Aaron Scheffler, PhD, MS
Assistant Professor
Epidemiology & Biostatistics
School of Medicine

A central theme in my research is to provide computationally efficient methods for these rich data structures that maintain information along each dimension while simultaneously providing interpretable components and inferences. In addition, I apply techniques from statistics and machine learning including mixed effects models, gradient boosting, and tree based methods, to assist collaborators in psychiatry, neurology, oncology, and HIV/AIDS research.

• CAPER: patient preferences to inform nonsurgical treatment of chronic low back pain: a discrete-choice experiment.
  Pain medicine (Malden, Mass.) 2023 Wilson L, Zheng P, Ionova Y, Denham A, Yoo C, Ma Y, Greco CM, Hanmer J, Williams DA, Hassett AL, Scheffler AW, Valone F, Mehling W, Berven S, Lotz J, O'Neill C
• Neonatal brain MRI and short-term outcomes after acute provoked seizures.
  Journal of perinatology : official journal of the California Perinatal Association 2023 Li Y, Scheffler A, Barkovich AJ, Chang T, Chu CJ, Massey SL, Abend NS, Lemmon ME, Thomas C, Numis A, Franck LS, Rogers E, Callen A, McCulloch CE, Shellhaas RA, Glass HC
• Network anatomy in logopenic variant of primary progressive aphasia.
  Human brain mapping 2023 Mandelli ML, Lorca-Puls DL, Lukic S, Montembeault M, Gajardo-Vidal A, Licata A, Scheffler A, Battistella G, Grasso SM, Bogley R, Ratnasiri BM, La Joie R, Mundada NS, Europa E, Rabinovici G, Miller BL,…
• Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis.
  BMJ open 2023 Kane JC, Allen I, Fatch R, Scheffler A, Emenyonu N, Puryear SB, Chirayil P, So-Armah K, Kahler CW, Magidson JF, Conroy AA, Edelman EJ, Woolf-King S, Parry C, Kiene SM, Chamie G, Adong J, Go VF, Cook …
• A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases.
  The European respiratory journal 2023 Addante A, Raymond W, Gitlin I, Charbit A, Orain X, Scheffler AW, Kuppe A, Duerr J, Daniltchenko M, Drescher M, Graeber SY, Healy AM, Oscarson S, Fahy JV, Mall MA
• Network anatomy in logopenic variant of primary progressive aphasia.
  medRxiv : the preprint server for health sciences 2023 Mandelli ML, Lorca-Puls DL, Lukic S, Montembeault M, Gajardo-Vidal A, Licata A, Scheffler A, Battistella G, Grasso SM, Bogley R, Ratnasiri BM, La Joie R, Mundada NS, Europa E, Rabinovici G, Miller BL,…
• Modeling longitudinal trends in event-related potentials.
  2023 Damla Senturk, Aaron Scheffler
• Point-of-care motion capture and biomechanical assessment improve clinical utility of dynamic balance testing for lower extremity osteoarthritis.
  PLOS digital health 2022 Halvorson RT, Castillo FT, Ahamed F, Khattab K, Scheffler A, Matthew RP, Lotz J, Vail TP, Feeley BT, Bailey JF
• Mild hypoxic-ischemic encephalopathy (HIE): timing and pattern of MRI brain injury.
  Pediatric research 2022 Li Y, Wisnowski JL, Chalak L, Mathur AM, McKinstry RC, Licona G, Mayock DE, Chang T, Van Meurs KP, Wu TW, Ahmad KA, Cornet MC, Rao R, Scheffler A, Wu YW
• 5-Year Revision Rates After Elective Multilevel Lumbar/Thoracolumbar Instrumented Fusions in Older Patients: An Analysis of State Databases.
  The Journal of the American Academy of Orthopaedic Surgeons 2022 Cummins DD, Callahan M, Scheffler A, Theologis AA
• Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy.
  Journal for immunotherapy of cancer 2022 Weidhaas J, Marco N, Scheffler AW, Kalbasi A, Wilenius K, Rietdorf E, Gill J, Heilig M, Desler C, Chin RK, Kaprealian T, McCloskey S, Raldow A, Raja NP, Kesari S, Carrillo J, Drakaki A, Scholz M, …
• Covariate-adjusted hybrid principal components analysis for region-referenced functional EEG data.
