cotter R, Castaneda JA, Olson SH, Prusiner SB
• A novel vector for transgenesis in the rat CNS.
  Acta neuropathologica communications 2017 Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB
• Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.
  Journal of virology 2016 Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB
• Towards authentic transgenic mouse models of heritable PrP prion diseases.
  Acta neuropathologica 2016 Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB
• Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.
  The Journal of pharmacology and experimental therapeutics 2016 Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB
• Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases.
  Journal of neuropathology and experimental neurology 2016 Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, DeArmond SJ
• Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes.
  Journal of neuropathology and experimental neurology 2015 Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, DeArmond B, DeArmond SJ
• Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K
• Propagation of prions causing synucleinopathies in cultured cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K…
• Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
  The Journal of pharmacology and experimental therapeutics 2015 Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB
• White matter involvement in sporadic Creutzfeldt-Jakob disease.
  Brain : a journal of neurology 2014 Caverzasi E, Mandelli ML, DeArmond SJ, Hess CP, Vitali P, Papinutto N, Oehler A, Miller BL, Lobach IV, Bastianello S, Geschwind MD, Henry RG
• Convection-enhanced delivery of AAV2-PrPshRNA in prion-infected mice.
  PloS one 2014 Ahn M, Bajsarowicz K, Oehler A, Lemus A, Bankiewicz K, DeArmond SJ
• Evidence that bank vole PrP is a universal acceptor for prions.
  PLoS pathogens 2014 Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB
• Transmission of multiple system atrophy prions to transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB
• Drug resistance confounding prion therapeutics.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K
• Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
  The Journal of pharmacology and experimental therapeutics 2013 Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB
• Convergent replication of mouse synthetic prion strains.
  The American journal of pathology 2013 Ghaemmaghami S, Colby DW, Nguyen HO, Hayashi S, Oehler A, DeArmond SJ, Prusiner SB
• Chimeric elk/mouse prion proteins in transgenic mice.
  The Journal of general virology 2012 Tamgüney G, Giles K, Oehler A, Johnson NL, DeArmond SJ, Prusiner SB
• Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K
• Identification of I137M and other mutations that modulate incubation periods for two human prion strains.
  Journal of virology 2012 Giles K, De Nicola GF, Patel S, Glidden DV, Korth C, Oehler A, DeArmond SJ, Prusiner SB
• Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB
• Spontaneous generation of anchorless prions in transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K
• Protease-resistant prions selectively decrease Shadoo protein.
  PLoS pathogens 2011 Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB