Aartik Sarma, MD
Assistant Professor
Medicine
School of Medicine

I am a physician-scientist at UCSF and affiliate faculty in the UCSF/UC Berkeley Joint Program in Computational Precision Health. My NHLBI-funded research focuses on applying computational methods to understand the biology of critical illness and develop precision treatments for the patients I take care of in the medical and neurological ICUs at UCSF Parnassus.

Awards

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• Emerging Generation Award, American Society for Clinical Investigation, 2023

Education & Training

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• MAS Clinical and Epidemiologic Research UCSF 2023
• Fellowship Pulmonology and Critical Care Medicine UCSF 2020
• Residency Internal Medicine Massachusetts General Hospital 2017
• MD Harvard Medical School 2014
• ScB Public Policy, Biomedical Engineering Brown University 2008

Interests

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• COPD
• air pollution
• ARDS
• pneumonia
• COVID-19
• sepsis

Websites

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• Twitter (twitter.com)
• LinkedIn (linkedin.com)

Grants and Projects

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• Evolution and resolution of ARDS molecular phenotypes, NHLBI, 2023
• Transcriptomic signatures of airway inflammation in acute respiratory diseases, NIH, 2020-2022

Publications (28)

Top publication keywords:
Precision MedicineSepsisElectronic Nicotine Delivery SystemsTracheaPrimary Graft DysfunctionBiomarkersCritical IllnessProne PositionInventionsRespiratory InsufficiencyRNANucleic Acid Amplification TechniquesAcute Lung InjuryCritical CareBronchoscopy

• Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
  Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, …
• Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans.
  Research square 2024 Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA
• Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.
  American journal of respiratory and critical care medicine 2024 Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee…
• Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs.
  Annals of the American Thoracic Society 2024 Bain W, Bastarache JA, Sarma A, McElvaney NG, Baron RM, McVerry BJ, Kitsios GD
• A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
  iScience 2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, …

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• Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
  The Lancet. Respiratory medicine 2023 Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, …
• Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
  Research square 2023 Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK
• Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
  Frontiers in immunology 2023 Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA
• NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
  JCI insight 2022 Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, …
• Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.
  Nature microbiology 2022 Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, …
• Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
  American journal of physiology. Lung cellular and molecular physiology 2022 Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA
• Hyperinflammatory ARDS is characterized by interferon-stimulated gene expression, T-cell activation, and an altered metatranscriptome in tracheal aspirates
  medRxiv 2022 Aartik Sarma, Stephanie A. Christenson, Beth Shoshana Zha, Angela Oliveira Pisco, Lucile P.A. Neyton, Eran Mick, Pratik Sinha, Jennifer G. Wilson, Farzad Moazed, Aleksandra Leligdowicz, Manoj V. …
• Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
  The Lancet. Respiratory medicine 2022 Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz …
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, …
• Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study.
  Thorax 2021 Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB…
• The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils.
  ERJ open research 2021 Ditz B, Sarma A, Kerstjens HAM, Liesker JJW, Bathoorn E, Vonk JM, Bernal V, Horvatovich P, Guryev V, Caldera S, Langelier C, Faiz A, Christenson SA, van den Berge M
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson…
• Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention.
  JAMA internal medicine 2020 Sarma A, Calfee CS
• Biomarkers and Precision Medicine: State of the Art.
  Critical care clinics 2019 Sarma A, Calfee CS, Ware LB
• A Systems Approach to Healthcare Innovation Using the MIT Hacking Medicine Model.
  Cell systems 2017 Gubin TA, Iyer HP, Liew SN, Sarma A, Revelos A, Ribas J, Movassaghi B, Chu ZM, Khalid AN, Majmudar MD, Lee CX
• A novel subtyping assay for detection of Clostridium difficile virulence genes.
  The Journal of molecular diagnostics : JMD 2014 Angione SL, Sarma AA, Novikov A, Seward L, Fieber JH, Mermel LA, Tripathi A
• Abstract 344: Interoperator Variability and Physician Learning with Medical Devices: Experience with Three New Vascular Closure Devices.
  Circulation Cardiovascular Quality and Outcomes 2013 Aartik Sarma, Sharon-Lise T Normand, Laura A Hatfield, Michael E Matheny, Frederic S Resnic
• THE LEARNING CURVE FOR MEDICAL DEVICES: EXPERIENCE WITH VASCULAR CLOSURE DEVICES IN MASSACHUSETTS.
  Journal of the American College of Cardiology 2013 Aartik Sarma, Sharon-Lise T. Normand, Laura A. Hatfield, Michael E. Matheny, Frederic S. Resnic
• A systematic review of reported cost for smear and culture tests during multidrug-resistant tuberculosis treatment.
  PloS one 2013 Lu C, Liu Q, Sarma A, Fitzpatrick C, Falzon D, Mitnick CD
• A simple method for amplifying RNA targets (SMART).
  The Journal of molecular diagnostics : JMD 2012 McCalla SE, Ong C, Sarma A, Opal SM, Artenstein AW, Tripathi A
• Ligation with nucleic acid sequence-based amplification.
  The Journal of molecular diagnostics : JMD 2012 Ong C, Tai W, Sarma A, Opal SM, Artenstein AW, Tripathi A
• The state of health policy education in U.S. medical schools.
  The New England journal of medicine 2011 Mou D, Sarma A, Sethi R, Merryman R
• Early in vitro transcription termination in human H5 influenza viral RNA synthesis.
  Applied biochemistry and biotechnology 2011 Kerby MB, Sarma AA, Patel MS, Artenstein AW, Opal SM, Tripathi A