  Statistics and its interface 2022 Scheffler AW, Dickinson A, DiStefano C, Jeste S, Sentürk D
• Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.
  Open forum infectious diseases 2021 Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Ngo LH, Deswal M, Munter SE, …
• BIOM-07. QUANTITATIVE MGMT PROMOTER METHYLATION INDEX INDICATES A NON-LINEAR PROGNOSTIC EFFECT IN GLIOBLASTOMA, SUGGESTING THAT USE OF OPTIMAL CUTOFF POINTS MAY BE CLINICALLY DISADVANTAGEOUS.
  Neuro-Oncology 2021 David Gibson, Akshay Ravi, Eduardo Rodriguez Almaraz, Susan Chang, Nancy Ann Oberheim-Bush, Jennie Taylor, Jennifer Clarke, David Solomon, Aaron Scheffler, John Witte, Hannah Lambing, Mitchel Berger, …
• Biomechanical changes in the lumbar spine following spaceflight and factors associated with postspaceflight disc herniation.
  The spine journal : official journal of the North American Spine Society 2021 Bailey JF, Nyayapati P, Johnson GTA, Dziesinski L, Scheffler AW, Crawford R, Scheuring R, O'Neill CW, Chang D, Hargens AR, Lotz JC
• Early Magnetic Resonance Imaging Predicts 30-Month Outcomes after Therapeutic Hypothermia for Neonatal Encephalopathy.
  The Journal of pediatrics 2021 Bach AM, Fang AY, Bonifacio S, Rogers EE, Scheffler A, Partridge JC, Xu D, Barkovich AJ, Ferriero DM, Glass HC, Gano D
• NGMA-6. Quantitative MGMT Promoter Methylation Index Indicates Non-Linear, Prognostic Effect in Glioblastoma.
  Neuro-Oncology Advances 2021 David Gibson, Akshay Ravi, Eduardo Rodriguez, Susan Chang, Nancy Bush, Jennie Taylor, Jennifer Clarke, David Solomon, Aaron Scheffler, John Witte, Hideho Okada, Mitchel Berger, Farid Chehab, Nicholas …
• Cortically constrained shape recognition: Automated white matter tract segmentation validated in the pediatric brain.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2021 Jordan KM, Lauricella M, Licata AE, Sacco S, Asteggiano C, Wang C, Sudarsan SP, Watson C, Scheffler AW, Battistella G, Miller ZA, Gorno-Tempini ML, Caverzasi E, Mandelli ML
• Functional connectivity during language processing in 3-month-old infants at familial risk for autism spectrum disorder.
  The European journal of neuroscience 2020 Tran XA, McDonald N, Dickinson A, Scheffler A, Frohlich J, Marin A, Kure Liu C, Nosco E, Sentürk D, Dapretto M, Spurling Jeste S
• A pilot randomized controlled trial (RCT) of daily versus weekly interactive voice response calls to support adherence among antiretroviral treatment patients in India.
  mHealth 2020 Swendeman D, Fehrenbacher AE, Roy S, Ray P, Sumstine S, Scheffler A, Das R, Jana S
• Properties of beta oscillations in Dup15q syndrome.
  Journal of neurodevelopmental disorders 2020 Saravanapandian V, Frohlich J, Hipp JF, Hyde C, Scheffler AW, Golshani P, Cook EH, Reiter LT, Senturk D, Jeste SS
• Day-to-Day Test-Retest Reliability of EEG Profiles in Children With Autism Spectrum Disorder and Typical Development.
  Frontiers in integrative neuroscience 2020 Levin AR, Naples AJ, Scheffler AW, Webb SJ, Shic F, Sugar CA, Murias M, Bernier RA, Chawarska K, Dawson G, Faja S, Jeste S, Nelson CA, McPartland JC, Sentürk D
• Covariate-Adjusted Hybrid Principal Components Analysis.
  2020 Aaron Wolfe Scheffler, Abigail Dickinson, Charlotte DiStefano, Shafali Jeste, Damla Sentürk
• Developmental Trajectories of Infants With Multiplex Family Risk for Autism: A Baby Siblings Research Consortium Study.
  JAMA neurology 2020 McDonald NM, Senturk D, Scheffler A, Brian JA, Carver LJ, Charman T, Chawarska K, Curtin S, Hertz-Piccioto I, Jones EJH, Klin A, Landa R, Messinger DS, Ozonoff S, Stone WL, Tager-Flusberg H, Webb SJ, …
• Hybrid principal components analysis for region-referenced longitudinal functional EEG data.
  Biostatistics (Oxford, England) 2020 Scheffler A, Telesca D, Li Q, Sugar CA, Distefano C, Jeste S, Sentürk D
• Covariate-adjusted region-referenced generalized functional linear model for EEG data.
  Statistics in medicine 2019 Scheffler AW, Telesca D, Sugar CA, Jeste S, Dickinson A, DiStefano C, Sentürk D
• A germline microRNA-based biomarker signature of immune-associated toxicity to anti-PD1/PDL1 therapy.
  Journal of Clinical Oncology 2019 Joanne B. Weidhaas, Aaron Wolfe Scheffler, David Salzman, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Mara Heilig, Mattias Pitka, Caroline Desler, Dan Ruan, Antoni Ribas, Alexandra Drakaki, Mark C.…
• Interhemispheric alpha-band hypoconnectivity in children with autism spectrum disorder.
  Behavioural brain research 2018 Dickinson A, DiStefano C, Lin YY, Scheffler AW, Senturk D, Jeste SS
• Maternal patterns of antenatal and postnatal depressed mood and the impact on child health at 3-years postpartum.
  Journal of consulting and clinical psychology 2018 Rotheram-Fuller EJ, Tomlinson M, Scheffler A, Weichle TW, Hayati Rezvan P, Comulada WS, Rotheram-Borus MJ
• A microRNA-based signature predicting immune-related toxicity (iRAEs) to pembrolizumab in prostate cancer patients.
  Journal of Clinical Oncology 2018 Joanne B. Weidhaas, Kirk Wilenius, Aaron Wolfe Scheffler, Juliana Higa, Donatello Telesca, Mark C. Scholz
• Antenatal depressed mood and child cognitive and physical growth at 18-months in South Africa: a cluster randomised controlled trial of home visiting by community health workers.
  Epidemiology and psychiatric sciences 2017 Tomlinson M, Rotheram-Borus MJ, Scheffler A, le Roux I
• Adjustment of a Population of South African Children of Mothers Living With/and Without HIV Through Three Years Post-Birth.
  AIDS and behavior 2017 Rotheram-Borus MJ, Tomlinson M, Scheffler A, Harris DM, Nelson S
• A multi-dimensional functional principal components analysis of EEG data.
  Biometrics 2017 Hasenstab K, Scheffler A, Telesca D, Sugar CA, Jeste S, DiStefano C, Sentürk D
• Thirty-Six-Month Outcomes of a Generalist Paraprofessional Perinatal Home Visiting Intervention in South Africa on Maternal Health and Child Health and Development.
  Prevention science : the official journal of the Society for Prevention Research 2016 Tomlinson M, Rotheram-Borus MJ, le Roux IM, Youssef M, Nelson SH, Scheffler A, Weiss RE, O'Connor M, Worthman CM
• Drug use and emotional distress differentiate unstably- versus stably-housed adults living with HIV who engage in unprotected sex.
  Journal of health psychology 2016 Arnold EM, Desmond KA, Rotheram-Borus MJ, Scheffler A, Comulada WS, Johnson MO, Kelly JA, Healthy Living Project Group
• Re-engagement in HIV care among mothers living with HIV in South Africa over 36 months post-birth.
  AIDS (London, England) 2015 Rotheram-Borus MJ, Tomlinson M, Scheffler A, Le Roux IM
• Smartphone self-monitoring to support self-management among people living with HIV: perceived benefits and theory of change from a mixed-methods randomized pilot study.
  Journal of acquired immune deficiency syndromes (1999) 2015 Swendeman D, Ramanathan N, Baetscher L, Medich M, Scheffler A, Comulada WS, Estrin D